ID	Description	NES	pvalue	p.adjust	GeneRatio	BgRatio	geneID	geneName	Count
REACTOME_159763	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	4.00121906191828	0.00973262694006223	0.24214005746191	2/226	9/13181	2155/2147	F7/F2	2
REACTOME_159740	Gamma-carboxylation of protein precursors	4.00121906191828	0.0120292695123071	0.24214005746191	2/226	10/13181	2155/2147	F7/F2	2
REACTOME_159782	Removal of aminoterminal propeptides from gamma-carboxylated proteins	4.00121906191828	0.0120292695123071	0.24214005746191	2/226	10/13181	2155/2147	F7/F2	2
REACTOME_5619039	Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	2.2961239414147	0.0171458918139746	0.24214005746191	1/226	1/13181	9990	SLC12A6	1
REACTOME_9717264	ASP-3026- resistant ALK mutants	2.50781989668471	0.0171458918139746	0.24214005746191	1/226	1/13181	238	ALK	1
REACTOME_9717301	NVP-TAE684-resistant ALK mutants	2.50781989668471	0.0171458918139746	0.24214005746191	1/226	1/13181	238	ALK	1
REACTOME_9717316	alectinib resistant ALK mutants	2.50781989668471	0.0171458918139746	0.24214005746191	1/226	1/13181	238	ALK	1
REACTOME_9717319	brigatinib-resistant ALK mutants	2.50781989668471	0.0171458918139746	0.24214005746191	1/226	1/13181	238	ALK	1
REACTOME_9717323	ceritinib-resistant ALK mutants	2.50781989668471	0.0171458918139746	0.24214005746191	1/226	1/13181	238	ALK	1
REACTOME_9717326	crizotinib-resistant ALK mutants	2.50781989668471	0.0171458918139746	0.24214005746191	1/226	1/13181	238	ALK	1
REACTOME_9717329	lorlatinib-resistant ALK mutants	2.50781989668471	0.0171458918139746	0.24214005746191	1/226	1/13181	238	ALK	1
REACTOME_1679131	Trafficking and processing of endosomal TLR	4.13018235098966	0.0172500335738227	0.24214005746191	2/226	12/13181	54106/1514	TLR9/CTSL	2
REACTOME_6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	3.88032568702179	0.0172500335738227	0.24214005746191	2/226	12/13181	843/58484	CASP10/NLRC4	2
REACTOME_9673324	WNT5:FZD7-mediated leishmania damping	3.85426423152751	0.0172500335738227	0.24214005746191	2/226	12/13181	124056/27035	NOXO1/NOX1	2
REACTOME_2559580	Oxidative Stress Induced Senescence	5.92068023926702	0.0173472367929254	0.24214005746191	4/226	58/13181	5931/1870/3456/50488	RBBP7/E2F2/IFNB1/MINK1	4
REACTOME_211935	Fatty acids	4.14096998267572	0.0232559829691829	0.24214005746191	2/226	14/13181	1580/1555	CYP4B1/CYP2B6	2
REACTOME_420499	Class C/3 (Metabotropic glutamate/pheromone receptors)	5.04509050545282	0.0270098577031874	0.24214005746191	3/226	38/13181	50834/2911/50839	TAS2R1/GRM1/TAS2R10	3
REACTOME_159418	Recycling of bile acids and salts	4.32740231462627	0.0299881740735154	0.24214005746191	2/226	16/13181	6579/80765	SLCO1A2/STARD5	2
REACTOME_9022699	MECP2 regulates neuronal receptors and channels	3.83401299701501	0.0299881740735154	0.24214005746191	2/226	16/13181	2904/4233	GRIN2B/MET	2
REACTOME_197264	Nicotinamide salvaging	3.91574598575588	0.0336090336945344	0.24214005746191	2/226	17/13181	9390/83594	SLC22A13/NUDT12	2
REACTOME_201556	Signaling by ALK	3.74744330893804	0.0336090336945344	0.24214005746191	2/226	17/13181	4613/238	MYCN/ALK	2
REACTOME_5620922	BBSome-mediated cargo-targeting to cilium	4.12404338007631	0.0336090336945344	0.24214005746191	2/226	17/13181	123016/84100	TTC8/ARL6	2
REACTOME_114294	Activation, translocation and oligomerization of BAX	3.1361298884285	0.0339990806189856	0.24214005746191	1/226	2/13181	581	BAX	1
REACTOME_162594	Early Phase of HIV Life Cycle	2.55380673720243	0.0339990806189856	0.24214005746191	1/226	2/13181	2237	FEN1	1
REACTOME_69166	Removal of the Flap Intermediate	2.55380673720243	0.0339990806189856	0.24214005746191	1/226	2/13181	2237	FEN1	1
REACTOME_844623	The IPAF inflammasome	2.62172364162658	0.0339990806189856	0.24214005746191	1/226	2/13181	58484	NLRC4	1
REACTOME_9033807	ABO blood group biosynthesis	2.73764841964457	0.0339990806189856	0.24214005746191	1/226	2/13181	2524	FUT2	1
REACTOME_9603505	NTRK3 as a dependence receptor	3.1361298884285	0.0339990806189856	0.24214005746191	1/226	2/13181	581	BAX	1
REACTOME_162588	Budding and maturation of HIV virion	3.86840084465539	0.0373907333082144	0.24214005746191	2/226	18/13181	137492/23327	VPS37A/NEDD4L	2
REACTOME_442982	Ras activation upon Ca2+ influx through NMDA receptor	3.69504539239148	0.0413267455860579	0.24214005746191	2/226	19/13181	1740/2904	DLG2/GRIN2B	2
REACTOME_438066	Unblocking of NMDA receptors, glutamate binding and activation	3.69504539239148	0.045410718007355	0.24214005746191	2/226	20/13181	1740/2904	DLG2/GRIN2B	2
REACTOME_9617324	Negative regulation of NMDA receptor-mediated neuronal transmission	3.69504539239148	0.045410718007355	0.24214005746191	2/226	20/13181	1740/2904	DLG2/GRIN2B	2
REACTOME_9620244	Long-term potentiation	3.69504539239148	0.0496364688273072	0.24214005746191	2/226	21/13181	1740/2904	DLG2/GRIN2B	2
REACTOME_1296053	Classical Kir channels	2.42552599804452	0.0505645414111636	0.24214005746191	1/226	3/13181	3770	KCNJ14	1
REACTOME_2644607	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	2.75060991672972	0.0505645414111636	0.24214005746191	1/226	3/13181	55294	FBXW7	1
REACTOME_500753	Pyrimidine biosynthesis	2.27627024675789	0.0505645414111636	0.24214005746191	1/226	3/13181	1723	DHODH	1
REACTOME_70688	Proline catabolism	3.07635512825175	0.0505645414111636	0.24214005746191	1/226	3/13181	5625	PRODH	1
REACTOME_8875791	MET activates STAT3	2.54024227537346	0.0505645414111636	0.24214005746191	1/226	3/13181	4233	MET	1
REACTOME_8981607	Intracellular oxygen transport	2.37647880853439	0.0505645414111636	0.24214005746191	1/226	3/13181	4151	MB	1
REACTOME_9657688	Defective factor XII causes hereditary angioedema	2.88471078267737	0.0505645414111636	0.24214005746191	1/226	3/13181	2147	F2	1
REACTOME_9672391	Defective F8 cleavage by thrombin	2.88471078267737	0.0505645414111636	0.24214005746191	1/226	3/13181	2147	F2	1
REACTOME_9678110	Attachment and Entry	2.80921158992343	0.0505645414111636	0.24214005746191	1/226	3/13181	1514	CTSL	1
REACTOME_6794361	Neurexins and neuroligins	4.63425113044771	0.0623553415150197	0.261743218038479	3/226	53/13181	1740/2911/2904	DLG2/GRM1/GRIN2B	3
REACTOME_5668599	RHO GTPases Activate NADPH Oxidases	3.85426423152751	0.0631050535916535	0.261743218038479	2/226	24/13181	124056/27035	NOXO1/NOX1	2
REACTOME_204626	Hypusine synthesis from eIF5A-lysine	2.1948571136508	0.0668471649990429	0.261743218038479	1/226	4/13181	1725	DHPS	1
REACTOME_2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	2.39570551812302	0.0668471649990429	0.261743218038479	1/226	4/13181	3479	IGF1	1
REACTOME_2564830	Cytosolic iron-sulfur cluster assembly	2.60638509763026	0.0668471649990429	0.261743218038479	1/226	4/13181	27158	NDOR1	1
REACTOME_3000497	Scavenging by Class H Receptors	2.21342565000636	0.0668471649990429	0.261743218038479	1/226	4/13181	6678	SPARC	1
REACTOME_5221030	TET1,2,3 and TDG demethylate DNA	2.73035602224438	0.0668471649990429	0.261743218038479	1/226	4/13181	200424	TET3	1
REACTOME_77108	Utilization of Ketone Bodies	2.30577092326792	0.0668471649990429	0.261743218038479	1/226	4/13181	622	BDH1	1
REACTOME_77595	Processing of Intronless Pre-mRNAs	2.46578925657987	0.0668471649990429	0.261743218038479	1/226	4/13181	23283	CSTF2T	1
REACTOME_888593	Reuptake of GABA	2.30437485543147	0.0668471649990429	0.261743218038479	1/226	4/13181	6539	SLC6A12	1
REACTOME_9032500	Activated NTRK2 signals through FYN	2.51876820419394	0.0668471649990429	0.261743218038479	1/226	4/13181	2904	GRIN2B	1
REACTOME_9640463	Wax biosynthesis	2.42788684198693	0.0668471649990429	0.261743218038479	1/226	4/13181	55711	FAR2	1
REACTOME_9694614	Attachment and Entry	2.80921158992343	0.0668471649990429	0.261743218038479	1/226	4/13181	1514	CTSL	1
REACTOME_400042	Adrenaline,noradrenaline inhibits insulin secretion	3.93997359500775	0.0776426832586763	0.273934504409581	2/226	27/13181	776/2793	CACNA1D/GNGT2	2
REACTOME_390471	Association of TriC/CCT with target proteins during biosynthesis	4.53303285852594	0.0827013313898709	0.273934504409581	2/226	28/13181	55294/26270	FBXW7/FBXO6	2
REACTOME_422356	Regulation of insulin secretion	3.99791199343689	0.0827013313898709	0.273934504409581	2/226	28/13181	776/777	CACNA1D/CACNA1E	2
REACTOME_111457	Release of apoptotic factors from the mitochondria	3.1361298884285	0.0828517594219174	0.273934504409581	1/226	5/13181	581	BAX	1
REACTOME_112303	Electric Transmission Across Gap Junctions	2.68993052096961	0.0828517594219174	0.273934504409581	1/226	5/13181	56666	PANX2	1
REACTOME_140834	Extrinsic Pathway of Fibrin Clot Formation	2.3949294222591	0.0828517594219174	0.273934504409581	1/226	5/13181	2155	F7	1
REACTOME_167826	The fatty acid cycling model	2.20644559872099	0.0828517594219174	0.273934504409581	1/226	5/13181	9016	SLC25A14	1
REACTOME_167827	The proton buffering model	2.20644559872099	0.0828517594219174	0.273934504409581	1/226	5/13181	9016	SLC25A14	1
REACTOME_168138	Toll Like Receptor 9 (TLR9) Cascade	2.64059669514201	0.0828517594219174	0.273934504409581	1/226	5/13181	54106	TLR9	1
REACTOME_74713	IRS activation	3.32051379207453	0.0828517594219174	0.273934504409581	1/226	5/13181	2887	GRB10	1
REACTOME_75157	FasL/ CD95L signaling	2.49839679877394	0.0828517594219174	0.273934504409581	1/226	5/13181	843	CASP10	1
REACTOME_8865999	MET activates PTPN11	2.54024227537346	0.0828517594219174	0.273934504409581	1/226	5/13181	4233	MET	1
REACTOME_8866376	Reelin signalling pathway	2.54927845298842	0.0828517594219174	0.273934504409581	1/226	5/13181	7436	VLDLR	1
REACTOME_8875513	MET interacts with TNS proteins	2.54024227537346	0.0828517594219174	0.273934504409581	1/226	5/13181	4233	MET	1
REACTOME_3214815	HDACs deacetylate histones	4.05088680104951	0.0878579956272089	0.287228062627414	2/226	29/13181	5931/79685	RBBP7/SAP30L	2
REACTOME_456926	Thrombin signalling through proteinase activated receptors (PARs)	3.91240832514879	0.0984462569996369	0.291885957536397	2/226	31/13181	2793/2147	GNGT2/F2	2
REACTOME_168179	Toll Like Receptor TLR1:TLR2 Cascade	2.34975692141932	0.0985830513444006	0.291885957536397	1/226	6/13181	653509	SFTPA1	1
REACTOME_2428928	IRS-related events triggered by IGF1R	2.39570551812302	0.0985830513444006	0.291885957536397	1/226	6/13181	3479	IGF1	1
REACTOME_5358493	Synthesis of diphthamide-EEF2	3.58257860587501	0.0985830513444006	0.291885957536397	1/226	6/13181	51611	DPH5	1
REACTOME_6798163	Choline catabolism	2.4210031543004	0.0985830513444006	0.291885957536397	1/226	6/13181	1757	SARDH	1
REACTOME_6806942	MET Receptor Activation	2.54024227537346	0.0985830513444006	0.291885957536397	1/226	6/13181	4233	MET	1
REACTOME_8851907	MET activates PI3K/AKT signaling	2.54024227537346	0.0985830513444006	0.291885957536397	1/226	6/13181	4233	MET	1
REACTOME_8949275	RUNX3 Regulates Immune Response and Cell Migration	2.23457334674389	0.0985830513444006	0.291885957536397	1/226	6/13181	3683	ITGAL	1
REACTOME_8964046	VLDL clearance	2.54927845298842	0.0985830513444006	0.291885957536397	1/226	6/13181	7436	VLDLR	1
REACTOME_9645460	Alpha-protein kinase 1 signaling pathway	2.29394690404917	0.0985830513444006	0.291885957536397	1/226	6/13181	92610	TIFA	1
REACTOME_352230	Amino acid transport across the plasma membrane	3.49488701990998	0.103868630510602	0.302933857229566	2/226	32/13181	6541/6539	SLC7A1/SLC6A12	2
REACTOME_110362	POLB-Dependent Long Patch Base Excision Repair	2.55380673720243	0.114045687427601	0.302933857229566	1/226	7/13181	2237	FEN1	1
REACTOME_174437	Removal of the Flap Intermediate from the C-strand	2.55380673720243	0.114045687427601	0.302933857229566	1/226	7/13181	2237	FEN1	1
REACTOME_174490	Membrane binding and targetting of GAG proteins	2.37809592042927	0.114045687427601	0.302933857229566	1/226	7/13181	137492	VPS37A	1
REACTOME_426117	Cation-coupled Chloride cotransporters	2.2961239414147	0.114045687427601	0.302933857229566	1/226	7/13181	9990	SLC12A6	1
REACTOME_444473	Formyl peptide receptors bind formyl peptides and many other ligands	2.4613318815684	0.114045687427601	0.302933857229566	1/226	7/13181	2358	FPR2	1
REACTOME_5688849	Defective CSF2RB causes SMDP5	2.34975692141932	0.114045687427601	0.302933857229566	1/226	7/13181	653509	SFTPA1	1
REACTOME_5688890	Defective CSF2RA causes SMDP4	2.34975692141932	0.114045687427601	0.302933857229566	1/226	7/13181	653509	SFTPA1	1
REACTOME_6814848	Glycerophospholipid catabolism	2.42839325119732	0.114045687427601	0.302933857229566	1/226	7/13181	51573	GDE1	1
REACTOME_9710421	Defective pyroptosis	3.00016156664602	0.114045687427601	0.302933857229566	1/226	7/13181	5931	RBBP7	1
REACTOME_975155	MyD88 dependent cascade initiated on endosome	2.64059669514201	0.114045687427601	0.302933857229566	1/226	7/13181	54106	TLR9	1
REACTOME_1433557	Signaling by SCF-KIT	4.46041186434129	0.120596082072494	0.315001289920471	2/226	35/13181	1215/2887	CMA1/GRB10	2
REACTOME_390522	Striated Muscle Contraction	3.86203300885713	0.120596082072494	0.315001289920471	2/226	35/13181	7111/7140	TMOD1/TNNT3	2
REACTOME_2672351	Stimuli-sensing channels	5.26966899193867	0.126122715172786	0.316136979354516	3/226	72/13181	203859/23327/51802	ANO5/NEDD4L/ASIC5	3
REACTOME_9609736	Assembly and cell surface presentation of NMDA receptors	3.69504539239148	0.12631144286084	0.316136979354516	2/226	36/13181	1740/2904	DLG2/GRIN2B	2
REACTOME_1236973	Cross-presentation of particulate exogenous antigens (phagosomes)	2.34560892349801	0.129244235677287	0.316136979354516	1/226	8/13181	3685	ITGAV	1
REACTOME_210747	Regulation of gene expression in early pancreatic precursor cells	2.55204042976991	0.129244235677287	0.316136979354516	1/226	8/13181	3651	PDX1	1
REACTOME_416550	Sema4D mediated inhibition of cell attachment and migration	2.54024227537346	0.129244235677287	0.316136979354516	1/226	8/13181	4233	MET	1
REACTOME_5651801	PCNA-Dependent Long Patch Base Excision Repair	2.55380673720243	0.129244235677287	0.316136979354516	1/226	8/13181	2237	FEN1	1
REACTOME_68689	CDC6 association with the ORC:origin complex	2.36170981627348	0.129244235677287	0.316136979354516	1/226	8/13181	1870	E2F2	1
REACTOME_75158	TRAIL  signaling	2.49839679877394	0.129244235677287	0.316136979354516	1/226	8/13181	843	CASP10	1
REACTOME_77111	Synthesis of Ketone Bodies	2.30577092326792	0.129244235677287	0.316136979354516	1/226	8/13181	622	BDH1	1
REACTOME_8850843	Phosphate bond hydrolysis by NTPDase proteins	2.86216881353532	0.129244235677287	0.316136979354516	1/226	8/13181	57089	ENTPD7	1
REACTOME_8939242	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	2.80921158992343	0.129244235677287	0.316136979354516	1/226	8/13181	1514	CTSL	1
REACTOME_9679191	Potential therapeutics for SARS	5.14598488986501	0.137759337186356	0.328641006714702	3/226	75/13181	5931/79685/54106	RBBP7/SAP30L/TLR9	3
REACTOME_2025928	Calcineurin activates NFAT	2.24740574813656	0.14418318676944	0.328641006714702	1/226	9/13181	4775	NFATC3	1
REACTOME_2428933	SHC-related events triggered by IGF1R	2.39570551812302	0.14418318676944	0.328641006714702	1/226	9/13181	3479	IGF1	1
REACTOME_390696	Adrenoceptors	2.19942174332764	0.14418318676944	0.328641006714702	1/226	9/13181	148	ADRA1A	1
REACTOME_5685939	HDR through MMEJ (alt-NHEJ)	2.55380673720243	0.14418318676944	0.328641006714702	1/226	9/13181	2237	FEN1	1
REACTOME_71288	Creatine metabolism	2.30437485543147	0.14418318676944	0.328641006714702	1/226	9/13181	6539	SLC6A12	1
REACTOME_74751	Insulin receptor signalling cascade	3.32051379207453	0.14418318676944	0.328641006714702	1/226	9/13181	2887	GRB10	1
REACTOME_9701898	STAT3 nuclear events downstream of ALK signaling	2.51480844424265	0.14418318676944	0.328641006714702	1/226	9/13181	29126	CD274	1
REACTOME_975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	2.64059669514201	0.14418318676944	0.328641006714702	1/226	9/13181	54106	TLR9	1
REACTOME_975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	2.64059669514201	0.14418318676944	0.328641006714702	1/226	9/13181	54106	TLR9	1
REACTOME_381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	5.80956403178345	0.154268826878601	0.341865600127927	4/226	121/13181	9210/7857/3479/2147	BMP15/SCG2/IGF1/F2	4
REACTOME_416476	G alpha (q) signalling events	6.37679338271126	0.15681363654562	0.341865600127927	5/226	166/13181	2358/2911/148/2793/2147	FPR2/GRM1/ADRA1A/GNGT2/F2	5
REACTOME_196025	Formation of annular gap junctions	2.31066028763399	0.158866955353566	0.341865600127927	1/226	10/13181	8218	CLTCL1	1
REACTOME_210990	PECAM1 interactions	2.34560892349801	0.158866955353566	0.341865600127927	1/226	10/13181	3685	ITGAV	1
REACTOME_388841	Costimulation by the CD28 family	2.23317709428392	0.158866955353566	0.341865600127927	1/226	10/13181	29851	ICOS	1
REACTOME_399997	Acetylcholine regulates insulin secretion	2.98190386550797	0.158866955353566	0.341865600127927	1/226	10/13181	4082	MARCKS	1
REACTOME_74749	Signal attenuation	3.32051379207453	0.158866955353566	0.341865600127927	1/226	10/13181	2887	GRB10	1
REACTOME_76009	Platelet Aggregation (Plug Formation)	2.88471078267737	0.158866955353566	0.341865600127927	1/226	10/13181	2147	F2	1
REACTOME_8875656	MET receptor recycling	2.54024227537346	0.158866955353566	0.341865600127927	1/226	10/13181	4233	MET	1
REACTOME_9690406	Transcriptional regulation of testis differentiation	2.54972879394035	0.158866955353566	0.341865600127927	1/226	10/13181	1761	DMRT1	1
REACTOME_9700645	ALK mutants bind TKIs	2.50781989668471	0.158866955353566	0.341865600127927	1/226	10/13181	238	ALK	1
REACTOME_5368286	Mitochondrial translation initiation	4.55016374037552	0.170422670465344	0.35567046735192	3/226	83/13181	64963/64960/64983	MRPS11/MRPS15/MRPL32	3
REACTOME_5389840	Mitochondrial translation elongation	4.55016374037552	0.170422670465344	0.35567046735192	3/226	83/13181	64963/64960/64983	MRPS11/MRPS15/MRPL32	3
REACTOME_5419276	Mitochondrial translation termination	4.55016374037552	0.170422670465344	0.35567046735192	3/226	83/13181	64963/64960/64983	MRPS11/MRPS15/MRPL32	3
REACTOME_1236977	Endosomal/Vacuolar pathway	2.80921158992343	0.173299881334137	0.35567046735192	1/226	11/13181	1514	CTSL	1
REACTOME_190873	Gap junction degradation	2.31066028763399	0.173299881334137	0.35567046735192	1/226	11/13181	8218	CLTCL1	1
REACTOME_211979	Eicosanoids	2.76936891888017	0.173299881334137	0.35567046735192	1/226	11/13181	1580	CYP4B1	1
REACTOME_211999	CYP2E1 reactions	2.69467373153354	0.173299881334137	0.35567046735192	1/226	11/13181	1555	CYP2B6	1
REACTOME_6803205	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	2.85903460958384	0.173299881334137	0.35567046735192	1/226	11/13181	79370	BCL2L14	1
REACTOME_8851680	Butyrophilin (BTN) family interactions	2.64107431962965	0.173299881334137	0.35567046735192	1/226	11/13181	11120	BTN2A1	1
REACTOME_8851805	MET activates RAS signaling	2.54024227537346	0.173299881334137	0.35567046735192	1/226	11/13181	4233	MET	1
REACTOME_8866427	VLDLR internalisation and degradation	2.54927845298842	0.173299881334137	0.35567046735192	1/226	11/13181	7436	VLDLR	1
REACTOME_8875360	InlB-mediated entry of Listeria monocytogenes into host cell	2.54024227537346	0.173299881334137	0.35567046735192	1/226	11/13181	4233	MET	1
REACTOME_8875555	MET activates RAP1 and RAC1	2.54024227537346	0.173299881334137	0.35567046735192	1/226	11/13181	4233	MET	1
REACTOME_9013423	RAC3 GTPase cycle	4.99903850797318	0.183202452397513	0.361163278098469	3/226	86/13181	4952/124056/27035	OCRL/NOXO1/NOX1	3
REACTOME_112308	Presynaptic depolarization and calcium channel opening	2.35419312759495	0.187486231130529	0.361163278098469	1/226	12/13181	777	CACNA1E	1
REACTOME_211958	Miscellaneous substrates	2.76936891888017	0.187486231130529	0.361163278098469	1/226	12/13181	1580	CYP4B1	1
REACTOME_212300	PRC2 methylates histones and DNA	3.00016156664602	0.187486231130529	0.361163278098469	1/226	12/13181	5931	RBBP7	1
REACTOME_2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	2.96118405471493	0.187486231130529	0.361163278098469	1/226	12/13181	50855	PARD6A	1
REACTOME_5607763	CLEC7A (Dectin-1) induces NFAT activation	2.24740574813656	0.187486231130529	0.361163278098469	1/226	12/13181	4775	NFATC3	1
REACTOME_73621	Pyrimidine catabolism	2.21959006272819	0.187486231130529	0.361163278098469	1/226	12/13181	51733	UPB1	1
REACTOME_879518	Transport of organic anions	2.43705013403977	0.187486231130529	0.361163278098469	1/226	12/13181	6579	SLCO1A2	1
REACTOME_9648895	Response of EIF2AK1 (HRI) to heme deficiency	3.32051379207453	0.187486231130529	0.361163278098469	1/226	12/13181	2887	GRB10	1
REACTOME_399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	2.71903556860323	0.20143019891582	0.372207976257494	1/226	13/13181	91584	PLXNA4	1
REACTOME_8878166	Transcriptional regulation by RUNX2	3.1361298884285	0.20143019891582	0.372207976257494	1/226	13/13181	581	BAX	1
REACTOME_933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	2.49839679877394	0.20143019891582	0.372207976257494	1/226	13/13181	843	CASP10	1
REACTOME_380259	Loss of Nlp from mitotic centrosomes	3.69109838133939	0.205071332064985	0.377909229821652	2/226	49/13181	22995/55722	CEP152/CEP72	2
REACTOME_380284	Loss of proteins required for interphase microtubule organization from the centrosome	3.69109838133939	0.205071332064985	0.377909229821652	2/226	49/13181	22995/55722	CEP152/CEP72	2
REACTOME_8854518	AURKA Activation by TPX2	3.69109838133939	0.211360845274836	0.384642639774738	2/226	50/13181	22995/55722	CEP152/CEP72	2
REACTOME_1855183	Synthesis of IP2, IP, and Ins in the cytosol	2.67200363872107	0.215135907834792	0.384642639774738	1/226	14/13181	4952	OCRL	1
REACTOME_391160	Signal regulatory protein family interactions	2.34975692141932	0.215135907834792	0.384642639774738	1/226	14/13181	653509	SFTPA1	1
REACTOME_427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	3.00016156664602	0.215135907834792	0.384642639774738	1/226	14/13181	5931	RBBP7	1
REACTOME_606279	Deposition of new CENPA-containing nucleosomes at the centromere	3.00016156664602	0.215135907834792	0.384642639774738	1/226	14/13181	5931	RBBP7	1
REACTOME_6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	3.1361298884285	0.215135907834792	0.384642639774738	1/226	14/13181	581	BAX	1
REACTOME_9725371	Nuclear events stimulated by ALK signaling in cancer	2.50781989668471	0.215135907834792	0.384642639774738	1/226	14/13181	238	ALK	1
REACTOME_983712	Ion channel transport	2.25515687793768	0.215135907834792	0.384642639774738	1/226	14/13181	155066	ATP6V0E2	1
REACTOME_380270	Recruitment of mitotic centrosome proteins and complexes	3.69109838133939	0.223994016462882	0.391240871519332	2/226	52/13181	22995/55722	CEP152/CEP72	2
REACTOME_156584	Cytosolic sulfonation of small molecules	3.38052333817283	0.228607411201492	0.391240871519332	1/226	15/13181	6822	SULT2A1	1
REACTOME_181429	Serotonin Neurotransmitter Release Cycle	3.0847976516741	0.228607411201492	0.391240871519332	1/226	15/13181	8541	PPFIA3	1
REACTOME_264642	Acetylcholine Neurotransmitter Release Cycle	3.0847976516741	0.228607411201492	0.391240871519332	1/226	15/13181	8541	PPFIA3	1
REACTOME_399954	Sema3A PAK dependent Axon repulsion	2.71903556860323	0.228607411201492	0.391240871519332	1/226	15/13181	91584	PLXNA4	1
REACTOME_399956	CRMPs in Sema3A signaling	2.71903556860323	0.228607411201492	0.391240871519332	1/226	15/13181	91584	PLXNA4	1
REACTOME_918233	TRAF3-dependent IRF activation pathway	2.40032785140264	0.228607411201492	0.391240871519332	1/226	15/13181	3456	IFNB1	1
REACTOME_975577	N-Glycan antennae elongation	2.49014888294138	0.228607411201492	0.391240871519332	1/226	15/13181	11282	MGAT4B	1
REACTOME_1660514	Synthesis of PIPs at the Golgi membrane	2.67200363872107	0.241848693676691	0.401441281611431	1/226	16/13181	4952	OCRL	1
REACTOME_181430	Norepinephrine Neurotransmitter Release Cycle	3.0847976516741	0.241848693676691	0.401441281611431	1/226	16/13181	8541	PPFIA3	1
REACTOME_2022377	Metabolism of Angiotensinogen to Angiotensins	2.56503494822908	0.241848693676691	0.401441281611431	1/226	16/13181	1215	CMA1	1
REACTOME_5676594	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	2.20865933940322	0.241848693676691	0.401441281611431	1/226	16/13181	959	CD40LG	1
REACTOME_6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	3.1361298884285	0.241848693676691	0.401441281611431	1/226	16/13181	581	BAX	1
REACTOME_77387	Insulin receptor recycling	2.25515687793768	0.241848693676691	0.401441281611431	1/226	16/13181	155066	ATP6V0E2	1
REACTOME_9604323	Negative regulation of NOTCH4 signaling	2.75060991672972	0.241848693676691	0.401441281611431	1/226	16/13181	55294	FBXW7	1
REACTOME_156588	Glucuronidation	2.36267250507695	0.254863672425575	0.411656288003305	1/226	17/13181	7366	UGT2B15	1
REACTOME_3232118	SUMOylation of transcription factors	2.39465257899885	0.254863672425575	0.411656288003305	1/226	17/13181	6670	SP3	1
REACTOME_422085	Synthesis, secretion, and deacylation of Ghrelin	2.39570551812302	0.254863672425575	0.411656288003305	1/226	17/13181	3479	IGF1	1
REACTOME_452723	Transcriptional regulation of pluripotent stem cells	2.22858794519319	0.254863672425575	0.411656288003305	1/226	17/13181	27086	FOXP1	1
REACTOME_5576886	Phase 4 - resting membrane potential	2.42552599804452	0.254863672425575	0.411656288003305	1/226	17/13181	3770	KCNJ14	1
REACTOME_6788467	IL-6-type cytokine receptor ligand interactions	2.44304901725477	0.254863672425575	0.411656288003305	1/226	17/13181	1489	CTF1	1
REACTOME_6807004	Negative regulation of MET activity	2.54024227537346	0.254863672425575	0.411656288003305	1/226	17/13181	4233	MET	1
REACTOME_8964315	G beta:gamma signalling through BTK	2.27774295253019	0.254863672425575	0.411656288003305	1/226	17/13181	2793	GNGT2	1
REACTOME_9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	2.36170981627348	0.254863672425575	0.411656288003305	1/226	17/13181	1870	E2F2	1
REACTOME_1566948	Elastic fibre formation	2.34560892349801	0.267656198256009	0.416808125528441	1/226	18/13181	3685	ITGAV	1
REACTOME_166016	Toll Like Receptor 4 (TLR4) Cascade	2.34975692141932	0.267656198256009	0.416808125528441	1/226	18/13181	653509	SFTPA1	1
REACTOME_210745	Regulation of gene expression in beta cells	2.55204042976991	0.267656198256009	0.416808125528441	1/226	18/13181	3651	PDX1	1
REACTOME_392851	Prostacyclin signalling through prostacyclin receptor	2.27774295253019	0.267656198256009	0.416808125528441	1/226	18/13181	2793	GNGT2	1
REACTOME_416700	Other semaphorin interactions	2.71903556860323	0.267656198256009	0.416808125528441	1/226	18/13181	91584	PLXNA4	1
REACTOME_8964616	G beta:gamma signalling through CDC42	2.27774295253019	0.267656198256009	0.416808125528441	1/226	18/13181	2793	GNGT2	1
REACTOME_9037629	Lewis blood group biosynthesis	2.73764841964457	0.267656198256009	0.416808125528441	1/226	18/13181	2524	FUT2	1
REACTOME_912446	Meiotic recombination	2.45195588154084	0.267656198256009	0.416808125528441	1/226	18/13181	27030	MLH3	1
REACTOME_9607240	FLT3 Signaling	3.32051379207453	0.267656198256009	0.416808125528441	1/226	18/13181	2887	GRB10	1
REACTOME_9704331	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	2.18165664351643	0.267656198256009	0.416808125528441	1/226	18/13181	116028	RMI2	1
REACTOME_9704646	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	2.18165664351643	0.267656198256009	0.416808125528441	1/226	18/13181	116028	RMI2	1
REACTOME_2565942	Regulation of PLK1 Activity at G2/M Transition	3.69109838133939	0.268534037162936	0.417565215387757	2/226	59/13181	22995/55722	CEP152/CEP72	2
REACTOME_140875	Common Pathway of Fibrin Clot Formation	2.88471078267737	0.280230056737672	0.424401867665071	1/226	19/13181	2147	F2	1
REACTOME_2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	2.72628959613406	0.280230056737672	0.424401867665071	1/226	19/13181	23327	NEDD4L	1
REACTOME_388844	Receptor-type tyrosine-protein phosphatases	3.0847976516741	0.280230056737672	0.424401867665071	1/226	19/13181	8541	PPFIA3	1
REACTOME_418217	G beta:gamma signalling through PLC beta	2.27774295253019	0.280230056737672	0.424401867665071	1/226	19/13181	2793	GNGT2	1
REACTOME_442660	Na+/Cl- dependent neurotransmitter transporters	2.30437485543147	0.280230056737672	0.424401867665071	1/226	19/13181	6539	SLC6A12	1
REACTOME_445144	Signal transduction by L1	2.34560892349801	0.280230056737672	0.424401867665071	1/226	19/13181	3685	ITGAV	1
REACTOME_5693579	Homologous DNA Pairing and Strand Exchange	2.18165664351643	0.280230056737672	0.424401867665071	1/226	19/13181	116028	RMI2	1
REACTOME_77289	Mitochondrial Fatty Acid Beta-Oxidation	3.18599203457413	0.280230056737672	0.424401867665071	1/226	19/13181	641371	ACOT1	1
REACTOME_380320	Recruitment of NuMA to mitotic centrosomes	3.69109838133939	0.287651229216993	0.43441157014334	2/226	62/13181	22995/55722	CEP152/CEP72	2
REACTOME_212676	Dopamine Neurotransmitter Release Cycle	3.0847976516741	0.292588969302426	0.43441157014334	1/226	20/13181	8541	PPFIA3	1
REACTOME_2142691	Synthesis of Leukotrienes (LT) and Eoxins (EX)	2.76936891888017	0.292588969302426	0.43441157014334	1/226	20/13181	1580	CYP4B1	1
REACTOME_2173788	Downregulation of TGF-beta receptor signaling	2.72628959613406	0.292588969302426	0.43441157014334	1/226	20/13181	23327	NEDD4L	1
REACTOME_500657	Presynaptic function of Kainate receptors	2.27774295253019	0.292588969302426	0.43441157014334	1/226	20/13181	2793	GNGT2	1
REACTOME_5686938	Regulation of TLR by endogenous ligand	2.34975692141932	0.292588969302426	0.43441157014334	1/226	20/13181	653509	SFTPA1	1
REACTOME_5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	2.18165664351643	0.292588969302426	0.43441157014334	1/226	20/13181	116028	RMI2	1
REACTOME_6804758	Regulation of TP53 Activity through Acetylation	3.00016156664602	0.292588969302426	0.43441157014334	1/226	20/13181	5931	RBBP7	1
REACTOME_917729	Endosomal Sorting Complex Required For Transport (ESCRT)	2.37809592042927	0.292588969302426	0.43441157014334	1/226	20/13181	137492	VPS37A	1
REACTOME_917977	Transferrin endocytosis and recycling	2.25515687793768	0.292588969302426	0.43441157014334	1/226	20/13181	155066	ATP6V0E2	1
REACTOME_389948	PD-1 signaling	2.51480844424265	0.304736594326182	0.442464521299225	1/226	21/13181	29126	CD274	1
REACTOME_392170	ADP signalling through P2Y purinoceptor 12	2.27774295253019	0.304736594326182	0.442464521299225	1/226	21/13181	2793	GNGT2	1
REACTOME_8849932	Synaptic adhesion-like molecules	2.51876820419394	0.304736594326182	0.442464521299225	1/226	21/13181	2904	GRIN2B	1
REACTOME_912694	Regulation of IFNA signaling	2.40032785140264	0.304736594326182	0.442464521299225	1/226	21/13181	3456	IFNB1	1
REACTOME_1461957	Beta defensins	2.31944680172791	0.316676528192616	0.451762319939117	1/226	22/13181	729230	CCR2	1
REACTOME_210500	Glutamate Neurotransmitter Release Cycle	3.0847976516741	0.316676528192616	0.451762319939117	1/226	22/13181	8541	PPFIA3	1
REACTOME_392451	G beta:gamma signalling through PI3Kgamma	2.27774295253019	0.316676528192616	0.451762319939117	1/226	22/13181	2793	GNGT2	1
REACTOME_427413	NoRC negatively regulates rRNA expression	2.34501561298431	0.316676528192616	0.451762319939117	1/226	22/13181	79685	SAP30L	1
REACTOME_428930	Thromboxane signalling through TP receptor	2.27774295253019	0.316676528192616	0.451762319939117	1/226	22/13181	2793	GNGT2	1
REACTOME_5685938	HDR through Single Strand Annealing (SSA)	2.18165664351643	0.316676528192616	0.451762319939117	1/226	22/13181	116028	RMI2	1
REACTOME_5693616	Presynaptic phase of homologous DNA pairing and strand exchange	2.18165664351643	0.316676528192616	0.451762319939117	1/226	22/13181	116028	RMI2	1
REACTOME_72187	mRNA 3'-end processing	2.46578925657987	0.316676528192616	0.451762319939117	1/226	22/13181	23283	CSTF2T	1
REACTOME_114608	Platelet degranulation 	4.58688218460875	0.32025684392379	0.455913441454662	3/226	116/13181	6678/22927/3479	SPARC/HABP4/IGF1	3
REACTOME_140837	Intrinsic Pathway of Fibrin Clot Formation	2.88471078267737	0.328412306339016	0.460771048783763	1/226	23/13181	2147	F2	1
REACTOME_202040	G-protein activation	2.27774295253019	0.328412306339016	0.460771048783763	1/226	23/13181	2793	GNGT2	1
REACTOME_211981	Xenobiotics	2.69467373153354	0.328412306339016	0.460771048783763	1/226	23/13181	1555	CYP2B6	1
REACTOME_3214858	RMTs methylate histone arginines	3.00016156664602	0.328412306339016	0.460771048783763	1/226	23/13181	5931	RBBP7	1
REACTOME_73762	RNA Polymerase I Transcription Initiation	3.00016156664602	0.328412306339016	0.460771048783763	1/226	23/13181	5931	RBBP7	1
REACTOME_198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	4.33858166042694	0.329660591068615	0.462204540054965	3/226	118/13181	3812/959/3683	KIR3DL2/CD40LG/ITGAL	3
REACTOME_1222556	ROS and RNS production in phagocytes	2.25515687793768	0.339947404284554	0.46825976012187	1/226	24/13181	155066	ATP6V0E2	1
REACTOME_418592	ADP signalling through P2Y purinoceptor 1	2.27774295253019	0.339947404284554	0.46825976012187	1/226	24/13181	2793	GNGT2	1
REACTOME_449836	Other interleukin signaling	2.68970656508821	0.339947404284554	0.46825976012187	1/226	24/13181	3603	IL16	1
REACTOME_5620971	Pyroptosis	3.1361298884285	0.339947404284554	0.46825976012187	1/226	24/13181	581	BAX	1
REACTOME_5683826	Surfactant metabolism	2.34975692141932	0.339947404284554	0.46825976012187	1/226	24/13181	653509	SFTPA1	1
REACTOME_6783310	Fanconi Anemia Pathway	2.5970094867609	0.339947404284554	0.46825976012187	1/226	24/13181	22909	FAN1	1
REACTOME_73856	RNA Polymerase II Transcription Termination	2.46578925657987	0.339947404284554	0.46825976012187	1/226	24/13181	23283	CSTF2T	1
REACTOME_1368108	BMAL1:CLOCK,NPAS2 activates circadian gene expression	2.3949294222591	0.351285238641298	0.473330176240587	1/226	25/13181	2155	F7	1
REACTOME_1855204	Synthesis of IP3 and IP4 in the cytosol	2.67200363872107	0.351285238641298	0.473330176240587	1/226	25/13181	4952	OCRL	1
REACTOME_3000170	Syndecan interactions	2.34560892349801	0.351285238641298	0.473330176240587	1/226	25/13181	3685	ITGAV	1
REACTOME_5685942	HDR through Homologous Recombination (HRR)	2.18165664351643	0.351285238641298	0.473330176240587	1/226	25/13181	116028	RMI2	1
REACTOME_5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	2.18165664351643	0.351285238641298	0.473330176240587	1/226	25/13181	116028	RMI2	1
REACTOME_933541	TRAF6 mediated IRF7 activation	2.40032785140264	0.351285238641298	0.473330176240587	1/226	25/13181	3456	IFNB1	1
REACTOME_9615710	Late endosomal microautophagy	2.37809592042927	0.351285238641298	0.473330176240587	1/226	25/13181	137492	VPS37A	1
REACTOME_3000178	ECM proteoglycans	3.45510211517712	0.356965021239384	0.480348709319488	2/226	73/13181	3685/6678	ITGAV/SPARC	2
REACTOME_1296041	Activation of G protein gated Potassium channels	2.27774295253019	0.362429168108238	0.480845954012211	1/226	26/13181	2793	GNGT2	1
REACTOME_182971	EGFR downregulation	3.05757446426583	0.362429168108238	0.480845954012211	1/226	26/13181	5774	PTPN3	1
REACTOME_9694548	Maturation of spike protein	2.49014888294138	0.362429168108238	0.480845954012211	1/226	26/13181	11282	MGAT4B	1
REACTOME_997272	Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits	2.27774295253019	0.362429168108238	0.480845954012211	1/226	26/13181	2793	GNGT2	1
REACTOME_5673001	RAF/MAP kinase cascade	4.77875120176321	0.367198831012968	0.486103579017817	3/226	126/13181	1740/2904/4233	DLG2/GRIN2B/MET	3
REACTOME_2219530	Constitutive Signaling by Aberrant PI3K in Cancer	3.61757540874566	0.369338374277039	0.487332238435801	2/226	75/13181	29851/4233	ICOS/MET	2
REACTOME_9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	2.71903556860323	0.373382494448606	0.487332238435801	1/226	27/13181	91584	PLXNA4	1
REACTOME_5620912	Anchoring of the basal body to the plasma membrane	3.69109838133939	0.375490293876072	0.489769948534006	2/226	76/13181	22995/55722	CEP152/CEP72	2
REACTOME_416482	G alpha (12/13) signalling events	3.3930563502536	0.381617684035543	0.492869726691569	2/226	77/13181	148/2793	ADRA1A/GNGT2	2
REACTOME_3295583	TRP channels	2.24890940061269	0.384148463450782	0.492869726691569	1/226	28/13181	56302	TRPV5	1
REACTOME_420029	Tight junction interactions	2.96118405471493	0.384148463450782	0.492869726691569	1/226	28/13181	50855	PARD6A	1
REACTOME_4608870	Asymmetric localization of PCP proteins	2.96118405471493	0.384148463450782	0.492869726691569	1/226	28/13181	50855	PARD6A	1
REACTOME_525793	Myogenesis	2.34363679425852	0.384148463450782	0.492869726691569	1/226	28/13181	4654	MYOD1	1
REACTOME_6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	2.27774295253019	0.384148463450782	0.492869726691569	1/226	28/13181	2793	GNGT2	1
REACTOME_8953750	Transcriptional Regulation by E2F6	3.00016156664602	0.384148463450782	0.492869726691569	1/226	28/13181	5931	RBBP7	1
REACTOME_1474228	Degradation of the extracellular matrix	4.77898622054604	0.393795048490236	0.501713235128365	2/226	79/13181	1514/6650	CTSL/CAPN15	2
REACTOME_202733	Cell surface interactions at the vascular wall	3.87969188181878	0.393795048490236	0.501713235128365	2/226	79/13181	3683/2147	ITGAL/F2	2
REACTOME_877300	Interferon gamma signaling	4.36865846333955	0.393795048490236	0.501713235128365	2/226	79/13181	4261/81603	CIITA/TRIM8	2
REACTOME_2559585	Oncogene Induced Senescence	2.36170981627348	0.394730265873052	0.501713235128365	1/226	29/13181	1870	E2F2	1
REACTOME_1251985	Nuclear signaling by ERBB4	2.21342565000636	0.405131038372496	0.510480122470595	1/226	30/13181	6678	SPARC	1
REACTOME_1592389	Activation of Matrix Metalloproteinases	2.56503494822908	0.405131038372496	0.510480122470595	1/226	30/13181	1215	CMA1	1
REACTOME_3000157	Laminin interactions	2.34560892349801	0.405131038372496	0.510480122470595	1/226	30/13181	3685	ITGAV	1
REACTOME_8874081	MET activates PTK2 signaling	2.54024227537346	0.405131038372496	0.510480122470595	1/226	30/13181	4233	MET	1
REACTOME_216083	Integrin cell surface interactions	3.47112907232143	0.411854230991518	0.517991757843833	2/226	82/13181	3685/3683	ITGAV/ITGAL	2
REACTOME_2514859	Inactivation, recovery and regulation of the phototransduction cascade	2.38052462800564	0.415353864418258	0.518556844194154	1/226	31/13181	2986	GUCY2F	1
REACTOME_2871809	FCERI mediated Ca+2 mobilization	2.24740574813656	0.415353864418258	0.518556844194154	1/226	31/13181	4775	NFATC3	1
REACTOME_5668541	TNFR2 non-canonical NF-kB pathway	2.20865933940322	0.415353864418258	0.518556844194154	1/226	31/13181	959	CD40LG	1
REACTOME_69473	G2/M DNA damage checkpoint	2.18165664351643	0.415353864418258	0.518556844194154	1/226	31/13181	116028	RMI2	1
REACTOME_420092	Glucagon-type ligand receptors	2.27774295253019	0.425401775189473	0.528513776727482	1/226	32/13181	2793	GNGT2	1
REACTOME_3299685	Detoxification of Reactive Oxygen Species	2.53866134089716	0.444984719456919	0.544093690318704	1/226	34/13181	79400	NOX5	1
REACTOME_5693607	Processing of DNA double-strand break ends	2.18165664351643	0.444984719456919	0.544093690318704	1/226	34/13181	116028	RMI2	1
REACTOME_8939902	Regulation of RUNX2 expression and activity	2.75060991672972	0.444984719456919	0.544093690318704	1/226	34/13181	55294	FBXW7	1
REACTOME_3214841	PKMTs methylate histone lysines	3.00016156664602	0.454525561732931	0.551595565696121	1/226	35/13181	5931	RBBP7	1
REACTOME_3769402	Deactivation of the beta-catenin transactivating complex	2.69415494341814	0.454525561732931	0.551595565696121	1/226	35/13181	64321	SOX17	1
REACTOME_9013424	RHOV GTPase cycle	2.96118405471493	0.454525561732931	0.551595565696121	1/226	35/13181	50855	PARD6A	1
REACTOME_9013148	CDC42 GTPase cycle	5.18538463728826	0.463296956046445	0.559526888855912	3/226	147/13181	50855/124056/27035	PARD6A/NOXO1/NOX1	3
REACTOME_2129379	Molecules associated with elastic fibres	2.34560892349801	0.46390310798642	0.559526888855912	1/226	36/13181	3685	ITGAV	1
REACTOME_1257604	PIP3 activates AKT signaling	3.61757540874566	0.464352462173068	0.559526888855912	2/226	91/13181	29851/4233	ICOS/MET	2
REACTOME_109704	PI3K Cascade	2.64059669514201	0.473120140895896	0.565415985604938	1/226	37/13181	54106	TLR9	1
REACTOME_5675221	Negative regulation of MAPK pathway	3.05757446426583	0.473120140895896	0.565415985604938	1/226	37/13181	5774	PTPN3	1
REACTOME_9013420	RHOU GTPase cycle	2.96118405471493	0.473120140895896	0.565415985604938	1/226	37/13181	50855	PARD6A	1
REACTOME_9639288	Amino acids regulate mTORC1	2.25515687793768	0.473120140895896	0.565415985604938	1/226	37/13181	155066	ATP6V0E2	1
REACTOME_9725370	Signaling by ALK fusions and activated point mutants	2.50781989668471	0.473120140895896	0.565415985604938	1/226	37/13181	238	ALK	1
REACTOME_2122947	NOTCH1 Intracellular Domain Regulates Transcription	2.75060991672972	0.491083562140856	0.580087126095742	1/226	39/13181	55294	FBXW7	1
REACTOME_3928662	EPHB-mediated forward signaling	2.51876820419394	0.491083562140856	0.580087126095742	1/226	39/13181	2904	GRIN2B	1
REACTOME_69231	Cyclin D associated events in G1	2.36170981627348	0.491083562140856	0.580087126095742	1/226	39/13181	1870	E2F2	1
REACTOME_1989781	PPARA activates gene expression	4.44393062537837	0.497791605768451	0.583665699616937	2/226	97/13181	6822/2274	SULT2A1/FHL2	2
REACTOME_3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	2.7017570791408	0.499835282956269	0.583665699616937	1/226	40/13181	55466	DNAJA4	1
REACTOME_419037	NCAM1 interactions	2.92108337431886	0.499835282956269	0.583665699616937	1/226	40/13181	776	CACNA1D	1
REACTOME_8853659	RET signaling	3.32051379207453	0.499835282956269	0.583665699616937	1/226	40/13181	2887	GRB10	1
REACTOME_9696264	RND3 GTPase cycle	2.2366277615671	0.499835282956269	0.583665699616937	1/226	40/13181	390	RND3	1
REACTOME_381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	2.27774295253019	0.508437156942411	0.589560242169057	1/226	41/13181	2793	GNGT2	1
REACTOME_977606	Regulation of Complement cascade	2.88471078267737	0.508437156942411	0.589560242169057	1/226	41/13181	2147	F2	1
REACTOME_432040	Vasopressin regulates renal water homeostasis via Aquaporins	2.27774295253019	0.516891738565776	0.595403244875315	1/226	42/13181	2793	GNGT2	1
REACTOME_1296072	Voltage gated Potassium channels	2.81129437718449	0.525201538937504	0.601916370467701	1/226	43/13181	3788	KCNS2	1
REACTOME_5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	3.00016156664602	0.525201538937504	0.601916370467701	1/226	43/13181	5931	RBBP7	1
REACTOME_6783783	Interleukin-10 signaling	2.31944680172791	0.525201538937504	0.601916370467701	1/226	43/13181	729230	CCR2	1
REACTOME_6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	3.61757540874566	0.529875228069743	0.606931760394315	2/226	103/13181	29851/4233	ICOS/MET	2
REACTOME_8957275	Post-translational protein phosphorylation	3.66395846548257	0.535086215228468	0.610842685543411	2/226	104/13181	9210/7857	BMP15/SCG2	2
REACTOME_5620924	Intraflagellar transport	2.65588053307167	0.549286728622435	0.624259011916305	1/226	46/13181	112752	IFT43	1
REACTOME_400253	Circadian Clock	2.37086988410145	0.557041673375486	0.6309633612915	1/226	47/13181	1407	CRY1	1
REACTOME_418597	G alpha (z) signalling events	2.27774295253019	0.557041673375486	0.6309633612915	1/226	47/13181	2793	GNGT2	1
REACTOME_9013149	RAC1 GTPase cycle	5.18538463728826	0.564619427126637	0.635714175124182	3/226	171/13181	50855/124056/27035	PARD6A/NOXO1/NOX1	3
REACTOME_2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	2.75060991672972	0.572155276383919	0.642729495497354	1/226	49/13181	55294	FBXW7	1
REACTOME_2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	2.75060991672972	0.572155276383919	0.642729495497354	1/226	49/13181	55294	FBXW7	1
REACTOME_1660499	Synthesis of PIPs at the plasma membrane	2.67200363872107	0.579518428039206	0.647435702738215	1/226	50/13181	4952	OCRL	1
REACTOME_2022090	Assembly of collagen fibrils and other multimeric structures	2.80921158992343	0.579518428039206	0.647435702738215	1/226	50/13181	1514	CTSL	1
REACTOME_3928665	EPH-ephrin mediated repulsion of cells	2.31066028763399	0.579518428039206	0.647435702738215	1/226	50/13181	8218	CLTCL1	1
REACTOME_141444	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal	2.2836888115787	0.586755411914246	0.653373930297522	1/226	51/13181	220134	SKA1	1
REACTOME_380108	Chemokine receptors bind chemokines	2.31944680172791	0.593868380452508	0.659494554231418	1/226	52/13181	729230	CCR2	1
REACTOME_9707564	Cytoprotection by HMOX1	2.61258585849494	0.593868380452508	0.659494554231418	1/226	52/13181	9997	SCO2	1
REACTOME_432722	Golgi Associated Vesicle Biogenesis	2.67200363872107	0.600859449537566	0.662927678235064	1/226	53/13181	4952	OCRL	1
REACTOME_9013409	RHOJ GTPase cycle	2.67200363872107	0.600859449537566	0.662927678235064	1/226	53/13181	4952	OCRL	1
REACTOME_936837	Ion transport by P-type ATPases	2.58856998082515	0.600859449537566	0.662927678235064	1/226	53/13181	286410	ATP11C	1
REACTOME_72163	mRNA Splicing - Major Pathway	2.46578925657987	0.60773069911134	0.668700445624128	1/226	54/13181	23283	CSTF2T	1
REACTOME_6805567	Keratinization	4.0102839157258	0.608435214722616	0.669114737484709	2/226	119/13181	8687/337879	KRT38/KRTAP8-1	2
REACTOME_9009391	Extra-nuclear estrogen signaling	2.27774295253019	0.61448417378193	0.674312917974792	1/226	55/13181	2793	GNGT2	1
REACTOME_8856828	Clathrin-mediated endocytosis	3.77615312926506	0.622010420223607	0.680011391884329	2/226	122/13181	8218/4952	CLTCL1/OCRL	2
REACTOME_8943724	Regulation of PTEN gene transcription	3.00016156664602	0.627645803752403	0.683607816153178	1/226	57/13181	5931	RBBP7	1
REACTOME_4420097	VEGFA-VEGFR2 Pathway	2.34560892349801	0.634057876927651	0.68838641241746	1/226	58/13181	3685	ITGAV	1
REACTOME_6804756	Regulation of TP53 Activity through Phosphorylation	2.18165664351643	0.634057876927651	0.68838641241746	1/226	58/13181	116028	RMI2	1
REACTOME_1442490	Collagen degradation	2.80921158992343	0.646554085961753	0.697130198394279	1/226	60/13181	1514	CTSL	1
REACTOME_4086398	Ca2+ pathway	2.27774295253019	0.646554085961753	0.697130198394279	1/226	60/13181	2793	GNGT2	1
REACTOME_909733	Interferon alpha/beta signaling	2.40032785140264	0.646554085961753	0.697130198394279	1/226	60/13181	3456	IFNB1	1
REACTOME_6802952	Signaling by BRAF and RAF1 fusions	2.23646517037185	0.66450623157791	0.709136609623159	1/226	63/13181	9444	QKI	1
REACTOME_68877	Mitotic Prometaphase	2.2836888115787	0.670286197400703	0.713665888672982	1/226	64/13181	220134	SKA1	1
REACTOME_9662360	Sensory processing of sound by inner hair cells of the cochlea	2.92108337431886	0.670286197400703	0.713665888672982	1/226	64/13181	776	CACNA1D	1
REACTOME_9648025	EML4 and NUDC in mitotic spindle formation	2.2836888115787	0.692431394077718	0.731896395812718	1/226	68/13181	220134	SKA1	1
REACTOME_2500257	Resolution of Sister Chromatid Cohesion	2.2836888115787	0.708062715914413	0.746870703446434	1/226	71/13181	220134	SKA1	1
REACTOME_611105	Respiratory electron transport	2.61258585849494	0.732376729608857	0.766965363656092	1/226	76/13181	9997	SCO2	1
REACTOME_983231	Factors involved in megakaryocyte development and platelet production	2.40032785140264	0.741527985433847	0.77456072211216	1/226	78/13181	3456	IFNB1	1
REACTOME_8876198	RAB GEFs exchange GTP for GDP on RABs	2.27325790621943	0.75036765560444	0.781393577045971	1/226	80/13181	84079	ANKRD27	1
REACTOME_5628897	TP53 Regulates Metabolic Genes	2.61258585849494	0.754673961217248	0.784276556741307	1/226	81/13181	9997	SCO2	1
REACTOME_5663220	RHO GTPases Activate Formins	2.2836888115787	0.782816471457448	0.80898966655177	1/226	88/13181	220134	SKA1	1
REACTOME_2467813	Separation of Sister Chromatids	2.2836888115787	0.790249710816537	0.813785668887297	1/226	90/13181	220134	SKA1	1
REACTOME_8856825	Cargo recognition for clathrin-mediated endocytosis	2.31066028763399	0.790249710816537	0.813785668887297	1/226	90/13181	8218	CLTCL1	1
REACTOME_2132295	MHC class II antigen presentation	2.80921158992343	0.829820323487425	0.845571158798375	1/226	102/13181	1514	CTSL	1
REACTOME_375276	Peptide ligand-binding receptors	2.88471078267737	0.835651007759827	0.850662702510004	1/226	104/13181	2147	F2	1
REACTOME_6809371	Formation of the cornified envelope	2.33664142941092	0.841282775251455	0.855541805340462	1/226	106/13181	8687	KRT38	1
REACTOME_9660821	ADORA2B mediated anti-inflammatory cytokines production	2.27774295253019	0.895593923167265	0.901337742112097	1/226	130/13181	2793	GNGT2	1
REACTOME_8980692	RHOA GTPase cycle	2.26034642361033	0.904327343665027	0.908334702647295	1/226	135/13181	23197	FAF2	1
REACTOME_418555	G alpha (s) signalling events	2.27774295253019	0.910787252525781	0.913923263724837	1/226	139/13181	2793	GNGT2	1
