ID	Description	NES	pvalue	p.adjust	GeneRatio	BgRatio	geneID	geneName	Count
KEGG_hsa05202	Transcriptional misregulation in cancer	-12.0093513677042	0.00218704291660541	0.333061037954299	12/375	161/13181	2115/6257/4193/861/4066/6692/51804/860/84444/466/8148/1991	ETV1/RXRB/MDM2/RUNX1/LYL1/SPINT1/SIX4/RUNX2/DOT1L/ATF1/TAF15/ELANE	12
KEGG_hsa05416	Viral myocarditis	-7.22009074993886	0.0211690639561978	0.333061037954299	5/375	56/13181	6444/2534/27/1604/3134	SGCD/FYN/ABL2/CD55/HLA-F	5
KEGG_hsa04924	Renin secretion	-7.59575238504434	0.0373071770024726	0.333061037954299	5/375	65/13181	134/3710/1909/3778/779	ADORA1/ITPR3/EDNRA/KCNMA1/CACNA1S	5
KEGG_hsa05222	Small cell lung cancer	-7.75706494798995	0.041189342742285	0.333061037954299	6/375	89/13181	6257/5925/317/1871/596/3915	RXRB/RB1/APAF1/E2F3/BCL2/LAMC1	6
KEGG_hsa04071	Sphingolipid signaling pathway	-7.93458129834019	0.0440654412770072	0.333061037954299	7/375	114/13181	134/5520/5603/596/2534/91012/6093	ADORA1/PPP2R2A/MAPK13/BCL2/FYN/CERS5/ROCK1	7
KEGG_hsa05218	Melanoma	-6.9441688246006	0.0488273014794569	0.333061037954299	5/375	70/13181	4193/5925/3082/1871/5156	MDM2/RB1/HGF/E2F3/PDGFRA	5
KEGG_hsa05223	Non-small cell lung cancer	-6.85181413227277	0.0488273014794569	0.333061037954299	5/375	70/13181	6257/5925/3082/3718/1871	RXRB/RB1/HGF/JAK3/E2F3	5
KEGG_hsa00230	Purine metabolism	-8.67002398563803	0.0494913532998636	0.333061037954299	7/375	117/13181	353/374659/5167/11164/53343/27115/84284	APRT/HDDC3/ENPP1/NUDT5/NUDT9/PDE7B/NTPCR	7
KEGG_hsa05215	Prostate cancer	-7.16705711184578	0.0514122556441039	0.333061037954299	6/375	94/13181	4193/5925/6692/1871/596/5156	MDM2/RB1/SPINT1/E2F3/BCL2/PDGFRA	6
KEGG_hsa04630	JAK-STAT signaling pathway	-9.39437255149917	0.0627661882614915	0.333061037954299	8/375	149/13181	3718/596/5156/3454/11009/3460/53342/4170	JAK3/BCL2/PDGFRA/IFNAR1/IL24/IFNGR2/IL17D/MCL1	8
KEGG_hsa04066	HIF-1 signaling pathway	-7.61394876939284	0.0630574379071875	0.333061037954299	6/375	99/13181	2872/7099/596/284/3460/112399	MKNK2/TLR4/BCL2/ANGPT1/IFNGR2/EGLN3	6
KEGG_hsa05161	Hepatitis B	-8.88908003982572	0.0647461507177291	0.333061037954299	8/375	150/13181	5925/3718/317/1871/7099/5603/596/3454	RB1/JAK3/APAF1/E2F3/TLR4/MAPK13/BCL2/IFNAR1	8
KEGG_hsa05162	Measles	-8.68203384999571	0.0659593176592909	0.333061037954299	7/375	125/13181	7128/103/3718/317/7099/596/3454	TNFAIP3/ADAR/JAK3/APAF1/TLR4/BCL2/IFNAR1	7
KEGG_hsa04530	Tight junction	-10.1999052173111	0.0688214361977489	0.333061037954299	8/375	152/13181	5520/1739/11149/861/54566/84552/5562/6093	PPP2R2A/DLG1/BVES/RUNX1/EPB41L4B/PARD6G/PRKAA1/ROCK1	8
KEGG_hsa00760	Nicotinate and nicotinamide metabolism	-4.76798506728402	0.071466219158663	0.333061037954299	3/375	34/13181	5167/23530/23409	ENPP1/NNT/SIRT4	3
KEGG_hsa04110	Cell cycle	-6.27194353311453	0.0807740761295305	0.333061037954299	5/375	81/13181	4193/5925/1871/25906/7027	MDM2/RB1/E2F3/ANAPC15/TFDP1	5
KEGG_hsa04725	Cholinergic synapse	-7.25315667192528	0.0876233498883136	0.342472635185437	6/375	108/13181	3786/3710/6572/779/596/2534	KCNQ3/ITPR3/SLC18A3/CACNA1S/BCL2/FYN	6
KEGG_hsa05152	Tuberculosis	-9.14717923322801	0.0890710916448871	0.342472635185437	8/375	161/13181	5869/317/7099/5603/596/64127/3460/10892	RAB5B/APAF1/TLR4/MAPK13/BCL2/NOD2/IFNGR2/MALT1	8
KEGG_hsa00670	One carbon pool by folate	-4.01998511406439	0.091572093539967	0.342472635185437	2/375	18/13181	160428/1719	ALDH1L2/DHFR	2
KEGG_hsa05219	Bladder cancer	-4.82396993157296	0.0928749245713212	0.342472635185437	3/375	38/13181	4193/5925/1871	MDM2/RB1/E2F3	3
KEGG_hsa00830	Retinol metabolism	-6.2627011653997	0.0952796593684886	0.342472635185437	4/375	61/13181	8694/157506/127/79799	DGAT1/RDH10/ADH4/UGT2A3	4
KEGG_hsa04621	NOD-like receptor signaling pathway	-10.1796340232784	0.096514340988105	0.342472635185437	8/375	164/13181	3710/7128/7099/5603/596/3454/64127/114769	ITPR3/TNFAIP3/TLR4/MAPK13/BCL2/IFNAR1/NOD2/CARD16	8
KEGG_hsa00532	Glycosaminoglycan biosynthesis	-5.16500923795603	0.109634321578231	0.342472635185437	2/375	20/13181	55790/51363	CSGALNACT1/CHST15	2
KEGG_hsa00071	Fatty acid degradation	-5.70850771524604	0.116573777824884	0.361310539457243	3/375	42/13181	1375/127/3033	CPT1B/ADH4/HADH	3
KEGG_hsa04141	Protein processing in endoplasmic reticulum	-8.69453129378938	0.116833399369967	0.361762619276041	7/375	144/13181	10961/596/10956/5611/3301/10484/7095	ERP29/BCL2/OS9/DNAJC3/DNAJA1/SEC23A/SEC62	7
KEGG_hsa01522	Endocrine resistance	-6.76760675582013	0.129743189169866	0.362203115160261	5/375	94/13181	4193/5925/1871/5603/596	MDM2/RB1/E2F3/MAPK13/BCL2	5
KEGG_hsa04217	Necroptosis	-8.315991794593	0.134717058871991	0.362743647089697	6/375	122/13181	7128/3718/7099/596/3454/3460	TNFAIP3/JAK3/TLR4/BCL2/IFNAR1/IFNGR2	6
KEGG_hsa00270	Cysteine and methionine metabolism	-4.94056097742514	0.13566789639507	0.364070810579175	3/375	45/13181	7263/64902/1491	TST/AGXT2/CTH	3
KEGG_hsa04660	T cell receptor signaling pathway	-6.57040453651434	0.138261616563864	0.367618679492549	5/375	96/13181	1739/1493/5603/2534/10892	DLG1/CTLA4/MAPK13/FYN/MALT1	5
KEGG_hsa04270	Vascular smooth muscle contraction	-8.3141164101448	0.146115591621083	0.382557479184204	6/375	125/13181	3710/1909/3778/779/157855/6093	ITPR3/EDNRA/KCNMA1/CACNA1S/KCNU1/ROCK1	6
KEGG_hsa05164	Influenza A	-8.4830531865259	0.14996345299117	0.382557479184204	7/375	154/13181	103/317/7099/23430/3454/3460/5611	ADAR/APAF1/TLR4/TPSD1/IFNAR1/IFNGR2/DNAJC3	7
KEGG_hsa05214	Glioma	-5.68593166205993	0.153982763962023	0.382557479184204	4/375	73/13181	4193/5925/1871/5156	MDM2/RB1/E2F3/PDGFRA	4
KEGG_hsa00750	Vitamin B6 metabolism	-2.5293912094284	0.159038046377836	0.382557479184204	1/375	6/13181	55163	PNPO	1
KEGG_hsa04022	cGMP-PKG signaling pathway	-8.83620126728613	0.160683279831996	0.386222849482803	7/375	157/13181	134/3710/1909/3778/779/157855/6093	ADORA1/ITPR3/EDNRA/KCNMA1/CACNA1S/KCNU1/ROCK1	7
KEGG_hsa05220	Chronic myeloid leukemia	-7.11258754565205	0.164861640854947	0.394774109878562	4/375	75/13181	4193/5925/861/1871	MDM2/RB1/RUNX1/E2F3	4
KEGG_hsa04625	C-type lectin receptor signaling pathway	-7.35844386975186	0.165217638744336	0.395328887288932	5/375	102/13181	3710/4193/5603/10892/53342	ITPR3/MDM2/MAPK13/MALT1/IL17D	5
KEGG_hsa00650	Butanoate metabolism	-5.44594484200697	0.168245376255695	0.395822052163494	2/375	26/13181	3033/7915	HADH/ALDH5A1	2
KEGG_hsa03018	RNA degradation	-5.24571200662507	0.169612973150055	0.395822052163494	3/375	50/13181	23019/9652/115752	CNOT1/TTC37/DIS3L	3
KEGG_hsa04659	Th17 cell differentiation	-7.96895277309817	0.17463760332196	0.395822052163494	5/375	104/13181	6257/861/3718/5603/3460	RXRB/RUNX1/JAK3/MAPK13/IFNGR2	5
KEGG_hsa05323	Rheumatoid arthritis	-6.17730579355323	0.176007177513234	0.395822052163494	4/375	77/13181	7099/1493/1435/284	TLR4/CTLA4/CSF1/ANGPT1	4
KEGG_hsa04215	Apoptosis	-3.66832103034305	0.178478309046191	0.395822052163494	2/375	27/13181	317/596	APAF1/BCL2	2
KEGG_hsa05145	Toxoplasmosis	-7.78860626780423	0.179423353345942	0.395822052163494	5/375	105/13181	7099/5603/596/3915/3460	TLR4/MAPK13/BCL2/LAMC1/IFNGR2	5
KEGG_hsa04122	Sulfur relay system	-2.65122486667562	0.18297434486803	0.395822052163494	1/375	7/13181	7263	TST	1
KEGG_hsa01212	Fatty acid metabolism	-5.79221927615974	0.205680693341143	0.410397327305273	3/375	55/13181	3295/1375/3033	HSD17B4/CPT1B/HADH	3
KEGG_hsa00740	Riboflavin metabolism	-2.60344873970846	0.206231109759065	0.410397327305273	1/375	8/13181	5167	ENPP1	1
KEGG_hsa00920	Sulfur metabolism	-2.65122486667562	0.206231109759065	0.410397327305273	1/375	8/13181	7263	TST	1
KEGG_hsa04152	AMPK signaling pathway	-7.66174108992375	0.214212866015258	0.421532743767649	5/375	112/13181	200186/10890/5520/1375/5562	CRTC2/RAB10/PPP2R2A/CPT1B/PRKAA1	5
KEGG_hsa00310	Lysine degradation	-5.53672269083259	0.220569080411281	0.4245459229694	3/375	57/13181	55217/84444/3033	TMLHE/DOT1L/HADH	3
KEGG_hsa04911	Insulin secretion	-6.21259280684057	0.228969290685902	0.424561133749952	4/375	86/13181	3710/3778/779/157855	ITPR3/KCNMA1/CACNA1S/KCNU1	4
KEGG_hsa04218	Cellular senescence	-8.22062463176327	0.231868113352097	0.427691763607697	6/375	145/13181	3710/4193/5925/1871/5603/3134	ITPR3/MDM2/RB1/E2F3/MAPK13/HLA-F	6
KEGG_hsa05160	Hepatitis C	-7.5837025179381	0.231868113352097	0.427691763607697	6/375	145/13181	5520/5925/439996/317/1871/3454	PPP2R2A/RB1/IFIT1B/APAF1/E2F3/IFNAR1	6
KEGG_hsa04380	Osteoclast differentiation	-6.58400659837815	0.240264206378359	0.440844789870969	5/375	117/13181	5603/1435/2534/3454/3460	MAPK13/CSF1/FYN/IFNAR1/IFNGR2	5
KEGG_hsa00250	Alanine, aspartate and glutamate metabolism	-5.34684697874088	0.251983330438445	0.44149145498306	2/375	34/13181	64902/7915	AGXT2/ALDH5A1	2
KEGG_hsa05231	Choline metabolism in cancer	-5.70555907904352	0.259946085094752	0.454441204288792	4/375	91/13181	1606/1120/5156/8936	DGKA/CHKB/PDGFRA/WASF1	4
KEGG_hsa05216	Thyroid cancer	-3.54094201933189	0.262613365079314	0.45588714237324	2/375	35/13181	6257/10342	RXRB/TFG	2
KEGG_hsa01524	Platinum drug resistance	-4.71779973426836	0.266349618697547	0.45588714237324	3/375	63/13181	4193/317/596	MDM2/APAF1/BCL2	3
KEGG_hsa04612	Antigen processing and presentation	-5.32762325675794	0.266349618697547	0.45588714237324	3/375	63/13181	10437/3821/3134	IFI30/KLRC1/HLA-F	3
KEGG_hsa05321	Inflammatory bowel disease	-5.32562857070264	0.266349618697547	0.45588714237324	3/375	63/13181	7099/64127/3460	TLR4/NOD2/IFNGR2	3
KEGG_hsa03060	Protein export	-2.33076575293514	0.272113914396474	0.45588714237324	1/375	11/13181	7095	SEC62	1
KEGG_hsa04620	Toll-like receptor signaling pathway	-6.05064284899064	0.272562263788079	0.45588714237324	4/375	93/13181	7099/5603/3454/6373	TLR4/MAPK13/IFNAR1/CXCL11	4
KEGG_hsa04115	p53 signaling pathway	-4.71779973426836	0.28186960252982	0.466081045371688	3/375	65/13181	4193/317/596	MDM2/APAF1/BCL2	3
KEGG_hsa00260	Glycine, serine and threonine metabolism	-3.80123739907142	0.283871222774852	0.466081045371688	2/375	37/13181	64902/1491	AGXT2/CTH	2
KEGG_hsa04962	Vasopressin-regulated water reabsorption	-3.77565192140551	0.283871222774852	0.466081045371688	2/375	37/13181	5869/8655	RAB5B/DYNLL1	2
KEGG_hsa04064	NF-kappa B signaling pathway	-7.07594467198328	0.285280675083448	0.466081045371688	4/375	95/13181	7128/7099/596/10892	TNFAIP3/TLR4/BCL2/MALT1	4
KEGG_hsa03030	DNA replication	-2.57283911223424	0.29283960020523	0.466081045371688	1/375	12/13181	29935	RPA4	1
KEGG_hsa03430	Mismatch repair	-2.57283911223424	0.29283960020523	0.466081045371688	1/375	12/13181	29935	RPA4	1
KEGG_hsa00860	Porphyrin and chlorophyll metabolism	-3.89844936304219	0.294482128230603	0.467758825061597	2/375	38/13181	1355/79799	COX15/UGT2A3	2
KEGG_hsa05332	Graft-versus-host disease	-4.38250746538082	0.294482128230603	0.467758825061597	2/375	38/13181	3821/3134	KLRC1/HLA-F	2
KEGG_hsa04920	Adipocytokine signaling pathway	-6.40289058307938	0.297466874287496	0.471792847997126	3/375	67/13181	6257/1375/5562	RXRB/CPT1B/PRKAA1	3
KEGG_hsa04922	Glucagon signaling pathway	-7.58405972458303	0.298084055904304	0.472300596799047	4/375	97/13181	3710/200186/1375/5562	ITPR3/CRTC2/CPT1B/PRKAA1	4
KEGG_hsa00380	Tryptophan metabolism	-4.29152332714165	0.305070537190378	0.478010648743276	2/375	39/13181	8942/3033	KYNU/HADH	2
KEGG_hsa05142	Chagas disease	-6.28755296581517	0.310955543822646	0.478010648743276	4/375	99/13181	5520/7099/5603/3460	PPP2R2A/TLR4/MAPK13/IFNGR2	4
KEGG_hsa00450	Selenocompound metabolism	-2.25882545267613	0.312976675907489	0.478010648743276	1/375	13/13181	1491	CTH	1
KEGG_hsa00730	Thiamine metabolism	-2.87110743035328	0.312976675907489	0.478010648743276	1/375	13/13181	84284	NTPCR	1
KEGG_hsa05140	Leishmaniasis	-5.54654293537722	0.313112006708253	0.478010648743276	3/375	69/13181	7099/5603/3460	TLR4/MAPK13/IFNGR2	3
KEGG_hsa04931	Insulin resistance	-7.16739834297416	0.323878714863422	0.492555864785117	4/375	101/13181	200186/11000/1375/5562	CRTC2/SLC27A3/CPT1B/PRKAA1	4
KEGG_hsa01521	EGFR tyrosine kinase inhibitor resistance	-5.31745510853854	0.344435528870346	0.506769208745054	3/375	73/13181	3082/596/5156	HGF/BCL2/PDGFRA	3
KEGG_hsa04928	Parathyroid hormone synthesis, secretion and action	-5.95688525320386	0.349816795727911	0.506769208745054	4/375	105/13181	3710/6257/860/596	ITPR3/RXRB/RUNX2/BCL2	4
KEGG_hsa00604	Glycosphingolipid biosynthesis	-2.28700489197515	0.351551218393582	0.506769208745054	1/375	15/13181	2583	B4GALNT1	1
KEGG_hsa01240	Biosynthesis of cofactors	-6.66282994213385	0.3563976965275	0.512462566805877	5/375	138/13181	1355/1719/55163/8942/79799	COX15/DHFR/PNPO/KYNU/UGT2A3	5
KEGG_hsa05144	Malaria	-4.83003710035506	0.357434582759571	0.512462566805877	2/375	44/13181	3082/7099	HGF/TLR4	2
KEGG_hsa05320	Autoimmune thyroid disease	-4.32314112883915	0.36774931235792	0.52064849920558	2/375	45/13181	1493/3134	CTLA4/HLA-F	2
KEGG_hsa04360	Axon guidance	-6.94254245727115	0.369990955915678	0.52064849920558	6/375	173/13181	6092/2534/5362/84552/6093/8633	ROBO2/FYN/PLXNA2/PARD6G/ROCK1/UNC5C	6
KEGG_hsa04668	TNF signaling pathway	-6.89792732275136	0.375776814788492	0.528280402753053	4/375	109/13181	7128/5603/1435/64127	TNFAIP3/MAPK13/CSF1/NOD2	4
KEGG_hsa05226	Gastric cancer	-6.92399582012419	0.384737068092901	0.532991575077415	5/375	143/13181	6257/5925/3082/1871/596	RXRB/RB1/HGF/E2F3/BCL2	5
KEGG_hsa00120	Primary bile acid biosynthesis	-2.84288038464503	0.387965353363024	0.532991575077415	1/375	17/13181	3295	HSD17B4	1
KEGG_hsa00280	Valine, leucine and isoleucine degradation	-4.27783350193238	0.388178769773363	0.532991575077415	2/375	47/13181	64902/3033	AGXT2/HADH	2
KEGG_hsa03010	Ribosome	-3.57229894409235	0.388178769773363	0.532991575077415	2/375	47/13181	51021/6146	MRPS16/RPL22	2
KEGG_hsa04921	Oxytocin signaling pathway	-7.78314499963478	0.39040252516078	0.535582411566557	5/375	144/13181	3710/779/5607/5562/6093	ITPR3/CACNA1S/MAP2K5/PRKAA1/ROCK1	5
KEGG_hsa04970	Salivary secretion	-6.5655072036806	0.391129347482469	0.536348134969491	3/375	79/13181	3710/3778/6558	ITPR3/KCNMA1/SLC12A2	3
KEGG_hsa04722	Neurotrophin signaling pathway	-6.60567261564425	0.395193020685582	0.541686985250065	4/375	112/13181	4909/5603/596/5607	NTF4/MAPK13/BCL2/MAP2K5	4
KEGG_hsa05167	Kaposi sarcoma-associated herpesvirus infection	-8.11408047834854	0.395478728773516	0.541845048470393	6/375	178/13181	3710/5925/1871/5603/3454/3134	ITPR3/RB1/E2F3/MAPK13/IFNAR1/HLA-F	6
KEGG_hsa04540	Gap junction	-5.17511095360506	0.398841445130685	0.543267087306769	3/375	80/13181	3710/5156/5607	ITPR3/PDGFRA/MAP2K5	3
KEGG_hsa04650	Natural killer cell mediated cytotoxicity	-5.57054215143167	0.401645957508567	0.543267087306769	4/375	113/13181	2534/3454/3821/3460	FYN/IFNAR1/KLRC1/IFNGR2	4
KEGG_hsa04146	Peroxisome	-5.19573186154645	0.406526690607279	0.544088752580449	3/375	81/13181	25824/3295/84188	PRDX5/HSD17B4/FAR1	3
KEGG_hsa05134	Legionellosis	-4.07387269071869	0.418257980025808	0.554288267756137	2/375	50/13181	317/7099	APAF1/TLR4	2
KEGG_hsa00564	Glycerophospholipid metabolism	-5.03759859620414	0.421807323502926	0.554288267756137	3/375	83/13181	1606/1120/10908	DGKA/CHKB/PNPLA6	3
KEGG_hsa04611	Platelet activation	-6.25240276092834	0.433697532480587	0.565617142338738	4/375	118/13181	3710/5603/2534/6093	ITPR3/MAPK13/FYN/ROCK1	4
KEGG_hsa04934	Cushing syndrome	-6.95922221230915	0.435507495521546	0.565617142338738	5/375	152/13181	3710/779/5925/1871/79798	ITPR3/CACNA1S/RB1/E2F3/ARMC5	5
KEGG_hsa00561	Glycerolipid metabolism	-4.40935949012272	0.437890446504355	0.565617142338738	2/375	52/13181	8694/1606	DGAT1/DGKA	2
KEGG_hsa00340	Histidine metabolism	-2.82907866496567	0.438797952877253	0.565617142338738	1/375	20/13181	3067	HDC	1
KEGG_hsa04512	ECM-receptor interaction	-6.03612520661058	0.444471008952286	0.571770958118233	3/375	86/13181	5649/3915/3161	RELN/LAMC1/HMMR	3
KEGG_hsa04657	IL-17 signaling pathway	-6.3568923517686	0.444471008952286	0.571770958118233	3/375	86/13181	7128/5603/53342	TNFAIP3/MAPK13/IL17D	3
KEGG_hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	-5.54654293537722	0.444471008952286	0.571770958118233	3/375	86/13181	7099/5603/3460	TLR4/MAPK13/IFNGR2	3
KEGG_hsa00770	Pantothenate and CoA biosynthesis	-2.60344873970846	0.454788437465889	0.576875640662755	1/375	21/13181	5167	ENPP1	1
KEGG_hsa04923	Regulation of lipolysis in adipocytes	-3.68181657482012	0.457157303752036	0.579187341008556	2/375	54/13181	134/51099	ADORA1/ABHD5	2
KEGG_hsa05410	Hypertrophic cardiomyopathy	-5.93245750753422	0.466778310813733	0.589731834877899	3/375	89/13181	779/6444/5562	CACNA1S/SGCD/PRKAA1	3
KEGG_hsa04210	Apoptosis	-6.38256929136439	0.471504642212025	0.591706693857238	4/375	124/13181	3710/317/596/4170	ITPR3/APAF1/BCL2/MCL1	4
KEGG_hsa00190	Oxidative phosphorylation	-5.61567576538723	0.474126465435536	0.594059164730104	3/375	90/13181	1355/1347/4731	COX15/COX7A2/NDUFV3	3
KEGG_hsa04061	Viral protein interaction with cytokine and cytokine receptor	-5.28173722413011	0.474126465435536	0.594059164730104	3/375	90/13181	1435/11009/6373	CSF1/IL24/CXCL11	3
KEGG_hsa04658	Th1 and Th2 cell differentiation	-5.11316374496111	0.474126465435536	0.594059164730104	3/375	90/13181	3718/5603/3460	JAK3/MAPK13/IFNGR2	3
KEGG_hsa04912	GnRH signaling pathway	-5.39018268248363	0.474126465435536	0.594059164730104	3/375	90/13181	3710/779/5603	ITPR3/CACNA1S/MAPK13	3
KEGG_hsa00982	Drug metabolism	-4.08769070685962	0.476037744397418	0.595515352944055	2/375	56/13181	127/79799	ADH4/UGT2A3	2
KEGG_hsa03013	Nucleocytoplasmic transport	-5.58307260680463	0.476037744397418	0.595515352944055	2/375	56/13181	64901/79023	RANBP17/NUP37	2
KEGG_hsa04640	Hematopoietic cell lineage	-4.88638509116366	0.48142806931079	0.600168083414576	3/375	91/13181	1435/1604/4254	CSF1/CD55/KITLG	3
KEGG_hsa04972	Pancreatic secretion	-6.5655072036806	0.48142806931079	0.600168083414576	3/375	91/13181	3710/3778/6558	ITPR3/KCNMA1/SLC12A2	3
KEGG_hsa05418	Fluid shear stress and atherosclerosis	-6.98786295456202	0.483903923693247	0.600168083414576	4/375	126/13181	5603/596/5607/5562	MAPK13/BCL2/MAP2K5/PRKAA1	4
KEGG_hsa00790	Folate biosynthesis	-2.23529527984194	0.485418965579337	0.600168083414576	1/375	23/13181	1719	DHFR	1
KEGG_hsa03420	Nucleotide excision repair	-2.57283911223424	0.485418965579337	0.600168083414576	1/375	23/13181	29935	RPA4	1
KEGG_hsa04114	Oocyte meiosis	-5.36274753564105	0.510139417461576	0.623220648301118	3/375	95/13181	3710/5603/25906	ITPR3/MAPK13/ANAPC15	3
KEGG_hsa04750	Inflammatory mediator regulation of TRP channels	-5.57637621574281	0.510139417461576	0.623220648301118	3/375	95/13181	3710/5603/162514	ITPR3/MAPK13/TRPV3	3
KEGG_hsa00980	Metabolism of xenobiotics by cytochrome P450	-4.08769070685962	0.51257317433005	0.623315109694789	2/375	60/13181	127/79799	ADH4/UGT2A3	2
KEGG_hsa00053	Ascorbate and aldarate metabolism	-2.68076725513855	0.514332971018593	0.623315109694789	1/375	25/13181	79799	UGT2A3	1
KEGG_hsa04925	Aldosterone synthesis and secretion	-5.20732088662962	0.517186727442189	0.62629618936259	3/375	96/13181	3710/779/466	ITPR3/CACNA1S/ATF1	3
KEGG_hsa00062	Fatty acid elongation	-2.88769778064469	0.528176474809109	0.63261815061882	1/375	26/13181	3033	HADH	1
KEGG_hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	-2.73994309996827	0.528176474809109	0.63261815061882	1/375	26/13181	5281	PIGF	1
KEGG_hsa00601	Glycosphingolipid biosynthesis	-2.20011744827674	0.528176474809109	0.63261815061882	1/375	26/13181	6484	ST3GAL4	1
KEGG_hsa01040	Biosynthesis of unsaturated fatty acids	-2.84288038464503	0.528176474809109	0.63261815061882	1/375	26/13181	3295	HSD17B4	1
KEGG_hsa01523	Antifolate resistance	-2.23529527984194	0.528176474809109	0.63261815061882	1/375	26/13181	1719	DHFR	1
KEGG_hsa03022	Basal transcription factors	-2.74701439766643	0.528176474809109	0.63261815061882	1/375	26/13181	8148	TAF15	1
KEGG_hsa05211	Renal cell carcinoma	-4.245042355658	0.530202635815833	0.634566948398324	2/375	62/13181	3082/112399	HGF/EGLN3	2
KEGG_hsa05146	Amoebiasis	-5.9124638136468	0.531116219860856	0.635182241127311	3/375	98/13181	5869/7099/3915	RAB5B/TLR4/LAMC1	3
KEGG_hsa04520	Adherens junction	-3.65576830513331	0.538853554409875	0.641240493503969	2/375	63/13181	2534/8936	FYN/WASF1	2
KEGG_hsa04929	GnRH secretion	-4.15779053074526	0.538853554409875	0.641240493503969	2/375	63/13181	3710/779	ITPR3/CACNA1S	2
KEGG_hsa03440	Homologous recombination	-2.57283911223424	0.541626404261529	0.641240493503969	1/375	27/13181	29935	RPA4	1
KEGG_hsa04723	Retrograde endocannabinoid signaling	-6.37955819220903	0.543991489926932	0.643800870103328	4/375	136/13181	3710/779/5603/4731	ITPR3/CACNA1S/MAPK13/NDUFV3	4
KEGG_hsa04664	Fc epsilon RI signaling pathway	-3.8930479928142	0.547394054438532	0.646624477382813	2/375	64/13181	5603/2534	MAPK13/FYN	2
KEGG_hsa04927	Cortisol synthesis and secretion	-4.15779053074526	0.547394054438532	0.646624477382813	2/375	64/13181	3710/779	ITPR3/CACNA1S	2
KEGG_hsa00040	Pentose and glucuronate interconversions	-2.68076725513855	0.554693919724652	0.646968674500656	1/375	28/13181	79799	UGT2A3	1
KEGG_hsa00500	Starch and sucrose metabolism	-2.60344873970846	0.554693919724652	0.646968674500656	1/375	28/13181	5167	ENPP1	1
KEGG_hsa04392	Hippo signaling pathway	-2.68163248759657	0.554693919724652	0.646968674500656	1/375	28/13181	60485	SAV1	1
KEGG_hsa04710	Circadian rhythm	-4.34063572413182	0.554693919724652	0.646968674500656	1/375	28/13181	5562	PRKAA1	1
KEGG_hsa04721	Synaptic vesicle cycle	-3.82665740606095	0.555823402118174	0.646968674500656	2/375	65/13181	6572/6507	SLC18A3/SLC1A3	2
KEGG_hsa04072	Phospholipase D signaling pathway	-5.89176341891246	0.567004264997847	0.656347680456981	4/375	140/13181	1606/5156/2534/4254	DGKA/PDGFRA/FYN/KITLG	4
KEGG_hsa04261	Adrenergic signaling in cardiomyocytes	-5.76348940165836	0.567004264997847	0.656347680456981	4/375	140/13181	5520/779/5603/596	PPP2R2A/CACNA1S/MAPK13/BCL2	4
KEGG_hsa00052	Galactose metabolism	-3.39929964429943	0.567389865904479	0.656347680456981	1/375	29/13181	2592	GALT	1
KEGG_hsa04130	SNARE interactions in vesicular transport	-2.43843261926722	0.567389865904479	0.656347680456981	1/375	29/13181	9482	STX8	1
KEGG_hsa04932	Non-alcoholic fatty liver disease	-7.73678405123201	0.572656938342963	0.661718409858511	4/375	141/13181	5603/1347/4731/5562	MAPK13/COX7A2/NDUFV3/PRKAA1	4
KEGG_hsa04613	Neutrophil extracellular trap formation	-5.23218040201475	0.578031921751833	0.664572747960501	3/375	105/13181	7099/5603/1991	TLR4/MAPK13/ELANE	3
KEGG_hsa05130	Pathogenic Escherichia coli infection	-6.99538627554232	0.589490121139774	0.67321442409516	5/375	181/13181	7099/5603/2534/8936/6093	TLR4/MAPK13/FYN/WASF1/ROCK1	5
KEGG_hsa00513	Various types of N-glycan biosynthesis	-2.22851701946232	0.591708904196847	0.67321442409516	1/375	31/13181	338707	B4GALNT4	1
KEGG_hsa04917	Prolactin signaling pathway	-4.75767764239828	0.596285947041371	0.676968693892025	2/375	70/13181	5603/2592	MAPK13/GALT	2
KEGG_hsa04390	Hippo signaling pathway	-5.50620278004497	0.6002879758851	0.681248246852801	4/375	146/13181	5520/1739/60485/84552	PPP2R2A/DLG1/SAV1/PARD6G	4
KEGG_hsa04919	Thyroid hormone signaling pathway	-5.09696529103862	0.603483116787529	0.681248246852801	3/375	109/13181	6257/4193/23389	RXRB/MDM2/MED13L	3
KEGG_hsa03320	PPAR signaling pathway	-4.2407185601537	0.604039828220986	0.681392924350031	2/375	71/13181	6257/1375	RXRB/CPT1B	2
KEGG_hsa05133	Pertussis	-4.49580744840162	0.611680717515437	0.688303142851766	2/375	72/13181	7099/5603	TLR4/MAPK13	2
KEGG_hsa05212	Pancreatic cancer	-3.7931855722103	0.611680717515437	0.688303142851766	2/375	72/13181	5925/1871	RB1/E2F3	2
KEGG_hsa00512	Mucin type O-glycan biosynthesis	-2.39832531334792	0.614664296070394	0.689464713052506	1/375	33/13181	56913	C1GALT1	1
KEGG_hsa00350	Tyrosine metabolism	-2.71297296935557	0.625654628362271	0.698098848488429	1/375	34/13181	127	ADH4	1
KEGG_hsa03040	Spliceosome	-2.99148466560299	0.625654628362271	0.698098848488429	1/375	34/13181	6629	SNRPB2	1
KEGG_hsa05340	Primary immunodeficiency	-2.38122227325096	0.625654628362271	0.698098848488429	1/375	34/13181	3718	JAK3	1
KEGG_hsa04914	Progesterone-mediated oocyte maturation	-3.8906353361689	0.633927207578146	0.706090549946937	2/375	75/13181	5603/25906	MAPK13/ANAPC15	2
KEGG_hsa05412	Arrhythmogenic right ventricular cardiomyopathy	-3.68745208850328	0.633927207578146	0.706090549946937	2/375	75/13181	779/6444	CACNA1S/SGCD	2
KEGG_hsa05330	Allograft rejection	-3.28016513039503	0.636332312576476	0.707035902862751	1/375	35/13181	3134	HLA-F	1
KEGG_hsa04935	Growth hormone synthesis, secretion and action	-5.39018268248363	0.645527149925964	0.716251338717574	3/375	116/13181	3710/779/5603	ITPR3/CACNA1S/MAPK13	3
KEGG_hsa04260	Cardiac muscle contraction	-4.40048503745574	0.65516642491802	0.72236714803985	2/375	78/13181	779/1347	CACNA1S/COX7A2	2
KEGG_hsa04975	Fat digestion and absorption	-3.08828526705486	0.656784969594102	0.72236714803985	1/375	37/13181	8694	DGAT1	1
KEGG_hsa05110	Vibrio cholerae infection	-3.89371615146838	0.656784969594102	0.72236714803985	1/375	37/13181	6558	SLC12A2	1
KEGG_hsa04068	FoxO signaling pathway	-6.25065247881712	0.678982588491011	0.742746691228557	3/375	122/13181	4193/5603/5562	MDM2/MAPK13/PRKAA1	3
KEGG_hsa04145	Phagosome	-5.64140814737501	0.678982588491011	0.742746691228557	3/375	122/13181	5869/7099/3134	RAB5B/TLR4/HLA-F	3
KEGG_hsa03460	Fanconi anemia pathway	-2.57283911223424	0.685332857134022	0.744570715984349	1/375	40/13181	29935	RPA4	1
KEGG_hsa04940	Type I diabetes mellitus	-3.28016513039503	0.685332857134022	0.744570715984349	1/375	40/13181	3134	HLA-F	1
KEGG_hsa04623	Cytosolic DNA-sensing pathway	-2.23360671949344	0.694312400439306	0.751020840436807	1/375	41/13181	103	ADAR	1
KEGG_hsa04350	TGF-beta signaling pathway	-3.60668478477215	0.694682064052838	0.751020840436807	2/375	84/13181	6093/7027	ROCK1/TFDP1	2
KEGG_hsa04742	Taste transduction	-4.5888114741771	0.694682064052838	0.751020840436807	2/375	84/13181	3710/50836	ITPR3/TAS2R8	2
KEGG_hsa04728	Dopaminergic synapse	-5.41729999025418	0.694812362441851	0.751020840436807	3/375	125/13181	3710/5520/5603	ITPR3/PPP2R2A/MAPK13	3
KEGG_hsa00510	N-Glycan biosynthesis	-4.20308521849728	0.703036361613983	0.755289064166374	1/375	42/13181	29929	ALG6	1
KEGG_hsa00514	Other types of O-glycan biosynthesis	-2.39832531334792	0.703036361613983	0.755289064166374	1/375	42/13181	56913	C1GALT1	1
KEGG_hsa05322	Systemic lupus erythematosus	-2.18728250531564	0.703036361613983	0.755289064166374	1/375	42/13181	1991	ELANE	1
KEGG_hsa05135	Yersinia infection	-5.47282511897808	0.705034603764644	0.756924388916802	3/375	127/13181	7099/5603/6093	TLR4/MAPK13/ROCK1	3
KEGG_hsa05032	Morphine addiction	-4.15612630758077	0.706997661719732	0.758775755743756	2/375	86/13181	134/27115	ADORA1/PDE7B	2
KEGG_hsa04910	Insulin signaling pathway	-5.97614905252531	0.714993761789865	0.764776374871097	3/375	129/13181	2872/5573/5562	MKNK2/PRKAR1A/PRKAA1	3
KEGG_hsa04070	Phosphatidylinositol signaling system	-4.48525646302463	0.718896800642681	0.767931335449169	2/375	88/13181	3710/1606	ITPR3/DGKA	2
KEGG_hsa02010	ABC transporters	-2.214679656587	0.719746354774302	0.767931335449169	1/375	44/13181	10350	ABCA9	1
KEGG_hsa04915	Estrogen signaling pathway	-5.89050133083084	0.724691707577072	0.77229308211271	3/375	131/13181	3710/3875/596	ITPR3/KRT18/BCL2	3
KEGG_hsa00520	Amino sugar and nucleotide sugar metabolism	-3.39929964429943	0.727746287556493	0.77424998140838	1/375	45/13181	2592	GALT	1
KEGG_hsa00600	Sphingolipid metabolism	-2.50479146127358	0.727746287556493	0.77424998140838	1/375	45/13181	91012	CERS5	1
KEGG_hsa00620	Pyruvate metabolism	-2.71297296935557	0.735518451241505	0.780951143555254	1/375	46/13181	127	ADH4	1
KEGG_hsa04514	Cell adhesion molecules	-5.79464082276344	0.738753813166369	0.784124541344811	3/375	134/13181	1493/1013/3134	CTLA4/CDH15/HLA-F	3
KEGG_hsa05414	Dilated cardiomyopathy	-3.68745208850328	0.746875089939178	0.790370311483057	2/375	93/13181	779/6444	CACNA1S/SGCD	2
KEGG_hsa00240	Pyrimidine metabolism	-2.60344873970846	0.757532097429108	0.799254170479284	1/375	49/13181	5167	ENPP1	1
KEGG_hsa04979	Cholesterol metabolism	-2.65973611064716	0.757532097429108	0.799254170479284	1/375	49/13181	4018	LPA	1
KEGG_hsa04933	AGE-RAGE signaling pathway in diabetic complications	-4.09025578802598	0.76249148390844	0.803686748037401	2/375	96/13181	5603/596	MAPK13/BCL2	2
KEGG_hsa03015	mRNA surveillance pathway	-2.33988744749259	0.771182810807694	0.808559623596594	1/375	51/13181	5520	PPP2R2A	1
KEGG_hsa04340	Hedgehog signaling pathway	-2.51863122763248	0.777717955205799	0.813533913669224	1/375	52/13181	596	BCL2	1
KEGG_hsa00140	Steroid hormone biosynthesis	-2.68076725513855	0.784066935843915	0.818291058740942	1/375	53/13181	79799	UGT2A3	1
KEGG_hsa05017	Spinocerebellar ataxia	-4.28822323202818	0.786666163856711	0.820465202054556	2/375	101/13181	3710/5649	ITPR3/RELN	2
KEGG_hsa00590	Arachidonic acid metabolism	-2.27390186641832	0.796227413497689	0.826911552881336	1/375	55/13181	80142	PTGES2	1
KEGG_hsa05204	Chemical carcinogenesis	-2.68076725513855	0.796227413497689	0.826911552881336	1/375	55/13181	79799	UGT2A3	1
KEGG_hsa04370	VEGF signaling pathway	-2.87849364175243	0.802049043844967	0.832413824878262	1/375	56/13181	5603	MAPK13	1
KEGG_hsa04330	Notch signaling pathway	-3.05006526093605	0.807704785449396	0.836100656812852	1/375	57/13181	23385	NCSTN	1
KEGG_hsa04730	Long-term depression	-3.18843192320265	0.807704785449396	0.836100656812852	1/375	57/13181	3710	ITPR3	1
KEGG_hsa04724	Glutamatergic synapse	-4.56194910059016	0.812800874594584	0.840420520885112	2/375	107/13181	3710/6507	ITPR3/SLC1A3	2
KEGG_hsa04213	Longevity regulating pathway	-4.34063572413182	0.81319935307028	0.840420520885112	1/375	58/13181	5562	PRKAA1	1
KEGG_hsa05120	Epithelial cell signaling in Helicobacter pylori infection	-2.87849364175243	0.81319935307028	0.840420520885112	1/375	58/13181	5603	MAPK13	1
KEGG_hsa00010	Glycolysis / Gluconeogenesis	-2.71297296935557	0.818537327816805	0.844564796384633	1/375	59/13181	127	ADH4	1
KEGG_hsa04120	Ubiquitin mediated proteolysis	-3.58932935607183	0.820857026390478	0.846134633361983	2/375	109/13181	4193/25906	MDM2/ANAPC15	2
KEGG_hsa04670	Leukocyte transendothelial migration	-4.1221576176741	0.820857026390478	0.846134633361983	2/375	109/13181	5603/6093	MAPK13/ROCK1	2
KEGG_hsa04726	Serotonergic synapse	-4.15779053074526	0.820857026390478	0.846134633361983	2/375	109/13181	3710/779	ITPR3/CACNA1S	2
KEGG_hsa05225	Hepatocellular carcinoma	-5.36435507566489	0.825098310668011	0.848855589752272	3/375	156/13181	5925/3082/1871	RB1/HGF/E2F3	3
KEGG_hsa04137	Mitophagy	-3.36596039750666	0.833655579760322	0.85599765697056	1/375	62/13181	10370	CITED2	1
KEGG_hsa05100	Bacterial invasion of epithelial cells	-2.56540121679177	0.838410451136942	0.859769504874388	1/375	63/13181	8936	WASF1	1
KEGG_hsa05221	Acute myeloid leukemia	-4.89767780170851	0.838410451136942	0.859769504874388	1/375	63/13181	861	RUNX1	1
KEGG_hsa00983	Drug metabolism	-2.68076725513855	0.843029759021044	0.86311482089083	1/375	64/13181	79799	UGT2A3	1
KEGG_hsa01230	Biosynthesis of amino acids	-2.25882545267613	0.843029759021044	0.86311482089083	1/375	64/13181	1491	CTH	1
KEGG_hsa04622	RIG-I-like receptor signaling pathway	-2.87849364175243	0.843029759021044	0.86311482089083	1/375	64/13181	5603	MAPK13	1
KEGG_hsa04720	Long-term potentiation	-3.18843192320265	0.847517358347651	0.866314753952276	1/375	65/13181	3710	ITPR3	1
KEGG_hsa05230	Central carbon metabolism in cancer	-2.41372563552681	0.856112307487141	0.874257269688217	1/375	67/13181	5156	PDGFRA	1
KEGG_hsa04142	Lysosome	-5.233790002171	0.869047297061757	0.886327903994992	2/375	123/13181	27074/3482	LAMP3/IGF2R	2
KEGG_hsa04926	Relaxin signaling pathway	-3.83674354260068	0.877691127826137	0.894569803361255	2/375	126/13181	5603/6019	MAPK13/RLN2	2
KEGG_hsa04062	Chemokine signaling pathway	-4.69230021600659	0.881231649785987	0.897028375902509	3/375	176/13181	3718/6373/6093	JAK3/CXCL11/ROCK1	3
KEGG_hsa04918	Thyroid hormone synthesis	-3.18843192320265	0.882563181577863	0.897808994695331	1/375	74/13181	3710	ITPR3	1
KEGG_hsa04371	Apelin signaling pathway	-5.70596628172115	0.885806763619081	0.899787781669883	2/375	129/13181	3710/5562	ITPR3/PRKAA1	2
KEGG_hsa04971	Gastric acid secretion	-3.18843192320265	0.885923127172454	0.899787781669883	1/375	75/13181	3710	ITPR3	1
KEGG_hsa04662	B cell receptor signaling pathway	-2.61060480780367	0.889187191517817	0.901950644027642	1/375	76/13181	10892	MALT1	1
KEGG_hsa05150	Staphylococcus aureus infection	-3.43408526755726	0.892358103626235	0.904878434161807	1/375	77/13181	3875	KRT18	1
KEGG_hsa04140	Autophagy	-5.19835227645321	0.893422073092376	0.90566853440668	2/375	132/13181	596/5562	BCL2/PRKAA1	2
KEGG_hsa04550	Signaling pathways regulating pluripotency of stem cells	-3.98611927375452	0.900563949698175	0.911368856978969	2/375	135/13181	3718/5603	JAK3/MAPK13	2
KEGG_hsa04012	ErbB signaling pathway	-3.37024760049466	0.901338067672597	0.911368856978969	1/375	80/13181	27	ABL2	1
KEGG_hsa04610	Complement and coagulation cascades	-2.26791085340931	0.901338067672597	0.911368856978969	1/375	80/13181	1604	CD55	1
KEGG_hsa04150	mTOR signaling pathway	-5.50997411046765	0.902843871768788	0.912601243555227	2/375	136/13181	8649/5562	LAMTOR3/PRKAA1	2
KEGG_hsa05210	Colorectal cancer	-2.51863122763248	0.904162144050185	0.913643348611245	1/375	81/13181	596	BCL2	1
KEGG_hsa04976	Bile secretion	-2.68076725513855	0.909570713768041	0.918233291994403	1/375	83/13181	79799	UGT2A3	1
KEGG_hsa04666	Fc gamma R-mediated phagocytosis	-2.56540121679177	0.912159733644128	0.920262675440459	1/375	84/13181	8936	WASF1	1
KEGG_hsa04727	GABAergic synapse	-2.29780557345236	0.912159733644128	0.920262675440459	1/375	84/13181	779	CACNA1S	1
KEGG_hsa05224	Breast cancer	-3.7931855722103	0.917488020574814	0.925051333363319	2/375	143/13181	5925/1871	RB1/E2F3	2
KEGG_hsa04211	Longevity regulating pathway	-4.34063572413182	0.919491561661788	0.92677754867971	1/375	87/13181	5562	PRKAA1	1
KEGG_hsa04713	Circadian entrainment	-3.18843192320265	0.930379878800015	0.935676158944986	1/375	92/13181	3710	ITPR3	1
KEGG_hsa04916	Melanogenesis	-2.85611684736861	0.944828692382706	0.949306553484046	1/375	100/13181	4254	KITLG	1
KEGG_hsa04310	Wnt signaling pathway	-2.46728986507517	0.988566634464633	0.988877602264087	1/375	154/13181	57680	CHD8	1
