ID	Description	NES	pvalue	p.adjust	GeneRatio	BgRatio	geneID	geneName	Count
REACTOME_6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	4.93090255064544	0.00149543827510317	0.246261740290968	3/262	12/13181	7157/843/58484	TP53/CASP10/NLRC4	3
REACTOME_5221030	TET1,2,3 and TDG demethylate DNA	4.02364668848847	0.00230005867900677	0.246261740290968	2/262	4/13181	200424/6996	TET3/TDG	2
REACTOME_74713	IRS activation	4.46545453547456	0.00378317546597386	0.246261740290968	2/262	5/13181	3630/2887	INS/GRB10	2
REACTOME_5358493	Synthesis of diphthamide-EEF2	4.66097474355412	0.00560048880276681	0.246261740290968	2/262	6/13181	51611/1801	DPH5/DPH1	2
REACTOME_2559580	Oxidative Stress Induced Senescence	6.74512401222903	0.00580234433021428	0.246261740290968	5/262	58/13181	7157/5931/1870/3456/50488	TP53/RBBP7/E2F2/IFNB1/MINK1	5
REACTOME_159763	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	4.00121906191828	0.0129219554775486	0.246261740290968	2/262	9/13181	2155/2147	F7/F2	2
REACTOME_5685939	HDR through MMEJ (alt-NHEJ)	4.12169334701527	0.0129219554775486	0.246261740290968	2/262	9/13181	3980/2237	LIG3/FEN1	2
REACTOME_74751	Insulin receptor signalling cascade	4.46545453547456	0.0129219554775486	0.246261740290968	2/262	9/13181	3630/2887	INS/GRB10	2
REACTOME_159740	Gamma-carboxylation of protein precursors	4.00121906191828	0.0159424182196556	0.246261740290968	2/262	10/13181	2155/2147	F7/F2	2
REACTOME_159782	Removal of aminoterminal propeptides from gamma-carboxylated proteins	4.00121906191828	0.0159424182196556	0.246261740290968	2/262	10/13181	2155/2147	F7/F2	2
REACTOME_74749	Signal attenuation	4.46545453547456	0.0159424182196556	0.246261740290968	2/262	10/13181	3630/2887	INS/GRB10	2
REACTOME_390471	Association of TriC/CCT with target proteins during biosynthesis	5.48588836282581	0.0176262028375992	0.246261740290968	3/262	28/13181	7157/55294/26270	TP53/FBXW7/FBXO6	3
REACTOME_422356	Regulation of insulin secretion	5.05653747157102	0.0176262028375992	0.246261740290968	3/262	28/13181	3630/776/777	INS/CACNA1D/CACNA1E	3
REACTOME_6803205	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	4.08554842589213	0.0192322379805228	0.246261740290968	2/262	11/13181	7157/79370	TP53/BCL2L14	2
REACTOME_5619039	Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	2.2961239414147	0.0198770958197401	0.246261740290968	1/262	1/13181	9990	SLC12A6	1
REACTOME_9717264	ASP-3026- resistant ALK mutants	2.50781989668471	0.0198770958197401	0.246261740290968	1/262	1/13181	238	ALK	1
REACTOME_9717301	NVP-TAE684-resistant ALK mutants	2.50781989668471	0.0198770958197401	0.246261740290968	1/262	1/13181	238	ALK	1
REACTOME_9717316	alectinib resistant ALK mutants	2.50781989668471	0.0198770958197401	0.246261740290968	1/262	1/13181	238	ALK	1
REACTOME_9717319	brigatinib-resistant ALK mutants	2.50781989668471	0.0198770958197401	0.246261740290968	1/262	1/13181	238	ALK	1
REACTOME_9717323	ceritinib-resistant ALK mutants	2.50781989668471	0.0198770958197401	0.246261740290968	1/262	1/13181	238	ALK	1
REACTOME_9717326	crizotinib-resistant ALK mutants	2.50781989668471	0.0198770958197401	0.246261740290968	1/262	1/13181	238	ALK	1
REACTOME_9717329	lorlatinib-resistant ALK mutants	2.50781989668471	0.0198770958197401	0.246261740290968	1/262	1/13181	238	ALK	1
REACTOME_9723905	Loss of function of TP53 in cancer due to loss of tetramerization ability	2.53187885822657	0.0198770958197401	0.246261740290968	1/262	1/13181	7157	TP53	1
REACTOME_1679131	Trafficking and processing of endosomal TLR	4.13018235098966	0.0227795979216068	0.246261740290968	2/262	12/13181	54106/1514	TLR9/CTSL	2
REACTOME_9673324	WNT5:FZD7-mediated leishmania damping	3.85426423152751	0.0227795979216068	0.246261740290968	2/262	12/13181	124056/27035	NOXO1/NOX1	2
REACTOME_352230	Amino acid transport across the plasma membrane	4.39763676818296	0.0251869723589953	0.246261740290968	3/262	32/13181	6539/6541/81539	SLC6A12/SLC7A1/SLC38A1	3
REACTOME_211935	Fatty acids	4.14096998267572	0.0306014625757507	0.246261740290968	2/262	14/13181	1580/1555	CYP4B1/CYP2B6	2
REACTOME_6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	4.29554737821546	0.0306014625757507	0.246261740290968	2/262	14/13181	7157/581	TP53/BAX	2
REACTOME_420499	Class C/3 (Metabotropic glutamate/pheromone receptors)	5.04509050545282	0.0392963903303867	0.246261740290968	3/262	38/13181	50834/2911/50839	TAS2R1/GRM1/TAS2R10	3
REACTOME_159418	Recycling of bile acids and salts	4.32740231462627	0.0393205115853957	0.246261740290968	2/262	16/13181	6579/80765	SLCO1A2/STARD5	2
REACTOME_6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	4.29554737821546	0.0393205115853957	0.246261740290968	2/262	16/13181	7157/581	TP53/BAX	2
REACTOME_77387	Insulin receptor recycling	3.65806497347275	0.0393205115853957	0.246261740290968	2/262	16/13181	155066/3630	ATP6V0E2/INS	2
REACTOME_9022699	MECP2 regulates neuronal receptors and channels	3.83401299701501	0.0393205115853957	0.246261740290968	2/262	16/13181	2904/4233	GRIN2B/MET	2
REACTOME_114294	Activation, translocation and oligomerization of BAX	3.1361298884285	0.0393605708497274	0.246261740290968	1/262	2/13181	581	BAX	1
REACTOME_162594	Early Phase of HIV Life Cycle	2.55380673720243	0.0393605708497274	0.246261740290968	1/262	2/13181	2237	FEN1	1
REACTOME_6804754	Regulation of TP53 Expression	2.53187885822657	0.0393605708497274	0.246261740290968	1/262	2/13181	7157	TP53	1
REACTOME_69166	Removal of the Flap Intermediate	2.55380673720243	0.0393605708497274	0.246261740290968	1/262	2/13181	2237	FEN1	1
REACTOME_74752	Signaling by Insulin receptor	2.57168879268085	0.0393605708497274	0.246261740290968	1/262	2/13181	3630	INS	1
REACTOME_844623	The IPAF inflammasome	2.62172364162658	0.0393605708497274	0.246261740290968	1/262	2/13181	58484	NLRC4	1
REACTOME_9033807	ABO blood group biosynthesis	2.73764841964457	0.0393605708497274	0.246261740290968	1/262	2/13181	2524	FUT2	1
REACTOME_9603505	NTRK3 as a dependence receptor	3.1361298884285	0.0393605708497274	0.246261740290968	1/262	2/13181	581	BAX	1
REACTOME_197264	Nicotinamide salvaging	3.91574598575588	0.0439905981083825	0.246261740290968	2/262	17/13181	9390/83594	SLC22A13/NUDT12	2
REACTOME_201556	Signaling by ALK	3.74744330893804	0.0439905981083825	0.246261740290968	2/262	17/13181	4613/238	MYCN/ALK	2
REACTOME_3232118	SUMOylation of transcription factors	3.73361265741842	0.0439905981083825	0.246261740290968	2/262	17/13181	7157/6670	TP53/SP3	2
REACTOME_422085	Synthesis, secretion, and deacylation of Ghrelin	3.76458092463746	0.0439905981083825	0.246261740290968	2/262	17/13181	3630/3479	INS/IGF1	2
REACTOME_5620922	BBSome-mediated cargo-targeting to cilium	4.12404338007631	0.0439905981083825	0.246261740290968	2/262	17/13181	123016/84100	TTC8/ARL6	2
REACTOME_162588	Budding and maturation of HIV virion	3.86840084465539	0.0488545620458948	0.246261740290968	2/262	18/13181	137492/23327	VPS37A/NEDD4L	2
REACTOME_210745	Regulation of gene expression in beta cells	3.88306063239103	0.0488545620458948	0.246261740290968	2/262	18/13181	3630/3651	INS/PDX1	2
REACTOME_442982	Ras activation upon Ca2+ influx through NMDA receptor	3.69504539239148	0.0539029154086762	0.246261740290968	2/262	19/13181	1740/2904	DLG2/GRIN2B	2
REACTOME_445144	Signal transduction by L1	3.75340033683435	0.0539029154086762	0.246261740290968	2/262	19/13181	1956/3685	EGFR/ITGAV	2
REACTOME_110381	Resolution of AP sites via the single-nucleotide replacement pathway	2.88480023996422	0.0584581905809188	0.246261740290968	1/262	3/13181	3980	LIG3	1
REACTOME_1296053	Classical Kir channels	2.42552599804452	0.0584581905809188	0.246261740290968	1/262	3/13181	3770	KCNJ14	1
REACTOME_2644607	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	2.75060991672972	0.0584581905809188	0.246261740290968	1/262	3/13181	55294	FBXW7	1
REACTOME_500753	Pyrimidine biosynthesis	2.27627024675789	0.0584581905809188	0.246261740290968	1/262	3/13181	1723	DHODH	1
REACTOME_70688	Proline catabolism	3.07635512825175	0.0584581905809188	0.246261740290968	1/262	3/13181	5625	PRODH	1
REACTOME_8875791	MET activates STAT3	2.54024227537346	0.0584581905809188	0.246261740290968	1/262	3/13181	4233	MET	1
REACTOME_8981607	Intracellular oxygen transport	2.37647880853439	0.0584581905809188	0.246261740290968	1/262	3/13181	4151	MB	1
REACTOME_9657688	Defective factor XII causes hereditary angioedema	2.88471078267737	0.0584581905809188	0.246261740290968	1/262	3/13181	2147	F2	1
REACTOME_9672391	Defective F8 cleavage by thrombin	2.88471078267737	0.0584581905809188	0.246261740290968	1/262	3/13181	2147	F2	1
REACTOME_9678110	Attachment and Entry	2.80921158992343	0.0584581905809188	0.246261740290968	1/262	3/13181	1514	CTSL	1
REACTOME_438066	Unblocking of NMDA receptors, glutamate binding and activation	3.69504539239148	0.0591264682571352	0.246261740290968	2/262	20/13181	1740/2904	DLG2/GRIN2B	2
REACTOME_6804758	Regulation of TP53 Activity through Acetylation	4.1925026592923	0.0591264682571352	0.246261740290968	2/262	20/13181	7157/5931	TP53/RBBP7	2
REACTOME_9617324	Negative regulation of NMDA receptor-mediated neuronal transmission	3.69504539239148	0.0591264682571352	0.246261740290968	2/262	20/13181	1740/2904	DLG2/GRIN2B	2
REACTOME_9679191	Potential therapeutics for SARS	6.02815471450434	0.062066059272425	0.257511283244937	4/262	75/13181	5931/79685/54106/3614	RBBP7/SAP30L/TLR9/IMPDH1	4
REACTOME_9620244	Long-term potentiation	3.69504539239148	0.064516320675802	0.263479155923509	2/262	21/13181	1740/2904	DLG2/GRIN2B	2
REACTOME_72187	mRNA 3'-end processing	3.9342871608966	0.0700638549471425	0.263479155923509	2/262	22/13181	23283/84324	CSTF2T/SARNP	2
REACTOME_380259	Loss of Nlp from mitotic centrosomes	4.56346105679611	0.0733730879250303	0.263479155923509	3/262	49/13181	22995/55722/80254	CEP152/CEP72/CEP63	3
REACTOME_380284	Loss of proteins required for interphase microtubule organization from the centrosome	4.56346105679611	0.0733730879250303	0.263479155923509	3/262	49/13181	22995/55722/80254	CEP152/CEP72/CEP63	3
REACTOME_3214858	RMTs methylate histone arginines	4.32167608587661	0.0757607279200218	0.263479155923509	2/262	23/13181	5931/8289	RBBP7/ARID1A	2
REACTOME_8854518	AURKA Activation by TPX2	4.56346105679611	0.0769597617690698	0.263479155923509	3/262	50/13181	22995/55722/80254	CEP152/CEP72/CEP63	3
REACTOME_1251932	PLCG1 events in ERBB2 signaling	2.60703251325256	0.0771775678815561	0.263479155923509	1/262	4/13181	1956	EGFR	1
REACTOME_204626	Hypusine synthesis from eIF5A-lysine	2.1948571136508	0.0771775678815561	0.263479155923509	1/262	4/13181	1725	DHPS	1
REACTOME_210455	Astrocytic Glutamate-Glutamine Uptake And Metabolism	2.21292208436344	0.0771775678815561	0.263479155923509	1/262	4/13181	81539	SLC38A1	1
REACTOME_2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	2.39570551812302	0.0771775678815561	0.263479155923509	1/262	4/13181	3479	IGF1	1
REACTOME_2564830	Cytosolic iron-sulfur cluster assembly	2.60638509763026	0.0771775678815561	0.263479155923509	1/262	4/13181	27158	NDOR1	1
REACTOME_3000497	Scavenging by Class H Receptors	2.21342565000636	0.0771775678815561	0.263479155923509	1/262	4/13181	6678	SPARC	1
REACTOME_6783984	Glycine degradation	2.42829366394332	0.0771775678815561	0.263479155923509	1/262	4/13181	1738	DLD	1
REACTOME_69895	Transcriptional  activation of  cell cycle inhibitor p21 	2.53187885822657	0.0771775678815561	0.263479155923509	1/262	4/13181	7157	TP53	1
REACTOME_77108	Utilization of Ketone Bodies	2.30577092326792	0.0771775678815561	0.263479155923509	1/262	4/13181	622	BDH1	1
REACTOME_77595	Processing of Intronless Pre-mRNAs	2.46578925657987	0.0771775678815561	0.263479155923509	1/262	4/13181	23283	CSTF2T	1
REACTOME_888593	Reuptake of GABA	2.30437485543147	0.0771775678815561	0.263479155923509	1/262	4/13181	6539	SLC6A12	1
REACTOME_9032500	Activated NTRK2 signals through FYN	2.51876820419394	0.0771775678815561	0.263479155923509	1/262	4/13181	2904	GRIN2B	1
REACTOME_9640463	Wax biosynthesis	2.42788684198693	0.0771775678815561	0.263479155923509	1/262	4/13181	55711	FAR2	1
REACTOME_9694614	Attachment and Entry	2.80921158992343	0.0771775678815561	0.263479155923509	1/262	4/13181	1514	CTSL	1
REACTOME_5628897	TP53 Regulates Metabolic Genes	6.23697468713117	0.077656258111696	0.264751690342603	4/262	81/13181	7157/9997/6341/5571	TP53/SCO2/SCO1/PRKAG1	4
REACTOME_5620971	Pyroptosis	4.29554737821546	0.0815988635682155	0.27444893681961	2/262	24/13181	7157/581	TP53/BAX	2
REACTOME_5668599	RHO GTPases Activate NADPH Oxidases	3.85426423152751	0.0815988635682155	0.27444893681961	2/262	24/13181	124056/27035	NOXO1/NOX1	2
REACTOME_73856	RNA Polymerase II Transcription Termination	3.9342871608966	0.0815988635682155	0.27444893681961	2/262	24/13181	23283/84324	CSTF2T/SARNP	2
REACTOME_380270	Recruitment of mitotic centrosome proteins and complexes	4.56346105679611	0.0843589078522883	0.280187662908034	3/262	52/13181	22995/55722/80254	CEP152/CEP72/CEP63	3
REACTOME_6794361	Neurexins and neuroligins	4.63425113044771	0.0881684324364726	0.280187662908034	3/262	53/13181	1740/2911/2904	DLG2/GRM1/GRIN2B	3
REACTOME_9013409	RHOJ GTPase cycle	4.56886602673231	0.0881684324364726	0.280187662908034	3/262	53/13181	57381/4952/9578	RHOJ/OCRL/CDC42BPB	3
REACTOME_182971	EGFR downregulation	4.29296931929751	0.0936679110557553	0.280187662908034	2/262	26/13181	1956/5774	EGFR/PTPN3	2
REACTOME_111448	Activation of NOXA and translocation to mitochondria	2.53187885822657	0.095526165985452	0.280187662908034	1/262	5/13181	7157	TP53	1
REACTOME_111457	Release of apoptotic factors from the mitochondria	3.1361298884285	0.095526165985452	0.280187662908034	1/262	5/13181	581	BAX	1
REACTOME_112303	Electric Transmission Across Gap Junctions	2.68993052096961	0.095526165985452	0.280187662908034	1/262	5/13181	56666	PANX2	1
REACTOME_140834	Extrinsic Pathway of Fibrin Clot Formation	2.3949294222591	0.095526165985452	0.280187662908034	1/262	5/13181	2155	F7	1
REACTOME_167826	The fatty acid cycling model	2.20644559872099	0.095526165985452	0.280187662908034	1/262	5/13181	9016	SLC25A14	1
REACTOME_167827	The proton buffering model	2.20644559872099	0.095526165985452	0.280187662908034	1/262	5/13181	9016	SLC25A14	1
REACTOME_168138	Toll Like Receptor 9 (TLR9) Cascade	2.64059669514201	0.095526165985452	0.280187662908034	1/262	5/13181	54106	TLR9	1
REACTOME_75157	FasL/ CD95L signaling	2.49839679877394	0.095526165985452	0.280187662908034	1/262	5/13181	843	CASP10	1
REACTOME_8865999	MET activates PTPN11	2.54024227537346	0.095526165985452	0.280187662908034	1/262	5/13181	4233	MET	1
REACTOME_8866376	Reelin signalling pathway	2.54927845298842	0.095526165985452	0.280187662908034	1/262	5/13181	7436	VLDLR	1
REACTOME_8875513	MET interacts with TNS proteins	2.54024227537346	0.095526165985452	0.280187662908034	1/262	5/13181	4233	MET	1
REACTOME_400042	Adrenaline,noradrenaline inhibits insulin secretion	3.93997359500775	0.0998839420653047	0.289289765120037	2/262	27/13181	776/2793	CACNA1D/GNGT2	2
REACTOME_9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	4.00961928161921	0.0998839420653047	0.289289765120037	2/262	27/13181	3630/91584	INS/PLXNA4	2
REACTOME_6804756	Regulation of TP53 Activity through Phosphorylation	5.21012055117504	0.108254246186097	0.29364880150471	3/262	58/13181	7157/116028/5571	TP53/RMI2/PRKAG1	3
REACTOME_2565942	Regulation of PLK1 Activity at G2/M Transition	4.56346105679611	0.112467984075405	0.29364880150471	3/262	59/13181	22995/55722/80254	CEP152/CEP72/CEP63	3
REACTOME_2559585	Oncogene Induced Senescence	3.70864671181369	0.112643620580867	0.29364880150471	2/262	29/13181	7157/1870	TP53/E2F2	2
REACTOME_3214815	HDACs deacetylate histones	4.05088680104951	0.112643620580867	0.29364880150471	2/262	29/13181	5931/79685	RBBP7/SAP30L	2
REACTOME_168179	Toll Like Receptor TLR1:TLR2 Cascade	2.34975692141932	0.113511301421989	0.29364880150471	1/262	6/13181	653509	SFTPA1	1
REACTOME_2428928	IRS-related events triggered by IGF1R	2.39570551812302	0.113511301421989	0.29364880150471	1/262	6/13181	3479	IGF1	1
REACTOME_2468052	Establishment of Sister Chromatid Cohesion	2.40031355988813	0.113511301421989	0.29364880150471	1/262	6/13181	10735	STAG2	1
REACTOME_2470946	Cohesin Loading onto Chromatin	2.40031355988813	0.113511301421989	0.29364880150471	1/262	6/13181	10735	STAG2	1
REACTOME_6798163	Choline catabolism	2.4210031543004	0.113511301421989	0.29364880150471	1/262	6/13181	1757	SARDH	1
REACTOME_6806942	MET Receptor Activation	2.54024227537346	0.113511301421989	0.29364880150471	1/262	6/13181	4233	MET	1
REACTOME_8851907	MET activates PI3K/AKT signaling	2.54024227537346	0.113511301421989	0.29364880150471	1/262	6/13181	4233	MET	1
REACTOME_8857538	PTK6 promotes HIF1A stabilization	2.60703251325256	0.113511301421989	0.29364880150471	1/262	6/13181	1956	EGFR	1
REACTOME_8941855	RUNX3 regulates CDKN1A transcription	2.53187885822657	0.113511301421989	0.29364880150471	1/262	6/13181	7157	TP53	1
REACTOME_8949275	RUNX3 Regulates Immune Response and Cell Migration	2.23457334674389	0.113511301421989	0.29364880150471	1/262	6/13181	3683	ITGAL	1
REACTOME_8964046	VLDL clearance	2.54927845298842	0.113511301421989	0.29364880150471	1/262	6/13181	7436	VLDLR	1
REACTOME_9645460	Alpha-protein kinase 1 signaling pathway	2.29394690404917	0.113511301421989	0.29364880150471	1/262	6/13181	92610	TIFA	1
REACTOME_3000157	Laminin interactions	3.43881267667705	0.119173802946635	0.30576522953146	2/262	30/13181	1294/3685	COL7A1/ITGAV	2
REACTOME_380320	Recruitment of NuMA to mitotic centrosomes	4.56346105679611	0.125473214630751	0.306566161904143	3/262	62/13181	22995/55722/80254	CEP152/CEP72/CEP63	3
REACTOME_456926	Thrombin signalling through proteinase activated receptors (PARs)	3.91240832514879	0.125795608096666	0.306566161904143	2/262	31/13181	2793/2147	GNGT2/F2	2
REACTOME_69473	G2/M DNA damage checkpoint	3.57219192341338	0.125795608096666	0.306566161904143	2/262	31/13181	7157/116028	TP53/RMI2	2
REACTOME_110362	POLB-Dependent Long Patch Base Excision Repair	2.55380673720243	0.131140146888967	0.306566161904143	1/262	7/13181	2237	FEN1	1
REACTOME_174437	Removal of the Flap Intermediate from the C-strand	2.55380673720243	0.131140146888967	0.306566161904143	1/262	7/13181	2237	FEN1	1
REACTOME_174490	Membrane binding and targetting of GAG proteins	2.37809592042927	0.131140146888967	0.306566161904143	1/262	7/13181	137492	VPS37A	1
REACTOME_199920	CREB phosphorylation	2.19544655261977	0.131140146888967	0.306566161904143	1/262	7/13181	9252	RPS6KA5	1
REACTOME_426117	Cation-coupled Chloride cotransporters	2.2961239414147	0.131140146888967	0.306566161904143	1/262	7/13181	9990	SLC12A6	1
REACTOME_444473	Formyl peptide receptors bind formyl peptides and many other ligands	2.4613318815684	0.131140146888967	0.306566161904143	1/262	7/13181	2358	FPR2	1
REACTOME_5649702	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	2.88480023996422	0.131140146888967	0.306566161904143	1/262	7/13181	3980	LIG3	1
REACTOME_5688849	Defective CSF2RB causes SMDP5	2.34975692141932	0.131140146888967	0.306566161904143	1/262	7/13181	653509	SFTPA1	1
REACTOME_5688890	Defective CSF2RA causes SMDP4	2.34975692141932	0.131140146888967	0.306566161904143	1/262	7/13181	653509	SFTPA1	1
REACTOME_6814848	Glycerophospholipid catabolism	2.42839325119732	0.131140146888967	0.306566161904143	1/262	7/13181	51573	GDE1	1
REACTOME_69541	Stabilization of p53	2.53187885822657	0.131140146888967	0.306566161904143	1/262	7/13181	7157	TP53	1
REACTOME_8951671	RUNX3 regulates YAP1-mediated transcription	2.36043703818501	0.131140146888967	0.306566161904143	1/262	7/13181	7003	TEAD1	1
REACTOME_9710421	Defective pyroptosis	3.00016156664602	0.131140146888967	0.306566161904143	1/262	7/13181	5931	RBBP7	1
REACTOME_975155	MyD88 dependent cascade initiated on endosome	2.64059669514201	0.131140146888967	0.306566161904143	1/262	7/13181	54106	TLR9	1
REACTOME_1236973	Cross-presentation of particulate exogenous antigens (phagosomes)	2.34560892349801	0.148419734069405	0.323366098900998	1/262	8/13181	3685	ITGAV	1
REACTOME_139915	Activation of PUMA and translocation to mitochondria	2.53187885822657	0.148419734069405	0.323366098900998	1/262	8/13181	7157	TP53	1
REACTOME_156902	Peptide chain elongation	2.39167044058876	0.148419734069405	0.323366098900998	1/262	8/13181	200916	RPL22L1	1
REACTOME_210747	Regulation of gene expression in early pancreatic precursor cells	2.55204042976991	0.148419734069405	0.323366098900998	1/262	8/13181	3651	PDX1	1
REACTOME_2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	2.53187885822657	0.148419734069405	0.323366098900998	1/262	8/13181	7157	TP53	1
REACTOME_416550	Sema4D mediated inhibition of cell attachment and migration	2.54024227537346	0.148419734069405	0.323366098900998	1/262	8/13181	4233	MET	1
REACTOME_5638303	Inhibition of Signaling by Overexpressed EGFR	2.60703251325256	0.148419734069405	0.323366098900998	1/262	8/13181	1956	EGFR	1
REACTOME_5651801	PCNA-Dependent Long Patch Base Excision Repair	2.55380673720243	0.148419734069405	0.323366098900998	1/262	8/13181	2237	FEN1	1
REACTOME_5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	2.88480023996422	0.148419734069405	0.323366098900998	1/262	8/13181	3980	LIG3	1
REACTOME_6811555	PI5P Regulates TP53 Acetylation	2.53187885822657	0.148419734069405	0.323366098900998	1/262	8/13181	7157	TP53	1
REACTOME_68689	CDC6 association with the ORC:origin complex	2.36170981627348	0.148419734069405	0.323366098900998	1/262	8/13181	1870	E2F2	1
REACTOME_75158	TRAIL  signaling	2.49839679877394	0.148419734069405	0.323366098900998	1/262	8/13181	843	CASP10	1
REACTOME_77111	Synthesis of Ketone Bodies	2.30577092326792	0.148419734069405	0.323366098900998	1/262	8/13181	622	BDH1	1
REACTOME_8850843	Phosphate bond hydrolysis by NTPDase proteins	2.86216881353532	0.148419734069405	0.323366098900998	1/262	8/13181	57089	ENTPD7	1
REACTOME_8939242	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	2.80921158992343	0.148419734069405	0.323366098900998	1/262	8/13181	1514	CTSL	1
REACTOME_6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	5.71600381137511	0.149030530335709	0.324414020303951	4/262	103/13181	3630/1956/29851/4233	INS/EGFR/ICOS/MET	4
REACTOME_1433557	Signaling by SCF-KIT	4.46041186434129	0.153078430939283	0.330633534068513	2/262	35/13181	1215/2887	CMA1/GRB10	2
REACTOME_390522	Striated Muscle Contraction	3.86203300885713	0.153078430939283	0.330633534068513	2/262	35/13181	7111/7140	TMOD1/TNNT3	2
REACTOME_9609736	Assembly and cell surface presentation of NMDA receptors	3.69504539239148	0.160069640920854	0.336778348840322	2/262	36/13181	1740/2904	DLG2/GRIN2B	2
REACTOME_110357	Displacement of DNA glycosylase by APEX1	2.57887761337131	0.165356956393387	0.336778348840322	1/262	9/13181	6996	TDG	1
REACTOME_2025928	Calcineurin activates NFAT	2.24740574813656	0.165356956393387	0.336778348840322	1/262	9/13181	4775	NFATC3	1
REACTOME_212718	EGFR interacts with phospholipase C-gamma	2.60703251325256	0.165356956393387	0.336778348840322	1/262	9/13181	1956	EGFR	1
REACTOME_2179392	EGFR Transactivation by Gastrin	2.60703251325256	0.165356956393387	0.336778348840322	1/262	9/13181	1956	EGFR	1
REACTOME_2428933	SHC-related events triggered by IGF1R	2.39570551812302	0.165356956393387	0.336778348840322	1/262	9/13181	3479	IGF1	1
REACTOME_390696	Adrenoceptors	2.19942174332764	0.165356956393387	0.336778348840322	1/262	9/13181	148	ADRA1A	1
REACTOME_71288	Creatine metabolism	2.30437485543147	0.165356956393387	0.336778348840322	1/262	9/13181	6539	SLC6A12	1
REACTOME_9613354	Lipophagy	3.37176701516344	0.165356956393387	0.336778348840322	1/262	9/13181	5571	PRKAG1	1
REACTOME_9701898	STAT3 nuclear events downstream of ALK signaling	2.51480844424265	0.165356956393387	0.336778348840322	1/262	9/13181	29126	CD274	1
REACTOME_975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	2.64059669514201	0.165356956393387	0.336778348840322	1/262	9/13181	54106	TLR9	1
REACTOME_975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	2.64059669514201	0.165356956393387	0.336778348840322	1/262	9/13181	54106	TLR9	1
REACTOME_2672351	Stimuli-sensing channels	5.26966899193867	0.172266367721016	0.348048295868255	3/262	72/13181	203859/23327/51802	ANO5/NEDD4L/ASIC5	3
REACTOME_192823	Viral mRNA Translation	2.39167044058876	0.181958571746024	0.351130865477462	1/262	10/13181	200916	RPL22L1	1
REACTOME_196025	Formation of annular gap junctions	2.31066028763399	0.181958571746024	0.351130865477462	1/262	10/13181	8218	CLTCL1	1
REACTOME_210990	PECAM1 interactions	2.34560892349801	0.181958571746024	0.351130865477462	1/262	10/13181	3685	ITGAV	1
REACTOME_2151209	Activation of PPARGC1A (PGC-1alpha) by phosphorylation	3.37176701516344	0.181958571746024	0.351130865477462	1/262	10/13181	5571	PRKAG1	1
REACTOME_388841	Costimulation by the CD28 family	2.23317709428392	0.181958571746024	0.351130865477462	1/262	10/13181	29851	ICOS	1
REACTOME_399997	Acetylcholine regulates insulin secretion	2.98190386550797	0.181958571746024	0.351130865477462	1/262	10/13181	4082	MARCKS	1
REACTOME_73817	Purine ribonucleoside monophosphate biosynthesis	2.50985308992354	0.181958571746024	0.351130865477462	1/262	10/13181	3614	IMPDH1	1
REACTOME_76009	Platelet Aggregation (Plug Formation)	2.88471078267737	0.181958571746024	0.351130865477462	1/262	10/13181	2147	F2	1
REACTOME_8875656	MET receptor recycling	2.54024227537346	0.181958571746024	0.351130865477462	1/262	10/13181	4233	MET	1
REACTOME_9690406	Transcriptional regulation of testis differentiation	2.54972879394035	0.181958571746024	0.351130865477462	1/262	10/13181	1761	DMRT1	1
REACTOME_9700645	ALK mutants bind TKIs	2.50781989668471	0.181958571746024	0.351130865477462	1/262	10/13181	238	ALK	1
REACTOME_975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	2.39167044058876	0.181958571746024	0.351130865477462	1/262	10/13181	200916	RPL22L1	1
REACTOME_2219530	Constitutive Signaling by Aberrant PI3K in Cancer	4.75591902117478	0.187165394871423	0.360066452489366	3/262	75/13181	1956/29851/4233	EGFR/ICOS/MET	3
REACTOME_5620912	Anchoring of the basal body to the plasma membrane	4.56346105679611	0.192204865963113	0.363982205438143	3/262	76/13181	22995/55722/80254	CEP152/CEP72/CEP63	3
REACTOME_977606	Regulation of Complement cascade	3.8888485272301	0.19579060937353	0.363982205438143	2/262	41/13181	3075/2147	CFH/F2	2
REACTOME_1236977	Endosomal/Vacuolar pathway	2.80921158992343	0.198231205122574	0.363982205438143	1/262	11/13181	1514	CTSL	1
REACTOME_190873	Gap junction degradation	2.31066028763399	0.198231205122574	0.363982205438143	1/262	11/13181	8218	CLTCL1	1
REACTOME_211979	Eicosanoids	2.76936891888017	0.198231205122574	0.363982205438143	1/262	11/13181	1580	CYP4B1	1
REACTOME_211999	CYP2E1 reactions	2.69467373153354	0.198231205122574	0.363982205438143	1/262	11/13181	1555	CYP2B6	1
REACTOME_72764	Eukaryotic Translation Termination	2.39167044058876	0.198231205122574	0.363982205438143	1/262	11/13181	200916	RPL22L1	1
REACTOME_8851680	Butyrophilin (BTN) family interactions	2.64107431962965	0.198231205122574	0.363982205438143	1/262	11/13181	11120	BTN2A1	1
REACTOME_8851805	MET activates RAS signaling	2.54024227537346	0.198231205122574	0.363982205438143	1/262	11/13181	4233	MET	1
REACTOME_8866427	VLDLR internalisation and degradation	2.54927845298842	0.198231205122574	0.363982205438143	1/262	11/13181	7436	VLDLR	1
REACTOME_8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	2.60703251325256	0.198231205122574	0.363982205438143	1/262	11/13181	1956	EGFR	1
REACTOME_8875360	InlB-mediated entry of Listeria monocytogenes into host cell	2.54024227537346	0.198231205122574	0.363982205438143	1/262	11/13181	4233	MET	1
REACTOME_8875555	MET activates RAP1 and RAC1	2.54024227537346	0.198231205122574	0.363982205438143	1/262	11/13181	4233	MET	1
REACTOME_114608	Platelet degranulation 	5.36245865649103	0.199738080493489	0.36647978205083	4/262	116/13181	3959/6678/22927/3479	LGALS3BP/SPARC/HABP4/IGF1	4
REACTOME_112308	Presynaptic depolarization and calcium channel opening	2.35419312759495	0.214181351231753	0.375080025738017	1/262	12/13181	777	CACNA1E	1
REACTOME_211958	Miscellaneous substrates	2.76936891888017	0.214181351231753	0.375080025738017	1/262	12/13181	1580	CYP4B1	1
REACTOME_212300	PRC2 methylates histones and DNA	3.00016156664602	0.214181351231753	0.375080025738017	1/262	12/13181	5931	RBBP7	1
REACTOME_2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	2.96118405471493	0.214181351231753	0.375080025738017	1/262	12/13181	50855	PARD6A	1
REACTOME_5607763	CLEC7A (Dectin-1) induces NFAT activation	2.24740574813656	0.214181351231753	0.375080025738017	1/262	12/13181	4775	NFATC3	1
REACTOME_6803211	TP53 Regulates Transcription of Death Receptors and Ligands	2.53187885822657	0.214181351231753	0.375080025738017	1/262	12/13181	7157	TP53	1
REACTOME_68962	Activation of the pre-replicative complex	2.80588198280685	0.214181351231753	0.375080025738017	1/262	12/13181	51053	GMNN	1
REACTOME_71064	Lysine catabolism	2.42829366394332	0.214181351231753	0.375080025738017	1/262	12/13181	1738	DLD	1
REACTOME_72689	Formation of a pool of free 40S subunits	2.39167044058876	0.214181351231753	0.375080025738017	1/262	12/13181	200916	RPL22L1	1
REACTOME_73621	Pyrimidine catabolism	2.21959006272819	0.214181351231753	0.375080025738017	1/262	12/13181	51733	UPB1	1
REACTOME_879518	Transport of organic anions	2.43705013403977	0.214181351231753	0.375080025738017	1/262	12/13181	6579	SLCO1A2	1
REACTOME_8847993	ERBB2 Activates PTK6 Signaling	2.60703251325256	0.214181351231753	0.375080025738017	1/262	12/13181	1956	EGFR	1
REACTOME_9648895	Response of EIF2AK1 (HRI) to heme deficiency	3.32051379207453	0.214181351231753	0.375080025738017	1/262	12/13181	2887	GRB10	1
REACTOME_381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	5.80956403178345	0.22048542925345	0.383639697557478	4/262	121/13181	9210/7857/3479/2147	BMP15/SCG2/IGF1/F2	4
REACTOME_216083	Integrin cell surface interactions	4.36390965126709	0.223099352576132	0.383639697557478	3/262	82/13181	1294/3685/3683	COL7A1/ITGAV/ITGAL	3
REACTOME_5368286	Mitochondrial translation initiation	4.55016374037552	0.228343719349452	0.383639697557478	3/262	83/13181	64963/64960/64983	MRPS11/MRPS15/MRPL32	3
REACTOME_5389840	Mitochondrial translation elongation	4.55016374037552	0.228343719349452	0.383639697557478	3/262	83/13181	64963/64960/64983	MRPS11/MRPS15/MRPL32	3
REACTOME_5419276	Mitochondrial translation termination	4.55016374037552	0.228343719349452	0.383639697557478	3/262	83/13181	64963/64960/64983	MRPS11/MRPS15/MRPL32	3
REACTOME_110328	Recognition and association of DNA glycosylase with site containing an affected pyrimidine	2.57887761337131	0.229815377048237	0.383639697557478	1/262	13/13181	6996	TDG	1
REACTOME_110329	Cleavage of the damaged pyrimidine 	2.57887761337131	0.229815377048237	0.383639697557478	1/262	13/13181	6996	TDG	1
REACTOME_177929	Signaling by EGFR	2.60703251325256	0.229815377048237	0.383639697557478	1/262	13/13181	1956	EGFR	1
REACTOME_179812	GRB2 events in EGFR signaling	2.60703251325256	0.229815377048237	0.383639697557478	1/262	13/13181	1956	EGFR	1
REACTOME_2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	2.36043703818501	0.229815377048237	0.383639697557478	1/262	13/13181	7003	TEAD1	1
REACTOME_2408557	Selenocysteine synthesis	2.39167044058876	0.229815377048237	0.383639697557478	1/262	13/13181	200916	RPL22L1	1
REACTOME_399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	2.71903556860323	0.229815377048237	0.383639697557478	1/262	13/13181	91584	PLXNA4	1
REACTOME_6785631	ERBB2 Regulates Cell Motility	2.60703251325256	0.229815377048237	0.383639697557478	1/262	13/13181	1956	EGFR	1
REACTOME_6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	2.53187885822657	0.229815377048237	0.383639697557478	1/262	13/13181	7157	TP53	1
REACTOME_6804759	Regulation of TP53 Activity through Association with Co-factors	2.53187885822657	0.229815377048237	0.383639697557478	1/262	13/13181	7157	TP53	1
REACTOME_6804760	Regulation of TP53 Activity through Methylation	2.53187885822657	0.229815377048237	0.383639697557478	1/262	13/13181	7157	TP53	1
REACTOME_8878166	Transcriptional regulation by RUNX2	3.1361298884285	0.229815377048237	0.383639697557478	1/262	13/13181	581	BAX	1
REACTOME_933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	2.49839679877394	0.229815377048237	0.383639697557478	1/262	13/13181	843	CASP10	1
REACTOME_416476	G alpha (q) signalling events	6.37679338271126	0.235199295927885	0.391320266660309	5/262	166/13181	2358/2911/148/2793/2147	FPR2/GRM1/ADRA1A/GNGT2/F2	5
REACTOME_5673001	RAF/MAP kinase cascade	5.75665379883405	0.241774817575296	0.396250757609355	4/262	126/13181	1740/1956/2904/4233	DLG2/EGFR/GRIN2B/MET	4
REACTOME_9013423	RAC3 GTPase cycle	4.99903850797318	0.244210364637472	0.396250757609355	3/262	86/13181	4952/124056/27035	OCRL/NOXO1/NOX1	3
REACTOME_1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	2.60703251325256	0.245139524315351	0.396250757609355	1/262	14/13181	1956	EGFR	1
REACTOME_180336	SHC1 events in EGFR signaling	2.60703251325256	0.245139524315351	0.396250757609355	1/262	14/13181	1956	EGFR	1
REACTOME_1855183	Synthesis of IP2, IP, and Ins in the cytosol	2.67200363872107	0.245139524315351	0.396250757609355	1/262	14/13181	4952	OCRL	1
REACTOME_196757	Metabolism of folate and pterines	2.83194893317556	0.245139524315351	0.396250757609355	1/262	14/13181	2356	FPGS	1
REACTOME_2559586	DNA Damage/Telomere Stress Induced Senescence	2.53187885822657	0.245139524315351	0.396250757609355	1/262	14/13181	7157	TP53	1
REACTOME_391160	Signal regulatory protein family interactions	2.34975692141932	0.245139524315351	0.396250757609355	1/262	14/13181	653509	SFTPA1	1
REACTOME_427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	3.00016156664602	0.245139524315351	0.396250757609355	1/262	14/13181	5931	RBBP7	1
REACTOME_5637810	Constitutive Signaling by EGFRvIII	2.60703251325256	0.245139524315351	0.396250757609355	1/262	14/13181	1956	EGFR	1
REACTOME_606279	Deposition of new CENPA-containing nucleosomes at the centromere	3.00016156664602	0.245139524315351	0.396250757609355	1/262	14/13181	5931	RBBP7	1
REACTOME_9665348	Signaling by ERBB2 ECD mutants	2.60703251325256	0.245139524315351	0.396250757609355	1/262	14/13181	1956	EGFR	1
REACTOME_9725371	Nuclear events stimulated by ALK signaling in cancer	2.50781989668471	0.245139524315351	0.396250757609355	1/262	14/13181	238	ALK	1
REACTOME_983712	Ion channel transport	2.25515687793768	0.245139524315351	0.396250757609355	1/262	14/13181	155066	ATP6V0E2	1
REACTOME_1227986	Signaling by ERBB2	2.60703251325256	0.260159911998907	0.404955091999945	1/262	15/13181	1956	EGFR	1
REACTOME_1474244	Extracellular matrix organization	2.19193160704346	0.260159911998907	0.404955091999945	1/262	15/13181	1294	COL7A1	1
REACTOME_156584	Cytosolic sulfonation of small molecules	3.38052333817283	0.260159911998907	0.404955091999945	1/262	15/13181	6822	SULT2A1	1
REACTOME_156827	L13a-mediated translational silencing of Ceruloplasmin expression	2.39167044058876	0.260159911998907	0.404955091999945	1/262	15/13181	200916	RPL22L1	1
REACTOME_181429	Serotonin Neurotransmitter Release Cycle	3.0847976516741	0.260159911998907	0.404955091999945	1/262	15/13181	8541	PPFIA3	1
REACTOME_1963640	GRB2 events in ERBB2 signaling	2.60703251325256	0.260159911998907	0.404955091999945	1/262	15/13181	1956	EGFR	1
REACTOME_1963642	PI3K events in ERBB2 signaling	2.60703251325256	0.260159911998907	0.404955091999945	1/262	15/13181	1956	EGFR	1
REACTOME_2214320	Anchoring fibril formation	2.19193160704346	0.260159911998907	0.404955091999945	1/262	15/13181	1294	COL7A1	1
REACTOME_264642	Acetylcholine Neurotransmitter Release Cycle	3.0847976516741	0.260159911998907	0.404955091999945	1/262	15/13181	8541	PPFIA3	1
REACTOME_349425	Autodegradation of the E3 ubiquitin ligase COP1	2.53187885822657	0.260159911998907	0.404955091999945	1/262	15/13181	7157	TP53	1
REACTOME_399954	Sema3A PAK dependent Axon repulsion	2.71903556860323	0.260159911998907	0.404955091999945	1/262	15/13181	91584	PLXNA4	1
REACTOME_399956	CRMPs in Sema3A signaling	2.71903556860323	0.260159911998907	0.404955091999945	1/262	15/13181	91584	PLXNA4	1
REACTOME_69481	G2/M Checkpoints	2.53187885822657	0.260159911998907	0.404955091999945	1/262	15/13181	7157	TP53	1
REACTOME_72706	GTP hydrolysis and joining of the 60S ribosomal subunit	2.39167044058876	0.260159911998907	0.404955091999945	1/262	15/13181	200916	RPL22L1	1
REACTOME_918233	TRAF3-dependent IRF activation pathway	2.40032785140264	0.260159911998907	0.404955091999945	1/262	15/13181	3456	IFNB1	1
REACTOME_975577	N-Glycan antennae elongation	2.49014888294138	0.260159911998907	0.404955091999945	1/262	15/13181	11282	MGAT4B	1
REACTOME_2022090	Assembly of collagen fibrils and other multimeric structures	3.79015779756675	0.261926371226107	0.406555280555305	2/262	50/13181	1294/1514	COL7A1/CTSL	2
REACTOME_1257604	PIP3 activates AKT signaling	4.75591902117478	0.27101456250157	0.415818077599371	3/262	91/13181	1956/29851/4233	EGFR/ICOS/MET	3
REACTOME_1660514	Synthesis of PIPs at the Golgi membrane	2.67200363872107	0.274882538693142	0.415818077599371	1/262	16/13181	4952	OCRL	1
REACTOME_181430	Norepinephrine Neurotransmitter Release Cycle	3.0847976516741	0.274882538693142	0.415818077599371	1/262	16/13181	8541	PPFIA3	1
REACTOME_2022377	Metabolism of Angiotensinogen to Angiotensins	2.56503494822908	0.274882538693142	0.415818077599371	1/262	16/13181	1215	CMA1	1
REACTOME_204174	Regulation of pyruvate dehydrogenase (PDH) complex	2.42829366394332	0.274882538693142	0.415818077599371	1/262	16/13181	1738	DLD	1
REACTOME_5676594	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	2.20865933940322	0.274882538693142	0.415818077599371	1/262	16/13181	959	CD40LG	1
REACTOME_9604323	Negative regulation of NOTCH4 signaling	2.75060991672972	0.274882538693142	0.415818077599371	1/262	16/13181	55294	FBXW7	1
REACTOME_3108214	SUMOylation of DNA damage response and repair proteins	3.77352127456584	0.276725247335966	0.417342421902583	2/262	52/13181	10735/6996	STAG2/TDG	2
REACTOME_9707564	Cytoprotection by HMOX1	3.75561051240587	0.276725247335966	0.417342421902583	2/262	52/13181	9997/6341	SCO2/SCO1	2
REACTOME_156588	Glucuronidation	2.36267250507695	0.289313284979689	0.427301358844115	1/262	17/13181	7366	UGT2B15	1
REACTOME_180292	GAB1 signalosome	2.60703251325256	0.289313284979689	0.427301358844115	1/262	17/13181	1956	EGFR	1
REACTOME_198753	ERK/MAPK targets	2.19544655261977	0.289313284979689	0.427301358844115	1/262	17/13181	9252	RPS6KA5	1
REACTOME_452723	Transcriptional regulation of pluripotent stem cells	2.22858794519319	0.289313284979689	0.427301358844115	1/262	17/13181	27086	FOXP1	1
REACTOME_5576886	Phase 4 - resting membrane potential	2.42552599804452	0.289313284979689	0.427301358844115	1/262	17/13181	3770	KCNJ14	1
REACTOME_6788467	IL-6-type cytokine receptor ligand interactions	2.44304901725477	0.289313284979689	0.427301358844115	1/262	17/13181	1489	CTF1	1
REACTOME_6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	2.53187885822657	0.289313284979689	0.427301358844115	1/262	17/13181	7157	TP53	1
REACTOME_6807004	Negative regulation of MET activity	2.54024227537346	0.289313284979689	0.427301358844115	1/262	17/13181	4233	MET	1
REACTOME_8863795	Downregulation of ERBB2 signaling	2.60703251325256	0.289313284979689	0.427301358844115	1/262	17/13181	1956	EGFR	1
REACTOME_8964315	G beta:gamma signalling through BTK	2.27774295253019	0.289313284979689	0.427301358844115	1/262	17/13181	2793	GNGT2	1
REACTOME_9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	2.36170981627348	0.289313284979689	0.427301358844115	1/262	17/13181	1870	E2F2	1
REACTOME_9009391	Extra-nuclear estrogen signaling	3.70196754858523	0.298884583078116	0.434082044324849	2/262	55/13181	1956/2793	EGFR/GNGT2	2
REACTOME_1236394	Signaling by ERBB4	2.60703251325256	0.3034579157405	0.434082044324849	1/262	18/13181	1956	EGFR	1
REACTOME_1566948	Elastic fibre formation	2.34560892349801	0.3034579157405	0.434082044324849	1/262	18/13181	3685	ITGAV	1
REACTOME_166016	Toll Like Receptor 4 (TLR4) Cascade	2.34975692141932	0.3034579157405	0.434082044324849	1/262	18/13181	653509	SFTPA1	1
REACTOME_392851	Prostacyclin signalling through prostacyclin receptor	2.27774295253019	0.3034579157405	0.434082044324849	1/262	18/13181	2793	GNGT2	1
REACTOME_416700	Other semaphorin interactions	2.71903556860323	0.3034579157405	0.434082044324849	1/262	18/13181	91584	PLXNA4	1
REACTOME_8964616	G beta:gamma signalling through CDC42	2.27774295253019	0.3034579157405	0.434082044324849	1/262	18/13181	2793	GNGT2	1
REACTOME_9037629	Lewis blood group biosynthesis	2.73764841964457	0.3034579157405	0.434082044324849	1/262	18/13181	2524	FUT2	1
REACTOME_912446	Meiotic recombination	2.45195588154084	0.3034579157405	0.434082044324849	1/262	18/13181	27030	MLH3	1
REACTOME_9607240	FLT3 Signaling	3.32051379207453	0.3034579157405	0.434082044324849	1/262	18/13181	2887	GRB10	1
REACTOME_9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	2.39167044058876	0.3034579157405	0.434082044324849	1/262	18/13181	200916	RPL22L1	1
REACTOME_9704331	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	2.18165664351643	0.3034579157405	0.434082044324849	1/262	18/13181	116028	RMI2	1
REACTOME_9704646	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	2.18165664351643	0.3034579157405	0.434082044324849	1/262	18/13181	116028	RMI2	1
REACTOME_8943724	Regulation of PTEN gene transcription	4.1925026592923	0.313600758785404	0.442022231873789	2/262	57/13181	7157/5931	TP53/RBBP7	2
REACTOME_140875	Common Pathway of Fibrin Clot Formation	2.88471078267737	0.317322082425602	0.442022231873789	1/262	19/13181	2147	F2	1
REACTOME_2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	2.72628959613406	0.317322082425602	0.442022231873789	1/262	19/13181	23327	NEDD4L	1
REACTOME_388844	Receptor-type tyrosine-protein phosphatases	3.0847976516741	0.317322082425602	0.442022231873789	1/262	19/13181	8541	PPFIA3	1
REACTOME_418217	G beta:gamma signalling through PLC beta	2.27774295253019	0.317322082425602	0.442022231873789	1/262	19/13181	2793	GNGT2	1
REACTOME_442660	Na+/Cl- dependent neurotransmitter transporters	2.30437485543147	0.317322082425602	0.442022231873789	1/262	19/13181	6539	SLC6A12	1
REACTOME_5693579	Homologous DNA Pairing and Strand Exchange	2.18165664351643	0.317322082425602	0.442022231873789	1/262	19/13181	116028	RMI2	1
REACTOME_68827	CDT1 association with the CDC6:ORC:origin complex	2.80588198280685	0.317322082425602	0.442022231873789	1/262	19/13181	51053	GMNN	1
REACTOME_77289	Mitochondrial Fatty Acid Beta-Oxidation	3.18599203457413	0.317322082425602	0.442022231873789	1/262	19/13181	641371	ACOT1	1
REACTOME_9665686	Signaling by ERBB2 TMD/JMD mutants	2.60703251325256	0.317322082425602	0.442022231873789	1/262	19/13181	1956	EGFR	1
REACTOME_212676	Dopamine Neurotransmitter Release Cycle	3.0847976516741	0.330911325276574	0.452625835723129	1/262	20/13181	8541	PPFIA3	1
REACTOME_2142691	Synthesis of Leukotrienes (LT) and Eoxins (EX)	2.76936891888017	0.330911325276574	0.452625835723129	1/262	20/13181	1580	CYP4B1	1
REACTOME_2173788	Downregulation of TGF-beta receptor signaling	2.72628959613406	0.330911325276574	0.452625835723129	1/262	20/13181	23327	NEDD4L	1
REACTOME_500657	Presynaptic function of Kainate receptors	2.27774295253019	0.330911325276574	0.452625835723129	1/262	20/13181	2793	GNGT2	1
REACTOME_5686938	Regulation of TLR by endogenous ligand	2.34975692141932	0.330911325276574	0.452625835723129	1/262	20/13181	653509	SFTPA1	1
REACTOME_5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	2.18165664351643	0.330911325276574	0.452625835723129	1/262	20/13181	116028	RMI2	1
REACTOME_9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	2.60703251325256	0.330911325276574	0.452625835723129	1/262	20/13181	1956	EGFR	1
REACTOME_917729	Endosomal Sorting Complex Required For Transport (ESCRT)	2.37809592042927	0.330911325276574	0.452625835723129	1/262	20/13181	137492	VPS37A	1
REACTOME_917977	Transferrin endocytosis and recycling	2.25515687793768	0.330911325276574	0.452625835723129	1/262	20/13181	155066	ATP6V0E2	1
REACTOME_9013148	CDC42 GTPase cycle	5.88589274763899	0.334973041652747	0.457707781739731	4/262	147/13181	50855/9578/124056/27035	PARD6A/CDC42BPB/NOXO1/NOX1	4
REACTOME_1442490	Collagen degradation	3.79015779756675	0.335542479450655	0.457707781739731	2/262	60/13181	1294/1514	COL7A1/CTSL	2
REACTOME_1250196	SHC1 events in ERBB2 signaling	2.60703251325256	0.344231075506612	0.461994338179927	1/262	21/13181	1956	EGFR	1
REACTOME_375165	NCAM signaling for neurite out-growth	2.19544655261977	0.344231075506612	0.461994338179927	1/262	21/13181	9252	RPS6KA5	1
REACTOME_389948	PD-1 signaling	2.51480844424265	0.344231075506612	0.461994338179927	1/262	21/13181	29126	CD274	1
REACTOME_392170	ADP signalling through P2Y purinoceptor 12	2.27774295253019	0.344231075506612	0.461994338179927	1/262	21/13181	2793	GNGT2	1
REACTOME_5362517	Signaling by Retinoic Acid	2.42829366394332	0.344231075506612	0.461994338179927	1/262	21/13181	1738	DLD	1
REACTOME_5621575	CD209 (DC-SIGN) signaling	2.19544655261977	0.344231075506612	0.461994338179927	1/262	21/13181	9252	RPS6KA5	1
REACTOME_6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	2.88480023996422	0.344231075506612	0.461994338179927	1/262	21/13181	3980	LIG3	1
REACTOME_70268	Pyruvate metabolism	2.42829366394332	0.344231075506612	0.461994338179927	1/262	21/13181	1738	DLD	1
REACTOME_70895	Branched-chain amino acid catabolism	2.42829366394332	0.344231075506612	0.461994338179927	1/262	21/13181	1738	DLD	1
REACTOME_71403	Citric acid cycle (TCA cycle)	2.42829366394332	0.344231075506612	0.461994338179927	1/262	21/13181	1738	DLD	1
REACTOME_8849932	Synaptic adhesion-like molecules	2.51876820419394	0.344231075506612	0.461994338179927	1/262	21/13181	2904	GRIN2B	1
REACTOME_912694	Regulation of IFNA signaling	2.40032785140264	0.344231075506612	0.461994338179927	1/262	21/13181	3456	IFNB1	1
REACTOME_1632852	Macroautophagy	4.52585622155931	0.357274537177927	0.470669139134212	2/262	63/13181	11337/5571	GABARAP/PRKAG1	2
REACTOME_1461957	Beta defensins	2.31944680172791	0.357286657438015	0.470669139134212	1/262	22/13181	729230	CCR2	1
REACTOME_210500	Glutamate Neurotransmitter Release Cycle	3.0847976516741	0.357286657438015	0.470669139134212	1/262	22/13181	8541	PPFIA3	1
REACTOME_392451	G beta:gamma signalling through PI3Kgamma	2.27774295253019	0.357286657438015	0.470669139134212	1/262	22/13181	2793	GNGT2	1
REACTOME_427413	NoRC negatively regulates rRNA expression	2.34501561298431	0.357286657438015	0.470669139134212	1/262	22/13181	79685	SAP30L	1
REACTOME_428930	Thromboxane signalling through TP receptor	2.27774295253019	0.357286657438015	0.470669139134212	1/262	22/13181	2793	GNGT2	1
REACTOME_5685938	HDR through Single Strand Annealing (SSA)	2.18165664351643	0.357286657438015	0.470669139134212	1/262	22/13181	116028	RMI2	1
REACTOME_5693616	Presynaptic phase of homologous DNA pairing and strand exchange	2.18165664351643	0.357286657438015	0.470669139134212	1/262	22/13181	116028	RMI2	1
REACTOME_9664565	Signaling by ERBB2 KD Mutants	2.60703251325256	0.357286657438015	0.470669139134212	1/262	22/13181	1956	EGFR	1
REACTOME_9662360	Sensory processing of sound by inner hair cells of the cochlea	3.93192857238219	0.364463062420442	0.478860774442001	2/262	64/13181	776/140469	CACNA1D/MYO3B	2
REACTOME_140837	Intrinsic Pathway of Fibrin Clot Formation	2.88471078267737	0.370083290597924	0.480185951819425	1/262	23/13181	2147	F2	1
REACTOME_202040	G-protein activation	2.27774295253019	0.370083290597924	0.480185951819425	1/262	23/13181	2793	GNGT2	1
REACTOME_211981	Xenobiotics	2.69467373153354	0.370083290597924	0.480185951819425	1/262	23/13181	1555	CYP2B6	1
REACTOME_264876	Insulin processing	2.57168879268085	0.370083290597924	0.480185951819425	1/262	23/13181	3630	INS	1
REACTOME_73762	RNA Polymerase I Transcription Initiation	3.00016156664602	0.370083290597924	0.480185951819425	1/262	23/13181	5931	RBBP7	1
REACTOME_9634638	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	2.60703251325256	0.370083290597924	0.480185951819425	1/262	23/13181	1956	EGFR	1
REACTOME_975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	2.39167044058876	0.370083290597924	0.480185951819425	1/262	23/13181	200916	RPL22L1	1
REACTOME_1222556	ROS and RNS production in phagocytes	2.25515687793768	0.382626091773129	0.489847645154226	1/262	24/13181	155066	ATP6V0E2	1
REACTOME_418592	ADP signalling through P2Y purinoceptor 1	2.27774295253019	0.382626091773129	0.489847645154226	1/262	24/13181	2793	GNGT2	1
REACTOME_449836	Other interleukin signaling	2.68970656508821	0.382626091773129	0.489847645154226	1/262	24/13181	3603	IL16	1
REACTOME_5683826	Surfactant metabolism	2.34975692141932	0.382626091773129	0.489847645154226	1/262	24/13181	653509	SFTPA1	1
REACTOME_6783310	Fanconi Anemia Pathway	2.5970094867609	0.382626091773129	0.489847645154226	1/262	24/13181	22909	FAN1	1
REACTOME_9619483	Activation of AMPK downstream of NMDARs	3.37176701516344	0.382626091773129	0.489847645154226	1/262	24/13181	5571	PRKAG1	1
REACTOME_1368108	BMAL1:CLOCK,NPAS2 activates circadian gene expression	2.3949294222591	0.39492007702474	0.497181497473463	1/262	25/13181	2155	F7	1
REACTOME_1855204	Synthesis of IP3 and IP4 in the cytosol	2.67200363872107	0.39492007702474	0.497181497473463	1/262	25/13181	4952	OCRL	1
REACTOME_3000170	Syndecan interactions	2.34560892349801	0.39492007702474	0.497181497473463	1/262	25/13181	3685	ITGAV	1
REACTOME_5685942	HDR through Homologous Recombination (HRR)	2.18165664351643	0.39492007702474	0.497181497473463	1/262	25/13181	116028	RMI2	1
REACTOME_5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	2.18165664351643	0.39492007702474	0.497181497473463	1/262	25/13181	116028	RMI2	1
REACTOME_933541	TRAF6 mediated IRF7 activation	2.40032785140264	0.39492007702474	0.497181497473463	1/262	25/13181	3456	IFNB1	1
REACTOME_9615710	Late endosomal microautophagy	2.37809592042927	0.39492007702474	0.497181497473463	1/262	25/13181	137492	VPS37A	1
REACTOME_1221632	Meiotic synapsis	2.40031355988813	0.406970163663499	0.506483286352133	1/262	26/13181	10735	STAG2	1
REACTOME_1296041	Activation of G protein gated Potassium channels	2.27774295253019	0.406970163663499	0.506483286352133	1/262	26/13181	2793	GNGT2	1
REACTOME_6791226	Major pathway of rRNA processing in the nucleolus and cytosol	2.39167044058876	0.406970163663499	0.506483286352133	1/262	26/13181	200916	RPL22L1	1
REACTOME_9694548	Maturation of spike protein	2.49014888294138	0.406970163663499	0.506483286352133	1/262	26/13181	11282	MGAT4B	1
REACTOME_997272	Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits	2.27774295253019	0.406970163663499	0.506483286352133	1/262	26/13181	2793	GNGT2	1
REACTOME_2500257	Resolution of Sister Chromatid Cohesion	3.54980999600313	0.413839090315945	0.514263494132048	2/262	71/13181	10735/220134	STAG2/SKA1	2
REACTOME_198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	4.33858166042694	0.417289027846546	0.51655189994772	3/262	118/13181	3812/959/3683	KIR3DL2/CD40LG/ITGAL	3
REACTOME_9619665	EGR2 and SOX10-mediated initiation of Schwann cell myelination	2.36043703818501	0.418781172186507	0.51655189994772	1/262	27/13181	7003	TEAD1	1
REACTOME_3000178	ECM proteoglycans	3.45510211517712	0.427601636420679	0.523340249446266	2/262	73/13181	6678/3685	SPARC/ITGAV	2
REACTOME_3295583	TRP channels	2.24890940061269	0.430357828176101	0.523340249446266	1/262	28/13181	56302	TRPV5	1
REACTOME_380972	Energy dependent regulation of mTOR by LKB1-AMPK	3.37176701516344	0.430357828176101	0.523340249446266	1/262	28/13181	5571	PRKAG1	1
REACTOME_420029	Tight junction interactions	2.96118405471493	0.430357828176101	0.523340249446266	1/262	28/13181	50855	PARD6A	1
REACTOME_4608870	Asymmetric localization of PCP proteins	2.96118405471493	0.430357828176101	0.523340249446266	1/262	28/13181	50855	PARD6A	1
REACTOME_525793	Myogenesis	2.34363679425852	0.430357828176101	0.523340249446266	1/262	28/13181	4654	MYOD1	1
REACTOME_6804757	Regulation of TP53 Degradation	2.53187885822657	0.430357828176101	0.523340249446266	1/262	28/13181	7157	TP53	1
REACTOME_6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	2.27774295253019	0.430357828176101	0.523340249446266	1/262	28/13181	2793	GNGT2	1
REACTOME_8950505	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	2.81898117145025	0.430357828176101	0.523340249446266	1/262	28/13181	1265	CNN2	1
REACTOME_8953750	Transcriptional Regulation by E2F6	3.00016156664602	0.430357828176101	0.523340249446266	1/262	28/13181	5931	RBBP7	1
REACTOME_8856828	Clathrin-mediated endocytosis	4.89075496117733	0.438413157852169	0.531961544886724	3/262	122/13181	1956/4952/8218	EGFR/OCRL/CLTCL1	3
REACTOME_389661	Glyoxylate metabolism and glycine degradation	2.42829366394332	0.441704764161646	0.531961544886724	1/262	29/13181	1738	DLD	1
REACTOME_6796648	TP53 Regulates Transcription of DNA Repair Genes	2.53187885822657	0.441704764161646	0.531961544886724	1/262	29/13181	7157	TP53	1
REACTOME_8853884	Transcriptional Regulation by VENTX	2.53187885822657	0.441704764161646	0.531961544886724	1/262	29/13181	7157	TP53	1
REACTOME_611105	Respiratory electron transport	3.75561051240587	0.447922925678926	0.539190458223332	2/262	76/13181	9997/6341	SCO2/SCO1	2
REACTOME_1251985	Nuclear signaling by ERBB4	2.21342565000636	0.452826521444922	0.541701042168913	1/262	30/13181	6678	SPARC	1
REACTOME_1592389	Activation of Matrix Metalloproteinases	2.56503494822908	0.452826521444922	0.541701042168913	1/262	30/13181	1215	CMA1	1
REACTOME_5694530	Cargo concentration in the ER	2.19193160704346	0.452826521444922	0.541701042168913	1/262	30/13181	1294	COL7A1	1
REACTOME_8874081	MET activates PTK2 signaling	2.54024227537346	0.452826521444922	0.541701042168913	1/262	30/13181	4233	MET	1
REACTOME_416482	G alpha (12/13) signalling events	3.3930563502536	0.454606783701665	0.543050837700985	2/262	77/13181	148/2793	ADRA1A/GNGT2	2
REACTOME_983231	Factors involved in megakaryocyte development and platelet production	3.73791370961937	0.46124422604369	0.550453352857298	2/262	78/13181	7157/3456	TP53/IFNB1	2
REACTOME_2514859	Inactivation, recovery and regulation of the phototransduction cascade	2.38052462800564	0.463727551889864	0.551048574499653	1/262	31/13181	2986	GUCY2F	1
REACTOME_2871809	FCERI mediated Ca+2 mobilization	2.24740574813656	0.463727551889864	0.551048574499653	1/262	31/13181	4775	NFATC3	1
REACTOME_5668541	TNFR2 non-canonical NF-kB pathway	2.20865933940322	0.463727551889864	0.551048574499653	1/262	31/13181	959	CD40LG	1
REACTOME_1474228	Degradation of the extracellular matrix	4.77898622054604	0.467834453141374	0.554347225415027	2/262	79/13181	1514/6650	CTSL/CAPN15	2
REACTOME_202733	Cell surface interactions at the vascular wall	3.87969188181878	0.467834453141374	0.554347225415027	2/262	79/13181	3683/2147	ITGAL/F2	2
REACTOME_877300	Interferon gamma signaling	4.36865846333955	0.467834453141374	0.554347225415027	2/262	79/13181	4261/81603	CIITA/TRIM8	2
REACTOME_1912408	Pre-NOTCH Transcription and Translation	2.53187885822657	0.474412219677305	0.558960932095043	1/262	32/13181	7157	TP53	1
REACTOME_420092	Glucagon-type ligand receptors	2.27774295253019	0.474412219677305	0.558960932095043	1/262	32/13181	2793	GNGT2	1
REACTOME_5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	2.53187885822657	0.474412219677305	0.558960932095043	1/262	32/13181	7157	TP53	1
REACTOME_8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	2.70232421646621	0.474412219677305	0.558960932095043	1/262	32/13181	8289	ARID1A	1
REACTOME_159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	2.72553377547541	0.484884803025434	0.567819645154901	1/262	33/13181	84324	SARNP	1
REACTOME_5689896	Ovarian tumor domain proteases	2.53187885822657	0.484884803025434	0.567819645154901	1/262	33/13181	7157	TP53	1
REACTOME_3299685	Detoxification of Reactive Oxygen Species	2.53866134089716	0.495149495876616	0.574722986621302	1/262	34/13181	79400	NOX5	1
REACTOME_5693607	Processing of DNA double-strand break ends	2.18165664351643	0.495149495876616	0.574722986621302	1/262	34/13181	116028	RMI2	1
REACTOME_8939902	Regulation of RUNX2 expression and activity	2.75060991672972	0.495149495876616	0.574722986621302	1/262	34/13181	55294	FBXW7	1
REACTOME_3214841	PKMTs methylate histone lysines	3.00016156664602	0.505210409551243	0.58341996925534	1/262	35/13181	5931	RBBP7	1
REACTOME_3769402	Deactivation of the beta-catenin transactivating complex	2.69415494341814	0.505210409551243	0.58341996925534	1/262	35/13181	64321	SOX17	1
REACTOME_8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	2.53187885822657	0.505210409551243	0.58341996925534	1/262	35/13181	7157	TP53	1
REACTOME_9013424	RHOV GTPase cycle	2.96118405471493	0.505210409551243	0.58341996925534	1/262	35/13181	50855	PARD6A	1
REACTOME_2129379	Molecules associated with elastic fibres	2.34560892349801	0.515071574369254	0.59152751118969	1/262	36/13181	3685	ITGAV	1
REACTOME_109704	PI3K Cascade	2.64059669514201	0.524736941239947	0.59877516719572	1/262	37/13181	54106	TLR9	1
REACTOME_5675221	Negative regulation of MAPK pathway	3.05757446426583	0.524736941239947	0.59877516719572	1/262	37/13181	5774	PTPN3	1
REACTOME_9013420	RHOU GTPase cycle	2.96118405471493	0.524736941239947	0.59877516719572	1/262	37/13181	50855	PARD6A	1
REACTOME_9639288	Amino acids regulate mTORC1	2.25515687793768	0.524736941239947	0.59877516719572	1/262	37/13181	155066	ATP6V0E2	1
REACTOME_9725370	Signaling by ALK fusions and activated point mutants	2.50781989668471	0.524736941239947	0.59877516719572	1/262	37/13181	238	ALK	1
REACTOME_2467813	Separation of Sister Chromatids	3.54980999600313	0.537028765634468	0.609185149941233	2/262	90/13181	10735/220134	STAG2/SKA1	2
REACTOME_8856825	Cargo recognition for clathrin-mediated endocytosis	3.72691422365633	0.537028765634468	0.609185149941233	2/262	90/13181	1956/8218	EGFR/CLTCL1	2
REACTOME_2122947	NOTCH1 Intracellular Domain Regulates Transcription	2.75060991672972	0.543495697045268	0.614012543813799	1/262	39/13181	55294	FBXW7	1
REACTOME_3928662	EPHB-mediated forward signaling	2.51876820419394	0.543495697045268	0.614012543813799	1/262	39/13181	2904	GRIN2B	1
REACTOME_69231	Cyclin D associated events in G1	2.36170981627348	0.543495697045268	0.614012543813799	1/262	39/13181	1870	E2F2	1
REACTOME_3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	2.7017570791408	0.552596604622055	0.61925511881189	1/262	40/13181	55466	DNAJA4	1
REACTOME_419037	NCAM1 interactions	2.92108337431886	0.552596604622055	0.61925511881189	1/262	40/13181	776	CACNA1D	1
REACTOME_437239	Recycling pathway of L1	2.19544655261977	0.552596604622055	0.61925511881189	1/262	40/13181	9252	RPS6KA5	1
REACTOME_8853659	RET signaling	3.32051379207453	0.552596604622055	0.61925511881189	1/262	40/13181	2887	GRB10	1
REACTOME_9696264	RND3 GTPase cycle	2.2366277615671	0.552596604622055	0.61925511881189	1/262	40/13181	390	RND3	1
REACTOME_381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	2.27774295253019	0.561516754503268	0.626162592371114	1/262	41/13181	2793	GNGT2	1
REACTOME_432040	Vasopressin regulates renal water homeostasis via Aquaporins	2.27774295253019	0.570259723325197	0.630845085697064	1/262	42/13181	2793	GNGT2	1
REACTOME_8854214	TBC/RABGAPs	2.60013607220479	0.570259723325197	0.630845085697064	1/262	42/13181	11337	GABARAP	1
REACTOME_8948216	Collagen chain trimerization	2.19193160704346	0.570259723325197	0.630845085697064	1/262	42/13181	1294	COL7A1	1
REACTOME_1989781	PPARA activates gene expression	4.44393062537837	0.577740141806301	0.637502738666253	2/262	97/13181	6822/2274	SULT2A1/FHL2	2
REACTOME_1296072	Voltage gated Potassium channels	2.81129437718449	0.578829017220379	0.637502738666253	1/262	43/13181	3788	KCNS2	1
REACTOME_5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	3.00016156664602	0.578829017220379	0.637502738666253	1/262	43/13181	5931	RBBP7	1
REACTOME_6783783	Interleukin-10 signaling	2.31944680172791	0.578829017220379	0.637502738666253	1/262	43/13181	729230	CCR2	1
REACTOME_9662361	Sensory processing of sound by outer hair cells of the cochlea	2.26712748153341	0.595460260521994	0.652369658502614	1/262	45/13181	140469	MYO3B	1
REACTOME_5620924	Intraflagellar transport	2.65588053307167	0.603528882000621	0.658898504202512	1/262	46/13181	112752	IFT43	1
REACTOME_9010553	Regulation of expression of SLITs and ROBOs	2.39167044058876	0.603528882000621	0.658898504202512	1/262	46/13181	200916	RPL22L1	1
REACTOME_977225	Amyloid fiber formation	2.57168879268085	0.603528882000621	0.658898504202512	1/262	46/13181	3630	INS	1
REACTOME_400253	Circadian Clock	2.37086988410145	0.611437175332622	0.665787146473299	1/262	47/13181	1407	CRY1	1
REACTOME_418597	G alpha (z) signalling events	2.27774295253019	0.611437175332622	0.665787146473299	1/262	47/13181	2793	GNGT2	1
REACTOME_8957275	Post-translational protein phosphorylation	3.66395846548257	0.615780105112164	0.669932295461601	2/262	104/13181	9210/7857	BMP15/SCG2	2
REACTOME_2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	2.75060991672972	0.626785410355843	0.678949605756069	1/262	49/13181	55294	FBXW7	1
REACTOME_2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	2.75060991672972	0.626785410355843	0.678949605756069	1/262	49/13181	55294	FBXW7	1
REACTOME_1660499	Synthesis of PIPs at the plasma membrane	2.67200363872107	0.634231513195225	0.683755199083204	1/262	50/13181	4952	OCRL	1
REACTOME_3928665	EPH-ephrin mediated repulsion of cells	2.31066028763399	0.634231513195225	0.683755199083204	1/262	50/13181	8218	CLTCL1	1
REACTOME_141444	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal	2.2836888115787	0.641529612619705	0.688948217420131	1/262	51/13181	220134	SKA1	1
REACTOME_373080	Class B/2 (Secretin family receptors)	2.18492331199236	0.641529612619705	0.688948217420131	1/262	51/13181	11211	FZD10	1
REACTOME_380108	Chemokine receptors bind chemokines	2.31944680172791	0.648682639389975	0.695733011088218	1/262	52/13181	729230	CCR2	1
REACTOME_432722	Golgi Associated Vesicle Biogenesis	2.67200363872107	0.655693466450667	0.700546375656356	1/262	53/13181	4952	OCRL	1
REACTOME_936837	Ion transport by P-type ATPases	2.58856998082515	0.655693466450667	0.700546375656356	1/262	53/13181	286410	ATP11C	1
REACTOME_72163	mRNA Splicing - Major Pathway	2.46578925657987	0.662564910066597	0.706076635503806	1/262	54/13181	23283	CSTF2T	1
REACTOME_9013149	RAC1 GTPase cycle	5.18538463728826	0.664526511360616	0.707865196884134	3/262	171/13181	50855/124056/27035	PARD6A/NOXO1/NOX1	3
REACTOME_204005	COPII-mediated vesicle transport	2.19193160704346	0.669299730936754	0.711736181962105	1/262	55/13181	1294	COL7A1	1
REACTOME_9013406	RHOQ GTPase cycle	2.2010182954909	0.68237027593829	0.722560728631266	1/262	57/13181	9578	CDC42BPB	1
REACTOME_6805567	Keratinization	4.0102839157258	0.688351207763307	0.727425791272511	2/262	119/13181	8687/337879	KRT38/KRTAP8-1	2
REACTOME_4420097	VEGFA-VEGFR2 Pathway	2.34560892349801	0.688711253361649	0.727425791272511	1/262	58/13181	3685	ITGAV	1
REACTOME_4086398	Ca2+ pathway	2.27774295253019	0.701017364791302	0.737307405140347	1/262	60/13181	2793	GNGT2	1
REACTOME_909733	Interferon alpha/beta signaling	2.40032785140264	0.701017364791302	0.737307405140347	1/262	60/13181	3456	IFNB1	1
REACTOME_6802952	Signaling by BRAF and RAF1 fusions	2.23646517037185	0.718573671780697	0.749776870889337	1/262	63/13181	9444	QKI	1
REACTOME_1650814	Collagen biosynthesis and modifying enzymes	2.19193160704346	0.724194475103875	0.75406749720191	1/262	64/13181	1294	COL7A1	1
REACTOME_68877	Mitotic Prometaphase	2.2836888115787	0.724194475103875	0.75406749720191	1/262	64/13181	220134	SKA1	1
REACTOME_1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	3.37176701516344	0.740394658351836	0.7671004358297	1/262	67/13181	5571	PRKAG1	1
REACTOME_9018519	Estrogen-dependent gene expression	2.40031355988813	0.745581222292038	0.771197453775179	1/262	68/13181	10735	STAG2	1
REACTOME_9648025	EML4 and NUDC in mitotic spindle formation	2.2836888115787	0.745581222292038	0.771197453775179	1/262	68/13181	220134	SKA1	1
REACTOME_6807878	COPI-mediated anterograde transport	2.57168879268085	0.765315417753688	0.788669372769677	1/262	72/13181	3630	INS	1
REACTOME_8876198	RAB GEFs exchange GTP for GDP on RABs	2.27325790621943	0.800325355733728	0.82068652604784	1/262	80/13181	84079	ANKRD27	1
REACTOME_5663220	RHO GTPases Activate Formins	2.2836888115787	0.830129490812363	0.847423855204287	1/262	88/13181	220134	SKA1	1
REACTOME_2132295	MHC class II antigen presentation	2.80921158992343	0.872016191343397	0.881540640035254	1/262	102/13181	1514	CTSL	1
REACTOME_6785807	Interleukin-4 and Interleukin-13 signaling	2.53187885822657	0.874579977402578	0.883417689381181	1/262	103/13181	7157	TP53	1
REACTOME_375276	Peptide ligand-binding receptors	2.88471078267737	0.877092597521902	0.885597737861509	1/262	104/13181	2147	F2	1
REACTOME_6809371	Formation of the cornified envelope	2.33664142941092	0.88196838896433	0.889442697345384	1/262	106/13181	8687	KRT38	1
REACTOME_9660821	ADORA2B mediated anti-inflammatory cytokines production	2.27774295253019	0.927417865289936	0.929649917913979	1/262	130/13181	2793	GNGT2	1
REACTOME_8980692	RHOA GTPase cycle	2.26034642361033	0.934417660241768	0.936290991557409	1/262	135/13181	23197	FAF2	1
REACTOME_418555	G alpha (s) signalling events	2.27774295253019	0.939529944988709	0.940282471977086	1/262	139/13181	2793	GNGT2	1
