ID	Description	NES	pvalue	p.adjust	GeneRatio	BgRatio	geneID	geneName	Count
REACTOME_8866376	Reelin signalling pathway	-1.3667071282937	0.00052770433439167	0.364752304596415	3/505	5/13181	7436/5649/2534	VLDLR/RELN/FYN	3
REACTOME_8875791	MET activates STAT3	-0.620520176946698	0.00428337370963086	0.364752304596415	2/505	3/13181	4233/3082	MET/HGF	2
REACTOME_9700645	ALK mutants bind TKIs	-1.87464033077219	0.00548428542270697	0.364752304596415	3/505	10/13181	238/5573/53335	ALK/PRKAR1A/BCL11A	3
REACTOME_9032500	Activated NTRK2 signals through FYN	0.235088398106771	0.00834946978698906	0.364752304596415	2/505	4/13181	2904/2534	GRIN2B/FYN	2
REACTOME_1679131	Trafficking and processing of endosomal TLR	1.76011666258247	0.00949634574862101	0.364752304596415	3/505	12/13181	54106/1514/10695	TLR9/CTSL/CNPY3	3
REACTOME_6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	1.81597062860616	0.00949634574862101	0.364752304596415	3/505	12/13181	843/58484/317	CASP10/NLRC4/APAF1	3
REACTOME_399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	-1.34579388803643	0.0119987422256502	0.364752304596415	3/505	13/13181	91584/2534/5362	PLXNA4/FYN/PLXNA2	3
REACTOME_8865999	MET activates PTPN11	-0.620520176946698	0.0135639800887207	0.364752304596415	2/505	5/13181	4233/3082	MET/HGF	2
REACTOME_8875513	MET interacts with TNS proteins	-0.620520176946698	0.0135639800887207	0.364752304596415	2/505	5/13181	4233/3082	MET/HGF	2
REACTOME_399954	Sema3A PAK dependent Axon repulsion	-1.34579388803643	0.018035587678202	0.364752304596415	3/505	15/13181	91584/2534/5362	PLXNA4/FYN/PLXNA2	3
REACTOME_399956	CRMPs in Sema3A signaling	-1.34579388803643	0.018035587678202	0.364752304596415	3/505	15/13181	91584/2534/5362	PLXNA4/FYN/PLXNA2	3
REACTOME_2393930	Phosphate bond hydrolysis by NUDT proteins	-4.07929097306464	0.0198332849852982	0.364752304596415	2/505	6/13181	11164/53343	NUDT5/NUDT9	2
REACTOME_6806942	MET Receptor Activation	-0.620520176946698	0.0198332849852982	0.364752304596415	2/505	6/13181	4233/3082	MET/HGF	2
REACTOME_8851907	MET activates PI3K/AKT signaling	-0.620520176946698	0.0198332849852982	0.364752304596415	2/505	6/13181	4233/3082	MET/HGF	2
REACTOME_5673001	RAF/MAP kinase cascade	-4.40745470118379	0.0228943330439941	0.364752304596415	10/505	126/13181	1740/2904/4233/1739/3082/3718/5156/2534/284/4254	DLG2/GRIN2B/MET/DLG1/HGF/JAK3/PDGFRA/FYN/ANGPT1/KITLG	10
REACTOME_201556	Signaling by ALK	1.54174352594264	0.0254730810906077	0.364752304596415	3/505	17/13181	4613/238/3718	MYCN/ALK/JAK3	3
REACTOME_6807004	Negative regulation of MET activity	-2.21713623608703	0.0254730810906077	0.364752304596415	3/505	17/13181	4233/3082/6456	MET/HGF/SH3GL2	3
REACTOME_426117	Cation-coupled Chloride cotransporters	-1.20789496699167	0.0270692286649427	0.364752304596415	2/505	7/13181	9990/6558	SLC12A6/SLC12A2	2
REACTOME_6814848	Glycerophospholipid catabolism	-0.405030004882635	0.0270692286649427	0.364752304596415	2/505	7/13181	51573/10908	GDE1/PNPLA6	2
REACTOME_877300	Interferon gamma signaling	-3.73481009237878	0.0314612057739461	0.364752304596415	7/505	79/13181	4261/81603/3660/10437/7726/3460/3134	CIITA/TRIM8/IRF2/IFI30/TRIM26/IFNGR2/HLA-F	7
REACTOME_442982	Ras activation upon Ca2+ influx through NMDA receptor	1.66791410272118	0.0343127708559862	0.364752304596415	3/505	19/13181	1740/2904/1739	DLG2/GRIN2B/DLG1	3
REACTOME_8939242	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	-1.61418937355448	0.0351888392179693	0.364752304596415	2/505	8/13181	1514/861	CTSL/RUNX1	2
REACTOME_1614603	Cysteine formation from homocysteine	-2.21124970207357	0.0383127228586601	0.364752304596415	1/505	1/13181	1491	CTH	1
REACTOME_5609978	Defective GALT can cause Galactosemia	-3.44442678954477	0.0383127228586601	0.364752304596415	1/505	1/13181	2592	GALT	1
REACTOME_5619039	Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	2.26455867164535	0.0383127228586601	0.364752304596415	1/505	1/13181	9990	SLC12A6	1
REACTOME_5619062	Defective SLC1A3 causes episodic ataxia 6 (EA6)	-2.81441169460555	0.0383127228586601	0.364752304596415	1/505	1/13181	6507	SLC1A3	1
REACTOME_5619078	Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)	-3.36744259950743	0.0383127228586601	0.364752304596415	1/505	1/13181	55343	SLC35C1	1
REACTOME_9661070	Defective translocation of RB1 mutants to the nucleus	-2.50500516405816	0.0383127228586601	0.364752304596415	1/505	1/13181	5925	RB1	1
REACTOME_9673163	Oleoyl-phe metabolism	-2.31405418288711	0.0383127228586601	0.364752304596415	1/505	1/13181	148811	PM20D1	1
REACTOME_9674396	Imatinib-resistant PDGFR mutants	-2.52168904425201	0.0383127228586601	0.364752304596415	1/505	1/13181	5156	PDGFRA	1
REACTOME_9674401	Sunitinib-resistant PDGFR mutants	-2.52168904425201	0.0383127228586601	0.364752304596415	1/505	1/13181	5156	PDGFRA	1
REACTOME_9674403	Regorafenib-resistant PDGFR mutants	-2.52168904425201	0.0383127228586601	0.364752304596415	1/505	1/13181	5156	PDGFRA	1
REACTOME_9674404	Sorafenib-resistant PDGFR mutants	-2.52168904425201	0.0383127228586601	0.364752304596415	1/505	1/13181	5156	PDGFRA	1
REACTOME_9674428	PDGFR mutants bind TKIs	-2.52168904425201	0.0383127228586601	0.364752304596415	1/505	1/13181	5156	PDGFRA	1
REACTOME_9717264	ASP-3026- resistant ALK mutants	2.48534201954397	0.0383127228586601	0.364752304596415	1/505	1/13181	238	ALK	1
REACTOME_9717301	NVP-TAE684-resistant ALK mutants	2.48534201954397	0.0383127228586601	0.364752304596415	1/505	1/13181	238	ALK	1
REACTOME_9717316	alectinib resistant ALK mutants	2.48534201954397	0.0383127228586601	0.364752304596415	1/505	1/13181	238	ALK	1
REACTOME_9717319	brigatinib-resistant ALK mutants	2.48534201954397	0.0383127228586601	0.364752304596415	1/505	1/13181	238	ALK	1
REACTOME_9717323	ceritinib-resistant ALK mutants	2.48534201954397	0.0383127228586601	0.364752304596415	1/505	1/13181	238	ALK	1
REACTOME_9717326	crizotinib-resistant ALK mutants	2.48534201954397	0.0383127228586601	0.364752304596415	1/505	1/13181	238	ALK	1
REACTOME_9717329	lorlatinib-resistant ALK mutants	2.48534201954397	0.0383127228586601	0.364752304596415	1/505	1/13181	238	ALK	1
REACTOME_438066	Unblocking of NMDA receptors, glutamate binding and activation	1.66791410272118	0.0392515373829173	0.364752304596415	3/505	20/13181	1740/2904/1739	DLG2/GRIN2B/DLG1	3
REACTOME_9617324	Negative regulation of NMDA receptor-mediated neuronal transmission	1.66791410272118	0.0392515373829173	0.364752304596415	3/505	20/13181	1740/2904/1739	DLG2/GRIN2B/DLG1	3
REACTOME_8854518	AURKA Activation by TPX2	-4.44293652602079	0.0416904681858959	0.364752304596415	5/505	50/13181	55722/80321/95681/10142/3161	CEP72/CEP70/CEP41/AKAP9/HMMR	5
REACTOME_1433557	Signaling by SCF-KIT	0.498260573901252	0.0436505389500124	0.364752304596415	4/505	35/13181	1215/2887/2534/4254	CMA1/GRB10/FYN/KITLG	4
REACTOME_159763	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	3.91500906904765	0.0441140620835143	0.364752304596415	2/505	9/13181	2155/2147	F7/F2	2
REACTOME_1614558	Degradation of cysteine and homocysteine	-3.65363917887439	0.0441140620835143	0.364752304596415	2/505	9/13181	7263/1491	TST/CTH	2
REACTOME_9620244	Long-term potentiation	1.66791410272118	0.0445297453428345	0.364752304596415	3/505	21/13181	1740/2904/1739	DLG2/GRIN2B/DLG1	3
REACTOME_9725370	Signaling by ALK fusions and activated point mutants	-3.05664005347527	0.051902826819587	0.364752304596415	4/505	37/13181	238/5573/53335/10342	ALK/PRKAR1A/BCL11A/TFG	4
REACTOME_159740	Gamma-carboxylation of protein precursors	3.91500906904765	0.0537715062487162	0.364752304596415	2/505	10/13181	2155/2147	F7/F2	2
REACTOME_159782	Removal of aminoterminal propeptides from gamma-carboxylated proteins	3.91500906904765	0.0537715062487162	0.364752304596415	2/505	10/13181	2155/2147	F7/F2	2
REACTOME_8875656	MET receptor recycling	-0.620520176946698	0.0537715062487162	0.364752304596415	2/505	10/13181	4233/3082	MET/HGF	2
REACTOME_8877330	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	-5.55698517476407	0.0537715062487162	0.364752304596415	2/505	10/13181	861/1493	RUNX1/CTLA4	2
REACTOME_420499	Class C/3 (Metabotropic glutamate/pheromone receptors)	2.83275475599402	0.0563258593672668	0.364752304596415	4/505	38/13181	50834/2911/50839/50836	TAS2R1/GRM1/TAS2R10/TAS2R8	4
REACTOME_1236977	Endosomal/Vacuolar pathway	-0.38729827655828	0.064092202617403	0.364752304596415	2/505	11/13181	1514/3134	CTSL/HLA-F	2
REACTOME_8851805	MET activates RAS signaling	-0.620520176946698	0.064092202617403	0.364752304596415	2/505	11/13181	4233/3082	MET/HGF	2
REACTOME_8875360	InlB-mediated entry of Listeria monocytogenes into host cell	-0.105938797917496	0.064092202617403	0.364752304596415	2/505	11/13181	4233/6456	MET/SH3GL2	2
REACTOME_8875555	MET activates RAP1 and RAC1	-0.620520176946698	0.064092202617403	0.364752304596415	2/505	11/13181	4233/3082	MET/HGF	2
REACTOME_2219530	Constitutive Signaling by Aberrant PI3K in Cancer	-2.98181653174405	0.0673082762211939	0.364752304596415	6/505	75/13181	29851/4233/3082/5156/2534/4254	ICOS/MET/HGF/PDGFRA/FYN/KITLG	6
REACTOME_9679191	Potential therapeutics for SARS	0.10795740596821	0.0673082762211939	0.364752304596415	6/505	75/13181	5931/79685/54106/3718/3460/6093	RBBP7/SAP30L/TLR9/JAK3/IFNGR2/ROCK1	6
REACTOME_2559580	Oxidative Stress Induced Senescence	3.97234420819356	0.0706401402679157	0.364752304596415	5/505	58/13181	5931/1870/3456/50488/1912	RBBP7/E2F2/IFNB1/MINK1/PHC2	5
REACTOME_5607763	CLEC7A (Dectin-1) induces NFAT activation	-0.766739199818331	0.0750113739911594	0.364752304596415	2/505	12/13181	4775/3710	NFATC3/ITPR3	2
REACTOME_73621	Pyrimidine catabolism	-0.37305870525536	0.0750113739911594	0.364752304596415	2/505	12/13181	51733/64902	UPB1/AGXT2	2
REACTOME_9648895	Response of EIF2AK1 (HRI) to heme deficiency	0.814334891636337	0.0750113739911594	0.364752304596415	2/505	12/13181	2887/467	GRB10/ATF3	2
REACTOME_9673324	WNT5:FZD7-mediated leishmania damping	3.78321024629039	0.0750113739911594	0.364752304596415	2/505	12/13181	124056/27035	NOXO1/NOX1	2
REACTOME_114294	Activation, translocation and oligomerization of BAX	3.1871772463653	0.0751603764972324	0.364752304596415	1/505	2/13181	581	BAX	1
REACTOME_198765	Signalling to ERK5	-2.4618256931755	0.0751603764972324	0.364752304596415	1/505	2/13181	5607	MAP2K5	1
REACTOME_73943	Reversal of alkylation damage by DNA dioxygenases	-2.66270755541432	0.0751603764972324	0.364752304596415	1/505	2/13181	54890	ALKBH5	1
REACTOME_844623	The IPAF inflammasome	2.67438627155001	0.0751603764972324	0.364752304596415	1/505	2/13181	58484	NLRC4	1
REACTOME_9026357	NTF4 activates NTRK2 (TRKB) signaling	-3.71732740128704	0.0751603764972324	0.364752304596415	1/505	2/13181	4909	NTF4	1
REACTOME_9033807	ABO blood group biosynthesis	2.68022562961786	0.0751603764972324	0.364752304596415	1/505	2/13181	2524	FUT2	1
REACTOME_916853	Degradation of GABA	-4.31635814729483	0.0751603764972324	0.364752304596415	1/505	2/13181	7915	ALDH5A1	1
REACTOME_9603505	NTRK3 as a dependence receptor	3.1871772463653	0.0751603764972324	0.364752304596415	1/505	2/13181	581	BAX	1
REACTOME_422356	Regulation of insulin secretion	1.33581082353174	0.0903312281279589	0.384353699149491	3/505	28/13181	776/777/3710	CACNA1D/CACNA1E/ITPR3	3
REACTOME_381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	-0.691038845886488	0.0931248395741099	0.384353699149491	8/505	121/13181	9210/7857/3479/2147/1435/3915/5611/56955	BMP15/SCG2/IGF1/F2/CSF1/LAMC1/DNAJC3/MEPE	8
REACTOME_211935	Fatty acids	4.12676624567501	0.0984056893862529	0.384353699149491	2/505	14/13181	1580/1555	CYP4B1/CYP2B6	2
REACTOME_168638	NOD1/2 Signaling Pathway	-6.13648736062931	0.105970467076693	0.384353699149491	3/505	30/13181	7128/5603/64127	TNFAIP3/MAPK13/NOD2	3
REACTOME_8874081	MET activates PTK2 signaling	-2.88385135939272	0.105970467076693	0.384353699149491	3/505	30/13181	4233/3082/3915	MET/HGF/LAMC1	3
REACTOME_1296053	Classical Kir channels	2.3884960673711	0.110598877891032	0.384353699149491	1/505	3/13181	3770	KCNJ14	1
REACTOME_2644607	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	2.72265035353937	0.110598877891032	0.384353699149491	1/505	3/13181	55294	FBXW7	1
REACTOME_417973	Adenosine P1 receptors	-2.26535314213077	0.110598877891032	0.384353699149491	1/505	3/13181	134	ADORA1	1
REACTOME_70688	Proline catabolism	2.99372368316517	0.110598877891032	0.384353699149491	1/505	3/13181	5625	PRODH	1
REACTOME_844455	The NLRP1 inflammasome	-2.54107412409629	0.110598877891032	0.384353699149491	1/505	3/13181	596	BCL2	1
REACTOME_8981607	Intracellular oxygen transport	2.35151346627473	0.110598877891032	0.384353699149491	1/505	3/13181	4151	MB	1
REACTOME_9026527	Activated NTRK2 signals through PLCG1	-3.71732740128704	0.110598877891032	0.384353699149491	1/505	3/13181	4909	NTF4	1
REACTOME_964975	Vitamins B6 activation to pyridoxal phosphate	-2.54758878207675	0.110598877891032	0.384353699149491	1/505	3/13181	55163	PNPO	1
REACTOME_9657688	Defective factor XII causes hereditary angioedema	2.79121315643124	0.110598877891032	0.384353699149491	1/505	3/13181	2147	F2	1
REACTOME_9672391	Defective F8 cleavage by thrombin	2.79121315643124	0.110598877891032	0.384353699149491	1/505	3/13181	2147	F2	1
REACTOME_9678110	Attachment and Entry	2.78346706919838	0.110598877891032	0.384353699149491	1/505	3/13181	1514	CTSL	1
REACTOME_1433559	Regulation of KIT signaling	-3.81810171170283	0.110770320418261	0.384353699149491	2/505	15/13181	2534/4254	FYN/KITLG	2
REACTOME_264642	Acetylcholine Neurotransmitter Release Cycle	0.620008395314246	0.110770320418261	0.384353699149491	2/505	15/13181	8541/6572	PPFIA3/SLC18A3	2
REACTOME_9013423	RAC3 GTPase cycle	-0.69391489873906	0.11180071286211	0.386725556910334	6/505	86/13181	4952/124056/27035/7112/8936/27	OCRL/NOXO1/NOX1/TMPO/WASF1/ABL2	6
REACTOME_380259	Loss of Nlp from mitotic centrosomes	-2.99193622145073	0.117330157991869	0.404735223898556	4/505	49/13181	55722/80321/95681/10142	CEP72/CEP70/CEP41/AKAP9	4
REACTOME_380284	Loss of proteins required for interphase microtubule organization from the centrosome	-2.99193622145073	0.117330157991869	0.404735223898556	4/505	49/13181	55722/80321/95681/10142	CEP72/CEP70/CEP41/AKAP9	4
REACTOME_159418	Recycling of bile acids and salts	4.37076566514682	0.123512013531337	0.404765158006461	2/505	16/13181	6579/80765	SLCO1A2/STARD5	2
REACTOME_6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.365291666362858	0.123512013531337	0.404765158006461	2/505	16/13181	581/94241	BAX/TP53INP1	2
REACTOME_9022699	MECP2 regulates neuronal receptors and channels	3.81545248913485	0.123512013531337	0.404765158006461	2/505	16/13181	2904/4233	GRIN2B/MET	2
REACTOME_1257604	PIP3 activates AKT signaling	-2.98181653174405	0.13596912213082	0.404765158006461	6/505	91/13181	29851/4233/3082/5156/2534/4254	ICOS/MET/HGF/PDGFRA/FYN/KITLG	6
REACTOME_156588	Glucuronidation	-0.325944690267897	0.136583871190101	0.404765158006461	2/505	17/13181	7366/79799	UGT2B15/UGT2A3	2
REACTOME_197264	Nicotinamide salvaging	3.85479946522981	0.136583871190101	0.404765158006461	2/505	17/13181	9390/83594	SLC22A13/NUDT12	2
REACTOME_5620922	BBSome-mediated cargo-targeting to cilium	4.16334357999435	0.136583871190101	0.404765158006461	2/505	17/13181	123016/84100	TTC8/ARL6	2
REACTOME_8963889	Assembly of active LPL and LIPC lipase complexes	-4.0859140294846	0.136583871190101	0.404765158006461	2/505	17/13181	91289/338328	LMF2/GPIHBP1	2
REACTOME_9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	-0.115783068141714	0.136583871190101	0.404765158006461	2/505	17/13181	1870/5925	E2F2/RB1	2
REACTOME_380270	Recruitment of mitotic centrosome proteins and complexes	-2.99193622145073	0.137515756976138	0.404765158006461	4/505	52/13181	55722/80321/95681/10142	CEP72/CEP70/CEP41/AKAP9	4
REACTOME_6794361	Neurexins and neuroligins	2.65999826230931	0.144536336431084	0.404765158006461	4/505	53/13181	1740/2911/2904/9066	DLG2/GRM1/GRIN2B/SYT7	4
REACTOME_204626	Hypusine synthesis from eIF5A-lysine	-3.20266942083102	0.144682013925714	0.404765158006461	1/505	4/13181	56648	EIF5A2	1
REACTOME_210455	Astrocytic Glutamate-Glutamine Uptake And Metabolism	-2.81441169460555	0.144682013925714	0.404765158006461	1/505	4/13181	6507	SLC1A3	1
REACTOME_210746	Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	-3.41594502264241	0.144682013925714	0.404765158006461	1/505	4/13181	3642	INSM1	1
REACTOME_2142753	Arachidonic acid metabolism	-2.62214983713355	0.144682013925714	0.404765158006461	1/505	4/13181	158584	FAAH2	1
REACTOME_2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	2.38607293239056	0.144682013925714	0.404765158006461	1/505	4/13181	3479	IGF1	1
REACTOME_3000497	Scavenging by Class H Receptors	2.23762612218956	0.144682013925714	0.404765158006461	1/505	4/13181	6678	SPARC	1
REACTOME_5221030	TET1,2,3 and TDG demethylate DNA	2.68602526416144	0.144682013925714	0.404765158006461	1/505	4/13181	200424	TET3	1
REACTOME_6787639	GDP-fucose biosynthesis	-3.36744259950743	0.144682013925714	0.404765158006461	1/505	4/13181	55343	SLC35C1	1
REACTOME_69200	Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	-2.50500516405816	0.144682013925714	0.404765158006461	1/505	4/13181	5925	RB1	1
REACTOME_71262	Carnitine synthesis	-3.01779613887344	0.144682013925714	0.404765158006461	1/505	4/13181	55217	TMLHE	1
REACTOME_77108	Utilization of Ketone Bodies	2.29145149757687	0.144682013925714	0.404765158006461	1/505	4/13181	622	BDH1	1
REACTOME_77595	Processing of Intronless Pre-mRNAs	2.4446651306904	0.144682013925714	0.404765158006461	1/505	4/13181	23283	CSTF2T	1
REACTOME_8866906	TFAP2 (AP-2) family regulates transcription of other transcription factors	-3.44482402478748	0.144682013925714	0.404765158006461	1/505	4/13181	10370	CITED2	1
REACTOME_888593	Reuptake of GABA	2.28867085087789	0.144682013925714	0.404765158006461	1/505	4/13181	6539	SLC6A12	1
REACTOME_8941333	RUNX2 regulates genes involved in differentiation of myeloid cells	-4.91340271708906	0.144682013925714	0.404765158006461	1/505	4/13181	861	RUNX1	1
REACTOME_8985801	Regulation of cortical dendrite branching	-2.33840470326527	0.144682013925714	0.404765158006461	1/505	4/13181	6092	ROBO2	1
REACTOME_9032759	NTRK2 activates RAC1	-2.24223405100501	0.144682013925714	0.404765158006461	1/505	4/13181	2534	FYN	1
REACTOME_9640463	Wax biosynthesis	-2.43771351394296	0.144682013925714	0.404765158006461	1/505	4/13181	84188	FAR1	1
REACTOME_9682706	Replication of the SARS-CoV-1 genome	-2.50500516405816	0.144682013925714	0.404765158006461	1/505	4/13181	5925	RB1	1
REACTOME_9694614	Attachment and Entry	2.78346706919838	0.144682013925714	0.404765158006461	1/505	4/13181	1514	CTSL	1
REACTOME_9694686	Replication of the SARS-CoV-2 genome	-2.50500516405816	0.144682013925714	0.404765158006461	1/505	4/13181	5925	RB1	1
REACTOME_390522	Striated Muscle Contraction	1.59567767186927	0.149101901058144	0.411820312310249	3/505	35/13181	7111/7140/4626	TMOD1/TNNT3/MYH8	3
REACTOME_162588	Budding and maturation of HIV virion	0.156785808341665	0.149942023285301	0.411820312310249	2/505	18/13181	23327/51534	NEDD4L/VTA1	2
REACTOME_166016	Toll Like Receptor 4 (TLR4) Cascade	-0.584033157033084	0.149942023285301	0.411820312310249	2/505	18/13181	653509/7099	SFTPA1/TLR4	2
REACTOME_416700	Other semaphorin interactions	0.116535688189437	0.149942023285301	0.411820312310249	2/505	18/13181	91584/5362	PLXNA4/PLXNA2	2
REACTOME_9609736	Assembly and cell surface presentation of NMDA receptors	1.66791410272118	0.158322313921339	0.426633838981751	3/505	36/13181	1740/2904/1739	DLG2/GRIN2B/DLG1	3
REACTOME_2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.0740578126959475	0.163545464747573	0.426633838981751	2/505	19/13181	23327/6497	NEDD4L/SKI	2
REACTOME_3928664	Ephrin signaling	-3.95492803637888	0.163545464747573	0.426633838981751	2/505	19/13181	2534/6386	FYN/SDCBP	2
REACTOME_9664323	FCGR3A-mediated IL10 synthesis	-5.34488154060978	0.177259675176898	0.426633838981751	3/505	38/13181	3710/5573/2534	ITPR3/PRKAR1A/FYN	3
REACTOME_2022870	Chondroitin sulfate biosynthesis	-5.12266319762405	0.177355901121424	0.426633838981751	2/505	20/13181	55790/51363	CSGALNACT1/CHST15	2
REACTOME_5686938	Regulation of TLR by endogenous ligand	-0.584033157033084	0.177355901121424	0.426633838981751	2/505	20/13181	653509/7099	SFTPA1/TLR4	2
REACTOME_111457	Release of apoptotic factors from the mitochondria	3.1871772463653	0.177461522384962	0.426633838981751	1/505	5/13181	581	BAX	1
REACTOME_112303	Electric Transmission Across Gap Junctions	2.71557956621912	0.177461522384962	0.426633838981751	1/505	5/13181	56666	PANX2	1
REACTOME_140834	Extrinsic Pathway of Fibrin Clot Formation	2.37467228092476	0.177461522384962	0.426633838981751	1/505	5/13181	2155	F7	1
REACTOME_1614517	Sulfide oxidation to sulfate	-2.60975609756098	0.177461522384962	0.426633838981751	1/505	5/13181	7263	TST	1
REACTOME_166166	MyD88-independent TLR4 cascade 	-3.02780646698975	0.177461522384962	0.426633838981751	1/505	5/13181	7099	TLR4	1
REACTOME_167826	The fatty acid cycling model	2.26074521331533	0.177461522384962	0.426633838981751	1/505	5/13181	9016	SLC25A14	1
REACTOME_167827	The proton buffering model	2.26074521331533	0.177461522384962	0.426633838981751	1/505	5/13181	9016	SLC25A14	1
REACTOME_168138	Toll Like Receptor 9 (TLR9) Cascade	2.58612060061969	0.177461522384962	0.426633838981751	1/505	5/13181	54106	TLR9	1
REACTOME_5676934	Protein repair	-2.38293477397315	0.177461522384962	0.426633838981751	1/505	5/13181	22921	MSRB2	1
REACTOME_70370	Galactose catabolism	-3.44442678954477	0.177461522384962	0.426633838981751	1/505	5/13181	2592	GALT	1
REACTOME_74713	IRS activation	3.34233733216811	0.177461522384962	0.426633838981751	1/505	5/13181	2887	GRB10	1
REACTOME_75157	FasL/ CD95L signaling	2.46138873440852	0.177461522384962	0.426633838981751	1/505	5/13181	843	CASP10	1
REACTOME_77310	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	-2.93497259076825	0.177461522384962	0.426633838981751	1/505	5/13181	3033	HADH	1
REACTOME_77348	Beta oxidation of octanoyl-CoA to hexanoyl-CoA	-2.93497259076825	0.177461522384962	0.426633838981751	1/505	5/13181	3033	HADH	1
REACTOME_77350	Beta oxidation of hexanoyl-CoA to butanoyl-CoA	-2.93497259076825	0.177461522384962	0.426633838981751	1/505	5/13181	3033	HADH	1
REACTOME_77352	Beta oxidation of butanoyl-CoA to acetyl-CoA	-2.93497259076825	0.177461522384962	0.426633838981751	1/505	5/13181	3033	HADH	1
REACTOME_8935964	RUNX1 regulates expression of components of tight junctions	-4.91340271708906	0.177461522384962	0.426633838981751	1/505	5/13181	861	RUNX1	1
REACTOME_8939247	RUNX1 regulates transcription of genes involved in interleukin signaling	-4.91340271708906	0.177461522384962	0.426633838981751	1/505	5/13181	861	RUNX1	1
REACTOME_9031525	NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 	-2.34507825534281	0.177461522384962	0.426633838981751	1/505	5/13181	6257	RXRB	1
REACTOME_9031528	NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	-2.34507825534281	0.177461522384962	0.426633838981751	1/505	5/13181	6257	RXRB	1
REACTOME_9632974	NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis 	-2.34507825534281	0.177461522384962	0.426633838981751	1/505	5/13181	6257	RXRB	1
REACTOME_9667769	Acetylcholine inhibits contraction of outer hair cells	-3.10407563359021	0.177461522384962	0.426633838981751	1/505	5/13181	3778	KCNMA1	1
REACTOME_4420097	VEGFA-VEGFR2 Pathway	-5.88581282723097	0.181587748032801	0.434885307390656	4/505	58/13181	5603/2534/8936/6093	MAPK13/FYN/WASF1/ROCK1	4
REACTOME_1474228	Degradation of the extracellular matrix	-1.66353716608304	0.185447604035344	0.443846588906997	5/505	79/13181	1514/6650/23385/3915/84467	CTSL/CAPN15/NCSTN/LAMC1/FBN3	5
REACTOME_3928662	EPHB-mediated forward signaling	-1.47521536017932	0.186952568514604	0.446595716400832	3/505	39/13181	2904/2534/6093	GRIN2B/FYN/ROCK1	3
REACTOME_2565942	Regulation of PLK1 Activity at G2/M Transition	-2.99193622145073	0.189348615934172	0.451172874469256	4/505	59/13181	55722/80321/95681/10142	CEP72/CEP70/CEP41/AKAP9	4
REACTOME_114508	Effects of PIP2 hydrolysis	-4.59254774080985	0.191337601729696	0.451335873590752	2/505	21/13181	3710/1606	ITPR3/DGKA	2
REACTOME_389513	CTLA4 inhibitory signaling	-3.53261787520053	0.191337601729696	0.451335873590752	2/505	21/13181	1493/2534	CTLA4/FYN	2
REACTOME_5362517	Signaling by Retinoic Acid	-4.26530854405987	0.191337601729696	0.451335873590752	2/505	21/13181	6257/1375	RXRB/CPT1B	2
REACTOME_5365859	RA biosynthesis pathway	-3.92557585451768	0.191337601729696	0.451335873590752	2/505	21/13181	157506/127	RDH10/ADH4	2
REACTOME_8849932	Synaptic adhesion-like molecules	0.14742321494799	0.191337601729696	0.451335873590752	2/505	21/13181	2904/1739	GRIN2B/DLG1	2
REACTOME_8876198	RAB GEFs exchange GTP for GDP on RABs	-4.32894016949852	0.192077555641127	0.451604459018394	5/505	80/13181	84079/25782/5869/79961/9610	ANKRD27/RAB3GAP2/RAB5B/DENND2D/RIN1	5
REACTOME_6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	-2.98181653174405	0.202629737286695	0.451604459018394	6/505	103/13181	29851/4233/3082/5156/2534/4254	ICOS/MET/HGF/PDGFRA/FYN/KITLG	6
REACTOME_1266695	Interleukin-7 signaling	-4.35411770969119	0.205457260075354	0.451604459018394	2/505	22/13181	3082/3718	HGF/JAK3	2
REACTOME_210500	Glutamate Neurotransmitter Release Cycle	0.204321290555853	0.205457260075354	0.451604459018394	2/505	22/13181	8541/6507	PPFIA3/SLC1A3	2
REACTOME_72187	mRNA 3'-end processing	-0.63189979206827	0.205457260075354	0.451604459018394	2/505	22/13181	23283/10212	CSTF2T/DDX39A	2
REACTOME_381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	-2.38016735872905	0.20672775288189	0.451604459018394	3/505	41/13181	2793/3710/5573	GNGT2/ITPR3/PRKAR1A	3
REACTOME_8957275	Post-translational protein phosphorylation	-3.30369061616895	0.208659730129576	0.451604459018394	6/505	104/13181	9210/7857/1435/3915/5611/56955	BMP15/SCG2/CSF1/LAMC1/DNAJC3/MEPE	6
REACTOME_111458	Formation of apoptosome	-2.31766902359577	0.208987169864895	0.451604459018394	1/505	6/13181	317	APAF1	1
REACTOME_111459	Activation of caspases through apoptosome-mediated cleavage	-2.31766902359577	0.208987169864895	0.451604459018394	1/505	6/13181	317	APAF1	1
REACTOME_168179	Toll Like Receptor TLR1:TLR2 Cascade	2.25717009613093	0.208987169864895	0.451604459018394	1/505	6/13181	653509	SFTPA1	1
REACTOME_2428928	IRS-related events triggered by IGF1R	2.38607293239056	0.208987169864895	0.451604459018394	1/505	6/13181	3479	IGF1	1
REACTOME_428890	Role of ABL in ROBO-SLIT signaling	-3.3343926273139	0.208987169864895	0.451604459018394	1/505	6/13181	27	ABL2	1
REACTOME_5358493	Synthesis of diphthamide-EEF2	3.4840708667673	0.208987169864895	0.451604459018394	1/505	6/13181	51611	DPH5	1
REACTOME_5660668	CLEC7A/inflammasome pathway	-2.57948677206642	0.208987169864895	0.451604459018394	1/505	6/13181	10892	MALT1	1
REACTOME_6798163	Choline catabolism	2.36867402875983	0.208987169864895	0.451604459018394	1/505	6/13181	1757	SARDH	1
REACTOME_77346	Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	-2.93497259076825	0.208987169864895	0.451604459018394	1/505	6/13181	3033	HADH	1
REACTOME_8931987	RUNX1 regulates estrogen receptor mediated transcription	-4.91340271708906	0.208987169864895	0.451604459018394	1/505	6/13181	861	RUNX1	1
REACTOME_8939245	RUNX1 regulates transcription of genes involved in BCR signaling	-4.91340271708906	0.208987169864895	0.451604459018394	1/505	6/13181	861	RUNX1	1
REACTOME_8939256	RUNX1 regulates transcription of genes involved in WNT signaling	-4.91340271708906	0.208987169864895	0.451604459018394	1/505	6/13181	861	RUNX1	1
REACTOME_8949275	RUNX3 Regulates Immune Response and Cell Migration	2.24978152061651	0.208987169864895	0.451604459018394	1/505	6/13181	3683	ITGAL	1
REACTOME_8964046	VLDL clearance	2.58091681894018	0.208987169864895	0.451604459018394	1/505	6/13181	7436	VLDLR	1
REACTOME_8964572	Lipid particle organization	-2.2382616985779	0.208987169864895	0.451604459018394	1/505	6/13181	1149	CIDEA	1
REACTOME_9028335	Activated NTRK2 signals through PI3K	-3.71732740128704	0.208987169864895	0.451604459018394	1/505	6/13181	4909	NTF4	1
REACTOME_9645460	Alpha-protein kinase 1 signaling pathway	2.33772940335267	0.208987169864895	0.451604459018394	1/505	6/13181	92610	TIFA	1
REACTOME_9706374	FLT3 signaling through SRC family kinases	-2.24223405100501	0.208987169864895	0.451604459018394	1/505	6/13181	2534	FYN	1
REACTOME_380320	Recruitment of NuMA to mitotic centrosomes	-2.99193622145073	0.213229664754597	0.459979081742561	4/505	62/13181	55722/80321/95681/10142	CEP72/CEP70/CEP41/AKAP9	4
REACTOME_8854691	Interleukin-20 family signaling	-4.43476847400519	0.219683861143238	0.4703936890083	2/505	23/13181	3718/11009	JAK3/IL24	2
REACTOME_983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	-4.61157397561629	0.219683861143238	0.4703936890083	2/505	23/13181	3134/10484	HLA-F/SEC23A	2
REACTOME_1296072	Voltage gated Potassium channels	-1.47521536017932	0.226945631663844	0.472084820834545	3/505	43/13181	3788/3786/3750	KCNS2/KCNQ3/KCND1	3
REACTOME_449836	Other interleukin signaling	0.176052881563375	0.233988555279622	0.472084820834545	2/505	24/13181	3603/1435	IL16/CSF1	2
REACTOME_5620971	Pyroptosis	0.514220121406295	0.233988555279622	0.472084820834545	2/505	24/13181	581/3660	BAX/IRF2	2
REACTOME_5668599	RHO GTPases Activate NADPH Oxidases	3.78321024629039	0.233988555279622	0.472084820834545	2/505	24/13181	124056/27035	NOXO1/NOX1	2
REACTOME_73856	RNA Polymerase II Transcription Termination	-0.63189979206827	0.233988555279622	0.472084820834545	2/505	24/13181	23283/10212	CSTF2T/DDX39A	2
REACTOME_111453	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	-2.54107412409629	0.239306826731554	0.472084820834545	1/505	7/13181	596	BCL2	1
REACTOME_111463	SMAC (DIABLO) binds to IAPs 	-2.31766902359577	0.239306826731554	0.472084820834545	1/505	7/13181	317	APAF1	1
REACTOME_111464	SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 	-2.31766902359577	0.239306826731554	0.472084820834545	1/505	7/13181	317	APAF1	1
REACTOME_1482883	Acyl chain remodeling of DAG and TAG	-3.1115039326289	0.239306826731554	0.472084820834545	1/505	7/13181	8694	DGAT1	1
REACTOME_1489509	DAG and IP3 signaling	-3.24843092079129	0.239306826731554	0.472084820834545	1/505	7/13181	3710	ITPR3	1
REACTOME_196843	Vitamin B2 (riboflavin) metabolism	-2.60467148645428	0.239306826731554	0.472084820834545	1/505	7/13181	5167	ENPP1	1
REACTOME_199920	CREB phosphorylation	-2.69015651068563	0.239306826731554	0.472084820834545	1/505	7/13181	466	ATF1	1
REACTOME_2408508	Metabolism of ingested SeMet, Sec, MeSec into H2Se	-2.21124970207357	0.239306826731554	0.472084820834545	1/505	7/13181	1491	CTH	1
REACTOME_429958	mRNA decay by 3' to 5' exoribonuclease	-2.78322872805275	0.239306826731554	0.472084820834545	1/505	7/13181	9652	TTC37	1
REACTOME_444473	Formyl peptide receptors bind formyl peptides and many other ligands	2.45932311114642	0.239306826731554	0.472084820834545	1/505	7/13181	2358	FPR2	1
REACTOME_447038	NrCAM interactions	-2.35790895368237	0.239306826731554	0.472084820834545	1/505	7/13181	1739	DLG1	1
REACTOME_447043	Neurofascin interactions	-2.97632477953444	0.239306826731554	0.472084820834545	1/505	7/13181	6386	SDCBP	1
REACTOME_5576890	Phase 3 - rapid repolarisation	-3.09370779375546	0.239306826731554	0.472084820834545	1/505	7/13181	10142	AKAP9	1
REACTOME_5576894	Phase 1 - inactivation of fast Na+ channels	-2.72872805275284	0.239306826731554	0.472084820834545	1/505	7/13181	3750	KCND1	1
REACTOME_5688849	Defective CSF2RB causes SMDP5	2.25717009613093	0.239306826731554	0.472084820834545	1/505	7/13181	653509	SFTPA1	1
REACTOME_5688890	Defective CSF2RA causes SMDP4	2.25717009613093	0.239306826731554	0.472084820834545	1/505	7/13181	653509	SFTPA1	1
REACTOME_70921	Histidine catabolism	-2.84801779613887	0.239306826731554	0.472084820834545	1/505	7/13181	3067	HDC	1
REACTOME_8939246	RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	-4.91340271708906	0.239306826731554	0.472084820834545	1/505	7/13181	861	RUNX1	1
REACTOME_9017802	Noncanonical activation of NOTCH3	-3.10308254548344	0.239306826731554	0.472084820834545	1/505	7/13181	23385	NCSTN	1
REACTOME_9033500	TYSND1 cleaves peroxisomal proteins	-2.921307698419	0.239306826731554	0.472084820834545	1/505	7/13181	3295	HSD17B4	1
REACTOME_9652817	Signaling by MAPK mutants	-2.78469849845078	0.239306826731554	0.472084820834545	1/505	7/13181	11221	DUSP10	1
REACTOME_9710421	Defective pyroptosis	2.93687931993327	0.239306826731554	0.472084820834545	1/505	7/13181	5931	RBBP7	1
REACTOME_975155	MyD88 dependent cascade initiated on endosome	2.58612060061969	0.239306826731554	0.472084820834545	1/505	7/13181	54106	TLR9	1
REACTOME_4570464	SUMOylation of RNA binding proteins	-5.20572234609077	0.248344538341847	0.485582664672567	2/505	25/13181	1912/79023	PHC2/NUP37	2
REACTOME_182971	EGFR downregulation	0.342773274534984	0.262726937824208	0.495792822945942	2/505	26/13181	5774/6456	PTPN3/SH3GL2	2
REACTOME_164944	Nef and signal transduction	-2.24223405100501	0.268466539233494	0.495792822945942	1/505	8/13181	2534	FYN	1
REACTOME_210747	Regulation of gene expression in early pancreatic precursor cells	2.52351632636848	0.268466539233494	0.495792822945942	1/505	8/13181	3651	PDX1	1
REACTOME_2299718	Condensation of Prophase Chromosomes	-2.50500516405816	0.268466539233494	0.495792822945942	1/505	8/13181	5925	RB1	1
REACTOME_2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	-2.50500516405816	0.268466539233494	0.495792822945942	1/505	8/13181	5925	RB1	1
REACTOME_2980766	Nuclear Envelope Breakdown	-3.22618574719949	0.268466539233494	0.495792822945942	1/505	8/13181	7112	TMPO	1
REACTOME_416550	Sema4D mediated inhibition of cell attachment and migration	2.48208469055375	0.268466539233494	0.495792822945942	1/505	8/13181	4233	MET	1
REACTOME_418886	Netrin mediated repulsion signals	-2.22265035353937	0.268466539233494	0.495792822945942	1/505	8/13181	8633	UNC5C	1
REACTOME_425393	Transport of inorganic cations/anions and amino acids/oligopeptides	-2.81441169460555	0.268466539233494	0.495792822945942	1/505	8/13181	6507	SLC1A3	1
REACTOME_444821	Relaxin receptors	-2.21796297767538	0.268466539233494	0.495792822945942	1/505	8/13181	6019	RLN2	1
REACTOME_6787450	tRNA modification in the mitochondrion	-2.56447127989195	0.268466539233494	0.495792822945942	1/505	8/13181	84705	GTPBP3	1
REACTOME_68689	CDC6 association with the ORC:origin complex	2.35222848971161	0.268466539233494	0.495792822945942	1/505	8/13181	1870	E2F2	1
REACTOME_75158	TRAIL  signaling	2.46138873440852	0.268466539233494	0.495792822945942	1/505	8/13181	843	CASP10	1
REACTOME_77111	Synthesis of Ketone Bodies	2.29145149757687	0.268466539233494	0.495792822945942	1/505	8/13181	622	BDH1	1
REACTOME_804914	Transport of fatty acids	-3.29780726146024	0.268466539233494	0.495792822945942	1/505	8/13181	347	APOD	1
REACTOME_8850843	Phosphate bond hydrolysis by NTPDase proteins	2.82569317549853	0.268466539233494	0.495792822945942	1/505	8/13181	57089	ENTPD7	1
REACTOME_9026519	Activated NTRK2 signals through RAS	-3.71732740128704	0.268466539233494	0.495792822945942	1/505	8/13181	4909	NTF4	1
REACTOME_9623433	NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	-2.34507825534281	0.268466539233494	0.495792822945942	1/505	8/13181	6257	RXRB	1
REACTOME_400042	Adrenaline,noradrenaline inhibits insulin secretion	3.99728549266474	0.277112704679461	0.507275447709237	2/505	27/13181	776/2793	CACNA1D/GNGT2	2
REACTOME_9619665	EGR2 and SOX10-mediated initiation of Schwann cell myelination	-4.46204342453467	0.277112704679461	0.507275447709237	2/505	27/13181	3915/5453	LAMC1/POU3F1	2
REACTOME_3295583	TRP channels	-0.226899891987544	0.291480510568038	0.512117524932673	2/505	28/13181	56302/162514	TRPV5/TRPV3	2
REACTOME_390471	Association of TriC/CCT with target proteins during biosynthesis	4.52276480998497	0.291480510568038	0.512117524932673	2/505	28/13181	55294/26270	FBXW7/FBXO6	2
REACTOME_420029	Tight junction interactions	0.534932225119633	0.291480510568038	0.512117524932673	2/505	28/13181	50855/84552	PARD6A/PARD6G	2
REACTOME_525793	Myogenesis	-0.783357050472056	0.291480510568038	0.512117524932673	2/505	28/13181	4654/1013	MYOD1/CDH15	2
REACTOME_8953750	Transcriptional Regulation by E2F6	0.469273652156274	0.291480510568038	0.512117524932673	2/505	28/13181	5931/317	RBBP7/APAF1	2
REACTOME_113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	-2.50500516405816	0.296510598877242	0.512117524932673	1/505	9/13181	5925	RB1	1
REACTOME_1296052	Ca2+ activated K+ channels	-3.10407563359021	0.296510598877242	0.512117524932673	1/505	9/13181	3778	KCNMA1	1
REACTOME_199220	Vitamin B5 (pantothenate) metabolism	-2.60467148645428	0.296510598877242	0.512117524932673	1/505	9/13181	5167	ENPP1	1
REACTOME_2025928	Calcineurin activates NFAT	2.23671248113133	0.296510598877242	0.512117524932673	1/505	9/13181	4775	NFATC3	1
REACTOME_2428933	SHC-related events triggered by IGF1R	2.38607293239056	0.296510598877242	0.512117524932673	1/505	9/13181	3479	IGF1	1
REACTOME_2562578	TRIF-mediated programmed cell death	-3.02780646698975	0.296510598877242	0.512117524932673	1/505	9/13181	7099	TLR4	1
REACTOME_389356	CD28 co-stimulation	-2.24223405100501	0.296510598877242	0.512117524932673	1/505	9/13181	2534	FYN	1
REACTOME_389887	Beta-oxidation of pristanoyl-CoA	-2.921307698419	0.296510598877242	0.512117524932673	1/505	9/13181	3295	HSD17B4	1
REACTOME_390696	Adrenoceptors	2.26090410741241	0.296510598877242	0.512117524932673	1/505	9/13181	148	ADRA1A	1
REACTOME_425986	Sodium/Proton exchangers	-2.29351712083896	0.296510598877242	0.512117524932673	1/505	9/13181	6549	SLC9A2	1
REACTOME_71288	Creatine metabolism	2.28867085087789	0.296510598877242	0.512117524932673	1/505	9/13181	6539	SLC6A12	1
REACTOME_727802	Transport of nucleotide sugars	-3.36744259950743	0.296510598877242	0.512117524932673	1/505	9/13181	55343	SLC35C1	1
REACTOME_74751	Insulin receptor signalling cascade	3.34233733216811	0.296510598877242	0.512117524932673	1/505	9/13181	2887	GRB10	1
REACTOME_8949664	Processing of SMDT1	-3.0564471279892	0.296510598877242	0.512117524932673	1/505	9/13181	91689	SMDT1	1
REACTOME_8951936	RUNX3 regulates p14-ARF	-4.91340271708906	0.296510598877242	0.512117524932673	1/505	9/13181	861	RUNX1	1
REACTOME_8985947	Interleukin-9 signaling	-2.44442678954477	0.296510598877242	0.512117524932673	1/505	9/13181	3718	JAK3	1
REACTOME_9010642	ROBO receptors bind AKAP5	-2.33840470326527	0.296510598877242	0.512117524932673	1/505	9/13181	6092	ROBO2	1
REACTOME_9029558	NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	-2.34507825534281	0.296510598877242	0.512117524932673	1/505	9/13181	6257	RXRB	1
REACTOME_9701898	STAT3 nuclear events downstream of ALK signaling	2.59164217049337	0.296510598877242	0.512117524932673	1/505	9/13181	29126	CD274	1
REACTOME_975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	2.58612060061969	0.296510598877242	0.512117524932673	1/505	9/13181	54106	TLR9	1
REACTOME_975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	2.58612060061969	0.296510598877242	0.512117524932673	1/505	9/13181	54106	TLR9	1
REACTOME_198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	-1.13375645588501	0.29859529629698	0.515244751756147	6/505	118/13181	3812/959/3683/10225/3821/3134	KIR3DL2/CD40LG/ITGAL/CD96/KLRC1/HLA-F	6
REACTOME_2559585	Oncogene Induced Senescence	-0.115783068141714	0.305810650279114	0.524087531927743	2/505	29/13181	1870/5925	E2F2/RB1	2
REACTOME_3214815	HDACs deacetylate histones	4.01652246108454	0.305810650279114	0.524087531927743	2/505	29/13181	5931/79685	RBBP7/SAP30L	2
REACTOME_373080	Class B/2 (Secretin family receptors)	-4.45306111152392	0.310534688769554	0.527193151000957	3/505	51/13181	976/1604/2015	ADGRE5/CD55/ADGRE1	3
REACTOME_1251985	Nuclear signaling by ERBB4	-0.655893319189681	0.320084949079287	0.527193151000957	2/505	30/13181	6678/23385	SPARC/NCSTN	2
REACTOME_3928663	EPHA-mediated growth cone collapse	-3.66935388547085	0.320084949079287	0.527193151000957	2/505	30/13181	2534/6093	FYN/ROCK1	2
REACTOME_5694530	Cargo concentration in the ER	-4.00267425220643	0.320084949079287	0.527193151000957	2/505	30/13181	4253/10484	MIA2/SEC23A	2
REACTOME_8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	-5.4744077031279	0.320084949079287	0.527193151000957	2/505	30/13181	861/161882	RUNX1/ZFPM1	2
REACTOME_983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	-4.161145929455	0.320084949079287	0.527193151000957	2/505	30/13181	3710/2534	ITPR3/FYN	2
REACTOME_1234158	Regulation of gene expression by Hypoxia-inducible Factor	-3.44482402478748	0.3234816091693	0.527193151000957	1/505	10/13181	10370	CITED2	1
REACTOME_190377	FGFR2b ligand binding and activation	-3.45809168189402	0.3234816091693	0.527193151000957	1/505	10/13181	143282	FGFBP3	1
REACTOME_192823	Viral mRNA Translation	-3.11007388575514	0.3234816091693	0.527193151000957	1/505	10/13181	5611	DNAJC3	1
REACTOME_210990	PECAM1 interactions	-2.24223405100501	0.3234816091693	0.527193151000957	1/505	10/13181	2534	FYN	1
REACTOME_388841	Costimulation by the CD28 family	2.27270199412092	0.3234816091693	0.527193151000957	1/505	10/13181	29851	ICOS	1
REACTOME_399997	Acetylcholine regulates insulin secretion	2.94553904822436	0.3234816091693	0.527193151000957	1/505	10/13181	4082	MARCKS	1
REACTOME_428542	Regulation of commissural axon pathfinding by SLIT and ROBO	-2.33840470326527	0.3234816091693	0.527193151000957	1/505	10/13181	6092	ROBO2	1
REACTOME_532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	-2.61273536188131	0.3234816091693	0.527193151000957	1/505	10/13181	9761	MLEC	1
REACTOME_549127	Organic cation transport	-4.91340271708906	0.3234816091693	0.527193151000957	1/505	10/13181	861	RUNX1	1
REACTOME_74749	Signal attenuation	3.34233733216811	0.3234816091693	0.527193151000957	1/505	10/13181	2887	GRB10	1
REACTOME_76009	Platelet Aggregation (Plug Formation)	2.79121315643124	0.3234816091693	0.527193151000957	1/505	10/13181	2147	F2	1
REACTOME_8963901	Chylomicron remodeling	-2.68070231190911	0.3234816091693	0.527193151000957	1/505	10/13181	338328	GPIHBP1	1
REACTOME_9020958	Interleukin-21 signaling	-2.44442678954477	0.3234816091693	0.527193151000957	1/505	10/13181	3718	JAK3	1
REACTOME_9028731	Activated NTRK2 signals through FRS2 and FRS3	-3.71732740128704	0.3234816091693	0.527193151000957	1/505	10/13181	4909	NTF4	1
REACTOME_937072	TRAF6-mediated induction of TAK1 complex within TLR4 complex	-3.02780646698975	0.3234816091693	0.527193151000957	1/505	10/13181	7099	TLR4	1
REACTOME_9615933	Postmitotic nuclear pore complex (NPC) reformation	-4.10105664574561	0.3234816091693	0.527193151000957	1/505	10/13181	79023	NUP37	1
REACTOME_9687136	Aberrant regulation of mitotic exit in cancer due to RB1 defects	-2.50500516405816	0.3234816091693	0.527193151000957	1/505	10/13181	5925	RB1	1
REACTOME_9690406	Transcriptional regulation of testis differentiation	2.60685628028919	0.3234816091693	0.527193151000957	1/505	10/13181	1761	DMRT1	1
REACTOME_975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	-3.02780646698975	0.3234816091693	0.527193151000957	1/505	10/13181	7099	TLR4	1
REACTOME_432722	Golgi Associated Vesicle Biogenesis	-2.04089675117727	0.331723165483394	0.538781469640415	3/505	53/13181	4952/3482/6456	OCRL/IGF2R/SH3GL2	3
REACTOME_5620912	Anchoring of the basal body to the plasma membrane	-2.99193622145073	0.332505977256711	0.539819721280326	4/505	76/13181	55722/80321/95681/10142	CEP72/CEP70/CEP41/AKAP9	4
REACTOME_2871809	FCERI mediated Ca+2 mobilization	-0.766739199818331	0.334286674755681	0.540609848207036	2/505	31/13181	4775/3710	NFATC3/ITPR3	2
REACTOME_456926	Thrombin signalling through proteinase activated receptors (PARs)	3.90278651947263	0.334286674755681	0.540609848207036	2/505	31/13181	2793/2147	GNGT2/F2	2
REACTOME_6782315	tRNA modification in the nucleus and cytosol	-3.95694505810678	0.334286674755681	0.540609848207036	2/505	31/13181	83480/93587	PUS3/TRMT10A	2
REACTOME_416482	G alpha (12/13) signalling events	-0.746398400804957	0.341276227730817	0.544476281533395	4/505	77/13181	148/2793/23263/6093	ADRA1A/GNGT2/MCF2L/ROCK1	4
REACTOME_163125	Post-translational modification: synthesis of GPI-anchored proteins	-5.16283140020626	0.342313107518445	0.544476281533395	3/505	54/13181	420/338328/8581	ART4/GPIHBP1/LY6D	3
REACTOME_8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	-5.82136554512822	0.348400454130865	0.544476281533395	2/505	32/13181	861/1912	RUNX1/PHC2	2
REACTOME_9013407	RHOH GTPase cycle	-3.96700006194436	0.348400454130865	0.544476281533395	2/505	32/13181	55717/6093	WDR11/ROCK1	2
REACTOME_1483213	Synthesis of PE	-2.21982998331612	0.34942054982449	0.544476281533395	1/505	11/13181	1120	CHKB	1
REACTOME_193692	Regulated proteolysis of p75NTR	-3.10308254548344	0.34942054982449	0.544476281533395	1/505	11/13181	23385	NCSTN	1
REACTOME_2029481	FCGR activation	-2.24223405100501	0.34942054982449	0.544476281533395	1/505	11/13181	2534	FYN	1
REACTOME_211979	Eicosanoids	2.73579884007309	0.34942054982449	0.544476281533395	1/505	11/13181	1580	CYP4B1	1
REACTOME_211999	CYP2E1 reactions	2.70950186700564	0.34942054982449	0.544476281533395	1/505	11/13181	1555	CYP2B6	1
REACTOME_376172	DSCAM interactions	-2.90899340589497	0.34942054982449	0.544476281533395	1/505	11/13181	5603	MAPK13	1
REACTOME_389359	CD28 dependent Vav1 pathway	-2.24223405100501	0.34942054982449	0.544476281533395	1/505	11/13181	2534	FYN	1
REACTOME_390247	Beta-oxidation of very long chain fatty acids	-2.921307698419	0.34942054982449	0.544476281533395	1/505	11/13181	3295	HSD17B4	1
REACTOME_451308	Activation of Ca-permeable Kainate Receptor	-2.35790895368237	0.34942054982449	0.544476281533395	1/505	11/13181	1739	DLG1	1
REACTOME_5578768	Physiological factors	-2.51437991578613	0.34942054982449	0.544476281533395	1/505	11/13181	6910	TBX5	1
REACTOME_6803205	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	2.85230793676015	0.34942054982449	0.544476281533395	1/505	11/13181	79370	BCL2L14	1
REACTOME_71240	Tryptophan catabolism	-2.82791769285771	0.34942054982449	0.544476281533395	1/505	11/13181	8942	KYNU	1
REACTOME_71384	Ethanol oxidation	-2.71327560181139	0.34942054982449	0.544476281533395	1/505	11/13181	127	ADH4	1
REACTOME_8851680	Butyrophilin (BTN) family interactions	2.63891316437594	0.34942054982449	0.544476281533395	1/505	11/13181	11120	BTN2A1	1
REACTOME_8866427	VLDLR internalisation and degradation	2.58091681894018	0.34942054982449	0.544476281533395	1/505	11/13181	7436	VLDLR	1
REACTOME_9013700	NOTCH4 Activation and Transmission of Signal to the Nucleus	-3.10308254548344	0.34942054982449	0.544476281533395	1/505	11/13181	23385	NCSTN	1
REACTOME_9627069	Regulation of the apoptosome activity	-2.31766902359577	0.34942054982449	0.544476281533395	1/505	11/13181	317	APAF1	1
REACTOME_9706369	Negative regulation of FLT3	-3.3343926273139	0.34942054982449	0.544476281533395	1/505	11/13181	27	ABL2	1
REACTOME_983231	Factors involved in megakaryocyte development and platelet production	-2.94103556938911	0.350053125787359	0.545236020281885	4/505	78/13181	3456/5573/3660/161882	IFNB1/PRKAR1A/IRF2/ZFPM1	4
REACTOME_159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	-5.59262926022423	0.362412193837097	0.558357521974477	2/505	33/13181	10212/79023	DDX39A/NUP37	2
REACTOME_5689896	Ovarian tumor domain proteases	-5.01238930823167	0.362412193837097	0.558357521974477	2/505	33/13181	7128/64127	TNFAIP3/NOD2	2
REACTOME_112043	PLC beta mediated events	-3.24843092079129	0.374366838536611	0.558357521974477	1/505	12/13181	3710	ITPR3	1
REACTOME_112308	Presynaptic depolarization and calcium channel opening	2.40549773575912	0.374366838536611	0.558357521974477	1/505	12/13181	777	CACNA1E	1
REACTOME_205043	NRIF signals cell death from the nucleus	-3.10308254548344	0.374366838536611	0.558357521974477	1/505	12/13181	23385	NCSTN	1
REACTOME_211958	Miscellaneous substrates	2.73579884007309	0.374366838536611	0.558357521974477	1/505	12/13181	1580	CYP4B1	1
REACTOME_212300	PRC2 methylates histones and DNA	2.93687931993327	0.374366838536611	0.558357521974477	1/505	12/13181	5931	RBBP7	1
REACTOME_2160916	Hyaluronan uptake and degradation	-3.24855009136411	0.374366838536611	0.558357521974477	1/505	12/13181	3161	HMMR	1
REACTOME_2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	2.97564947962183	0.374366838536611	0.558357521974477	1/505	12/13181	50855	PARD6A	1
REACTOME_373760	L1CAM interactions	-3.65651068562803	0.374366838536611	0.558357521974477	1/505	12/13181	3915	LAMC1	1
REACTOME_418885	DCC mediated attractive signaling	-2.24223405100501	0.374366838536611	0.558357521974477	1/505	12/13181	2534	FYN	1
REACTOME_5689901	Metalloprotease DUBs	-2.36414554699293	0.374366838536611	0.558357521974477	1/505	12/13181	57559	STAMBPL1	1
REACTOME_68962	Activation of the pre-replicative complex	-2.61531739095893	0.374366838536611	0.558357521974477	1/505	12/13181	29935	RPA4	1
REACTOME_879518	Transport of organic anions	2.4648446810201	0.374366838536611	0.558357521974477	1/505	12/13181	6579	SLCO1A2	1
REACTOME_8866907	Activation of the TFAP2 (AP-2) family of transcription factors	-3.44482402478748	0.374366838536611	0.558357521974477	1/505	12/13181	10370	CITED2	1
REACTOME_8949215	Mitochondrial calcium ion transport	-3.0564471279892	0.374366838536611	0.558357521974477	1/505	12/13181	91689	SMDT1	1
REACTOME_9020558	Interleukin-2 signaling	-2.44442678954477	0.374366838536611	0.558357521974477	1/505	12/13181	3718	JAK3	1
REACTOME_936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	-3.02780646698975	0.374366838536611	0.558357521974477	1/505	12/13181	7099	TLR4	1
REACTOME_9673767	Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	-2.52168904425201	0.374366838536611	0.558357521974477	1/505	12/13181	5156	PDGFRA	1
REACTOME_9673770	Signaling by PDGFRA extracellular domain mutants	-2.52168904425201	0.374366838536611	0.558357521974477	1/505	12/13181	5156	PDGFRA	1
REACTOME_3299685	Detoxification of Reactive Oxygen Species	-0.218952224283589	0.376309005147075	0.559803369191348	2/505	34/13181	79400/25824	NOX5/PRDX5	2
REACTOME_6804756	Regulation of TP53 Activity through Phosphorylation	-6.32404098531106	0.384467966099932	0.570931892786628	3/505	58/13181	94241/5562/8148	TP53INP1/PRKAA1/TAF15	3
REACTOME_3214841	PKMTs methylate histone lysines	0.180207344226806	0.390079132667617	0.57278300111598	2/505	35/13181	5931/84444	RBBP7/DOT1L	2
REACTOME_112409	RAF-independent MAPK1/3 activation	-2.78469849845078	0.3983583904038	0.57278300111598	1/505	13/13181	11221	DUSP10	1
REACTOME_159227	Transport of the SLBP independent Mature mRNA	-4.10105664574561	0.3983583904038	0.57278300111598	1/505	13/13181	79023	NUP37	1
REACTOME_159230	Transport of the SLBP Dependant Mature mRNA	-4.10105664574561	0.3983583904038	0.57278300111598	1/505	13/13181	79023	NUP37	1
REACTOME_159231	Transport of Mature mRNA Derived from an Intronless Transcript	-4.10105664574561	0.3983583904038	0.57278300111598	1/505	13/13181	79023	NUP37	1
REACTOME_1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	-2.79049813299436	0.3983583904038	0.57278300111598	1/505	13/13181	10484	SEC23A	1
REACTOME_168333	NEP/NS2 Interacts with the Cellular Export Machinery	-4.10105664574561	0.3983583904038	0.57278300111598	1/505	13/13181	79023	NUP37	1
REACTOME_171007	p38MAPK events	-2.90899340589497	0.3983583904038	0.57278300111598	1/505	13/13181	5603	MAPK13	1
REACTOME_177504	Retrograde neurotrophin signalling	-2.62187177246365	0.3983583904038	0.57278300111598	1/505	13/13181	6456	SH3GL2	1
REACTOME_180746	Nuclear import of Rev protein	-4.10105664574561	0.3983583904038	0.57278300111598	1/505	13/13181	79023	NUP37	1
REACTOME_2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	-2.51437991578613	0.3983583904038	0.57278300111598	1/505	13/13181	6910	TBX5	1
REACTOME_2046106	alpha-linolenic acid (ALA) metabolism	-2.921307698419	0.3983583904038	0.57278300111598	1/505	13/13181	3295	HSD17B4	1
REACTOME_442720	CREB1 phosphorylation through the activation of Adenylate Cyclase	-2.8037657901009	0.3983583904038	0.57278300111598	1/505	13/13181	5573	PRKAR1A	1
REACTOME_5357786	TNFR1-induced proapoptotic signaling	-4.12608246603639	0.3983583904038	0.57278300111598	1/505	13/13181	7128	TNFAIP3	1
REACTOME_74217	Purine salvage	-2.55156113450385	0.3983583904038	0.57278300111598	1/505	13/13181	353	APRT	1
REACTOME_75109	Triglyceride biosynthesis	-3.1115039326289	0.3983583904038	0.57278300111598	1/505	13/13181	8694	DGAT1	1
REACTOME_877312	Regulation of IFNG signaling	-2.62095813140542	0.3983583904038	0.57278300111598	1/505	13/13181	3460	IFNGR2	1
REACTOME_8878166	Transcriptional regulation by RUNX2	3.1871772463653	0.3983583904038	0.57278300111598	1/505	13/13181	581	BAX	1
REACTOME_9013422	RHOBTB1 GTPase cycle	-2.59950742829904	0.3983583904038	0.57278300111598	1/505	13/13181	6093	ROCK1	1
REACTOME_933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	2.46138873440852	0.3983583904038	0.57278300111598	1/505	13/13181	843	CASP10	1
REACTOME_9614657	FOXO-mediated transcription of cell death genes	-3.44482402478748	0.3983583904038	0.57278300111598	1/505	13/13181	10370	CITED2	1
REACTOME_2129379	Molecules associated with elastic fibres	-4.25305588968294	0.403711886711515	0.578049007629588	2/505	36/13181	2192/84467	FBLN1/FBN3	2
REACTOME_909733	Interferon alpha/beta signaling	-2.12731425314609	0.405326458365425	0.579698548289844	3/505	60/13181	3456/3660/3134	IFNB1/IRF2/HLA-F	3
REACTOME_8873719	RAB geranylgeranylation	-6.07418279907951	0.415679103026557	0.588544318116211	3/505	61/13181	5869/83871/8934	RAB5B/RAB34/RAB29	3
REACTOME_4551638	SUMOylation of chromatin organization proteins	-5.20572234609077	0.417197579171282	0.588544318116211	2/505	37/13181	1912/79023	PHC2/NUP37	2
REACTOME_5675221	Negative regulation of MAPK pathway	0.219373691510314	0.417197579171282	0.588544318116211	2/505	37/13181	5774/11221	PTPN3/DUSP10	2
REACTOME_9029569	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	-4.27650753036999	0.417197579171282	0.588544318116211	2/505	37/13181	6257/347	RXRB/APOD	2
REACTOME_165054	Rev-mediated nuclear export of HIV RNA	-4.10105664574561	0.421431675097457	0.588544318116211	1/505	14/13181	79023	NUP37	1
REACTOME_168271	Transport of Ribonucleoproteins into the Host Nucleus	-4.10105664574561	0.421431675097457	0.588544318116211	1/505	14/13181	79023	NUP37	1
REACTOME_168325	Viral Messenger RNA Synthesis	-4.10105664574561	0.421431675097457	0.588544318116211	1/505	14/13181	79023	NUP37	1
REACTOME_1855183	Synthesis of IP2, IP, and Ins in the cytosol	2.64475252244379	0.421431675097457	0.588544318116211	1/505	14/13181	4952	OCRL	1
REACTOME_192105	Synthesis of bile acids and bile salts	-2.84023198538174	0.421431675097457	0.588544318116211	1/505	14/13181	26031	OSBPL3	1
REACTOME_196757	Metabolism of folate and pterines	-3.10824660363868	0.421431675097457	0.588544318116211	1/505	14/13181	160428	ALDH1L2	1
REACTOME_200425	Carnitine metabolism	-3.2830301104314	0.421431675097457	0.588544318116211	1/505	14/13181	1375	CPT1B	1
REACTOME_2162123	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	-2.34253594978947	0.421431675097457	0.588544318116211	1/505	14/13181	80142	PTGES2	1
REACTOME_391160	Signal regulatory protein family interactions	2.25717009613093	0.421431675097457	0.588544318116211	1/505	14/13181	653509	SFTPA1	1
REACTOME_427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	2.93687931993327	0.421431675097457	0.588544318116211	1/505	14/13181	5931	RBBP7	1
REACTOME_4419969	Depolymerisation of the Nuclear Lamina	-3.22618574719949	0.421431675097457	0.588544318116211	1/505	14/13181	7112	TMPO	1
REACTOME_5083632	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	-2.43787240804004	0.421431675097457	0.588544318116211	1/505	14/13181	56913	C1GALT1	1
REACTOME_5576893	Phase 2 - plateau phase	-3.09370779375546	0.421431675097457	0.588544318116211	1/505	14/13181	10142	AKAP9	1
REACTOME_5682910	LGI-ADAM interactions	-2.29721140859617	0.421431675097457	0.588544318116211	1/505	14/13181	8745	ADAM23	1
REACTOME_606279	Deposition of new CENPA-containing nucleosomes at the centromere	2.93687931993327	0.421431675097457	0.588544318116211	1/505	14/13181	5931	RBBP7	1
REACTOME_6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	3.1871772463653	0.421431675097457	0.588544318116211	1/505	14/13181	581	BAX	1
REACTOME_8983432	Interleukin-15 signaling	-2.44442678954477	0.421431675097457	0.588544318116211	1/505	14/13181	3718	JAK3	1
REACTOME_9725371	Nuclear events stimulated by ALK signaling in cancer	2.48534201954397	0.421431675097457	0.588544318116211	1/505	14/13181	238	ALK	1
REACTOME_983712	Ion channel transport	2.23993008659728	0.421431675097457	0.588544318116211	1/505	14/13181	155066	ATP6V0E2	1
REACTOME_9031628	NGF-stimulated transcription	-4.1294455730449	0.430527462726525	0.598883928912961	2/505	38/13181	4066/466	LYL1/ATF1	2
REACTOME_9035034	RHOF GTPase cycle	-4.40990190762842	0.430527462726525	0.598883928912961	2/505	38/13181	7112/26049	TMPO/FAM169A	2
REACTOME_111447	Activation of BAD and translocation to mitochondria 	-2.54107412409629	0.443621771860257	0.600968375837174	1/505	15/13181	596	BCL2	1
REACTOME_1227986	Signaling by ERBB2	-2.24223405100501	0.443621771860257	0.600968375837174	1/505	15/13181	2534	FYN	1
REACTOME_139853	Elevation of cytosolic Ca2+ levels	-3.24843092079129	0.443621771860257	0.600968375837174	1/505	15/13181	3710	ITPR3	1
REACTOME_140534	Caspase activation via Death Receptors in the presence of ligand	-3.02780646698975	0.443621771860257	0.600968375837174	1/505	15/13181	7099	TLR4	1
REACTOME_156584	Cytosolic sulfonation of small molecules	3.33832525621673	0.443621771860257	0.600968375837174	1/505	15/13181	6822	SULT2A1	1
REACTOME_170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	-4.10105664574561	0.443621771860257	0.600968375837174	1/505	15/13181	79023	NUP37	1
REACTOME_180910	Vpr-mediated nuclear import of PICs	-4.10105664574561	0.443621771860257	0.600968375837174	1/505	15/13181	79023	NUP37	1
REACTOME_181429	Serotonin Neurotransmitter Release Cycle	3.08401525383332	0.443621771860257	0.600968375837174	1/505	15/13181	8541	PPFIA3	1
REACTOME_2730905	Role of LAT2/NTAL/LAB on calcium mobilization	-2.24223405100501	0.443621771860257	0.600968375837174	1/505	15/13181	2534	FYN	1
REACTOME_2995383	Initiation of Nuclear Envelope (NE) Reformation	-3.22618574719949	0.443621771860257	0.600968375837174	1/505	15/13181	7112	TMPO	1
REACTOME_376176	Signaling by ROBO receptors	-2.33840470326527	0.443621771860257	0.600968375837174	1/505	15/13181	6092	ROBO2	1
REACTOME_418457	cGMP effects	-3.10407563359021	0.443621771860257	0.600968375837174	1/505	15/13181	3778	KCNMA1	1
REACTOME_429947	Deadenylation of mRNA	-3.12854532454119	0.443621771860257	0.600968375837174	1/505	15/13181	10605	PAIP1	1
REACTOME_4655427	SUMOylation of DNA methylation proteins	-2.76793517120839	0.443621771860257	0.600968375837174	1/505	15/13181	1912	PHC2	1
REACTOME_5617833	Cilium Assembly	-2.61488043219194	0.443621771860257	0.600968375837174	1/505	15/13181	79969	ATAT1	1
REACTOME_5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	-4.10105664574561	0.443621771860257	0.600968375837174	1/505	15/13181	79023	NUP37	1
REACTOME_75892	Platelet Adhesion to exposed collagen	-2.24223405100501	0.443621771860257	0.600968375837174	1/505	15/13181	2534	FYN	1
REACTOME_918233	TRAF3-dependent IRF activation pathway	2.50190672916501	0.443621771860257	0.600968375837174	1/505	15/13181	3456	IFNB1	1
REACTOME_975577	N-Glycan antennae elongation	2.47390164455391	0.443621771860257	0.600968375837174	1/505	15/13181	11282	MGAT4B	1
REACTOME_69231	Cyclin D associated events in G1	-0.115783068141714	0.443693673224467	0.600968375837174	2/505	39/13181	1870/5925	E2F2/RB1	2
REACTOME_8856825	Cargo recognition for clathrin-mediated endocytosis	-6.11483153874802	0.454343937360426	0.612525351192256	4/505	90/13181	6572/64708/3482/6456	SLC18A3/COPS7B/IGF2R/SH3GL2	4
REACTOME_419037	NCAM1 interactions	0.433599461894202	0.456689175080421	0.613639420246524	2/505	40/13181	776/779	CACNA1D/CACNA1S	2
REACTOME_9696264	RND3 GTPase cycle	-0.24824419654097	0.456689175080421	0.613639420246524	2/505	40/13181	390/6093	RND3/ROCK1	2
REACTOME_111465	Apoptotic cleavage of cellular proteins	-2.59950742829904	0.464962422415518	0.613639420246524	1/505	16/13181	6093	ROCK1	1
REACTOME_1660514	Synthesis of PIPs at the Golgi membrane	2.64475252244379	0.464962422415518	0.613639420246524	1/505	16/13181	4952	OCRL	1
REACTOME_181430	Norepinephrine Neurotransmitter Release Cycle	3.08401525383332	0.464962422415518	0.613639420246524	1/505	16/13181	8541	PPFIA3	1
REACTOME_2022377	Metabolism of Angiotensinogen to Angiotensins	2.56320012711528	0.464962422415518	0.613639420246524	1/505	16/13181	1215	CMA1	1
REACTOME_4085377	SUMOylation of SUMOylation proteins	-4.10105664574561	0.464962422415518	0.613639420246524	1/505	16/13181	79023	NUP37	1
REACTOME_5676594	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	2.24465718598554	0.464962422415518	0.613639420246524	1/505	16/13181	959	CD40LG	1
REACTOME_6781823	Formation of TC-NER Pre-Incision Complex	-2.56872169698896	0.464962422415518	0.613639420246524	1/505	16/13181	64708	COPS7B	1
REACTOME_77387	Insulin receptor recycling	2.23993008659728	0.464962422415518	0.613639420246524	1/505	16/13181	155066	ATP6V0E2	1
REACTOME_901032	ER Quality Control Compartment (ERQC)	-2.89282593151664	0.464962422415518	0.613639420246524	1/505	16/13181	10956	OS9	1
REACTOME_9604323	Negative regulation of NOTCH4 signaling	2.72265035353937	0.464962422415518	0.613639420246524	1/505	16/13181	55294	FBXW7	1
REACTOME_977606	Regulation of Complement cascade	0.362100557360512	0.46950770955214	0.618552553579554	2/505	41/13181	2147/1604	F2/CD55	2
REACTOME_9013106	RHOC GTPase cycle	-5.89310536752516	0.476388764703785	0.626004001310124	3/505	67/13181	23263/7112/6093	MCF2L/TMPO/ROCK1	3
REACTOME_432040	Vasopressin regulates renal water homeostasis via Aquaporins	-0.337414619795196	0.482143745748647	0.626004001310124	2/505	42/13181	2793/5573	GNGT2/PRKAR1A	2
REACTOME_9707616	Heme signaling	-4.19820494060488	0.482143745748647	0.626004001310124	2/505	42/13181	200186/7099	CRTC2/TLR4	2
REACTOME_9013149	RAC1 GTPase cycle	-2.02465531215726	0.483788789091924	0.626004001310124	7/505	171/13181	50855/124056/27035/23263/7112/8936/27	PARD6A/NOXO1/NOX1/MCF2L/TMPO/WASF1/ABL2	7
REACTOME_164378	PKA activation in glucagon signalling	-2.8037657901009	0.485486081867107	0.626004001310124	1/505	17/13181	5573	PRKAR1A	1
REACTOME_3232118	SUMOylation of transcription factors	2.32096607611027	0.485486081867107	0.626004001310124	1/505	17/13181	6670	SP3	1
REACTOME_380994	ATF4 activates genes in response to endoplasmic reticulum  stress	-2.26781600063558	0.485486081867107	0.626004001310124	1/505	17/13181	467	ATF3	1
REACTOME_399719	Trafficking of AMPA receptors	-2.35790895368237	0.485486081867107	0.626004001310124	1/505	17/13181	1739	DLG1	1
REACTOME_422085	Synthesis, secretion, and deacylation of Ghrelin	2.38607293239056	0.485486081867107	0.626004001310124	1/505	17/13181	3479	IGF1	1
REACTOME_450321	JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1	-2.48780487804878	0.485486081867107	0.626004001310124	1/505	17/13181	64127	NOD2	1
REACTOME_452723	Transcriptional regulation of pluripotent stem cells	2.2440216095972	0.485486081867107	0.626004001310124	1/505	17/13181	27086	FOXP1	1
REACTOME_5576886	Phase 4 - resting membrane potential	2.3884960673711	0.485486081867107	0.626004001310124	1/505	17/13181	3770	KCNJ14	1
REACTOME_5578749	Transcriptional regulation by small RNAs	-4.10105664574561	0.485486081867107	0.626004001310124	1/505	17/13181	79023	NUP37	1
REACTOME_5601884	PIWI-interacting RNA (piRNA) biogenesis	-2.24866926193692	0.485486081867107	0.626004001310124	1/505	17/13181	143689	PIWIL4	1
REACTOME_5602498	MyD88 deficiency (TLR2/4)	-3.02780646698975	0.485486081867107	0.626004001310124	1/505	17/13181	7099	TLR4	1
REACTOME_5675482	Regulation of necroptotic cell death	-2.97632477953444	0.485486081867107	0.626004001310124	1/505	17/13181	6386	SDCBP	1
REACTOME_6788467	IL-6-type cytokine receptor ligand interactions	2.43755461984587	0.485486081867107	0.626004001310124	1/505	17/13181	1489	CTF1	1
REACTOME_8934593	Regulation of RUNX1 Expression and Activity	-4.91340271708906	0.485486081867107	0.626004001310124	1/505	17/13181	861	RUNX1	1
REACTOME_8964315	G beta:gamma signalling through BTK	2.35854453007071	0.485486081867107	0.626004001310124	1/505	17/13181	2793	GNGT2	1
REACTOME_6783783	Interleukin-10 signaling	-0.161632681449002	0.494592434240589	0.637090631293119	2/505	43/13181	729230/1435	CCR2/CSF1	2
REACTOME_8856828	Clathrin-mediated endocytosis	-4.1183713915988	0.503607052778239	0.637772516248315	5/505	122/13181	4952/5869/6572/3482/6456	OCRL/RAB5B/SLC18A3/IGF2R/SH3GL2	5
REACTOME_1566948	Elastic fibre formation	-2.67716691824899	0.505223967666037	0.637772516248315	1/505	18/13181	84467	FBN3	1
REACTOME_162710	Synthesis of glycosylphosphatidylinositol (GPI)	-2.68892508143323	0.505223967666037	0.637772516248315	1/505	18/13181	5281	PIGF	1
REACTOME_191859	snRNP Assembly	-4.10105664574561	0.505223967666037	0.637772516248315	1/505	18/13181	79023	NUP37	1
REACTOME_210745	Regulation of gene expression in beta cells	2.52351632636848	0.505223967666037	0.637772516248315	1/505	18/13181	3651	PDX1	1
REACTOME_210993	Tie2 Signaling	-2.83645825057599	0.505223967666037	0.637772516248315	1/505	18/13181	284	ANGPT1	1
REACTOME_2979096	NOTCH2 Activation and Transmission of Signal to the Nucleus	-3.10308254548344	0.505223967666037	0.637772516248315	1/505	18/13181	23385	NCSTN	1
REACTOME_3301854	Nuclear Pore Complex (NPC) Disassembly	-4.10105664574561	0.505223967666037	0.637772516248315	1/505	18/13181	79023	NUP37	1
REACTOME_392851	Prostacyclin signalling through prostacyclin receptor	2.35854453007071	0.505223967666037	0.637772516248315	1/505	18/13181	2793	GNGT2	1
REACTOME_450302	activated TAK1 mediates p38 MAPK activation	-2.48780487804878	0.505223967666037	0.637772516248315	1/505	18/13181	64127	NOD2	1
REACTOME_4615885	SUMOylation of DNA replication proteins	-4.10105664574561	0.505223967666037	0.637772516248315	1/505	18/13181	79023	NUP37	1
REACTOME_5218921	VEGFR2 mediated cell proliferation	-3.24843092079129	0.505223967666037	0.637772516248315	1/505	18/13181	3710	ITPR3	1
REACTOME_5603041	IRAK4 deficiency (TLR2/4)	-3.02780646698975	0.505223967666037	0.637772516248315	1/505	18/13181	7099	TLR4	1
REACTOME_8964616	G beta:gamma signalling through CDC42	2.35854453007071	0.505223967666037	0.637772516248315	1/505	18/13181	2793	GNGT2	1
REACTOME_9037629	Lewis blood group biosynthesis	2.68022562961786	0.505223967666037	0.637772516248315	1/505	18/13181	2524	FUT2	1
REACTOME_912446	Meiotic recombination	2.40569635338047	0.505223967666037	0.637772516248315	1/505	18/13181	27030	MLH3	1
REACTOME_912631	Regulation of signaling by CBL	-2.24223405100501	0.505223967666037	0.637772516248315	1/505	18/13181	2534	FYN	1
REACTOME_937041	IKK complex recruitment mediated by RIP1	-3.02780646698975	0.505223967666037	0.637772516248315	1/505	18/13181	7099	TLR4	1
REACTOME_9607240	FLT3 Signaling	3.34233733216811	0.505223967666037	0.637772516248315	1/505	18/13181	2887	GRB10	1
REACTOME_9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	-2.26781600063558	0.505223967666037	0.637772516248315	1/505	18/13181	467	ATF3	1
REACTOME_9648002	RAS processing	-3.05168030507667	0.505223967666037	0.637772516248315	1/505	18/13181	51114	ZDHHC9	1
REACTOME_1989781	PPARA activates gene expression	0.161371722111981	0.512695468110622	0.645374944792749	4/505	97/13181	6822/2274/6257/23389	SULT2A1/FHL2/RXRB/MED13L	4
REACTOME_140875	Common Pathway of Fibrin Clot Formation	2.79121315643124	0.524206106717062	0.64892238806644	1/505	19/13181	2147	F2	1
REACTOME_163615	PKA activation	-2.8037657901009	0.524206106717062	0.64892238806644	1/505	19/13181	5573	PRKAR1A	1
REACTOME_167161	HIV Transcription Initiation	-2.76658457138317	0.524206106717062	0.64892238806644	1/505	19/13181	8148	TAF15	1
REACTOME_167162	RNA Polymerase II HIV Promoter Escape	-2.76658457138317	0.524206106717062	0.64892238806644	1/505	19/13181	8148	TAF15	1
REACTOME_167172	Transcription of the HIV genome	-2.76658457138317	0.524206106717062	0.64892238806644	1/505	19/13181	8148	TAF15	1
REACTOME_388844	Receptor-type tyrosine-protein phosphatases	3.08401525383332	0.524206106717062	0.64892238806644	1/505	19/13181	8541	PPFIA3	1
REACTOME_389357	CD28 dependent PI3K/Akt signaling	-2.24223405100501	0.524206106717062	0.64892238806644	1/505	19/13181	2534	FYN	1
REACTOME_418217	G beta:gamma signalling through PLC beta	2.35854453007071	0.524206106717062	0.64892238806644	1/505	19/13181	2793	GNGT2	1
REACTOME_442660	Na+/Cl- dependent neurotransmitter transporters	2.28867085087789	0.524206106717062	0.64892238806644	1/505	19/13181	6539	SLC6A12	1
REACTOME_5362768	Hh mutants are degraded by ERAD	-2.89282593151664	0.524206106717062	0.64892238806644	1/505	19/13181	10956	OS9	1
REACTOME_5627117	RHO GTPases Activate ROCKs	-2.59950742829904	0.524206106717062	0.64892238806644	1/505	19/13181	6093	ROCK1	1
REACTOME_73776	RNA Polymerase II Promoter Escape	-2.76658457138317	0.524206106717062	0.64892238806644	1/505	19/13181	8148	TAF15	1
REACTOME_73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	-2.76658457138317	0.524206106717062	0.64892238806644	1/505	19/13181	8148	TAF15	1
REACTOME_75953	RNA Polymerase II Transcription Initiation	-2.76658457138317	0.524206106717062	0.64892238806644	1/505	19/13181	8148	TAF15	1
REACTOME_76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	-2.76658457138317	0.524206106717062	0.64892238806644	1/505	19/13181	8148	TAF15	1
REACTOME_77289	Mitochondrial Fatty Acid Beta-Oxidation	3.25832207833479	0.524206106717062	0.64892238806644	1/505	19/13181	641371	ACOT1	1
REACTOME_2672351	Stimuli-sensing channels	5.26688564946671	0.524660654181377	0.64892238806644	3/505	72/13181	203859/23327/51802	ANO5/NEDD4L/ASIC5	3
REACTOME_5620924	Intraflagellar transport	0.111327557459193	0.530775235267685	0.656269281356954	2/505	46/13181	112752/28981	IFT43/IFT81	2
REACTOME_400253	Circadian Clock	-0.0910369209725798	0.54243817948554	0.661152282468763	2/505	47/13181	1407/200186	CRY1/CRTC2	2
REACTOME_168276	NS1 Mediated Effects on Host Pathways	-4.10105664574561	0.54246138069578	0.661152282468763	1/505	20/13181	79023	NUP37	1
REACTOME_2028269	Signaling by Hippo	-2.69663144514181	0.54246138069578	0.661152282468763	1/505	20/13181	60485	SAV1	1
REACTOME_212676	Dopamine Neurotransmitter Release Cycle	3.08401525383332	0.54246138069578	0.661152282468763	1/505	20/13181	8541	PPFIA3	1
REACTOME_2142691	Synthesis of Leukotrienes (LT) and Eoxins (EX)	2.73579884007309	0.54246138069578	0.661152282468763	1/505	20/13181	1580	CYP4B1	1
REACTOME_2173788	Downregulation of TGF-beta receptor signaling	2.71029633749106	0.54246138069578	0.661152282468763	1/505	20/13181	23327	NEDD4L	1
REACTOME_3214842	HDMs demethylate histones	-3.01445936283467	0.54246138069578	0.661152282468763	1/505	20/13181	5253	PHF2	1
REACTOME_3232142	SUMOylation of ubiquitinylation proteins	-4.10105664574561	0.54246138069578	0.661152282468763	1/505	20/13181	79023	NUP37	1
REACTOME_500657	Presynaptic function of Kainate receptors	2.35854453007071	0.54246138069578	0.661152282468763	1/505	20/13181	2793	GNGT2	1
REACTOME_6804758	Regulation of TP53 Activity through Acetylation	2.93687931993327	0.54246138069578	0.661152282468763	1/505	20/13181	5931	RBBP7	1
REACTOME_9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	-3.10308254548344	0.54246138069578	0.661152282468763	1/505	20/13181	23385	NCSTN	1
REACTOME_917729	Endosomal Sorting Complex Required For Transport (ESCRT)	-2.50341622308731	0.54246138069578	0.661152282468763	1/505	20/13181	51534	VTA1	1
REACTOME_917977	Transferrin endocytosis and recycling	2.23993008659728	0.54246138069578	0.661152282468763	1/505	20/13181	155066	ATP6V0E2	1
REACTOME_9670439	Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	-2.24223405100501	0.54246138069578	0.661152282468763	1/505	20/13181	2534	FYN	1
REACTOME_2132295	MHC class II antigen presentation	-2.96106729171546	0.55256854669637	0.672381144200114	4/505	102/13181	1514/10437/10484/6456	CTSL/IFI30/SEC23A/SH3GL2	4
REACTOME_373753	Nephrin family interactions	-2.24223405100501	0.560017569644084	0.674410815272089	1/505	21/13181	2534	FYN	1
REACTOME_375165	NCAM signaling for neurite out-growth	-2.24223405100501	0.560017569644084	0.674410815272089	1/505	21/13181	2534	FYN	1
REACTOME_389948	PD-1 signaling	2.59164217049337	0.560017569644084	0.674410815272089	1/505	21/13181	29126	CD274	1
REACTOME_392170	ADP signalling through P2Y purinoceptor 12	2.35854453007071	0.560017569644084	0.674410815272089	1/505	21/13181	2793	GNGT2	1
REACTOME_416572	Sema4D induced cell migration and growth-cone collapse	-2.59950742829904	0.560017569644084	0.674410815272089	1/505	21/13181	6093	ROCK1	1
REACTOME_5213460	RIPK1-mediated regulated necrosis	-2.97632477953444	0.560017569644084	0.674410815272089	1/505	21/13181	6386	SDCBP	1
REACTOME_5621575	CD209 (DC-SIGN) signaling	-2.24223405100501	0.560017569644084	0.674410815272089	1/505	21/13181	2534	FYN	1
REACTOME_5696394	DNA Damage Recognition in GG-NER	-2.56872169698896	0.560017569644084	0.674410815272089	1/505	21/13181	64708	COPS7B	1
REACTOME_71403	Citric acid cycle (TCA cycle)	-2.59239691745452	0.560017569644084	0.674410815272089	1/505	21/13181	23530	NNT	1
REACTOME_912694	Regulation of IFNA signaling	2.50190672916501	0.560017569644084	0.674410815272089	1/505	21/13181	3456	IFNB1	1
REACTOME_2151201	Transcriptional activation of mitochondrial biogenesis	-3.65896772881227	0.565153973649821	0.679123982397995	2/505	49/13181	200186/23409	CRTC2/SIRT4	2
REACTOME_2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	-0.288313687881745	0.565153973649821	0.679123982397995	2/505	49/13181	55294/23385	FBXW7/NCSTN	2
REACTOME_2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	-0.288313687881745	0.565153973649821	0.679123982397995	2/505	49/13181	55294/23385	FBXW7/NCSTN	2
REACTOME_1660499	Synthesis of PIPs at the plasma membrane	0.0487998838943624	0.576204034395511	0.686439633259121	2/505	50/13181	4952/84725	OCRL/PLEKHA8	2
REACTOME_3928665	EPH-ephrin mediated repulsion of cells	-4.05099245927025	0.576204034395511	0.686439633259121	2/505	50/13181	23385/2534	NCSTN/FYN	2
REACTOME_1461957	Beta defensins	2.29621832048939	0.576901393909262	0.686439633259121	1/505	22/13181	729230	CCR2	1
REACTOME_163560	Triglyceride catabolism	-2.61650909668706	0.576901393909262	0.686439633259121	1/505	22/13181	51099	ABHD5	1
REACTOME_2029485	Role of phospholipids in phagocytosis	-3.24843092079129	0.576901393909262	0.686439633259121	1/505	22/13181	3710	ITPR3	1
REACTOME_2453902	The canonical retinoid cycle in rods (twilight vision)	-2.46655279256376	0.576901393909262	0.686439633259121	1/505	22/13181	157506	RDH10	1
REACTOME_392451	G beta:gamma signalling through PI3Kgamma	2.35854453007071	0.576901393909262	0.686439633259121	1/505	22/13181	2793	GNGT2	1
REACTOME_427413	NoRC negatively regulates rRNA expression	2.3629538412648	0.576901393909262	0.686439633259121	1/505	22/13181	79685	SAP30L	1
REACTOME_428930	Thromboxane signalling through TP receptor	2.35854453007071	0.576901393909262	0.686439633259121	1/505	22/13181	2793	GNGT2	1
REACTOME_1236974	ER-Phagosome pathway	-4.79142006222019	0.587047681155754	0.697408935591038	2/505	51/13181	7099/3134	TLR4/HLA-F	2
REACTOME_202733	Cell surface interactions at the vascular wall	1.80350459677594	0.58789665700153	0.698028471011159	3/505	79/13181	3683/2147/2534	ITGAL/F2/FYN	3
REACTOME_140837	Intrinsic Pathway of Fibrin Clot Formation	2.79121315643124	0.593138554489536	0.698028471011159	1/505	23/13181	2147	F2	1
REACTOME_193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	-2.921307698419	0.593138554489536	0.698028471011159	1/505	23/13181	3295	HSD17B4	1
REACTOME_202040	G-protein activation	2.35854453007071	0.593138554489536	0.698028471011159	1/505	23/13181	2793	GNGT2	1
REACTOME_211981	Xenobiotics	2.70950186700564	0.593138554489536	0.698028471011159	1/505	23/13181	1555	CYP2B6	1
REACTOME_3214858	RMTs methylate histone arginines	2.93687931993327	0.593138554489536	0.698028471011159	1/505	23/13181	5931	RBBP7	1
REACTOME_5358346	Hedgehog ligand biogenesis	-2.89282593151664	0.593138554489536	0.698028471011159	1/505	23/13181	10956	OS9	1
REACTOME_5621480	Dectin-2 family	-2.24223405100501	0.593138554489536	0.698028471011159	1/505	23/13181	2534	FYN	1
REACTOME_69202	Cyclin E associated events during G1/S transition 	-2.50500516405816	0.593138554489536	0.698028471011159	1/505	23/13181	5925	RB1	1
REACTOME_73762	RNA Polymerase I Transcription Initiation	2.93687931993327	0.593138554489536	0.698028471011159	1/505	23/13181	5931	RBBP7	1
REACTOME_75876	Synthesis of very long-chain fatty acyl-CoAs	-2.53022960197029	0.593138554489536	0.698028471011159	1/505	23/13181	11000	SLC27A3	1
REACTOME_9634638	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	-2.54107412409629	0.593138554489536	0.698028471011159	1/505	23/13181	596	BCL2	1
REACTOME_3108214	SUMOylation of DNA damage response and repair proteins	-5.20572234609077	0.597684481018239	0.702129836837609	2/505	52/13181	1912/79023	PHC2/NUP37	2
REACTOME_380108	Chemokine receptors bind chemokines	-0.0352527230353475	0.597684481018239	0.702129836837609	2/505	52/13181	729230/6373	CCR2/CXCL11	2
REACTOME_5628897	TP53 Regulates Metabolic Genes	-2.99758150194234	0.604944725101799	0.706237020099598	3/505	81/13181	9997/25824/5562	SCO2/PRDX5/PRKAA1	3
REACTOME_9013409	RHOJ GTPase cycle	-0.440643985540889	0.608114336529409	0.706237020099598	2/505	53/13181	4952/7112	OCRL/TMPO	2
REACTOME_1222556	ROS and RNS production in phagocytes	2.23993008659728	0.608753771846488	0.706237020099598	1/505	24/13181	155066	ATP6V0E2	1
REACTOME_174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	-2.50500516405816	0.608753771846488	0.706237020099598	1/505	24/13181	5925	RB1	1
REACTOME_418592	ADP signalling through P2Y purinoceptor 1	2.35854453007071	0.608753771846488	0.706237020099598	1/505	24/13181	2793	GNGT2	1
REACTOME_5357956	TNFR1-induced NFkappaB signaling pathway	-4.12608246603639	0.608753771846488	0.706237020099598	1/505	24/13181	7128	TNFAIP3	1
REACTOME_5678895	Defective CFTR causes cystic fibrosis	-2.89282593151664	0.608753771846488	0.706237020099598	1/505	24/13181	10956	OS9	1
REACTOME_5683826	Surfactant metabolism	2.25717009613093	0.608753771846488	0.706237020099598	1/505	24/13181	653509	SFTPA1	1
REACTOME_6783310	Fanconi Anemia Pathway	2.58735202987209	0.608753771846488	0.706237020099598	1/505	24/13181	22909	FAN1	1
REACTOME_69656	Cyclin A:Cdk2-associated events at S phase entry	-2.50500516405816	0.608753771846488	0.706237020099598	1/505	24/13181	5925	RB1	1
REACTOME_8940973	RUNX2 regulates osteoblast differentiation	-2.50500516405816	0.608753771846488	0.706237020099598	1/505	24/13181	5925	RB1	1
REACTOME_9619483	Activation of AMPK downstream of NMDARs	-4.34217843807103	0.608753771846488	0.706237020099598	1/505	24/13181	5562	PRKAA1	1
REACTOME_416476	G alpha (q) signalling events	4.18189937954376	0.615543672361552	0.713673823027887	6/505	166/13181	2358/2911/148/2793/2147/1909	FPR2/GRM1/ADRA1A/GNGT2/F2/EDNRA	6
REACTOME_9664422	FCGR3A-mediated phagocytosis	-3.59171360134774	0.618337460722139	0.716029828246148	2/505	54/13181	2534/8936	FYN/WASF1	2
REACTOME_1368108	BMAL1:CLOCK,NPAS2 activates circadian gene expression	2.37467228092476	0.623770823242515	0.717021796206621	1/505	25/13181	2155	F7	1
REACTOME_180024	DARPP-32 events	-2.8037657901009	0.623770823242515	0.717021796206621	1/505	25/13181	5573	PRKAR1A	1
REACTOME_1855204	Synthesis of IP3 and IP4 in the cytosol	2.64475252244379	0.623770823242515	0.717021796206621	1/505	25/13181	4952	OCRL	1
REACTOME_6807505	RNA polymerase II transcribes snRNA genes	-2.60792881544451	0.623770823242515	0.717021796206621	1/505	25/13181	5452	POU2F2	1
REACTOME_933541	TRAF6 mediated IRF7 activation	2.50190672916501	0.623770823242515	0.717021796206621	1/505	25/13181	3456	IFNB1	1
REACTOME_204005	COPII-mediated vesicle transport	-3.94333768764395	0.628354353558144	0.721408357062174	2/505	55/13181	10342/10484	TFG/SEC23A	2
REACTOME_1296041	Activation of G protein gated Potassium channels	2.35854453007071	0.638212578659247	0.726735098654988	1/505	26/13181	2793	GNGT2	1
REACTOME_166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	-3.02780646698975	0.638212578659247	0.726735098654988	1/505	26/13181	7099	TLR4	1
REACTOME_2682334	EPH-Ephrin signaling	-2.24223405100501	0.638212578659247	0.726735098654988	1/505	26/13181	2534	FYN	1
REACTOME_445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	-2.48780487804878	0.638212578659247	0.726735098654988	1/505	26/13181	64127	NOD2	1
REACTOME_912526	Interleukin receptor SHC signaling	-2.44442678954477	0.638212578659247	0.726735098654988	1/505	26/13181	3718	JAK3	1
REACTOME_9694548	Maturation of spike protein	2.47390164455391	0.638212578659247	0.726735098654988	1/505	26/13181	11282	MGAT4B	1
REACTOME_997272	Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits	2.35854453007071	0.638212578659247	0.726735098654988	1/505	26/13181	2793	GNGT2	1
REACTOME_8943724	Regulation of PTEN gene transcription	0.128035722518645	0.647772747640886	0.736506057190726	2/505	57/13181	5931/1912	RBBP7/PHC2	2
REACTOME_1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	-2.29184873281958	0.652101035350778	0.736527453565312	1/505	27/13181	112399	EGLN3	1
REACTOME_1483191	Synthesis of PC	-2.21982998331612	0.652101035350778	0.736527453565312	1/505	27/13181	1120	CHKB	1
REACTOME_201451	Signaling by BMP	-2.61257646778422	0.652101035350778	0.736527453565312	1/505	27/13181	6497	SKI	1
REACTOME_2122948	Activated NOTCH1 Transmits Signal to the Nucleus	-3.10308254548344	0.652101035350778	0.736527453565312	1/505	27/13181	23385	NCSTN	1
REACTOME_418990	Adherens junctions interactions	-3.35214904266307	0.652101035350778	0.736527453565312	1/505	27/13181	1013	CDH15	1
REACTOME_6784531	tRNA processing in the nucleus	-4.10105664574561	0.652101035350778	0.736527453565312	1/505	27/13181	79023	NUP37	1
REACTOME_9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	2.73929451020895	0.652101035350778	0.736527453565312	1/505	27/13181	91584	PLXNA4	1
REACTOME_114608	Platelet degranulation 	2.18172378038743	0.654154304136847	0.738402937122349	4/505	116/13181	6678/22927/3479/3082	SPARC/HABP4/IGF1/HGF	4
REACTOME_380972	Energy dependent regulation of mTOR by LKB1-AMPK	-4.34217843807103	0.665457351083472	0.745343949977317	1/505	28/13181	5562	PRKAA1	1
REACTOME_4608870	Asymmetric localization of PCP proteins	2.97564947962183	0.665457351083472	0.745343949977317	1/505	28/13181	50855	PARD6A	1
REACTOME_6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	2.35854453007071	0.665457351083472	0.745343949977317	1/505	28/13181	2793	GNGT2	1
REACTOME_9013148	CDC42 GTPase cycle	0.746954709513286	0.668828520341544	0.748450963239347	5/505	147/13181	50855/124056/27035/23263/7112	PARD6A/NOXO1/NOX1/MCF2L/TMPO	5
REACTOME_4086398	Ca2+ pathway	-0.674407772363668	0.675380236891707	0.754114445352414	2/505	60/13181	2793/3710	GNGT2/ITPR3	2
REACTOME_186763	Downstream signal transduction	-2.52168904425201	0.678301876112198	0.754114445352414	1/505	29/13181	5156	PDGFRA	1
REACTOME_2424491	DAP12 signaling	-2.24223405100501	0.678301876112198	0.754114445352414	1/505	29/13181	2534	FYN	1
REACTOME_389661	Glyoxylate metabolism and glycine degradation	-2.70842933185032	0.678301876112198	0.754114445352414	1/505	29/13181	64902	AGXT2	1
REACTOME_5357905	Regulation of TNFR1 signaling	-4.12608246603639	0.678301876112198	0.754114445352414	1/505	29/13181	7128	TNFAIP3	1
REACTOME_9616222	Transcriptional regulation of granulopoiesis	-4.91340271708906	0.678301876112198	0.754114445352414	1/505	29/13181	861	RUNX1	1
REACTOME_1169091	Activation of NF-kappaB in B cells	-2.57948677206642	0.69065418394092	0.763108942585324	1/505	30/13181	10892	MALT1	1
REACTOME_1592389	Activation of Matrix Metalloproteinases	2.56320012711528	0.69065418394092	0.763108942585324	1/505	30/13181	1215	CMA1	1
REACTOME_3000157	Laminin interactions	-3.65651068562803	0.69065418394092	0.763108942585324	1/505	30/13181	3915	LAMC1	1
REACTOME_936440	Negative regulators of DDX58/IFIH1 signaling	-4.12608246603639	0.69065418394092	0.763108942585324	1/505	30/13181	7128	TNFAIP3	1
REACTOME_6802952	Signaling by BRAF and RAF1 fusions	-0.661101449919924	0.701203384198026	0.77013150638734	2/505	63/13181	9444/10142	QKI/AKAP9	2
REACTOME_114604	GPVI-mediated activation cascade	-2.24223405100501	0.702533100913761	0.77013150638734	1/505	31/13181	2534	FYN	1
REACTOME_186797	Signaling by PDGF	-2.52168904425201	0.702533100913761	0.77013150638734	1/505	31/13181	5156	PDGFRA	1
REACTOME_202433	Generation of second messenger molecules	-2.46468578692302	0.702533100913761	0.77013150638734	1/505	31/13181	9398	CD101	1
REACTOME_2514859	Inactivation, recovery and regulation of the phototransduction cascade	2.45185508858346	0.702533100913761	0.77013150638734	1/505	31/13181	2986	GUCY2F	1
REACTOME_445095	Interaction between L1 and Ankyrins	-2.35477079526496	0.702533100913761	0.77013150638734	1/505	31/13181	3786	KCNQ3	1
REACTOME_5668541	TNFR2 non-canonical NF-kB pathway	2.24465718598554	0.702533100913761	0.77013150638734	1/505	31/13181	959	CD40LG	1
REACTOME_9662360	Sensory processing of sound by inner hair cells of the cochlea	-0.142606446642563	0.709423992843212	0.776545622442642	2/505	64/13181	776/3778	CACNA1D/KCNMA1	2
REACTOME_190861	Gap junction assembly	-2.32386589338206	0.713956734680951	0.777433339820555	1/505	32/13181	10804	GJB6	1
REACTOME_1912408	Pre-NOTCH Transcription and Translation	-4.91340271708906	0.713956734680951	0.777433339820555	1/505	32/13181	861	RUNX1	1
REACTOME_352230	Amino acid transport across the plasma membrane	2.28867085087789	0.713956734680951	0.777433339820555	1/505	32/13181	6539	SLC6A12	1
REACTOME_420092	Glucagon-type ligand receptors	2.35854453007071	0.713956734680951	0.777433339820555	1/505	32/13181	2793	GNGT2	1
REACTOME_5663213	RHO GTPases Activate WASPs and WAVEs	-2.49706045920394	0.713956734680951	0.777433339820555	1/505	32/13181	8936	WASF1	1
REACTOME_8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	-4.91340271708906	0.713956734680951	0.777433339820555	1/505	32/13181	861	RUNX1	1
REACTOME_9013026	RHOB GTPase cycle	-4.4857660084389	0.717454846390618	0.78034632970442	2/505	65/13181	23263/6093	MCF2L/ROCK1	2
REACTOME_9013408	RHOG GTPase cycle	-4.96069936335405	0.717454846390618	0.78034632970442	2/505	65/13181	23263/7112	MCF2L/TMPO	2
REACTOME_432720	Lysosome Vesicle Biogenesis	-2.62187177246365	0.724942501582322	0.785302162474656	1/505	33/13181	6456	SH3GL2	1
REACTOME_674695	RNA Polymerase II Pre-transcription Events	-2.76658457138317	0.73550715298945	0.792863215378536	1/505	34/13181	8148	TAF15	1
REACTOME_8939902	Regulation of RUNX2 expression and activity	2.72265035353937	0.73550715298945	0.792863215378536	1/505	34/13181	55294	FBXW7	1
REACTOME_9018519	Estrogen-dependent gene expression	-5.64943702142637	0.74043373274339	0.797488065057332	2/505	68/13181	861/596	RUNX1/BCL2	2
REACTOME_3769402	Deactivation of the beta-catenin transactivating complex	2.67835862397712	0.745666800645975	0.801059191551104	1/505	35/13181	64321	SOX17	1
REACTOME_3899300	SUMOylation of transcription cofactors	-2.76793517120839	0.745666800645975	0.801059191551104	1/505	35/13181	1912	PHC2	1
REACTOME_9013424	RHOV GTPase cycle	2.97564947962183	0.745666800645975	0.801059191551104	1/505	35/13181	50855	PARD6A	1
REACTOME_6785807	Interleukin-4 and Interleukin-13 signaling	-5.33968522754708	0.760749902565777	0.814470282929191	3/505	103/13181	3082/3718/596	HGF/JAK3/BCL2	3
REACTOME_109704	PI3K Cascade	2.58612060061969	0.764832478873903	0.814665756534242	1/505	37/13181	54106	TLR9	1
REACTOME_6811436	COPI-independent Golgi-to-ER retrograde traffic	-2.27373480575197	0.764832478873903	0.814665756534242	1/505	37/13181	25782	RAB3GAP2	1
REACTOME_9013420	RHOU GTPase cycle	2.97564947962183	0.764832478873903	0.814665756534242	1/505	37/13181	50855	PARD6A	1
REACTOME_9639288	Amino acids regulate mTORC1	2.23993008659728	0.764832478873903	0.814665756534242	1/505	37/13181	155066	ATP6V0E2	1
REACTOME_1660661	Sphingolipid de novo biosynthesis	-2.51326765710654	0.773867749580589	0.823356745450768	1/505	38/13181	91012	CERS5	1
REACTOME_3000178	ECM proteoglycans	-1.07531341938478	0.775180119379124	0.82407946353268	2/505	73/13181	6678/3915	SPARC/LAMC1	2
REACTOME_2122947	NOTCH1 Intracellular Domain Regulates Transcription	2.72265035353937	0.782556541063644	0.830017657094303	1/505	39/13181	55294	FBXW7	1
REACTOME_3000171	Non-integrin membrane-ECM interactions	-3.65651068562803	0.790912114550394	0.834173787015282	1/505	40/13181	3915	LAMC1	1
REACTOME_3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	2.75299912608247	0.790912114550394	0.834173787015282	1/505	40/13181	55466	DNAJA4	1
REACTOME_382556	ABC-family proteins mediated transport	-2.89282593151664	0.790912114550394	0.834173787015282	1/505	40/13181	10956	OS9	1
REACTOME_437239	Recycling pathway of L1	-2.62187177246365	0.790912114550394	0.834173787015282	1/505	40/13181	6456	SH3GL2	1
REACTOME_5607764	CLEC7A (Dectin-1) signaling	-2.57948677206642	0.790912114550394	0.834173787015282	1/505	40/13181	10892	MALT1	1
REACTOME_8853659	RET signaling	3.34233733216811	0.790912114550394	0.834173787015282	1/505	40/13181	2887	GRB10	1
REACTOME_611105	Respiratory electron transport	-0.166238716141067	0.794021523413549	0.836046185392031	2/505	76/13181	9997/4731	SCO2/NDUFV3	2
REACTOME_381038	XBP1(S) activates chaperone genes	-3.11007388575514	0.79894722467535	0.840291346791417	1/505	41/13181	5611	DNAJC3	1
REACTOME_2871837	FCERI mediated NF-kB activation	-2.57948677206642	0.806674138795514	0.844873192721764	1/505	42/13181	10892	MALT1	1
REACTOME_8854214	TBC/RABGAPs	-2.4068880591086	0.806674138795514	0.844873192721764	1/505	42/13181	5869	RAB5B	1
REACTOME_3371453	Regulation of HSF1-mediated heat shock response	-4.10105664574561	0.814104655570631	0.850287084707103	1/505	43/13181	79023	NUP37	1
REACTOME_5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	2.93687931993327	0.814104655570631	0.850287084707103	1/505	43/13181	5931	RBBP7	1
REACTOME_975634	Retinoid metabolism and transport	-2.68070231190911	0.814104655570631	0.850287084707103	1/505	43/13181	338328	GPIHBP1	1
REACTOME_1660662	Glycosphingolipid metabolism	-2.35369826010964	0.821250122836336	0.856085517567126	1/505	44/13181	2583	B4GALNT1	1
REACTOME_1169408	ISG15 antiviral mechanism	-4.10105664574561	0.83472914856435	0.866532743954156	1/505	46/13181	79023	NUP37	1
REACTOME_6811440	Retrograde transport at the Trans-Golgi-Network	-3.19003734011282	0.83472914856435	0.866532743954156	1/505	46/13181	3482	IGF2R	1
REACTOME_9010553	Regulation of expression of SLITs and ROBOs	-2.33840470326527	0.83472914856435	0.866532743954156	1/505	46/13181	6092	ROBO2	1
REACTOME_977225	Amyloid fiber formation	-3.10308254548344	0.83472914856435	0.866532743954156	1/505	46/13181	23385	NCSTN	1
REACTOME_418597	G alpha (z) signalling events	2.35854453007071	0.841083300066063	0.871204740564296	1/505	47/13181	2793	GNGT2	1
REACTOME_9013405	RHOD GTPase cycle	-3.22618574719949	0.841083300066063	0.871204740564296	1/505	47/13181	7112	TMPO	1
REACTOME_9020702	Interleukin-1 signaling	-2.48780487804878	0.847193619349346	0.876085810988322	1/505	48/13181	64127	NOD2	1
REACTOME_913709	O-linked glycosylation of mucins	-2.43787240804004	0.847193619349346	0.876085810988322	1/505	48/13181	56913	C1GALT1	1
REACTOME_2022090	Assembly of collagen fibrils and other multimeric structures	2.78346706919838	0.858719759809703	0.885083962961755	1/505	50/13181	1514	CTSL	1
REACTOME_6799198	Complex I biogenesis	-2.73961229840311	0.858719759809703	0.885083962961755	1/505	50/13181	4731	NDUFV3	1
REACTOME_141444	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal	-4.10105664574561	0.864153201382782	0.889465107363608	1/505	51/13181	79023	NUP37	1
REACTOME_383280	Nuclear Receptor transcription pathway	-2.34507825534281	0.864153201382782	0.889465107363608	1/505	51/13181	6257	RXRB	1
REACTOME_5578775	Ion homeostasis	-3.24843092079129	0.864153201382782	0.889465107363608	1/505	51/13181	3710	ITPR3	1
REACTOME_9707564	Cytoprotection by HMOX1	2.52025899737825	0.869378078252675	0.892400102164908	1/505	52/13181	9997	SCO2	1
REACTOME_936837	Ion transport by P-type ATPases	2.63966791133709	0.874402380978122	0.89657838900402	1/505	53/13181	286410	ATP11C	1
REACTOME_5610787	Hedgehog 'off' state	-2.8037657901009	0.879233794567858	0.899814661833191	1/505	54/13181	5573	PRKAR1A	1
REACTOME_72163	mRNA Splicing - Major Pathway	2.4446651306904	0.879233794567858	0.899814661833191	1/505	54/13181	23283	CSTF2T	1
REACTOME_9660821	ADORA2B mediated anti-inflammatory cytokines production	-1.71613998355923	0.879851792353404	0.900202105918041	3/505	130/13181	2793/5573/6019	GNGT2/PRKAR1A/RLN2	3
REACTOME_193648	NRAGE signals death through JNK	-3.31949630571224	0.883879710142112	0.902894312395551	1/505	55/13181	23263	MCF2L	1
REACTOME_202424	Downstream TCR signaling	-2.57948677206642	0.883879710142112	0.902894312395551	1/505	55/13181	10892	MALT1	1
REACTOME_2029482	Regulation of actin dynamics for phagocytic cup formation	-2.49706045920394	0.883879710142112	0.902894312395551	1/505	55/13181	8936	WASF1	1
REACTOME_9009391	Extra-nuclear estrogen signaling	2.35854453007071	0.883879710142112	0.902894312395551	1/505	55/13181	2793	GNGT2	1
REACTOME_8980692	RHOA GTPase cycle	-5.89310536752516	0.894979223484482	0.910969648159624	3/505	135/13181	23263/7112/6093	MCF2L/TMPO/ROCK1	3
REACTOME_9033241	Peroxisomal protein import	-2.921307698419	0.900746544923759	0.915105919728002	1/505	59/13181	3295	HSD17B4	1
REACTOME_1442490	Collagen degradation	2.78346706919838	0.904566312856506	0.918242261431011	1/505	60/13181	1514	CTSL	1
REACTOME_418555	G alpha (s) signalling events	-2.01115233847354	0.90582677371805	0.919273594920342	3/505	139/13181	2793/27115/6019	GNGT2/PDE7B/RLN2	3
REACTOME_375276	Peptide ligand-binding receptors	-0.620369652937153	0.912390813361806	0.924438010843544	2/505	104/13181	2147/1909	F2/EDNRA	2
REACTOME_1632852	Macroautophagy	-4.34217843807103	0.915167559212989	0.926003773584726	1/505	63/13181	5562	PRKAA1	1
REACTOME_68877	Mitotic Prometaphase	-4.10105664574561	0.918433330107748	0.928558569831979	1/505	64/13181	79023	NUP37	1
REACTOME_381340	Transcriptional regulation of white adipocyte differentiation	-3.16985778978311	0.930288801383659	0.938274112983519	1/505	68/13181	23389	MED13L	1
REACTOME_9648025	EML4 and NUDC in mitotic spindle formation	-4.10105664574561	0.930288801383659	0.938274112983519	1/505	68/13181	79023	NUP37	1
REACTOME_2500257	Resolution of Sister Chromatid Cohesion	-4.10105664574561	0.938037206837648	0.945328302790018	1/505	71/13181	79023	NUP37	1
REACTOME_6807878	COPI-mediated anterograde transport	-2.31341860649877	0.940424026864116	0.947479726958487	1/505	72/13181	1604	CD55	1
REACTOME_6805567	Keratinization	4.030912556397	0.945788565363942	0.951609581420503	2/505	119/13181	8687/337879	KRT38/KRTAP8-1	2
REACTOME_9013404	RAC2 GTPase cycle	-3.22618574719949	0.956494455150543	0.960582038292212	1/505	80/13181	7112	TMPO	1
REACTOME_216083	Integrin cell surface interactions	2.24978152061651	0.959783923949487	0.963370943419666	1/505	82/13181	3683	ITGAL	1
REACTOME_5663220	RHO GTPases Activate Formins	-4.10105664574561	0.968236158011979	0.971077074986674	1/505	88/13181	79023	NUP37	1
REACTOME_2467813	Separation of Sister Chromatids	-4.10105664574561	0.970639271383231	0.972968184591029	1/505	90/13181	79023	NUP37	1
REACTOME_6809371	Formation of the cornified envelope	2.37598315722571	0.984359687028472	0.984883561263186	1/505	106/13181	8687	KRT38	1
