ID	Description	NES	pvalue	p.adjust	GeneRatio	BgRatio	geneID	geneName	Count
REACTOME_8941333	RUNX2 regulates genes involved in differentiation of myeloid cells	-5.4751807179825	0.00466298997665687	0.333061037954299	2/375	4/13181	861/860	RUNX1/RUNX2	2
REACTOME_8866376	Reelin signalling pathway	-3.58340143154845	0.00762570124716297	0.333061037954299	2/375	5/13181	5649/2534	RELN/FYN	2
REACTOME_2559585	Oncogene Induced Senescence	-5.56221542795548	0.00872374194974851	0.333061037954299	4/375	29/13181	4193/5925/1871/7027	MDM2/RB1/E2F3/TFDP1	4
REACTOME_2393930	Phosphate bond hydrolysis by NUDT proteins	-4.11753339957518	0.01122425092046	0.333061037954299	2/375	6/13181	11164/53343	NUDT5/NUDT9	2
REACTOME_6806942	MET Receptor Activation	-4.22648841214077	0.01122425092046	0.333061037954299	2/375	6/13181	3082/6692	HGF/SPINT1	2
REACTOME_9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	-4.64186749738011	0.0115470698144789	0.333061037954299	3/375	17/13181	5925/1871/7027	RB1/E2F3/TFDP1	3
REACTOME_8854518	AURKA Activation by TPX2	-7.13511371350943	0.0134694551003338	0.333061037954299	5/375	50/13181	80321/95681/8655/10142/3161	CEP70/CEP41/DYNLL1/AKAP9/HMMR	5
REACTOME_5576890	Phase 3 - rapid repolarisation	-4.01715396134881	0.0154202554366694	0.333061037954299	2/375	7/13181	23704/10142	KCNE4/AKAP9	2
REACTOME_8939246	RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	-5.4751807179825	0.0154202554366694	0.333061037954299	2/375	7/13181	861/860	RUNX1/RUNX2	2
REACTOME_2299718	Condensation of Prophase Chromosomes	-3.80509568853209	0.0201769906307888	0.333061037954299	2/375	8/13181	5925/6418	RB1/SET	2
REACTOME_69231	Cyclin D associated events in G1	-5.48121463609762	0.0242152697300412	0.333061037954299	4/375	39/13181	5520/5925/1871/7027	PPP2R2A/RB1/E2F3/TFDP1	4
REACTOME_2559580	Oxidative Stress Induced Senescence	-6.63498022723778	0.0242617801883516	0.333061037954299	5/375	58/13181	4193/1871/1912/23512/7027	MDM2/E2F3/PHC2/SUZ12/TFDP1	5
REACTOME_113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	-3.61721927337538	0.0254593287886856	0.333061037954299	2/375	9/13181	5925/7027	RB1/TFDP1	2
REACTOME_1614558	Degradation of cysteine and homocysteine	-3.72112230572056	0.0254593287886856	0.333061037954299	2/375	9/13181	7263/1491	TST/CTH	2
REACTOME_1614603	Cysteine formation from homocysteine	-2.25882545267613	0.0284500417267278	0.333061037954299	1/375	1/13181	1491	CTH	1
REACTOME_4724289	Defective ALG6 causes ALG6-CDG (CDG-1c)	-4.20308521849728	0.0284500417267278	0.333061037954299	1/375	1/13181	29929	ALG6	1
REACTOME_5609978	Defective GALT can cause Galactosemia	-3.39929964429943	0.0284500417267278	0.333061037954299	1/375	1/13181	2592	GALT	1
REACTOME_5619062	Defective SLC1A3 causes episodic ataxia 6 (EA6)	-2.83109600356936	0.0284500417267278	0.333061037954299	1/375	1/13181	6507	SLC1A3	1
REACTOME_5619078	Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)	-3.3223790735698	0.0284500417267278	0.333061037954299	1/375	1/13181	55343	SLC35C1	1
REACTOME_9661070	Defective translocation of RB1 mutants to the nucleus	-2.57462628526921	0.0284500417267278	0.333061037954299	1/375	1/13181	5925	RB1	1
REACTOME_9673163	Oleoyl-phe metabolism	-2.25940294090106	0.0284500417267278	0.333061037954299	1/375	1/13181	148811	PM20D1	1
REACTOME_9674396	Imatinib-resistant PDGFR mutants	-2.41372563552681	0.0284500417267278	0.333061037954299	1/375	1/13181	5156	PDGFRA	1
REACTOME_9674401	Sunitinib-resistant PDGFR mutants	-2.41372563552681	0.0284500417267278	0.333061037954299	1/375	1/13181	5156	PDGFRA	1
REACTOME_9674403	Regorafenib-resistant PDGFR mutants	-2.41372563552681	0.0284500417267278	0.333061037954299	1/375	1/13181	5156	PDGFRA	1
REACTOME_9674404	Sorafenib-resistant PDGFR mutants	-2.41372563552681	0.0284500417267278	0.333061037954299	1/375	1/13181	5156	PDGFRA	1
REACTOME_9674428	PDGFR mutants bind TKIs	-2.41372563552681	0.0284500417267278	0.333061037954299	1/375	1/13181	5156	PDGFRA	1
REACTOME_192823	Viral mRNA Translation	-4.17606114611829	0.0312336779264997	0.333061037954299	2/375	10/13181	6146/5611	RPL22/DNAJC3	2
REACTOME_8877330	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	-5.54898650506432	0.0312336779264997	0.333061037954299	2/375	10/13181	861/1493	RUNX1/CTLA4	2
REACTOME_9687136	Aberrant regulation of mitotic exit in cancer due to RB1 defects	-3.66034694304722	0.0312336779264997	0.333061037954299	2/375	10/13181	5925/25906	RB1/ANAPC15	2
REACTOME_9700645	ALK mutants bind TKIs	-3.98393833542275	0.0312336779264997	0.333061037954299	2/375	10/13181	5573/53335	PRKAR1A/BCL11A	2
REACTOME_2467813	Separation of Sister Chromatids	-8.48847236025462	0.0431213932868736	0.333061037954299	6/375	90/13181	23421/23244/8655/25906/91687/79023	ITGB3BP/PDS5A/DYNLL1/ANAPC15/CENPL/NUP37	6
REACTOME_205043	NRIF signals cell death from the nucleus	-3.97639594447934	0.0441313705001536	0.333061037954299	2/375	12/13181	23385/23421	NCSTN/ITGB3BP	2
REACTOME_72689	Formation of a pool of free 40S subunits	-3.85791949974218	0.0441313705001536	0.333061037954299	2/375	12/13181	8669/6146	EIF3J/RPL22	2
REACTOME_8953750	Transcriptional Regulation by E2F6	-4.73041527933534	0.044250998803149	0.333061037954299	3/375	28/13181	317/23512/7027	APAF1/SUZ12/TFDP1	3
REACTOME_9616222	Transcriptional regulation of granulopoiesis	-7.52746908825173	0.0483502976708491	0.333061037954299	3/375	29/13181	4602/861/7027	MYB/RUNX1/TFDP1	3
REACTOME_380259	Loss of Nlp from mitotic centrosomes	-5.96540155008754	0.0501224848127676	0.333061037954299	4/375	49/13181	80321/95681/8655/10142	CEP70/CEP41/DYNLL1/AKAP9	4
REACTOME_380284	Loss of proteins required for interphase microtubule organization from the centrosome	-5.96540155008754	0.0501224848127676	0.333061037954299	4/375	49/13181	80321/95681/8655/10142	CEP70/CEP41/DYNLL1/AKAP9	4
REACTOME_2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	-3.67230649742619	0.0511946917781321	0.333061037954299	2/375	13/13181	860/6910	RUNX2/TBX5	2
REACTOME_399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	-3.64688453474243	0.0511946917781321	0.333061037954299	2/375	13/13181	2534/5362	FYN/PLXNA2	2
REACTOME_2500257	Resolution of Sister Chromatid Cohesion	-7.94597208203594	0.0513563687261156	0.333061037954299	5/375	71/13181	23421/23244/8655/91687/79023	ITGB3BP/PDS5A/DYNLL1/CENPL/NUP37	5
REACTOME_168638	NOD1/2 Signaling Pathway	-6.15467274447011	0.0526287122940214	0.333061037954299	3/375	30/13181	7128/5603/64127	TNFAIP3/MAPK13/NOD2	3
REACTOME_111446	Activation of BIM and translocation to mitochondria 	-2.56133329658573	0.0560927757443664	0.333061037954299	1/375	2/13181	8655	DYNLL1	1
REACTOME_198765	Signalling to ERK5	-2.42881546914345	0.0560927757443664	0.333061037954299	1/375	2/13181	5607	MAP2K5	1
REACTOME_73943	Reversal of alkylation damage by DNA dioxygenases	-2.61799871702636	0.0560927757443664	0.333061037954299	1/375	2/13181	54890	ALKBH5	1
REACTOME_75102	C6 deamination of adenosine	-2.23360671949344	0.0560927757443664	0.333061037954299	1/375	2/13181	103	ADAR	1
REACTOME_77042	Formation of editosomes by ADAR proteins	-2.23360671949344	0.0560927757443664	0.333061037954299	1/375	2/13181	103	ADAR	1
REACTOME_9026357	NTF4 activates NTRK2 (TRKB) signaling	-3.67520369446941	0.0560927757443664	0.333061037954299	1/375	2/13181	4909	NTF4	1
REACTOME_916853	Degradation of GABA	-4.29826952001635	0.0560927757443664	0.333061037954299	1/375	2/13181	7915	ALDH5A1	1
REACTOME_141444	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal	-6.56032042385244	0.0566045654861682	0.333061037954299	4/375	51/13181	23421/8655/91687/79023	ITGB3BP/DYNLL1/CENPL/NUP37	4
REACTOME_196757	Metabolism of folate and pterines	-4.01998511406439	0.0586298726760953	0.333061037954299	2/375	14/13181	160428/1719	ALDH1L2/DHFR	2
REACTOME_5576893	Phase 2 - plateau phase	-4.01715396134881	0.0586298726760953	0.333061037954299	2/375	14/13181	23704/10142	KCNE4/AKAP9	2
REACTOME_606279	Deposition of new CENPA-containing nucleosomes at the centromere	-3.65147055691749	0.0586298726760953	0.333061037954299	2/375	14/13181	23421/91687	ITGB3BP/CENPL	2
REACTOME_380270	Recruitment of mitotic centrosome proteins and complexes	-5.96540155008754	0.0600064370116176	0.333061037954299	4/375	52/13181	80321/95681/8655/10142	CEP70/CEP41/DYNLL1/AKAP9	4
REACTOME_1912408	Pre-NOTCH Transcription and Translation	-6.13882799105743	0.0617099063835121	0.333061037954299	3/375	32/13181	861/1871/7027	RUNX1/E2F3/TFDP1	3
REACTOME_5620912	Anchoring of the basal body to the plasma membrane	-6.60290610087309	0.0651313768211387	0.333061037954299	5/375	76/13181	80321/95681/91147/8655/10142	CEP70/CEP41/TMEM67/DYNLL1/AKAP9	5
REACTOME_1433559	Regulation of KIT signaling	-3.87608955383772	0.0664101617537987	0.333061037954299	2/375	15/13181	2534/4254	FYN/KITLG	2
REACTOME_156827	L13a-mediated translational silencing of Ceruloplasmin expression	-3.85791949974218	0.0664101617537987	0.333061037954299	2/375	15/13181	8669/6146	EIF3J/RPL22	2
REACTOME_2995383	Initiation of Nuclear Envelope (NE) Reformation	-4.20995310074168	0.0664101617537987	0.333061037954299	2/375	15/13181	5520/7112	PPP2R2A/TMPO	2
REACTOME_399954	Sema3A PAK dependent Axon repulsion	-3.64688453474243	0.0664101617537987	0.333061037954299	2/375	15/13181	2534/5362	FYN/PLXNA2	2
REACTOME_399956	CRMPs in Sema3A signaling	-3.64688453474243	0.0664101617537987	0.333061037954299	2/375	15/13181	2534/5362	FYN/PLXNA2	2
REACTOME_429947	Deadenylation of mRNA	-3.99263408856753	0.0664101617537987	0.333061037954299	2/375	15/13181	23019/10605	CNOT1/PAIP1	2
REACTOME_72706	GTP hydrolysis and joining of the 60S ribosomal subunit	-3.85791949974218	0.0664101617537987	0.333061037954299	2/375	15/13181	8669/6146	EIF3J/RPL22	2
REACTOME_163125	Post-translational modification: synthesis of GPI-anchored proteins	-5.85231314942803	0.0671281031605599	0.333061037954299	4/375	54/13181	4061/420/338328/8581	LY6E/ART4/GPIHBP1/LY6D	4
REACTOME_5673001	RAF/MAP kinase cascade	-8.44086511647124	0.0682247638213543	0.333061037954299	7/375	126/13181	1739/3082/3718/5156/2534/284/4254	DLG1/HGF/JAK3/PDGFRA/FYN/ANGPT1/KITLG	7
REACTOME_877300	Interferon gamma signaling	-7.26188352432354	0.0742952461307537	0.333061037954299	5/375	79/13181	3660/10437/7726/3460/3134	IRF2/IFI30/TRIM26/IFNGR2/HLA-F	5
REACTOME_8876198	RAB GEFs exchange GTP for GDP on RABs	-6.58716420519488	0.0774979849145729	0.333061037954299	5/375	80/13181	25782/10890/5869/79961/9610	RAB3GAP2/RAB10/RAB5B/DENND2D/RIN1	5
REACTOME_4420097	VEGFA-VEGFR2 Pathway	-5.89456558714493	0.0826152232282768	0.333061037954299	4/375	58/13181	5603/2534/8936/6093	MAPK13/FYN/WASF1/ROCK1	4
REACTOME_6804756	Regulation of TP53 Activity through Phosphorylation	-7.06537124346287	0.0826152232282768	0.333061037954299	4/375	58/13181	4193/94241/5562/8148	MDM2/TP53INP1/PRKAA1/TAF15	4
REACTOME_399719	Trafficking of AMPA receptors	-3.65054899116554	0.08290508187665	0.333061037954299	2/375	17/13181	1739/4193	DLG1/MDM2	2
REACTOME_6807004	Negative regulation of MET activity	-4.51111892895607	0.08290508187665	0.333061037954299	2/375	17/13181	3082/6456	HGF/SH3GL2	2
REACTOME_8963889	Assembly of active LPL and LIPC lipase complexes	-4.01933689013633	0.08290508187665	0.333061037954299	2/375	17/13181	91289/338328	LMF2/GPIHBP1	2
REACTOME_417973	Adenosine P1 receptors	-2.21983188107921	0.0829510509622028	0.333061037954299	1/375	3/13181	134	ADORA1	1
REACTOME_844455	The NLRP1 inflammasome	-2.51863122763248	0.0829510509622028	0.333061037954299	1/375	3/13181	596	BCL2	1
REACTOME_8875791	MET activates STAT3	-3.31951231151986	0.0829510509622028	0.333061037954299	1/375	3/13181	3082	HGF	1
REACTOME_9026527	Activated NTRK2 signals through PLCG1	-3.67520369446941	0.0829510509622028	0.333061037954299	1/375	3/13181	4909	NTF4	1
REACTOME_964975	Vitamins B6 activation to pyridoxal phosphate	-2.5293912094284	0.0829510509622028	0.333061037954299	1/375	3/13181	55163	PNPO	1
REACTOME_2565942	Regulation of PLK1 Activity at G2/M Transition	-5.96540155008754	0.0867391311797298	0.342472635185437	4/375	59/13181	80321/95681/8655/10142	CEP70/CEP41/DYNLL1/AKAP9	4
REACTOME_4551638	SUMOylation of chromatin organization proteins	-6.16276312496987	0.0872965345290445	0.342472635185437	3/375	37/13181	1912/79023/23512	PHC2/NUP37/SUZ12	3
REACTOME_9725370	Signaling by ALK fusions and activated point mutants	-4.8919359486565	0.0872965345290445	0.342472635185437	3/375	37/13181	5573/53335/10342	PRKAR1A/BCL11A/TFG	3
REACTOME_909733	Interferon alpha/beta signaling	-5.89976341988527	0.0909611207869458	0.342472635185437	4/375	60/13181	103/3660/3454/3134	ADAR/IRF2/IFNAR1/HLA-F	4
REACTOME_69205	G1/S-Specific Transcription	-3.36005446014701	0.091572093539967	0.342472635185437	2/375	18/13181	1719/7027	DHFR/TFDP1	2
REACTOME_9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	-3.5364661941777	0.091572093539967	0.342472635185437	2/375	18/13181	6146/467	RPL22/ATF3	2
REACTOME_9664323	FCGR3A-mediated IL10 synthesis	-5.24355038146998	0.0928749245713212	0.342472635185437	3/375	38/13181	3710/5573/2534	ITPR3/PRKAR1A/FYN	3
REACTOME_8873719	RAB geranylgeranylation	-6.6358922706186	0.0952796593684886	0.342472635185437	4/375	61/13181	10890/5869/83871/8934	RAB10/RAB5B/RAB34/RAB29	4
REACTOME_380320	Recruitment of NuMA to mitotic centrosomes	-5.96540155008754	0.0996931370163826	0.342472635185437	4/375	62/13181	80321/95681/8655/10142	CEP70/CEP41/DYNLL1/AKAP9	4
REACTOME_3928664	Ephrin signaling	-3.91707029556092	0.100488885372371	0.342472635185437	2/375	19/13181	2534/6386	FYN/SDCBP	2
REACTOME_68877	Mitotic Prometaphase	-6.56032042385244	0.108798110610375	0.342472635185437	4/375	64/13181	23421/8655/91687/79023	ITGB3BP/DYNLL1/CENPL/NUP37	4
REACTOME_204626	Hypusine synthesis from eIF5A-lysine	-3.25209749725446	0.109047071290718	0.342472635185437	1/375	4/13181	56648	EIF5A2	1
REACTOME_210455	Astrocytic Glutamate-Glutamine Uptake And Metabolism	-2.83109600356936	0.109047071290718	0.342472635185437	1/375	4/13181	6507	SLC1A3	1
REACTOME_210746	Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	-3.43543939157937	0.109047071290718	0.342472635185437	1/375	4/13181	3642	INSM1	1
REACTOME_2142753	Arachidonic acid metabolism	-2.66136431153196	0.109047071290718	0.342472635185437	1/375	4/13181	158584	FAAH2	1
REACTOME_6787639	GDP-fucose biosynthesis	-3.3223790735698	0.109047071290718	0.342472635185437	1/375	4/13181	55343	SLC35C1	1
REACTOME_68911	G2 Phase	-2.43051208429189	0.109047071290718	0.342472635185437	1/375	4/13181	1871	E2F3	1
REACTOME_69200	Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	-2.57462628526921	0.109047071290718	0.342472635185437	1/375	4/13181	5925	RB1	1
REACTOME_71262	Carnitine synthesis	-3.08274551567582	0.109047071290718	0.342472635185437	1/375	4/13181	55217	TMLHE	1
REACTOME_8866906	TFAP2 (AP-2) family regulates transcription of other transcription factors	-3.36596039750666	0.109047071290718	0.342472635185437	1/375	4/13181	10370	CITED2	1
REACTOME_8985801	Regulation of cortical dendrite branching	-2.35763851839963	0.109047071290718	0.342472635185437	1/375	4/13181	6092	ROBO2	1
REACTOME_9032500	Activated NTRK2 signals through FYN	-2.25841398178445	0.109047071290718	0.342472635185437	1/375	4/13181	2534	FYN	1
REACTOME_9032759	NTRK2 activates RAC1	-2.25841398178445	0.109047071290718	0.342472635185437	1/375	4/13181	2534	FYN	1
REACTOME_9640463	Wax biosynthesis	-2.41791310708093	0.109047071290718	0.342472635185437	1/375	4/13181	84188	FAR1	1
REACTOME_9682706	Replication of the SARS-CoV-1 genome	-2.57462628526921	0.109047071290718	0.342472635185437	1/375	4/13181	5925	RB1	1
REACTOME_9694686	Replication of the SARS-CoV-2 genome	-2.57462628526921	0.109047071290718	0.342472635185437	1/375	4/13181	5925	RB1	1
REACTOME_2022870	Chondroitin sulfate biosynthesis	-5.16500923795603	0.109634321578231	0.342472635185437	2/375	20/13181	55790/51363	CSGALNACT1/CHST15	2
REACTOME_3232142	SUMOylation of ubiquitinylation proteins	-4.9439807541684	0.109634321578231	0.342472635185437	2/375	20/13181	4193/79023	MDM2/NUP37	2
REACTOME_114508	Effects of PIP2 hydrolysis	-4.48525646302463	0.118988261104546	0.362203115160261	2/375	21/13181	3710/1606	ITPR3/DGKA	2
REACTOME_389513	CTLA4 inhibitory signaling	-3.54879855743911	0.118988261104546	0.362203115160261	2/375	21/13181	1493/2534	CTLA4/FYN	2
REACTOME_5362517	Signaling by Retinoic Acid	-4.2407185601537	0.118988261104546	0.362203115160261	2/375	21/13181	6257/1375	RXRB/CPT1B	2
REACTOME_5365859	RA biosynthesis pathway	-3.89155949007296	0.118988261104546	0.362203115160261	2/375	21/13181	157506/127	RDH10/ADH4	2
REACTOME_5696394	DNA Damage Recognition in GG-NER	-4.06966908415973	0.118988261104546	0.362203115160261	2/375	21/13181	64708/54617	COPS7B/INO80	2
REACTOME_9648025	EML4 and NUDC in mitotic spindle formation	-6.56032042385244	0.128068955159738	0.362203115160261	4/375	68/13181	23421/8655/91687/79023	ITGB3BP/DYNLL1/CENPL/NUP37	4
REACTOME_1266695	Interleukin-7 signaling	-4.32034892570796	0.128531518396274	0.362203115160261	2/375	22/13181	3082/3718	HGF/JAK3	2
REACTOME_111448	Activation of NOXA and translocation to mitochondria	-2.1983231609498	0.134402413801606	0.362203115160261	1/375	5/13181	7027	TFDP1	1
REACTOME_1614517	Sulfide oxidation to sulfate	-2.65122486667562	0.134402413801606	0.362203115160261	1/375	5/13181	7263	TST	1
REACTOME_166166	MyD88-independent TLR4 cascade 	-3.05375985172521	0.134402413801606	0.362203115160261	1/375	5/13181	7099	TLR4	1
REACTOME_167242	Abortive elongation of HIV-1 transcript in the absence of Tat	-2.82127332505249	0.134402413801606	0.362203115160261	1/375	5/13181	6827	SUPT4H1	1
REACTOME_5676934	Protein repair	-2.38096700435765	0.134402413801606	0.362203115160261	1/375	5/13181	22921	MSRB2	1
REACTOME_70370	Galactose catabolism	-3.39929964429943	0.134402413801606	0.362203115160261	1/375	5/13181	2592	GALT	1
REACTOME_72695	Formation of the ternary complex, and subsequently, the 43S complex	-2.7032961607758	0.134402413801606	0.362203115160261	1/375	5/13181	8669	EIF3J	1
REACTOME_77310	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	-2.88769778064469	0.134402413801606	0.362203115160261	1/375	5/13181	3033	HADH	1
REACTOME_77348	Beta oxidation of octanoyl-CoA to hexanoyl-CoA	-2.88769778064469	0.134402413801606	0.362203115160261	1/375	5/13181	3033	HADH	1
REACTOME_77350	Beta oxidation of hexanoyl-CoA to butanoyl-CoA	-2.88769778064469	0.134402413801606	0.362203115160261	1/375	5/13181	3033	HADH	1
REACTOME_77352	Beta oxidation of butanoyl-CoA to acetyl-CoA	-2.88769778064469	0.134402413801606	0.362203115160261	1/375	5/13181	3033	HADH	1
REACTOME_8852405	Signaling by MST1	-2.25737258308986	0.134402413801606	0.362203115160261	1/375	5/13181	6692	SPINT1	1
REACTOME_8865999	MET activates PTPN11	-3.31951231151986	0.134402413801606	0.362203115160261	1/375	5/13181	3082	HGF	1
REACTOME_8875513	MET interacts with TNS proteins	-3.31951231151986	0.134402413801606	0.362203115160261	1/375	5/13181	3082	HGF	1
REACTOME_8935964	RUNX1 regulates expression of components of tight junctions	-4.89767780170851	0.134402413801606	0.362203115160261	1/375	5/13181	861	RUNX1	1
REACTOME_8939247	RUNX1 regulates transcription of genes involved in interleukin signaling	-4.89767780170851	0.134402413801606	0.362203115160261	1/375	5/13181	861	RUNX1	1
REACTOME_8941284	RUNX2 regulates chondrocyte maturation	-2.32686646858061	0.134402413801606	0.362203115160261	1/375	5/13181	860	RUNX2	1
REACTOME_8941326	RUNX2 regulates bone development	-2.32686646858061	0.134402413801606	0.362203115160261	1/375	5/13181	860	RUNX2	1
REACTOME_9031525	NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 	-2.33761000591826	0.134402413801606	0.362203115160261	1/375	5/13181	6257	RXRB	1
REACTOME_9031528	NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	-2.33761000591826	0.134402413801606	0.362203115160261	1/375	5/13181	6257	RXRB	1
REACTOME_9632974	NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis 	-2.33761000591826	0.134402413801606	0.362203115160261	1/375	5/13181	6257	RXRB	1
REACTOME_9667769	Acetylcholine inhibits contraction of outer hair cells	-3.10650521987013	0.134402413801606	0.362203115160261	1/375	5/13181	3778	KCNMA1	1
REACTOME_69202	Cyclin E associated events during G1/S transition 	-3.61721927337538	0.138245825570089	0.367618679492549	2/375	23/13181	5925/7027	RB1/TFDP1	2
REACTOME_8854691	Interleukin-20 family signaling	-4.37966175140715	0.138245825570089	0.367618679492549	2/375	23/13181	3718/11009	JAK3/IL24	2
REACTOME_975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	-3.58250719617338	0.138245825570089	0.367618679492549	2/375	23/13181	5520/6146	PPP2R2A/RPL22	2
REACTOME_983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	-4.55037023963623	0.138245825570089	0.367618679492549	2/375	23/13181	3134/10484	HLA-F/SEC23A	2
REACTOME_174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	-3.66034694304722	0.148113795957949	0.382557479184204	2/375	24/13181	5925/25906	RB1/ANAPC15	2
REACTOME_5620971	Pyroptosis	-3.54893280358324	0.148113795957949	0.382557479184204	2/375	24/13181	3660/1991	IRF2/ELANE	2
REACTOME_69656	Cyclin A:Cdk2-associated events at S phase entry	-3.61721927337538	0.148113795957949	0.382557479184204	2/375	24/13181	5925/7027	RB1/TFDP1	2
REACTOME_8940973	RUNX2 regulates osteoblast differentiation	-3.71463688382042	0.148113795957949	0.382557479184204	2/375	24/13181	5925/860	RB1/RUNX2	2
REACTOME_4570464	SUMOylation of RNA binding proteins	-5.11012716302331	0.158118888973476	0.382557479184204	2/375	25/13181	1912/79023	PHC2/NUP37	2
REACTOME_6807505	RNA polymerase II transcribes snRNA genes	-4.17398513562353	0.158118888973476	0.382557479184204	2/375	25/13181	5452/6827	POU2F2/SUPT4H1	2
REACTOME_111458	Formation of apoptosome	-2.32174739115976	0.159038046377836	0.382557479184204	1/375	6/13181	317	APAF1	1
REACTOME_111459	Activation of caspases through apoptosome-mediated cleavage	-2.32174739115976	0.159038046377836	0.382557479184204	1/375	6/13181	317	APAF1	1
REACTOME_2468052	Establishment of Sister Chromatid Cohesion	-3.70419977011851	0.159038046377836	0.382557479184204	1/375	6/13181	23244	PDS5A	1
REACTOME_2470946	Cohesin Loading onto Chromatin	-3.70419977011851	0.159038046377836	0.382557479184204	1/375	6/13181	23244	PDS5A	1
REACTOME_428890	Role of ABL in ROBO-SLIT signaling	-3.37024760049466	0.159038046377836	0.382557479184204	1/375	6/13181	27	ABL2	1
REACTOME_450520	HuR (ELAVL1) binds and stabilizes mRNA	-2.44622757699673	0.159038046377836	0.382557479184204	1/375	6/13181	6418	SET	1
REACTOME_5660668	CLEC7A/inflammasome pathway	-2.61060480780367	0.159038046377836	0.382557479184204	1/375	6/13181	10892	MALT1	1
REACTOME_77346	Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	-2.88769778064469	0.159038046377836	0.382557479184204	1/375	6/13181	3033	HADH	1
REACTOME_8851907	MET activates PI3K/AKT signaling	-3.31951231151986	0.159038046377836	0.382557479184204	1/375	6/13181	3082	HGF	1
REACTOME_8931987	RUNX1 regulates estrogen receptor mediated transcription	-4.89767780170851	0.159038046377836	0.382557479184204	1/375	6/13181	861	RUNX1	1
REACTOME_8939245	RUNX1 regulates transcription of genes involved in BCR signaling	-4.89767780170851	0.159038046377836	0.382557479184204	1/375	6/13181	861	RUNX1	1
REACTOME_8939256	RUNX1 regulates transcription of genes involved in WNT signaling	-4.89767780170851	0.159038046377836	0.382557479184204	1/375	6/13181	861	RUNX1	1
REACTOME_8964572	Lipid particle organization	-2.25688660910488	0.159038046377836	0.382557479184204	1/375	6/13181	1149	CIDEA	1
REACTOME_9028335	Activated NTRK2 signals through PI3K	-3.67520369446941	0.159038046377836	0.382557479184204	1/375	6/13181	4909	NTF4	1
REACTOME_9706374	FLT3 signaling through SRC family kinases	-2.25841398178445	0.159038046377836	0.382557479184204	1/375	6/13181	2534	FYN	1
REACTOME_2219530	Constitutive Signaling by Aberrant PI3K in Cancer	-6.23040707430441	0.164861640854947	0.394774109878562	4/375	75/13181	3082/5156/2534/4254	HGF/PDGFRA/FYN/KITLG	4
REACTOME_9679191	Potential therapeutics for SARS	-5.67446839312318	0.164861640854947	0.394774109878562	4/375	75/13181	3718/3454/3460/6093	JAK3/IFNAR1/IFNGR2/ROCK1	4
REACTOME_373080	Class B/2 (Secretin family receptors)	-4.40633190275904	0.176675998629048	0.395822052163494	3/375	51/13181	976/1604/2015	ADGRE5/CD55/ADGRE1	3
REACTOME_418990	Adherens junctions interactions	-4.16003036941312	0.178478309046191	0.395822052163494	2/375	27/13181	1013/1005	CDH15/CDH7	2
REACTOME_9619665	EGR2 and SOX10-mediated initiation of Schwann cell myelination	-4.52171601603862	0.178478309046191	0.395822052163494	2/375	27/13181	3915/5453	LAMC1/POU3F1	2
REACTOME_983231	Factors involved in megakaryocyte development and platelet production	-6.89963701364066	0.181674251416498	0.395822052163494	4/375	78/13181	4602/5573/3660/161882	MYB/PRKAR1A/IRF2/ZFPM1	4
REACTOME_111453	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	-2.51863122763248	0.18297434486803	0.395822052163494	1/375	7/13181	596	BCL2	1
REACTOME_111463	SMAC (DIABLO) binds to IAPs 	-2.32174739115976	0.18297434486803	0.395822052163494	1/375	7/13181	317	APAF1	1
REACTOME_111464	SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 	-2.32174739115976	0.18297434486803	0.395822052163494	1/375	7/13181	317	APAF1	1
REACTOME_141430	Inactivation of APC/C via direct inhibition of the APC/C complex	-2.25523046225499	0.18297434486803	0.395822052163494	1/375	7/13181	25906	ANAPC15	1
REACTOME_1482883	Acyl chain remodeling of DAG and TAG	-3.08828526705486	0.18297434486803	0.395822052163494	1/375	7/13181	8694	DGAT1	1
REACTOME_1489509	DAG and IP3 signaling	-3.18843192320265	0.18297434486803	0.395822052163494	1/375	7/13181	3710	ITPR3	1
REACTOME_167238	Pausing and recovery of Tat-mediated HIV elongation	-2.82127332505249	0.18297434486803	0.395822052163494	1/375	7/13181	6827	SUPT4H1	1
REACTOME_167243	Tat-mediated HIV elongation arrest and recovery	-2.82127332505249	0.18297434486803	0.395822052163494	1/375	7/13181	6827	SUPT4H1	1
REACTOME_176409	APC/C:Cdc20 mediated degradation of mitotic proteins	-2.25523046225499	0.18297434486803	0.395822052163494	1/375	7/13181	25906	ANAPC15	1
REACTOME_196843	Vitamin B2 (riboflavin) metabolism	-2.60344873970846	0.18297434486803	0.395822052163494	1/375	7/13181	5167	ENPP1	1
REACTOME_199920	CREB phosphorylation	-2.59472037321818	0.18297434486803	0.395822052163494	1/375	7/13181	466	ATF1	1
REACTOME_2408508	Metabolism of ingested SeMet, Sec, MeSec into H2Se	-2.25882545267613	0.18297434486803	0.395822052163494	1/375	7/13181	1491	CTH	1
REACTOME_426117	Cation-coupled Chloride cotransporters	-3.89371615146838	0.18297434486803	0.395822052163494	1/375	7/13181	6558	SLC12A2	1
REACTOME_429958	mRNA decay by 3' to 5' exoribonuclease	-2.68639310380018	0.18297434486803	0.395822052163494	1/375	7/13181	9652	TTC37	1
REACTOME_447038	NrCAM interactions	-2.33601025505576	0.18297434486803	0.395822052163494	1/375	7/13181	1739	DLG1	1
REACTOME_447043	Neurofascin interactions	-2.91019126026171	0.18297434486803	0.395822052163494	1/375	7/13181	6386	SDCBP	1
REACTOME_5576894	Phase 1 - inactivation of fast Na+ channels	-2.70649275927337	0.18297434486803	0.395822052163494	1/375	7/13181	3750	KCND1	1
REACTOME_6814848	Glycerophospholipid catabolism	-2.8627465966389	0.18297434486803	0.395822052163494	1/375	7/13181	10908	PNPLA6	1
REACTOME_69541	Stabilization of p53	-2.48091801745118	0.18297434486803	0.395822052163494	1/375	7/13181	4193	MDM2	1
REACTOME_70921	Histidine catabolism	-2.82907866496567	0.18297434486803	0.395822052163494	1/375	7/13181	3067	HDC	1
REACTOME_72702	Ribosomal scanning and start codon recognition	-2.7032961607758	0.18297434486803	0.395822052163494	1/375	7/13181	8669	EIF3J	1
REACTOME_9017802	Noncanonical activation of NOTCH3	-3.05006526093605	0.18297434486803	0.395822052163494	1/375	7/13181	23385	NCSTN	1
REACTOME_9033500	TYSND1 cleaves peroxisomal proteins	-2.84288038464503	0.18297434486803	0.395822052163494	1/375	7/13181	3295	HSD17B4	1
REACTOME_9652817	Signaling by MAPK mutants	-2.74751944767856	0.18297434486803	0.395822052163494	1/375	7/13181	11221	DUSP10	1
REACTOME_9710421	Defective pyroptosis	-2.82080346190859	0.18297434486803	0.395822052163494	1/375	7/13181	23512	SUZ12	1
REACTOME_1474228	Degradation of the extracellular matrix	-6.6302737748373	0.187401131698404	0.404847553533238	4/375	79/13181	23385/3915/84467/1991	NCSTN/LAMC1/FBN3/ELANE	4
REACTOME_380972	Energy dependent regulation of mTOR by LKB1-AMPK	-5.50997411046765	0.188803486757194	0.405946644954616	2/375	28/13181	8649/5562	LAMTOR3/PRKAA1	2
REACTOME_139915	Activation of PUMA and translocation to mitochondria	-2.1983231609498	0.206231109759065	0.410397327305273	1/375	8/13181	7027	TFDP1	1
REACTOME_156902	Peptide chain elongation	-2.387259138259	0.206231109759065	0.410397327305273	1/375	8/13181	6146	RPL22	1
REACTOME_164944	Nef and signal transduction	-2.25841398178445	0.206231109759065	0.410397327305273	1/375	8/13181	2534	FYN	1
REACTOME_167287	HIV elongation arrest and recovery	-2.82127332505249	0.206231109759065	0.410397327305273	1/375	8/13181	6827	SUPT4H1	1
REACTOME_167290	Pausing and recovery of HIV elongation	-2.82127332505249	0.206231109759065	0.410397327305273	1/375	8/13181	6827	SUPT4H1	1
REACTOME_174048	APC/C:Cdc20 mediated degradation of Cyclin B	-2.25523046225499	0.206231109759065	0.410397327305273	1/375	8/13181	25906	ANAPC15	1
REACTOME_176412	Phosphorylation of the APC/C	-2.25523046225499	0.206231109759065	0.410397327305273	1/375	8/13181	25906	ANAPC15	1
REACTOME_179409	APC-Cdc20 mediated degradation of Nek2A	-2.25523046225499	0.206231109759065	0.410397327305273	1/375	8/13181	25906	ANAPC15	1
REACTOME_2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	-2.57462628526921	0.206231109759065	0.410397327305273	1/375	8/13181	5925	RB1	1
REACTOME_2980766	Nuclear Envelope Breakdown	-3.21517897291893	0.206231109759065	0.410397327305273	1/375	8/13181	7112	TMPO	1
REACTOME_418886	Netrin mediated repulsion signals	-2.25627021742891	0.206231109759065	0.410397327305273	1/375	8/13181	8633	UNC5C	1
REACTOME_425393	Transport of inorganic cations/anions and amino acids/oligopeptides	-2.83109600356936	0.206231109759065	0.410397327305273	1/375	8/13181	6507	SLC1A3	1
REACTOME_444821	Relaxin receptors	-2.18411981431598	0.206231109759065	0.410397327305273	1/375	8/13181	6019	RLN2	1
REACTOME_6787450	tRNA modification in the mitochondrion	-2.48415880071305	0.206231109759065	0.410397327305273	1/375	8/13181	84705	GTPBP3	1
REACTOME_68689	CDC6 association with the ORC:origin complex	-2.43051208429189	0.206231109759065	0.410397327305273	1/375	8/13181	1871	E2F3	1
REACTOME_72649	Translation initiation complex formation	-2.7032961607758	0.206231109759065	0.410397327305273	1/375	8/13181	8669	EIF3J	1
REACTOME_804914	Transport of fatty acids	-3.28683649071724	0.206231109759065	0.410397327305273	1/375	8/13181	347	APOD	1
REACTOME_8939242	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	-4.89767780170851	0.206231109759065	0.410397327305273	1/375	8/13181	861	RUNX1	1
REACTOME_8941332	RUNX2 regulates genes involved in cell migration	-2.32686646858061	0.206231109759065	0.410397327305273	1/375	8/13181	860	RUNX2	1
REACTOME_9026519	Activated NTRK2 signals through RAS	-3.67520369446941	0.206231109759065	0.410397327305273	1/375	8/13181	4909	NTF4	1
REACTOME_9623433	NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	-2.33761000591826	0.206231109759065	0.410397327305273	1/375	8/13181	6257	RXRB	1
REACTOME_3928663	EPHA-mediated growth cone collapse	-3.65222511108929	0.209677334860623	0.413631467032742	2/375	30/13181	2534/6093	FYN/ROCK1	2
REACTOME_5694530	Cargo concentration in the ER	-3.92773752838681	0.209677334860623	0.413631467032742	2/375	30/13181	4253/10484	MIA2/SEC23A	2
REACTOME_8874081	MET activates PTK2 signaling	-5.32040309920638	0.209677334860623	0.413631467032742	2/375	30/13181	3082/3915	HGF/LAMC1	2
REACTOME_8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	-5.41056097224233	0.209677334860623	0.413631467032742	2/375	30/13181	861/161882	RUNX1/ZFPM1	2
REACTOME_983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	-4.12793728670913	0.209677334860623	0.413631467032742	2/375	30/13181	3710/2534	ITPR3/FYN	2
REACTOME_6782315	tRNA modification in the nucleus and cytosol	-3.87223012608109	0.220201077904451	0.4245459229694	2/375	31/13181	83480/93587	PUS3/TRMT10A	2
REACTOME_8943724	Regulation of PTEN gene transcription	-5.44562669444796	0.220569080411281	0.4245459229694	3/375	57/13181	8649/1912/23512	LAMTOR3/PHC2/SUZ12	3
REACTOME_113418	Formation of the Early Elongation Complex	-2.82127332505249	0.228827582380362	0.4245459229694	1/375	9/13181	6827	SUPT4H1	1
REACTOME_1296052	Ca2+ activated K+ channels	-3.10650521987013	0.228827582380362	0.4245459229694	1/375	9/13181	3778	KCNMA1	1
REACTOME_1300642	Sperm Motility And Taxes	-2.22400961852388	0.228827582380362	0.4245459229694	1/375	9/13181	157855	KCNU1	1
REACTOME_167158	Formation of the HIV-1 Early Elongation Complex	-2.82127332505249	0.228827582380362	0.4245459229694	1/375	9/13181	6827	SUPT4H1	1
REACTOME_176407	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	-2.25523046225499	0.228827582380362	0.4245459229694	1/375	9/13181	25906	ANAPC15	1
REACTOME_199220	Vitamin B5 (pantothenate) metabolism	-2.60344873970846	0.228827582380362	0.4245459229694	1/375	9/13181	5167	ENPP1	1
REACTOME_2562578	TRIF-mediated programmed cell death	-3.05375985172521	0.228827582380362	0.4245459229694	1/375	9/13181	7099	TLR4	1
REACTOME_389356	CD28 co-stimulation	-2.25841398178445	0.228827582380362	0.4245459229694	1/375	9/13181	2534	FYN	1
REACTOME_389887	Beta-oxidation of pristanoyl-CoA	-2.84288038464503	0.228827582380362	0.4245459229694	1/375	9/13181	3295	HSD17B4	1
REACTOME_425986	Sodium/Proton exchangers	-2.31091145789524	0.228827582380362	0.4245459229694	1/375	9/13181	6549	SLC9A2	1
REACTOME_442380	Zinc influx into cells by the SLC39 gene family	-2.90329604377919	0.228827582380362	0.4245459229694	1/375	9/13181	57181	SLC39A10	1
REACTOME_446193	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	-4.20308521849728	0.228827582380362	0.4245459229694	1/375	9/13181	29929	ALG6	1
REACTOME_5666185	RHO GTPases Activate Rhotekin and Rhophilins	-2.82750020091235	0.228827582380362	0.4245459229694	1/375	9/13181	30851	TAX1BP3	1
REACTOME_727802	Transport of nucleotide sugars	-3.3223790735698	0.228827582380362	0.4245459229694	1/375	9/13181	55343	SLC35C1	1
REACTOME_8949664	Processing of SMDT1	-3.06787093426081	0.228827582380362	0.4245459229694	1/375	9/13181	91689	SMDT1	1
REACTOME_8951936	RUNX3 regulates p14-ARF	-4.89767780170851	0.228827582380362	0.4245459229694	1/375	9/13181	861	RUNX1	1
REACTOME_8985947	Interleukin-9 signaling	-2.38122227325096	0.228827582380362	0.4245459229694	1/375	9/13181	3718	JAK3	1
REACTOME_9010642	ROBO receptors bind AKAP5	-2.35763851839963	0.228827582380362	0.4245459229694	1/375	9/13181	6092	ROBO2	1
REACTOME_9029558	NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	-2.33761000591826	0.228827582380362	0.4245459229694	1/375	9/13181	6257	RXRB	1
REACTOME_9683673	Maturation of protein 3a	-2.20011744827674	0.228827582380362	0.4245459229694	1/375	9/13181	6484	ST3GAL4	1
REACTOME_9694719	Maturation of protein 3a	-2.20011744827674	0.228827582380362	0.4245459229694	1/375	9/13181	6484	ST3GAL4	1
REACTOME_8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	-7.18688107059824	0.230767156005846	0.426155375202434	2/375	32/13181	4602/861	MYB/RUNX1	2
REACTOME_8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	-5.75807636919725	0.230767156005846	0.426155375202434	2/375	32/13181	861/1912	RUNX1/PHC2	2
REACTOME_9013407	RHOH GTPase cycle	-3.93366605661596	0.230767156005846	0.426155375202434	2/375	32/13181	55717/6093	WDR11/ROCK1	2
REACTOME_5663220	RHO GTPases Activate Formins	-6.56032042385244	0.241252134702385	0.440844789870969	4/375	88/13181	23421/8655/91687/79023	ITGB3BP/DYNLL1/CENPL/NUP37	4
REACTOME_159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	-5.46480132377985	0.241364676833752	0.440844789870969	2/375	33/13181	10212/79023	DDX39A/NUP37	2
REACTOME_5689896	Ovarian tumor domain proteases	-5.05689125557615	0.241364676833752	0.440844789870969	2/375	33/13181	7128/64127	TNFAIP3/NOD2	2
REACTOME_1234158	Regulation of gene expression by Hypoxia-inducible Factor	-3.36596039750666	0.250782460653014	0.440844789870969	1/375	10/13181	10370	CITED2	1
REACTOME_190377	FGFR2b ligand binding and activation	-3.39335501286362	0.250782460653014	0.440844789870969	1/375	10/13181	143282	FGFBP3	1
REACTOME_210990	PECAM1 interactions	-2.25841398178445	0.250782460653014	0.440844789870969	1/375	10/13181	2534	FYN	1
REACTOME_428542	Regulation of commissural axon pathfinding by SLIT and ROBO	-2.35763851839963	0.250782460653014	0.440844789870969	1/375	10/13181	6092	ROBO2	1
REACTOME_532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	-2.60599444036837	0.250782460653014	0.440844789870969	1/375	10/13181	9761	MLEC	1
REACTOME_549127	Organic cation transport	-4.89767780170851	0.250782460653014	0.440844789870969	1/375	10/13181	861	RUNX1	1
REACTOME_8875656	MET receptor recycling	-3.31951231151986	0.250782460653014	0.440844789870969	1/375	10/13181	3082	HGF	1
REACTOME_8963901	Chylomicron remodeling	-2.60495444168599	0.250782460653014	0.440844789870969	1/375	10/13181	338328	GPIHBP1	1
REACTOME_9020958	Interleukin-21 signaling	-2.38122227325096	0.250782460653014	0.440844789870969	1/375	10/13181	3718	JAK3	1
REACTOME_9028731	Activated NTRK2 signals through FRS2 and FRS3	-3.67520369446941	0.250782460653014	0.440844789870969	1/375	10/13181	4909	NTF4	1
REACTOME_937072	TRAF6-mediated induction of TAK1 complex within TLR4 complex	-3.05375985172521	0.250782460653014	0.440844789870969	1/375	10/13181	7099	TLR4	1
REACTOME_9615933	Postmitotic nuclear pore complex (NPC) reformation	-4.04270369838297	0.250782460653014	0.440844789870969	1/375	10/13181	79023	NUP37	1
REACTOME_975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	-3.05375985172521	0.250782460653014	0.440844789870969	1/375	10/13181	7099	TLR4	1
REACTOME_975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	-2.387259138259	0.250782460653014	0.440844789870969	1/375	10/13181	6146	RPL22	1
REACTOME_674695	RNA Polymerase II Pre-transcription Events	-4.21997297421076	0.251983330438445	0.44149145498306	2/375	34/13181	8148/6827	TAF15/SUPT4H1	2
REACTOME_8856825	Cargo recognition for clathrin-mediated endocytosis	-6.13047023526272	0.25368182678146	0.44422258213934	4/375	90/13181	6572/64708/3482/6456	SLC18A3/COPS7B/IGF2R/SH3GL2	4
REACTOME_1257604	PIP3 activates AKT signaling	-6.23040707430441	0.259946085094752	0.454441204288792	4/375	91/13181	3082/5156/2534/4254	HGF/PDGFRA/FYN/KITLG	4
REACTOME_1433557	Signaling by SCF-KIT	-3.87608955383772	0.262613365079314	0.45588714237324	2/375	35/13181	2534/4254	FYN/KITLG	2
REACTOME_3214841	PKMTs methylate histone lysines	-4.12464277244497	0.262613365079314	0.45588714237324	2/375	35/13181	84444/23512	DOT1L/SUZ12	2
REACTOME_1632852	Macroautophagy	-6.3355451655513	0.266349618697547	0.45588714237324	3/375	63/13181	8655/8649/5562	DYNLL1/LAMTOR3/PRKAA1	3
REACTOME_1236977	Endosomal/Vacuolar pathway	-3.28016513039503	0.272113914396474	0.45588714237324	1/375	11/13181	3134	HLA-F	1
REACTOME_1474151	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	-2.23529527984194	0.272113914396474	0.45588714237324	1/375	11/13181	1719	DHFR	1
REACTOME_1483213	Synthesis of PE	-2.22492902643912	0.272113914396474	0.45588714237324	1/375	11/13181	1120	CHKB	1
REACTOME_167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	-2.82127332505249	0.272113914396474	0.45588714237324	1/375	11/13181	6827	SUPT4H1	1
REACTOME_167246	Tat-mediated elongation of the HIV-1 transcript	-2.82127332505249	0.272113914396474	0.45588714237324	1/375	11/13181	6827	SUPT4H1	1
REACTOME_176408	Regulation of APC/C activators between G1/S and early anaphase	-2.25523046225499	0.272113914396474	0.45588714237324	1/375	11/13181	25906	ANAPC15	1
REACTOME_193692	Regulated proteolysis of p75NTR	-3.05006526093605	0.272113914396474	0.45588714237324	1/375	11/13181	23385	NCSTN	1
REACTOME_2029481	FCGR activation	-2.25841398178445	0.272113914396474	0.45588714237324	1/375	11/13181	2534	FYN	1
REACTOME_376172	DSCAM interactions	-2.87849364175243	0.272113914396474	0.45588714237324	1/375	11/13181	5603	MAPK13	1
REACTOME_389359	CD28 dependent Vav1 pathway	-2.25841398178445	0.272113914396474	0.45588714237324	1/375	11/13181	2534	FYN	1
REACTOME_390247	Beta-oxidation of very long chain fatty acids	-2.84288038464503	0.272113914396474	0.45588714237324	1/375	11/13181	3295	HSD17B4	1
REACTOME_451308	Activation of Ca-permeable Kainate Receptor	-2.33601025505576	0.272113914396474	0.45588714237324	1/375	11/13181	1739	DLG1	1
REACTOME_5578768	Physiological factors	-2.51877100555595	0.272113914396474	0.45588714237324	1/375	11/13181	6910	TBX5	1
REACTOME_71240	Tryptophan catabolism	-2.77500119878512	0.272113914396474	0.45588714237324	1/375	11/13181	8942	KYNU	1
REACTOME_71384	Ethanol oxidation	-2.71297296935557	0.272113914396474	0.45588714237324	1/375	11/13181	127	ADH4	1
REACTOME_72764	Eukaryotic Translation Termination	-2.387259138259	0.272113914396474	0.45588714237324	1/375	11/13181	6146	RPL22	1
REACTOME_8851805	MET activates RAS signaling	-3.31951231151986	0.272113914396474	0.45588714237324	1/375	11/13181	3082	HGF	1
REACTOME_8875360	InlB-mediated entry of Listeria monocytogenes into host cell	-2.63294480167501	0.272113914396474	0.45588714237324	1/375	11/13181	6456	SH3GL2	1
REACTOME_8875555	MET activates RAP1 and RAC1	-3.31951231151986	0.272113914396474	0.45588714237324	1/375	11/13181	3082	HGF	1
REACTOME_9013700	NOTCH4 Activation and Transmission of Signal to the Nucleus	-3.05006526093605	0.272113914396474	0.45588714237324	1/375	11/13181	23385	NCSTN	1
REACTOME_9627069	Regulation of the apoptosome activity	-2.32174739115976	0.272113914396474	0.45588714237324	1/375	11/13181	317	APAF1	1
REACTOME_9706369	Negative regulation of FLT3	-3.37024760049466	0.272113914396474	0.45588714237324	1/375	11/13181	27	ABL2	1
REACTOME_2129379	Molecules associated with elastic fibres	-4.20411113557512	0.273245563950754	0.45588714237324	2/375	36/13181	2192/84467	FBLN1/FBN3	2
REACTOME_6811436	COPI-independent Golgi-to-ER retrograde traffic	-3.62028725763513	0.283871222774852	0.466081045371688	2/375	37/13181	25782/8655	RAB3GAP2/DYNLL1	2
REACTOME_9029569	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	-4.26253336620089	0.283871222774852	0.466081045371688	2/375	37/13181	6257/347	RXRB/APOD	2
REACTOME_112043	PLC beta mediated events	-3.18843192320265	0.29283960020523	0.466081045371688	1/375	12/13181	3710	ITPR3	1
REACTOME_167152	Formation of HIV elongation complex in the absence of HIV Tat	-2.82127332505249	0.29283960020523	0.466081045371688	1/375	12/13181	6827	SUPT4H1	1
REACTOME_1679131	Trafficking and processing of endosomal TLR	-2.65285515706961	0.29283960020523	0.466081045371688	1/375	12/13181	10695	CNPY3	1
REACTOME_212300	PRC2 methylates histones and DNA	-2.82080346190859	0.29283960020523	0.466081045371688	1/375	12/13181	23512	SUZ12	1
REACTOME_2160916	Hyaluronan uptake and degradation	-3.19641996447534	0.29283960020523	0.466081045371688	1/375	12/13181	3161	HMMR	1
REACTOME_373760	L1CAM interactions	-3.70080166638359	0.29283960020523	0.466081045371688	1/375	12/13181	3915	LAMC1	1
REACTOME_418885	DCC mediated attractive signaling	-2.25841398178445	0.29283960020523	0.466081045371688	1/375	12/13181	2534	FYN	1
REACTOME_5607763	CLEC7A (Dectin-1) induces NFAT activation	-3.18843192320265	0.29283960020523	0.466081045371688	1/375	12/13181	3710	ITPR3	1
REACTOME_5689901	Metalloprotease DUBs	-2.38435607402698	0.29283960020523	0.466081045371688	1/375	12/13181	57559	STAMBPL1	1
REACTOME_6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	-2.32174739115976	0.29283960020523	0.466081045371688	1/375	12/13181	317	APAF1	1
REACTOME_68962	Activation of the pre-replicative complex	-2.57283911223424	0.29283960020523	0.466081045371688	1/375	12/13181	29935	RPA4	1
REACTOME_73621	Pyrimidine catabolism	-2.7569373661244	0.29283960020523	0.466081045371688	1/375	12/13181	64902	AGXT2	1
REACTOME_8866907	Activation of the TFAP2 (AP-2) family of transcription factors	-3.36596039750666	0.29283960020523	0.466081045371688	1/375	12/13181	10370	CITED2	1
REACTOME_8949215	Mitochondrial calcium ion transport	-3.06787093426081	0.29283960020523	0.466081045371688	1/375	12/13181	91689	SMDT1	1
REACTOME_9020558	Interleukin-2 signaling	-2.38122227325096	0.29283960020523	0.466081045371688	1/375	12/13181	3718	JAK3	1
REACTOME_936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	-3.05375985172521	0.29283960020523	0.466081045371688	1/375	12/13181	7099	TLR4	1
REACTOME_9648895	Response of EIF2AK1 (HRI) to heme deficiency	-2.27913598113939	0.29283960020523	0.466081045371688	1/375	12/13181	467	ATF3	1
REACTOME_9673767	Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	-2.41372563552681	0.29283960020523	0.466081045371688	1/375	12/13181	5156	PDGFRA	1
REACTOME_9673770	Signaling by PDGFRA extracellular domain mutants	-2.41372563552681	0.29283960020523	0.466081045371688	1/375	12/13181	5156	PDGFRA	1
REACTOME_9031628	NGF-stimulated transcription	-4.00553945361294	0.294482128230603	0.467758825061597	2/375	38/13181	4066/466	LYL1/ATF1	2
REACTOME_9035034	RHOF GTPase cycle	-4.37412292709822	0.294482128230603	0.467758825061597	2/375	38/13181	7112/26049	TMPO/FAM169A	2
REACTOME_9013106	RHOC GTPase cycle	-5.84676707993267	0.297466874287496	0.471792847997126	3/375	67/13181	23263/7112/6093	MCF2L/TMPO/ROCK1	3
REACTOME_1989781	PPARA activates gene expression	-6.04539578465863	0.298084055904304	0.472300596799047	4/375	97/13181	55588/6257/9439/23389	MED29/RXRB/MED23/MED13L	4
REACTOME_3928662	EPHB-mediated forward signaling	-3.65222511108929	0.305070537190378	0.478010648743276	2/375	39/13181	2534/6093	FYN/ROCK1	2
REACTOME_381340	Transcriptional regulation of white adipocyte differentiation	-5.27632100969184	0.3052852397857	0.478010648743276	3/375	68/13181	55588/9439/23389	MED29/MED23/MED13L	3
REACTOME_9018519	Estrogen-dependent gene expression	-7.73387368937099	0.3052852397857	0.478010648743276	3/375	68/13181	4602/861/596	MYB/RUNX1/BCL2	3
REACTOME_112409	RAF-independent MAPK1/3 activation	-2.74751944767856	0.312976675907489	0.478010648743276	1/375	13/13181	11221	DUSP10	1
REACTOME_1362300	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	-2.1983231609498	0.312976675907489	0.478010648743276	1/375	13/13181	7027	TFDP1	1
REACTOME_159227	Transport of the SLBP independent Mature mRNA	-4.04270369838297	0.312976675907489	0.478010648743276	1/375	13/13181	79023	NUP37	1
REACTOME_159230	Transport of the SLBP Dependant Mature mRNA	-4.04270369838297	0.312976675907489	0.478010648743276	1/375	13/13181	79023	NUP37	1
REACTOME_159231	Transport of Mature mRNA Derived from an Intronless Transcript	-4.04270369838297	0.312976675907489	0.478010648743276	1/375	13/13181	79023	NUP37	1
REACTOME_1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	-2.72408439775053	0.312976675907489	0.478010648743276	1/375	13/13181	10484	SEC23A	1
REACTOME_168333	NEP/NS2 Interacts with the Cellular Export Machinery	-4.04270369838297	0.312976675907489	0.478010648743276	1/375	13/13181	79023	NUP37	1
REACTOME_171007	p38MAPK events	-2.87849364175243	0.312976675907489	0.478010648743276	1/375	13/13181	5603	MAPK13	1
REACTOME_177504	Retrograde neurotrophin signalling	-2.63294480167501	0.312976675907489	0.478010648743276	1/375	13/13181	6456	SH3GL2	1
REACTOME_180746	Nuclear import of Rev protein	-4.04270369838297	0.312976675907489	0.478010648743276	1/375	13/13181	79023	NUP37	1
REACTOME_2046106	alpha-linolenic acid (ALA) metabolism	-2.84288038464503	0.312976675907489	0.478010648743276	1/375	13/13181	3295	HSD17B4	1
REACTOME_2408557	Selenocysteine synthesis	-2.387259138259	0.312976675907489	0.478010648743276	1/375	13/13181	6146	RPL22	1
REACTOME_442720	CREB1 phosphorylation through the activation of Adenylate Cyclase	-2.69033454609929	0.312976675907489	0.478010648743276	1/375	13/13181	5573	PRKAR1A	1
REACTOME_5357786	TNFR1-induced proapoptotic signaling	-4.13693935293315	0.312976675907489	0.478010648743276	1/375	13/13181	7128	TNFAIP3	1
REACTOME_6804760	Regulation of TP53 Activity through Methylation	-2.48091801745118	0.312976675907489	0.478010648743276	1/375	13/13181	4193	MDM2	1
REACTOME_74217	Purine salvage	-2.44163695695388	0.312976675907489	0.478010648743276	1/375	13/13181	353	APRT	1
REACTOME_75109	Triglyceride biosynthesis	-3.08828526705486	0.312976675907489	0.478010648743276	1/375	13/13181	8694	DGAT1	1
REACTOME_877312	Regulation of IFNG signaling	-2.675124611319	0.312976675907489	0.478010648743276	1/375	13/13181	3460	IFNGR2	1
REACTOME_8878166	Transcriptional regulation by RUNX2	-2.32686646858061	0.312976675907489	0.478010648743276	1/375	13/13181	860	RUNX2	1
REACTOME_9013422	RHOBTB1 GTPase cycle	-2.56072594422129	0.312976675907489	0.478010648743276	1/375	13/13181	6093	ROCK1	1
REACTOME_9614657	FOXO-mediated transcription of cell death genes	-3.36596039750666	0.312976675907489	0.478010648743276	1/375	13/13181	10370	CITED2	1
REACTOME_3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	-4.10403746129328	0.315629156735363	0.480929908202422	2/375	40/13181	8655/3301	DYNLL1/DNAJA1	2
REACTOME_381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	-4.4552718640834	0.326151124922647	0.493920116993907	2/375	41/13181	3710/5573	ITPR3/PRKAR1A	2
REACTOME_977606	Regulation of Complement cascade	-3.37640519041325	0.326151124922647	0.493920116993907	2/375	41/13181	1604/1991	CD55/ELANE	2
REACTOME_2132295	MHC class II antigen presentation	-5.97510255895936	0.330354677153997	0.493920116993907	4/375	102/13181	8655/10437/10484/6456	DYNLL1/IFI30/SEC23A/SH3GL2	4
REACTOME_1362277	Transcription of E2F targets under negative control by DREAM complex	-2.1983231609498	0.332541814617596	0.493920116993907	1/375	14/13181	7027	TFDP1	1
REACTOME_165054	Rev-mediated nuclear export of HIV RNA	-4.04270369838297	0.332541814617596	0.493920116993907	1/375	14/13181	79023	NUP37	1
REACTOME_168271	Transport of Ribonucleoproteins into the Host Nucleus	-4.04270369838297	0.332541814617596	0.493920116993907	1/375	14/13181	79023	NUP37	1
REACTOME_168325	Viral Messenger RNA Synthesis	-4.04270369838297	0.332541814617596	0.493920116993907	1/375	14/13181	79023	NUP37	1
REACTOME_189451	Heme biosynthesis	-2.46326751914318	0.332541814617596	0.493920116993907	1/375	14/13181	1355	COX15	1
REACTOME_192105	Synthesis of bile acids and bile salts	-2.88511190390057	0.332541814617596	0.493920116993907	1/375	14/13181	26031	OSBPL3	1
REACTOME_198323	AKT phosphorylates targets in the cytosol	-2.48091801745118	0.332541814617596	0.493920116993907	1/375	14/13181	4193	MDM2	1
REACTOME_200425	Carnitine metabolism	-3.258051681566	0.332541814617596	0.493920116993907	1/375	14/13181	1375	CPT1B	1
REACTOME_2162123	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	-2.27390186641832	0.332541814617596	0.493920116993907	1/375	14/13181	80142	PTGES2	1
REACTOME_4419969	Depolymerisation of the Nuclear Lamina	-3.21517897291893	0.332541814617596	0.493920116993907	1/375	14/13181	7112	TMPO	1
REACTOME_5083632	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	-2.39832531334792	0.332541814617596	0.493920116993907	1/375	14/13181	56913	C1GALT1	1
REACTOME_5682910	LGI-ADAM interactions	-2.28459045062181	0.332541814617596	0.493920116993907	1/375	14/13181	8745	ADAM23	1
REACTOME_6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	-2.1983231609498	0.332541814617596	0.493920116993907	1/375	14/13181	7027	TFDP1	1
REACTOME_8983432	Interleukin-15 signaling	-2.38122227325096	0.332541814617596	0.493920116993907	1/375	14/13181	3718	JAK3	1
REACTOME_9707616	Heme signaling	-4.14643626519405	0.336629992277535	0.498206335021804	2/375	42/13181	200186/7099	CRTC2/TLR4	2
REACTOME_6785807	Interleukin-4 and Interleukin-13 signaling	-6.49201455419148	0.336837616445559	0.498206335021804	4/375	103/13181	3082/3718/596/4170	HGF/JAK3/BCL2/MCL1	4
REACTOME_6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	-6.23040707430441	0.336837616445559	0.498206335021804	4/375	103/13181	3082/5156/2534/4254	HGF/PDGFRA/FYN/KITLG	4
REACTOME_8957275	Post-translational protein phosphorylation	-6.64533156948598	0.343325616970503	0.506769208745054	4/375	104/13181	1435/3915/5611/56955	CSF1/LAMC1/DNAJC3/MEPE	4
REACTOME_1296072	Voltage gated Potassium channels	-3.84771537317578	0.347059703985567	0.506769208745054	2/375	43/13181	3786/3750	KCNQ3/KCND1	2
REACTOME_111447	Activation of BAD and translocation to mitochondria 	-2.51863122763248	0.351551218393582	0.506769208745054	1/375	15/13181	596	BCL2	1
REACTOME_1227986	Signaling by ERBB2	-2.25841398178445	0.351551218393582	0.506769208745054	1/375	15/13181	2534	FYN	1
REACTOME_139853	Elevation of cytosolic Ca2+ levels	-3.18843192320265	0.351551218393582	0.506769208745054	1/375	15/13181	3710	ITPR3	1
REACTOME_140534	Caspase activation via Death Receptors in the presence of ligand	-3.05375985172521	0.351551218393582	0.506769208745054	1/375	15/13181	7099	TLR4	1
REACTOME_170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	-4.04270369838297	0.351551218393582	0.506769208745054	1/375	15/13181	79023	NUP37	1
REACTOME_180910	Vpr-mediated nuclear import of PICs	-4.04270369838297	0.351551218393582	0.506769208745054	1/375	15/13181	79023	NUP37	1
REACTOME_264642	Acetylcholine Neurotransmitter Release Cycle	-2.21820871554574	0.351551218393582	0.506769208745054	1/375	15/13181	6572	SLC18A3	1
REACTOME_2730905	Role of LAT2/NTAL/LAB on calcium mobilization	-2.25841398178445	0.351551218393582	0.506769208745054	1/375	15/13181	2534	FYN	1
REACTOME_376176	Signaling by ROBO receptors	-2.35763851839963	0.351551218393582	0.506769208745054	1/375	15/13181	6092	ROBO2	1
REACTOME_418457	cGMP effects	-3.10650521987013	0.351551218393582	0.506769208745054	1/375	15/13181	3778	KCNMA1	1
REACTOME_4655427	SUMOylation of DNA methylation proteins	-2.70014951828173	0.351551218393582	0.506769208745054	1/375	15/13181	1912	PHC2	1
REACTOME_5617833	Cilium Assembly	-2.59939115049605	0.351551218393582	0.506769208745054	1/375	15/13181	79969	ATAT1	1
REACTOME_5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	-4.04270369838297	0.351551218393582	0.506769208745054	1/375	15/13181	79023	NUP37	1
REACTOME_75892	Platelet Adhesion to exposed collagen	-2.25841398178445	0.351551218393582	0.506769208745054	1/375	15/13181	2534	FYN	1
REACTOME_975577	N-Glycan antennae elongation	-2.20011744827674	0.351551218393582	0.506769208745054	1/375	15/13181	6484	ST3GAL4	1
REACTOME_111465	Apoptotic cleavage of cellular proteins	-2.56072594422129	0.370020631510884	0.52064849920558	1/375	16/13181	6093	ROCK1	1
REACTOME_1538133	G0 and Early G1	-2.1983231609498	0.370020631510884	0.52064849920558	1/375	16/13181	7027	TFDP1	1
REACTOME_165159	MTOR signalling	-2.92981870278409	0.370020631510884	0.52064849920558	1/375	16/13181	8649	LAMTOR3	1
REACTOME_4085377	SUMOylation of SUMOylation proteins	-4.04270369838297	0.370020631510884	0.52064849920558	1/375	16/13181	79023	NUP37	1
REACTOME_6781823	Formation of TC-NER Pre-Incision Complex	-2.59789059452521	0.370020631510884	0.52064849920558	1/375	16/13181	64708	COPS7B	1
REACTOME_6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	-2.73295769253626	0.370020631510884	0.52064849920558	1/375	16/13181	94241	TP53INP1	1
REACTOME_901032	ER Quality Control Compartment (ERQC)	-2.78400064077483	0.370020631510884	0.52064849920558	1/375	16/13181	10956	OS9	1
REACTOME_5620924	Intraflagellar transport	-3.84401336575449	0.377998921730961	0.530466271449451	2/375	46/13181	8655/28981	DYNLL1/IFT81	2
REACTOME_9010553	Regulation of expression of SLITs and ROBOs	-3.59595999229693	0.377998921730961	0.530466271449451	2/375	46/13181	6092/6146	ROBO2/RPL22	2
REACTOME_156588	Glucuronidation	-2.68076725513855	0.387965353363024	0.532991575077415	1/375	17/13181	79799	UGT2A3	1
REACTOME_164378	PKA activation in glucagon signalling	-2.69033454609929	0.387965353363024	0.532991575077415	1/375	17/13181	5573	PRKAR1A	1
REACTOME_1912420	Pre-NOTCH Processing in Golgi	-2.20011744827674	0.387965353363024	0.532991575077415	1/375	17/13181	6484	ST3GAL4	1
REACTOME_201556	Signaling by ALK	-2.38122227325096	0.387965353363024	0.532991575077415	1/375	17/13181	3718	JAK3	1
REACTOME_3232118	SUMOylation of transcription factors	-2.48091801745118	0.387965353363024	0.532991575077415	1/375	17/13181	4193	MDM2	1
REACTOME_380994	ATF4 activates genes in response to endoplasmic reticulum  stress	-2.27913598113939	0.387965353363024	0.532991575077415	1/375	17/13181	467	ATF3	1
REACTOME_450321	JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1	-2.53566866271786	0.387965353363024	0.532991575077415	1/375	17/13181	64127	NOD2	1
REACTOME_5578749	Transcriptional regulation by small RNAs	-4.04270369838297	0.387965353363024	0.532991575077415	1/375	17/13181	79023	NUP37	1
REACTOME_5601884	PIWI-interacting RNA (piRNA) biogenesis	-2.23075294727645	0.387965353363024	0.532991575077415	1/375	17/13181	143689	PIWIL4	1
REACTOME_5602498	MyD88 deficiency (TLR2/4)	-3.05375985172521	0.387965353363024	0.532991575077415	1/375	17/13181	7099	TLR4	1
REACTOME_5675482	Regulation of necroptotic cell death	-2.91019126026171	0.387965353363024	0.532991575077415	1/375	17/13181	6386	SDCBP	1
REACTOME_6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	-2.24636856452653	0.387965353363024	0.532991575077415	1/375	17/13181	23019	CNOT1	1
REACTOME_69273	Cyclin A/B1/B2 associated events during G2/M transition	-2.33988744749259	0.387965353363024	0.532991575077415	1/375	17/13181	5520	PPP2R2A	1
REACTOME_8934593	Regulation of RUNX1 Expression and Activity	-4.89767780170851	0.387965353363024	0.532991575077415	1/375	17/13181	861	RUNX1	1
REACTOME_1369062	ABC transporters in lipid homeostasis	-2.214679656587	0.405400250999674	0.543267087306769	1/375	18/13181	10350	ABCA9	1
REACTOME_1566948	Elastic fibre formation	-2.60582770634899	0.405400250999674	0.543267087306769	1/375	18/13181	84467	FBN3	1
REACTOME_162588	Budding and maturation of HIV virion	-2.48446550605601	0.405400250999674	0.543267087306769	1/375	18/13181	51534	VTA1	1
REACTOME_162710	Synthesis of glycosylphosphatidylinositol (GPI)	-2.73994309996827	0.405400250999674	0.543267087306769	1/375	18/13181	5281	PIGF	1
REACTOME_166016	Toll Like Receptor 4 (TLR4) Cascade	-3.05375985172521	0.405400250999674	0.543267087306769	1/375	18/13181	7099	TLR4	1
REACTOME_174084	Autodegradation of Cdh1 by Cdh1:APC/C	-2.25523046225499	0.405400250999674	0.543267087306769	1/375	18/13181	25906	ANAPC15	1
REACTOME_191859	snRNP Assembly	-4.04270369838297	0.405400250999674	0.543267087306769	1/375	18/13181	79023	NUP37	1
REACTOME_210993	Tie2 Signaling	-2.81841306084885	0.405400250999674	0.543267087306769	1/375	18/13181	284	ANGPT1	1
REACTOME_2979096	NOTCH2 Activation and Transmission of Signal to the Nucleus	-3.05006526093605	0.405400250999674	0.543267087306769	1/375	18/13181	23385	NCSTN	1
REACTOME_3301854	Nuclear Pore Complex (NPC) Disassembly	-4.04270369838297	0.405400250999674	0.543267087306769	1/375	18/13181	79023	NUP37	1
REACTOME_416700	Other semaphorin interactions	-2.55367901148351	0.405400250999674	0.543267087306769	1/375	18/13181	5362	PLXNA2	1
REACTOME_450302	activated TAK1 mediates p38 MAPK activation	-2.53566866271786	0.405400250999674	0.543267087306769	1/375	18/13181	64127	NOD2	1
REACTOME_4615885	SUMOylation of DNA replication proteins	-4.04270369838297	0.405400250999674	0.543267087306769	1/375	18/13181	79023	NUP37	1
REACTOME_5218921	VEGFR2 mediated cell proliferation	-3.18843192320265	0.405400250999674	0.543267087306769	1/375	18/13181	3710	ITPR3	1
REACTOME_5603041	IRAK4 deficiency (TLR2/4)	-3.05375985172521	0.405400250999674	0.543267087306769	1/375	18/13181	7099	TLR4	1
REACTOME_9037629	Lewis blood group biosynthesis	-2.20011744827674	0.405400250999674	0.543267087306769	1/375	18/13181	6484	ST3GAL4	1
REACTOME_912631	Regulation of signaling by CBL	-2.25841398178445	0.405400250999674	0.543267087306769	1/375	18/13181	2534	FYN	1
REACTOME_937041	IKK complex recruitment mediated by RIP1	-3.05375985172521	0.405400250999674	0.543267087306769	1/375	18/13181	7099	TLR4	1
REACTOME_9648002	RAS processing	-3.09358092544246	0.405400250999674	0.543267087306769	1/375	18/13181	51114	ZDHHC9	1
REACTOME_5628897	TP53 Regulates Metabolic Genes	-6.49074534031644	0.406526690607279	0.544088752580449	3/375	81/13181	25824/8649/5562	PRDX5/LAMTOR3/PRKAA1	3
REACTOME_2151201	Transcriptional activation of mitochondrial biogenesis	-3.50835001029779	0.408312179750778	0.545789294496626	2/375	49/13181	200186/23409	CRTC2/SIRT4	2
REACTOME_3928665	EPH-ephrin mediated repulsion of cells	-4.02307496558401	0.418257980025808	0.554288267756137	2/375	50/13181	23385/2534	NCSTN/FYN	2
REACTOME_5389840	Mitochondrial translation elongation	-5.19763675091958	0.421807323502926	0.554288267756137	3/375	83/13181	10102/7818/51021	TSFM/DAP3/MRPS16	3
REACTOME_163615	PKA activation	-2.69033454609929	0.422339771312302	0.554288267756137	1/375	19/13181	5573	PRKAR1A	1
REACTOME_166208	mTORC1-mediated signalling	-2.92981870278409	0.422339771312302	0.554288267756137	1/375	19/13181	8649	LAMTOR3	1
REACTOME_167161	HIV Transcription Initiation	-2.74701439766643	0.422339771312302	0.554288267756137	1/375	19/13181	8148	TAF15	1
REACTOME_167162	RNA Polymerase II HIV Promoter Escape	-2.74701439766643	0.422339771312302	0.554288267756137	1/375	19/13181	8148	TAF15	1
REACTOME_167172	Transcription of the HIV genome	-2.74701439766643	0.422339771312302	0.554288267756137	1/375	19/13181	8148	TAF15	1
REACTOME_2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	-2.60921708680067	0.422339771312302	0.554288267756137	1/375	19/13181	6497	SKI	1
REACTOME_389357	CD28 dependent PI3K/Akt signaling	-2.25841398178445	0.422339771312302	0.554288267756137	1/375	19/13181	2534	FYN	1
REACTOME_442982	Ras activation upon Ca2+ influx through NMDA receptor	-2.33601025505576	0.422339771312302	0.554288267756137	1/375	19/13181	1739	DLG1	1
REACTOME_5362768	Hh mutants are degraded by ERAD	-2.78400064077483	0.422339771312302	0.554288267756137	1/375	19/13181	10956	OS9	1
REACTOME_5627117	RHO GTPases Activate ROCKs	-2.56072594422129	0.422339771312302	0.554288267756137	1/375	19/13181	6093	ROCK1	1
REACTOME_73776	RNA Polymerase II Promoter Escape	-2.74701439766643	0.422339771312302	0.554288267756137	1/375	19/13181	8148	TAF15	1
REACTOME_73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	-2.74701439766643	0.422339771312302	0.554288267756137	1/375	19/13181	8148	TAF15	1
REACTOME_75953	RNA Polymerase II Transcription Initiation	-2.74701439766643	0.422339771312302	0.554288267756137	1/375	19/13181	8148	TAF15	1
REACTOME_76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	-2.74701439766643	0.422339771312302	0.554288267756137	1/375	19/13181	8148	TAF15	1
REACTOME_8941858	Regulation of RUNX3 expression and activity	-2.48091801745118	0.422339771312302	0.554288267756137	1/375	19/13181	4193	MDM2	1
REACTOME_1236974	ER-Phagosome pathway	-4.80021751321686	0.42811846906241	0.560946325347534	2/375	51/13181	7099/3134	TLR4/HLA-F	2
REACTOME_3108214	SUMOylation of DNA damage response and repair proteins	-5.11012716302331	0.437890446504355	0.565617142338738	2/375	52/13181	1912/79023	PHC2/NUP37	2
REACTOME_112382	Formation of RNA Pol II elongation complex 	-2.82127332505249	0.438797952877253	0.565617142338738	1/375	20/13181	6827	SUPT4H1	1
REACTOME_168276	NS1 Mediated Effects on Host Pathways	-4.04270369838297	0.438797952877253	0.565617142338738	1/375	20/13181	79023	NUP37	1
REACTOME_2028269	Signaling by Hippo	-2.68163248759657	0.438797952877253	0.565617142338738	1/375	20/13181	60485	SAV1	1
REACTOME_3214842	HDMs demethylate histones	-2.95738089123824	0.438797952877253	0.565617142338738	1/375	20/13181	5253	PHF2	1
REACTOME_438066	Unblocking of NMDA receptors, glutamate binding and activation	-2.33601025505576	0.438797952877253	0.565617142338738	1/375	20/13181	1739	DLG1	1
REACTOME_5686938	Regulation of TLR by endogenous ligand	-3.05375985172521	0.438797952877253	0.565617142338738	1/375	20/13181	7099	TLR4	1
REACTOME_75955	RNA Polymerase II Transcription Elongation	-2.82127332505249	0.438797952877253	0.565617142338738	1/375	20/13181	6827	SUPT4H1	1
REACTOME_9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	-3.05006526093605	0.438797952877253	0.565617142338738	1/375	20/13181	23385	NCSTN	1
REACTOME_917729	Endosomal Sorting Complex Required For Transport (ESCRT)	-2.48446550605601	0.438797952877253	0.565617142338738	1/375	20/13181	51534	VTA1	1
REACTOME_9617324	Negative regulation of NMDA receptor-mediated neuronal transmission	-2.33601025505576	0.438797952877253	0.565617142338738	1/375	20/13181	1739	DLG1	1
REACTOME_9670439	Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	-2.25841398178445	0.438797952877253	0.565617142338738	1/375	20/13181	2534	FYN	1
REACTOME_977068	Termination of O-glycan biosynthesis	-2.20011744827674	0.438797952877253	0.565617142338738	1/375	20/13181	6484	ST3GAL4	1
REACTOME_9013423	RAC3 GTPase cycle	-5.89673866009586	0.444471008952286	0.571770958118233	3/375	86/13181	7112/8936/27	TMPO/WASF1/ABL2	3
REACTOME_432722	Golgi Associated Vesicle Biogenesis	-4.43928321707001	0.447570962023766	0.574828618431169	2/375	53/13181	3482/6456	IGF2R/SH3GL2	2
REACTOME_381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	-6.64533156948598	0.452706280468016	0.576875640662755	4/375	121/13181	1435/3915/5611/56955	CSF1/LAMC1/DNAJC3/MEPE	4
REACTOME_174154	APC/C:Cdc20 mediated degradation of Securin	-2.25523046225499	0.454788437465889	0.576875640662755	1/375	21/13181	25906	ANAPC15	1
REACTOME_174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	-2.25523046225499	0.454788437465889	0.576875640662755	1/375	21/13181	25906	ANAPC15	1
REACTOME_373753	Nephrin family interactions	-2.25841398178445	0.454788437465889	0.576875640662755	1/375	21/13181	2534	FYN	1
REACTOME_375165	NCAM signaling for neurite out-growth	-2.25841398178445	0.454788437465889	0.576875640662755	1/375	21/13181	2534	FYN	1
REACTOME_416572	Sema4D induced cell migration and growth-cone collapse	-2.56072594422129	0.454788437465889	0.576875640662755	1/375	21/13181	6093	ROCK1	1
REACTOME_5213460	RIPK1-mediated regulated necrosis	-2.91019126026171	0.454788437465889	0.576875640662755	1/375	21/13181	6386	SDCBP	1
REACTOME_5621575	CD209 (DC-SIGN) signaling	-2.25841398178445	0.454788437465889	0.576875640662755	1/375	21/13181	2534	FYN	1
REACTOME_71403	Citric acid cycle (TCA cycle)	-2.58392779281662	0.454788437465889	0.576875640662755	1/375	21/13181	23530	NNT	1
REACTOME_8849932	Synaptic adhesion-like molecules	-2.33601025505576	0.454788437465889	0.576875640662755	1/375	21/13181	1739	DLG1	1
REACTOME_912694	Regulation of IFNA signaling	-2.26275048328763	0.454788437465889	0.576875640662755	1/375	21/13181	3454	IFNAR1	1
REACTOME_9620244	Long-term potentiation	-2.33601025505576	0.454788437465889	0.576875640662755	1/375	21/13181	1739	DLG1	1
REACTOME_9664422	FCGR3A-mediated phagocytosis	-3.65576830513331	0.457157303752036	0.579187341008556	2/375	54/13181	2534/8936	FYN/WASF1	2
REACTOME_8856828	Clathrin-mediated endocytosis	-6.02868332019802	0.45899743386517	0.581055668666896	4/375	122/13181	5869/6572/3482/6456	RAB5B/SLC18A3/IGF2R/SH3GL2	4
REACTOME_204005	COPII-mediated vesicle transport	-3.83383483844799	0.466646987163768	0.589731834877899	2/375	55/13181	10342/10484	TFG/SEC23A	2
REACTOME_163560	Triglyceride catabolism	-2.63835421541071	0.470324481231109	0.590458685477665	1/375	22/13181	51099	ABHD5	1
REACTOME_2029485	Role of phospholipids in phagocytosis	-3.18843192320265	0.470324481231109	0.590458685477665	1/375	22/13181	3710	ITPR3	1
REACTOME_210500	Glutamate Neurotransmitter Release Cycle	-2.83109600356936	0.470324481231109	0.590458685477665	1/375	22/13181	6507	SLC1A3	1
REACTOME_2453902	The canonical retinoid cycle in rods (twilight vision)	-2.42197056303904	0.470324481231109	0.590458685477665	1/375	22/13181	157506	RDH10	1
REACTOME_72187	mRNA 3'-end processing	-3.16814487914673	0.470324481231109	0.590458685477665	1/375	22/13181	10212	DDX39A	1
REACTOME_193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	-2.84288038464503	0.485418965579337	0.600168083414576	1/375	23/13181	3295	HSD17B4	1
REACTOME_2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	-2.1983231609498	0.485418965579337	0.600168083414576	1/375	23/13181	7027	TFDP1	1
REACTOME_5358346	Hedgehog ligand biogenesis	-2.78400064077483	0.485418965579337	0.600168083414576	1/375	23/13181	10956	OS9	1
REACTOME_5621480	Dectin-2 family	-2.25841398178445	0.485418965579337	0.600168083414576	1/375	23/13181	2534	FYN	1
REACTOME_5674400	Constitutive Signaling by AKT1 E17K in Cancer	-2.48091801745118	0.485418965579337	0.600168083414576	1/375	23/13181	4193	MDM2	1
REACTOME_75876	Synthesis of very long-chain fatty acyl-CoAs	-2.46298232227597	0.485418965579337	0.600168083414576	1/375	23/13181	11000	SLC27A3	1
REACTOME_9634638	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	-2.51863122763248	0.485418965579337	0.600168083414576	1/375	23/13181	596	BCL2	1
REACTOME_449836	Other interleukin signaling	-2.4588873753904	0.500084407736788	0.611877036015001	1/375	24/13181	1435	CSF1	1
REACTOME_5357956	TNFR1-induced NFkappaB signaling pathway	-4.13693935293315	0.500084407736788	0.611877036015001	1/375	24/13181	7128	TNFAIP3	1
REACTOME_5678895	Defective CFTR causes cystic fibrosis	-2.78400064077483	0.500084407736788	0.611877036015001	1/375	24/13181	10956	OS9	1
REACTOME_73856	RNA Polymerase II Transcription Termination	-3.16814487914673	0.500084407736788	0.611877036015001	1/375	24/13181	10212	DDX39A	1
REACTOME_9619483	Activation of AMPK downstream of NMDARs	-4.34063572413182	0.500084407736788	0.611877036015001	1/375	24/13181	5562	PRKAA1	1
REACTOME_180024	DARPP-32 events	-2.69033454609929	0.514332971018593	0.623315109694789	1/375	25/13181	5573	PRKAR1A	1
REACTOME_69017	CDK-mediated phosphorylation and removal of Cdc6	-2.25523046225499	0.514332971018593	0.623315109694789	1/375	25/13181	25906	ANAPC15	1
REACTOME_166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	-3.05375985172521	0.528176474809109	0.63261815061882	1/375	26/13181	7099	TLR4	1
REACTOME_182971	EGFR downregulation	-2.63294480167501	0.528176474809109	0.63261815061882	1/375	26/13181	6456	SH3GL2	1
REACTOME_2682334	EPH-Ephrin signaling	-2.25841398178445	0.528176474809109	0.63261815061882	1/375	26/13181	2534	FYN	1
REACTOME_3238698	WNT ligand biogenesis and trafficking	-2.37626718837996	0.528176474809109	0.63261815061882	1/375	26/13181	55737	VPS35	1
REACTOME_445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	-2.53566866271786	0.528176474809109	0.63261815061882	1/375	26/13181	64127	NOD2	1
REACTOME_6791226	Major pathway of rRNA processing in the nucleolus and cytosol	-2.387259138259	0.528176474809109	0.63261815061882	1/375	26/13181	6146	RPL22	1
REACTOME_912526	Interleukin receptor SHC signaling	-2.38122227325096	0.528176474809109	0.63261815061882	1/375	26/13181	3718	JAK3	1
REACTOME_9694548	Maturation of spike protein	-2.20011744827674	0.528176474809109	0.63261815061882	1/375	26/13181	6484	ST3GAL4	1
REACTOME_1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	-2.28185465833687	0.541626404261529	0.641240493503969	1/375	27/13181	112399	EGLN3	1
REACTOME_1483191	Synthesis of PC	-2.22492902643912	0.541626404261529	0.641240493503969	1/375	27/13181	1120	CHKB	1
REACTOME_201451	Signaling by BMP	-2.60921708680067	0.541626404261529	0.641240493503969	1/375	27/13181	6497	SKI	1
REACTOME_2122948	Activated NOTCH1 Transmits Signal to the Nucleus	-3.05006526093605	0.541626404261529	0.641240493503969	1/375	27/13181	23385	NCSTN	1
REACTOME_6784531	tRNA processing in the nucleus	-4.04270369838297	0.541626404261529	0.641240493503969	1/375	27/13181	79023	NUP37	1
REACTOME_9662360	Sensory processing of sound by inner hair cells of the cochlea	-4.00889516483507	0.547394054438532	0.646624477382813	2/375	64/13181	3778/9478	KCNMA1/CABP1	2
REACTOME_2022854	Keratan sulfate biosynthesis	-2.20011744827674	0.554693919724652	0.646968674500656	1/375	28/13181	6484	ST3GAL4	1
REACTOME_3295583	TRP channels	-2.58674918393228	0.554693919724652	0.646968674500656	1/375	28/13181	162514	TRPV3	1
REACTOME_420029	Tight junction interactions	-2.22932567343673	0.554693919724652	0.646968674500656	1/375	28/13181	84552	PARD6G	1
REACTOME_422356	Regulation of insulin secretion	-3.18843192320265	0.554693919724652	0.646968674500656	1/375	28/13181	3710	ITPR3	1
REACTOME_525793	Myogenesis	-3.28796879434378	0.554693919724652	0.646968674500656	1/375	28/13181	1013	CDH15	1
REACTOME_6804757	Regulation of TP53 Degradation	-2.48091801745118	0.554693919724652	0.646968674500656	1/375	28/13181	4193	MDM2	1
REACTOME_9013026	RHOB GTPase cycle	-4.4396100955221	0.555823402118174	0.646968674500656	2/375	65/13181	23263/6093	MCF2L/ROCK1	2
REACTOME_9013408	RHOG GTPase cycle	-4.93559274432206	0.555823402118174	0.646968674500656	2/375	65/13181	23263/7112	MCF2L/TMPO	2
REACTOME_186763	Downstream signal transduction	-2.41372563552681	0.567389865904479	0.656347680456981	1/375	29/13181	5156	PDGFRA	1
REACTOME_2424491	DAP12 signaling	-2.25841398178445	0.567389865904479	0.656347680456981	1/375	29/13181	2534	FYN	1
REACTOME_389661	Glyoxylate metabolism and glycine degradation	-2.7569373661244	0.567389865904479	0.656347680456981	1/375	29/13181	64902	AGXT2	1
REACTOME_5357905	Regulation of TNFR1 signaling	-4.13693935293315	0.567389865904479	0.656347680456981	1/375	29/13181	7128	TNFAIP3	1
REACTOME_6796648	TP53 Regulates Transcription of DNA Repair Genes	-2.82127332505249	0.567389865904479	0.656347680456981	1/375	29/13181	6827	SUPT4H1	1
REACTOME_8853884	Transcriptional Regulation by VENTX	-2.25523046225499	0.567389865904479	0.656347680456981	1/375	29/13181	25906	ANAPC15	1
REACTOME_1169091	Activation of NF-kappaB in B cells	-2.61060480780367	0.57972478076806	0.664572747960501	1/375	30/13181	10892	MALT1	1
REACTOME_1251985	Nuclear signaling by ERBB4	-3.05006526093605	0.57972478076806	0.664572747960501	1/375	30/13181	23385	NCSTN	1
REACTOME_1592389	Activation of Matrix Metalloproteinases	-2.18728250531564	0.57972478076806	0.664572747960501	1/375	30/13181	1991	ELANE	1
REACTOME_3000157	Laminin interactions	-3.70080166638359	0.57972478076806	0.664572747960501	1/375	30/13181	3915	LAMC1	1
REACTOME_936440	Negative regulators of DDX58/IFIH1 signaling	-4.13693935293315	0.57972478076806	0.664572747960501	1/375	30/13181	7128	TNFAIP3	1
REACTOME_9646399	Aggrephagy	-2.56133329658573	0.57972478076806	0.664572747960501	1/375	30/13181	8655	DYNLL1	1
REACTOME_114604	GPVI-mediated activation cascade	-2.25841398178445	0.591708904196847	0.67321442409516	1/375	31/13181	2534	FYN	1
REACTOME_186797	Signaling by PDGF	-2.41372563552681	0.591708904196847	0.67321442409516	1/375	31/13181	5156	PDGFRA	1
REACTOME_202433	Generation of second messenger molecules	-2.36722792871329	0.591708904196847	0.67321442409516	1/375	31/13181	9398	CD101	1
REACTOME_2871809	FCERI mediated Ca+2 mobilization	-3.18843192320265	0.591708904196847	0.67321442409516	1/375	31/13181	3710	ITPR3	1
REACTOME_445095	Interaction between L1 and Ankyrins	-2.37059811403456	0.591708904196847	0.67321442409516	1/375	31/13181	3786	KCNQ3	1
REACTOME_190861	Gap junction assembly	-2.28950702247156	0.603352186396557	0.681248246852801	1/375	32/13181	10804	GJB6	1
REACTOME_5663213	RHO GTPases Activate WASPs and WAVEs	-2.56540121679177	0.603352186396557	0.681248246852801	1/375	32/13181	8936	WASF1	1
REACTOME_6807878	COPI-mediated anterograde transport	-3.65988268093545	0.611680717515437	0.688303142851766	2/375	72/13181	8655/1604	DYNLL1/CD55	2
REACTOME_4085001	Sialic acid metabolism	-2.20011744827674	0.614664296070394	0.689464713052506	1/375	33/13181	6484	ST3GAL4	1
REACTOME_432720	Lysosome Vesicle Biogenesis	-2.63294480167501	0.614664296070394	0.689464713052506	1/375	33/13181	6456	SH3GL2	1
REACTOME_3299685	Detoxification of Reactive Oxygen Species	-2.80218000086592	0.625654628362271	0.698098848488429	1/375	34/13181	25824	PRDX5	1
REACTOME_6803157	Antimicrobial peptides	-2.18728250531564	0.625654628362271	0.698098848488429	1/375	34/13181	1991	ELANE	1
REACTOME_8939902	Regulation of RUNX2 expression and activity	-2.32686646858061	0.625654628362271	0.698098848488429	1/375	34/13181	860	RUNX2	1
REACTOME_3769402	Deactivation of the beta-catenin transactivating complex	-2.46728986507517	0.636332312576476	0.707035902862751	1/375	35/13181	57680	CHD8	1
REACTOME_3899300	SUMOylation of transcription cofactors	-2.70014951828173	0.636332312576476	0.707035902862751	1/375	35/13181	1912	PHC2	1
REACTOME_390522	Striated Muscle Contraction	-2.67647952194165	0.636332312576476	0.707035902862751	1/375	35/13181	4626	MYH8	1
REACTOME_9609736	Assembly and cell surface presentation of NMDA receptors	-2.33601025505576	0.646706219680068	0.716309919394851	1/375	36/13181	1739	DLG1	1
REACTOME_416482	G alpha (12/13) signalling events	-4.4396100955221	0.648197871278046	0.717462314884854	2/375	77/13181	23263/6093	MCF2L/ROCK1	2
REACTOME_2559582	Senescence-Associated Secretory Phenotype (SASP)	-2.25523046225499	0.656784969594102	0.72236714803985	1/375	37/13181	25906	ANAPC15	1
REACTOME_5675221	Negative regulation of MAPK pathway	-2.74751944767856	0.656784969594102	0.72236714803985	1/375	37/13181	11221	DUSP10	1
REACTOME_9639288	Amino acids regulate mTORC1	-2.92981870278409	0.656784969594102	0.72236714803985	1/375	37/13181	8649	LAMTOR3	1
REACTOME_198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	-5.83705427452958	0.656945217651335	0.72236714803985	3/375	118/13181	10225/3821/3134	CD96/KLRC1/HLA-F	3
REACTOME_1660661	Sphingolipid de novo biosynthesis	-2.50479146127358	0.666576938279602	0.731188224811706	1/375	38/13181	91012	CERS5	1
REACTOME_420499	Class C/3 (Metabotropic glutamate/pheromone receptors)	-2.86654111801946	0.666576938279602	0.731188224811706	1/375	38/13181	50836	TAS2R8	1
REACTOME_3000171	Non-integrin membrane-ECM interactions	-3.70080166638359	0.685332857134022	0.744570715984349	1/375	40/13181	3915	LAMC1	1
REACTOME_382556	ABC-family proteins mediated transport	-2.78400064077483	0.685332857134022	0.744570715984349	1/375	40/13181	10956	OS9	1
REACTOME_419037	NCAM1 interactions	-2.29780557345236	0.685332857134022	0.744570715984349	1/375	40/13181	779	CACNA1S	1
REACTOME_437239	Recycling pathway of L1	-2.63294480167501	0.685332857134022	0.744570715984349	1/375	40/13181	6456	SH3GL2	1
REACTOME_5607764	CLEC7A (Dectin-1) signaling	-2.61060480780367	0.685332857134022	0.744570715984349	1/375	40/13181	10892	MALT1	1
REACTOME_5674135	MAP2K and MAPK activation	-2.92981870278409	0.685332857134022	0.744570715984349	1/375	40/13181	8649	LAMTOR3	1
REACTOME_9696264	RND3 GTPase cycle	-2.56072594422129	0.685332857134022	0.744570715984349	1/375	40/13181	6093	ROCK1	1
REACTOME_5368286	Mitochondrial translation initiation	-3.63260299125626	0.688365783402612	0.746845169300684	2/375	83/13181	7818/51021	DAP3/MRPS16	2
REACTOME_5419276	Mitochondrial translation termination	-3.63260299125626	0.688365783402612	0.746845169300684	2/375	83/13181	7818/51021	DAP3/MRPS16	2
REACTOME_381038	XBP1(S) activates chaperone genes	-3.12308657991539	0.694312400439306	0.751020840436807	1/375	41/13181	5611	DNAJC3	1
REACTOME_5689603	UCH proteinases	-2.77206995625144	0.694312400439306	0.751020840436807	1/375	41/13181	54617	INO80	1
REACTOME_2871837	FCERI mediated NF-kB activation	-2.61060480780367	0.703036361613983	0.755289064166374	1/375	42/13181	10892	MALT1	1
REACTOME_432040	Vasopressin regulates renal water homeostasis via Aquaporins	-2.69033454609929	0.703036361613983	0.755289064166374	1/375	42/13181	5573	PRKAR1A	1
REACTOME_8854214	TBC/RABGAPs	-2.42066928203372	0.703036361613983	0.755289064166374	1/375	42/13181	5869	RAB5B	1
REACTOME_3371453	Regulation of HSF1-mediated heat shock response	-4.04270369838297	0.711511996319422	0.761564506326409	1/375	43/13181	79023	NUP37	1
REACTOME_5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	-2.82080346190859	0.711511996319422	0.761564506326409	1/375	43/13181	23512	SUZ12	1
REACTOME_6783783	Interleukin-10 signaling	-2.4588873753904	0.711511996319422	0.761564506326409	1/375	43/13181	1435	CSF1	1
REACTOME_975634	Retinoid metabolism and transport	-2.60495444168599	0.711511996319422	0.761564506326409	1/375	43/13181	338328	GPIHBP1	1
REACTOME_1660662	Glycosphingolipid metabolism	-2.28700489197515	0.719746354774302	0.767931335449169	1/375	44/13181	2583	B4GALNT1	1
REACTOME_9013149	RAC1 GTPase cycle	-7.14961486018724	0.721276230904296	0.769167811628324	4/375	171/13181	23263/7112/8936/27	MCF2L/TMPO/WASF1/ABL2	4
REACTOME_1169408	ISG15 antiviral mechanism	-4.04270369838297	0.735518451241505	0.780951143555254	1/375	46/13181	79023	NUP37	1
REACTOME_6811440	Retrograde transport at the Trans-Golgi-Network	-3.2247245214102	0.735518451241505	0.780951143555254	1/375	46/13181	3482	IGF2R	1
REACTOME_977225	Amyloid fiber formation	-3.05006526093605	0.735518451241505	0.780951143555254	1/375	46/13181	23385	NCSTN	1
REACTOME_400253	Circadian Clock	-2.41749560171395	0.743069313882117	0.787124859412025	1/375	47/13181	200186	CRTC2	1
REACTOME_9013405	RHOD GTPase cycle	-3.21517897291893	0.743069313882117	0.787124859412025	1/375	47/13181	7112	TMPO	1
REACTOME_8980692	RHOA GTPase cycle	-5.84676707993267	0.743313192708903	0.787124859412025	3/375	135/13181	23263/7112/6093	MCF2L/TMPO/ROCK1	3
REACTOME_9020702	Interleukin-1 signaling	-2.53566866271786	0.750405160333632	0.79305031899666	1/375	48/13181	64127	NOD2	1
REACTOME_913709	O-linked glycosylation of mucins	-2.39832531334792	0.750405160333632	0.79305031899666	1/375	48/13181	56913	C1GALT1	1
REACTOME_2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	-3.05006526093605	0.757532097429108	0.799254170479284	1/375	49/13181	23385	NCSTN	1
REACTOME_2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	-3.05006526093605	0.757532097429108	0.799254170479284	1/375	49/13181	23385	NCSTN	1
REACTOME_1660499	Synthesis of PIPs at the plasma membrane	-2.59143107486542	0.764456059008767	0.804158209608958	1/375	50/13181	84725	PLEKHA8	1
REACTOME_6799198	Complex I biogenesis	-2.74272481720851	0.764456059008767	0.804158209608958	1/375	50/13181	4731	NDUFV3	1
REACTOME_383280	Nuclear Receptor transcription pathway	-2.33761000591826	0.771182810807694	0.808559623596594	1/375	51/13181	6257	RXRB	1
REACTOME_5578775	Ion homeostasis	-3.18843192320265	0.771182810807694	0.808559623596594	1/375	51/13181	3710	ITPR3	1
REACTOME_380108	Chemokine receptors bind chemokines	-2.33977710421967	0.777717955205799	0.813533913669224	1/375	52/13181	6373	CXCL11	1
REACTOME_6794361	Neurexins and neuroligins	-2.56335830206798	0.784066935843915	0.818291058740942	1/375	53/13181	9066	SYT7	1
REACTOME_9013409	RHOJ GTPase cycle	-3.21517897291893	0.784066935843915	0.818291058740942	1/375	53/13181	7112	TMPO	1
REACTOME_5610787	Hedgehog 'off' state	-2.69033454609929	0.7902350421098	0.823107577435035	1/375	54/13181	5573	PRKAR1A	1
REACTOME_72163	mRNA Splicing - Major Pathway	-2.99148466560299	0.7902350421098	0.823107577435035	1/375	54/13181	6629	SNRPB2	1
REACTOME_193648	NRAGE signals death through JNK	-3.29737469756733	0.796227413497689	0.826911552881336	1/375	55/13181	23263	MCF2L	1
REACTOME_202424	Downstream TCR signaling	-2.61060480780367	0.796227413497689	0.826911552881336	1/375	55/13181	10892	MALT1	1
REACTOME_2029482	Regulation of actin dynamics for phagocytic cup formation	-2.56540121679177	0.796227413497689	0.826911552881336	1/375	55/13181	8936	WASF1	1
REACTOME_9033241	Peroxisomal protein import	-2.84288038464503	0.818537327816805	0.844564796384633	1/375	59/13181	3295	HSD17B4	1
REACTOME_1442490	Collagen degradation	-2.18728250531564	0.82372316092675	0.847715097652772	1/375	60/13181	1991	ELANE	1
REACTOME_4086398	Ca2+ pathway	-3.18843192320265	0.82372316092675	0.847715097652772	1/375	60/13181	3710	ITPR3	1
REACTOME_6802952	Signaling by BRAF and RAF1 fusions	-3.06879177409089	0.838410451136942	0.859769504874388	1/375	63/13181	10142	AKAP9	1
REACTOME_1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	-2.22923314835029	0.856112307487141	0.874257269688217	1/375	67/13181	10890	RAB10	1
REACTOME_3000178	ECM proteoglycans	-3.70080166638359	0.87910454599251	0.895436404950731	1/375	73/13181	3915	LAMC1	1
REACTOME_9660821	ADORA2B mediated anti-inflammatory cytokines production	-3.69414561339014	0.888399443440891	0.901950644027642	2/375	130/13181	5573/6019	PRKAR1A/RLN2	2
REACTOME_611105	Respiratory electron transport	-2.74272481720851	0.889187191517817	0.901950644027642	1/375	76/13181	4731	NDUFV3	1
REACTOME_202733	Cell surface interactions at the vascular wall	-2.25841398178445	0.898431002015115	0.910165844666475	1/375	79/13181	2534	FYN	1
REACTOME_9013404	RAC2 GTPase cycle	-3.21517897291893	0.901338067672597	0.911368856978969	1/375	80/13181	7112	TMPO	1
REACTOME_418555	G alpha (s) signalling events	-4.12906162197209	0.909394598023437	0.918233291994403	2/375	139/13181	27115/6019	PDE7B/RLN2	2
REACTOME_9013148	CDC42 GTPase cycle	-4.93559274432206	0.924899481434968	0.931637741831865	2/375	147/13181	23263/7112	MCF2L/TMPO	2
REACTOME_375276	Peptide ligand-binding receptors	-3.64710934769585	0.950888972738982	0.953287179479811	1/375	104/13181	1909	EDNRA	1
REACTOME_6809371	Formation of the cornified envelope	-3.43408526755726	0.953665337157107	0.955769231692279	1/375	106/13181	3875	KRT18	1
REACTOME_114608	Platelet degranulation 	-3.31951231151986	0.965367640205181	0.966887904205504	1/375	116/13181	3082	HGF	1
REACTOME_6805567	Keratinization	-3.43408526755726	0.968265200301121	0.969484677883364	1/375	119/13181	3875	KRT18	1
REACTOME_416476	G alpha (q) signalling events	-3.64710934769585	0.991948328005883	0.991948328005883	1/375	166/13181	1909	EDNRA	1
